{"id":"https://openalex.org/W3134989152","doi":"https://doi.org/10.1155/2021/8813498","title":"No Early Effect of Intrathecal Rituximab in Progressive Multiple Sclerosis (EFFRITE Clinical Trial)","display_name":"No Early Effect of Intrathecal Rituximab in Progressive Multiple Sclerosis (EFFRITE Clinical Trial)","publication_year":2021,"publication_date":"2021-03-08","ids":{"openalex":"https://openalex.org/W3134989152","doi":"https://doi.org/10.1155/2021/8813498","mag":"3134989152","pmid":"https://pubmed.ncbi.nlm.nih.gov/33763241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7964121"},"language":"en","primary_location":{"id":"doi:10.1155/2021/8813498","doi":"https://doi.org/10.1155/2021/8813498","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8813498","pdf_url":"https://downloads.hindawi.com/journals/msi/2021/8813498.pdf","source":{"id":"https://openalex.org/S204941185","display_name":"Multiple Sclerosis International","issn_l":"2090-2654","issn":["2090-2654","2090-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/msi/2021/8813498.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087387199","display_name":"Micka\u00ebl Bonnan","orcid":"https://orcid.org/0000-0003-1401-3921","observed_orcids":["https://orcid.org/0000-0003-1401-3921"]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mickael Bonnan","raw_affiliation_strings":["Service de Neurologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":"https://orcid.org/0000-0003-1401-3921","affiliations":[{"raw_affiliation_string":"Service de Neurologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112615815","display_name":"Sylvie Ferrari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Ferrari","raw_affiliation_strings":["Pharmacie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018918838","display_name":"Henri Courtade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Henri Courtade","raw_affiliation_strings":["Biologie M\u00e9dicale, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biologie M\u00e9dicale, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075358157","display_name":"Paul Money","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Money","raw_affiliation_strings":["Service de Radiologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Radiologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075333549","display_name":"Pauline Desblache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pauline Desblache","raw_affiliation_strings":["Service de Radiologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Radiologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103496641","display_name":"Bruno Thierry Barroso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Barroso","raw_affiliation_strings":["Service de Neurologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047674947","display_name":"St\u00e9phane Debeugny","orcid":"https://orcid.org/0000-0001-7688-5173","observed_orcids":["https://orcid.org/0000-0001-7688-5173"]},"institutions":[{"id":"https://openalex.org/I4210103922","display_name":"Centre Hospitalier De Pau","ror":"https://ror.org/01e6msy72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210103922"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Debeugny","raw_affiliation_strings":["D\u00e9partement de Recherche Clinique, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France"],"raw_orcid":"https://orcid.org/0000-0001-7688-5173","affiliations":[{"raw_affiliation_string":"D\u00e9partement de Recherche Clinique, H\u00f4pital F. Mitterrand, 4 bd Hauterive, 64046 Pau, France","institution_ids":["https://openalex.org/I4210103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087387199"],"corresponding_institution_ids":["https://openalex.org/I4210103922"],"apc_list":{"value":950,"currency":"USD","value_usd":950},"apc_paid":{"value":950,"currency":"USD","value_usd":950},"fwci":2.1242,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88413737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-multiple-sclerosis","display_name":"progressive multiple sclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9459999799728394},{"id":"https://openalex.org/keywords/axonal-loss","display_name":"axonal loss","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.7409999966621399},{"id":"https://openalex.org/keywords/leptomeningeal-enhancement","display_name":"leptomeningeal enhancement","score":0.8840000033378601},{"id":"https://openalex.org/keywords/intrathecal-drug-delivery","display_name":"intrathecal drug delivery","score":0.7110000252723694},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.911392092704773},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.8254247903823853},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7697833776473999},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5390891432762146},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.515526533126831},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5084144473075867},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46743741631507874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4624301493167877},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4550221860408783},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3548086881637573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24451962113380432},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.06992697715759277}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/8813498","doi":"https://doi.org/10.1155/2021/8813498","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8813498","pdf_url":"https://downloads.hindawi.com/journals/msi/2021/8813498.pdf","source":{"id":"https://openalex.org/S204941185","display_name":"Multiple Sclerosis International","issn_l":"2090-2654","issn":["2090-2654","2090-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis International","raw_type":"journal-article"},{"id":"pmid:33763241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33763241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7964121","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7964121/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mult Scler Int","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6efba2219a614df6897cf01e0ac55c75","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6efba2219a614df6897cf01e0ac55c75","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Multiple Sclerosis International, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/8813498","doi":"https://doi.org/10.1155/2021/8813498","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8813498","pdf_url":"https://downloads.hindawi.com/journals/msi/2021/8813498.pdf","source":{"id":"https://openalex.org/S204941185","display_name":"Multiple Sclerosis International","issn_l":"2090-2654","issn":["2090-2654","2090-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134989152.pdf","grobid_xml":"https://content.openalex.org/works/W3134989152.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1964007754","https://openalex.org/W1964428385","https://openalex.org/W1998455368","https://openalex.org/W2030970982","https://openalex.org/W2069839237","https://openalex.org/W2076372621","https://openalex.org/W2081003782","https://openalex.org/W2105660515","https://openalex.org/W2113485611","https://openalex.org/W2116734097","https://openalex.org/W2117259705","https://openalex.org/W2122442488","https://openalex.org/W2128948123","https://openalex.org/W2129134090","https://openalex.org/W2129288507","https://openalex.org/W2130974415","https://openalex.org/W2145420680","https://openalex.org/W2145727048","https://openalex.org/W2159953815","https://openalex.org/W2160872052","https://openalex.org/W2166094722","https://openalex.org/W2166686431","https://openalex.org/W2169159041","https://openalex.org/W2278124719","https://openalex.org/W2278613505","https://openalex.org/W2332018470","https://openalex.org/W2476303787","https://openalex.org/W2745539521","https://openalex.org/W2789213042","https://openalex.org/W2892640099","https://openalex.org/W2913489076","https://openalex.org/W2944582362","https://openalex.org/W2977847630","https://openalex.org/W3138675931"],"related_works":["https://openalex.org/W2278613505","https://openalex.org/W2913489076","https://openalex.org/W4389436880","https://openalex.org/W2105660515","https://openalex.org/W2607231478","https://openalex.org/W2051992016","https://openalex.org/W2897441883","https://openalex.org/W2278124719","https://openalex.org/W3084290826","https://openalex.org/W3024077366"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,101],"progressive":[2,71],"phase":[3,57],"of":[4,15,67,109,112,121,124,152,161],"multiple":[5],"sclerosis":[6],"(MS)":[7],"is":[8],"characterized":[9],"by":[10,39],"an":[11],"intrathecal":[12],"(IT)":[13],"compartmentalization":[14],"inflammation,":[16],"involving":[17],"B-cells":[18],"within":[19],"meningeal":[20],"follicles,":[21],"and":[22,65,97,130,132,142,150],"resisting":[23],"all":[24],"the":[25,44,63],"available":[26],"immunosuppressive":[27,41],"treatments.":[28],"A":[29],"new":[30],"therapeutic":[31],"paradigm":[32],"may":[33],"be":[34],"to":[35,61,165],"target":[36],"this":[37],"inflammation":[38,113,153],"injecting":[40],"drugs":[42],"inside":[43],"central":[45],"nervous":[46],"system":[47],"compartment.":[48],"METHODS:":[49],"We":[50],"designed":[51,60],"a":[52,105],"single-center,":[53],"open-label,":[54],"randomized,":[55],"controlled,":[56],"II":[58],"study":[59],"evaluate":[62],"safety":[64],"efficacy":[66],"IT":[68,91,159],"rituximab":[69,92],"in":[70,107,119,169],"MS":[72],"(EFFRITE":[73],"trial;":[74],"ClinicalTrial":[75],"Registration":[76],"NCT02545959).":[77],"Patients":[78],"were":[79,117,154],"randomized":[80],"into":[81],"three":[82],"arms":[83],"(1":[84],":":[85,87],"1":[86],"1):":[88],"control":[89],"group,":[90,96],"(20":[93],"mg,":[94],"IT)":[95],"intravenous+IT":[98],"(IV+IT)":[99],"group.":[100],"main":[102],"outcome":[103,149],"was":[104],"change":[106],"levels":[108,120],"CSF":[110,122],"biomarkers":[111,123,151],"(osteopontin).":[114],"Secondary":[115],"outcomes":[116],"changes":[118],"axonal":[125],"loss":[126],"(neurofilament":[127],"light":[128],"chain)":[129],"clinical":[131],"MRI":[133],"changes.":[134],"RESULTS:":[135],"=":[136],"0.02).":[137],"Clinical":[138,148],"parameters":[139],"remained":[140,145],"stable":[141],"leptomeningeal":[143],"enhancements":[144],"unchanged.":[146],"CONCLUSION:":[147],"not":[155],"dramatically":[156],"modified":[157],"after":[158],"injection":[160],"rituximab,":[162],"probably":[163],"due":[164],"its":[166],"limited":[167],"efficiency":[168],"CSF.":[170],"Drug":[171],"issues":[172],"for":[173],"future":[174],"studies":[175],"are":[176],"discussed.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
