{"id":"https://openalex.org/W3134976366","doi":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","title":"CHARACTERISTICS OF THE IMMUNE MICROENVIRONMENT OF THE NORMAL MUCOUS MEMBRANE OF THE PERITUMORAL AREA IS AN ADDITIONAL INDEPENDENT PROGNOSTIC FACTOR IN GASTRIC CANCER","display_name":"CHARACTERISTICS OF THE IMMUNE MICROENVIRONMENT OF THE NORMAL MUCOUS MEMBRANE OF THE PERITUMORAL AREA IS AN ADDITIONAL INDEPENDENT PROGNOSTIC FACTOR IN GASTRIC CANCER","publication_year":2021,"publication_date":"2021-03-06","ids":{"openalex":"https://openalex.org/W3134976366","doi":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","mag":"3134976366"},"language":"en","primary_location":{"id":"doi:10.21294/1814-4861-2021-20-1-74-86","doi":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","pdf_url":null,"source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055068736","display_name":"Natalia V. Danilova","orcid":"https://orcid.org/0000-0001-7848-6707","observed_orcids":["https://orcid.org/0000-0001-7848-6707"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. V. Danilova","raw_affiliation_strings":["Lomonosov Moscow State University"],"raw_orcid":"https://orcid.org/0000-0001-7848-6707","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067859004","display_name":"Vladimir M. Khomyakov","orcid":"https://orcid.org/0000-0001-8301-4528","observed_orcids":["https://orcid.org/0000-0001-8301-4528","https://orcid.org/0009-0009-1106-6674"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210139937","display_name":"P.A. Hertzen Moscow Oncology Research Institute","ror":"https://ror.org/04rbazs75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. M. Kkomyakov","raw_affiliation_strings":["P. Hertsen Moscow Oncology Research Institute \u2013 branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-8301-4528","affiliations":[{"raw_affiliation_string":"P. Hertsen Moscow Oncology Research Institute \u2013 branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114212798","display_name":"A.V. Chayka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210139937","display_name":"P.A. Hertzen Moscow Oncology Research Institute","ror":"https://ror.org/04rbazs75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Chayka","raw_affiliation_strings":["P. Hertsen Moscow Oncology Research Institute \u2013 branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-2178-9317","affiliations":[{"raw_affiliation_string":"P. Hertsen Moscow Oncology Research Institute \u2013 branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046755696","display_name":"I. \u0410. Mikhailov","orcid":"https://orcid.org/0000-0001-8020-369X","observed_orcids":["https://orcid.org/0000-0001-8020-369X"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. A. Mikhailov","raw_affiliation_strings":["Lomonosov Moscow State University"],"raw_orcid":"https://orcid.org/0000-0001-8020-369X","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022298649","display_name":"N A Oleynikova","orcid":"https://orcid.org/0000-0001-8564-8874","observed_orcids":["https://orcid.org/0000-0001-8564-8874"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Oleynikova","raw_affiliation_strings":["Lomonosov Moscow State University"],"raw_orcid":"https://orcid.org/0000-0001-8564-8874","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085018641","display_name":"Pavel G. Malkov","orcid":"https://orcid.org/0000-0001-5074-3513","observed_orcids":["https://orcid.org/0000-0001-5074-3513"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P. G. Malkov","raw_affiliation_strings":["Lomonosov Moscow State University"],"raw_orcid":"https://orcid.org/0000-0001-5074-3513","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9637,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.8643735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"74","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-microenvironment","display_name":"immune microenvironment","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.6060000061988831},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.925000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-invasion-depth","display_name":"depth of invasion","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8650000095367432},{"id":"https://openalex.org/keywords/morphometrics","display_name":"morphometrics","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.3199999928474426},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.47200000286102295},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7820466756820679},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.665266752243042},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.647102952003479},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.6307679414749146},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5770012736320496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5691046714782715},{"id":"https://openalex.org/C2779890267","wikidata":"https://www.wikidata.org/wiki/Q1219805","display_name":"Mucous membrane","level":2,"score":0.5196679830551147},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.48777657747268677},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4391053318977356},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4270459711551666},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4227035939693451},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2169983685016632},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1864652931690216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09506464004516602},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21294/1814-4861-2021-20-1-74-86","doi":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","pdf_url":null,"source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},{"id":"pmh:oai:oai.oncotomsk.elpub.ru:article/1694","doi":null,"is_oa":true,"landing_page_url":"https://www.siboncoj.ru/jour/article/view/1694","pdf_url":"https://www.siboncoj.ru/jour/article/download/1694/830","source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Siberian journal of oncology; \u0422\u043e\u043c 20, \u2116 1 (2021); 74-86","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2f6da94afbc845dcb4c76cd9e348029a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2f6da94afbc845dcb4c76cd9e348029a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0421\u0438\u0431\u0438\u0440\u0441\u043a\u0438\u0439 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b, Vol 20, Iss 1, Pp 74-86 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21294/1814-4861-2021-20-1-74-86","doi":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2021-20-1-74-86","pdf_url":null,"source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329591","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1989305669","https://openalex.org/W2037740963","https://openalex.org/W2049491375","https://openalex.org/W2126547130","https://openalex.org/W2132566055","https://openalex.org/W2313945592","https://openalex.org/W2485073741","https://openalex.org/W2611125136","https://openalex.org/W2744685612","https://openalex.org/W2766985996","https://openalex.org/W2790019582","https://openalex.org/W2889646458","https://openalex.org/W2911879897","https://openalex.org/W3088178066","https://openalex.org/W3088219902"],"related_works":["https://openalex.org/W4387115810","https://openalex.org/W3142355738","https://openalex.org/W7131350539","https://openalex.org/W2313945592","https://openalex.org/W4220802006","https://openalex.org/W4376273996","https://openalex.org/W4282980075","https://openalex.org/W7162381519","https://openalex.org/W3041161413","https://openalex.org/W4319081324"],"abstract_inverted_index":{"The":[0,128,209,323],"aim":[1],"of":[2,13,17,25,38,54,82,89,98,108,113,118,139,150,158,162,166,180,190,204,238,246,267,275,297,307,325,352,357,362,384,391],"the":[3,10,14,26,36,74,79,95,105,109,119,125,133,140,146,167,178,188,193,200,235,247,256,264,276,295,298,308,333,342,363,375,381,385],"study":[4,7],"was":[5,70,170,185,261,279,310,339,346,366],"to":[6,64,73,124,234,251,331],"and":[8,20,43,111,136,153,175,184,198,227],"evaluate":[9,332],"predictive":[11],"value":[12],"immune":[15,334],"microenvironment":[16,335],"gastric":[18,55,205,337],"cancer":[19,56,206,338],"morphologically":[21,114,358],"normal":[22,115,163,243,272,359],"mucous":[23,116,164,244,273,360,382],"membrane":[24,117,165,245,274,361,383],"peritumoral":[27,120,168,248,277,364,386],"area":[28,81,169,237,266,278,365],"using":[29,94,255,326],"an":[30,327,367],"automatic":[31,96,328],"morphometric":[32,99,389],"analysis":[33,100,254,329],"system":[34,97,330],"on":[35],"example":[37],"CD":[39,65,83,159,239,268,353,392],"8+":[40,84,160,240,269,354,393],"cells.":[41],"Material":[42],"Methods.":[44],"Surgical":[45],"samples":[46],"from":[47,380],"130":[48],"patients":[49],"with":[50,62,132,145,187,199,294,314],"a":[51,67,280,349],"verified":[52],"diagnosis":[53],"were":[57,130,212],"used.":[58],"After":[59],"immunohistochemical":[60],"staining":[61],"antibodies":[63],"8,":[66],"morphological":[68,137],"assessment":[69,390],"performed":[71],"according":[72,233],"original":[75],"method.":[76],"We":[77],"assessed":[78,303],"average":[80,236,265],"cells":[85,241,270],"in":[86,104,172,192,242,271,291,304,336],"three":[87],"fields":[88],"view":[90],"(lens":[91],"magn.":[92],"\u00d720)":[93],"LAS":[101],"X":[102],"(Leica)":[103],"central":[106,305],"part":[107,306],"tumor":[110,126,141,299,309],"areas":[112],"region":[121,387],"directly":[122],"adjacent":[123],"tissue.":[127],"results":[129],"compared":[131],"main":[134],"clinical":[135],"characteristics":[138],"as":[142,144],"well":[143],"overall":[147],"five-year":[148],"survival":[149,253,316],"patients.":[151],"Results":[152],"Discussion.":[154],"A":[155,300],"high":[156,350],"density":[157],"infiltration":[161,356],"observed":[171],"groups":[173],"T4a":[174],"T4b":[176],"by":[177],"depth":[179],"invasion":[181],"(n=96,":[182,196,207],"p=0.0089)":[183],"associated":[186,313],"presence":[189],"emboli":[191],"lymphatic":[194],"vessels":[195],"p=0.0102)":[197],"more":[201,228],"advanced":[202],"stage":[203,296],"p=0.0107).":[208],"studied":[210],"cases":[211],"divided":[213],"into":[214],"two":[215],"groups:":[216],"less":[217],"than":[218,229],"3300":[219,230],"square":[220,231],"micrometers":[221,232],"(better":[222],"patient":[223,315],"survival;":[224],"n=79,":[225],"p=0.01)":[226],"area.":[249],"According":[250],"multivariate":[252],"Cox":[257],"regression":[258],"model,":[259],"it":[260],"found":[262,347],"that":[263,348],"significant":[281],"negative":[282,369],"prognostic":[283,370],"factor":[284],"(RR=1.537;":[285],"CI":[286,318],":":[287,319],"0.761\u20133.105;":[288],"p<0.01)":[289],"comparable":[290],"degree":[292],"covariance":[293],"similar":[301],"indicator":[302],"not":[311],"significantly":[312],"(RR=0.803;":[317],"0.574\u20131.122;":[320],"p>0.05).":[321],"Conclusion.":[322],"possibility":[324],"demonstrated":[340],"for":[341,388],"first":[343],"time.":[344],"It":[345],"level":[351],"lymphocyte":[355,394],"independent":[368],"factor.":[371],"Therefore,":[372],"we":[373],"recommend":[374],"mandatory":[376],"preoperative":[377],"biopsy":[378],"sampling":[379],"infiltration.":[395]},"counts_by_year":[{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-03-15T00:00:00"}