{"id":"https://openalex.org/W3134965374","doi":"https://doi.org/10.4322/2179-443x.0709","title":"In silico, in vitro and ex-vivo Toxicological Profiling of 5,7,4'-Trihydroxyflavone-8 -C-\u00df-Glucopyranoside - Vitexin","display_name":"In silico, in vitro and ex-vivo Toxicological Profiling of 5,7,4'-Trihydroxyflavone-8 -C-\u00df-Glucopyranoside - Vitexin","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3134965374","doi":"https://doi.org/10.4322/2179-443x.0709","mag":"3134965374"},"language":"pt","primary_location":{"id":"doi:10.4322/2179-443x.0709","doi":"https://doi.org/10.4322/2179-443x.0709","is_oa":true,"landing_page_url":"https://doi.org/10.4322/2179-443x.0709","pdf_url":null,"source":{"id":"https://openalex.org/S4306526592","display_name":"Revista de ciencias farmaceuticas","issn_l":"1808-4532","issn":["1808-4532","2179-443X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eautica B\u00e1sica e Aplicadas - RCFBA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4322/2179-443x.0709","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039016883","display_name":"Aleson Pereira de Sousa","orcid":"https://orcid.org/0000-0002-3430-477X","observed_orcids":["https://orcid.org/0000-0002-3430-477X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aleson Pereira de Sousa","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036285487","display_name":"Maria Denise Leite Ferreira","orcid":"https://orcid.org/0000-0001-8156-3443","observed_orcids":["https://orcid.org/0000-0001-8156-3443"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Denise Leite Ferreira","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050466703","display_name":"Di\u00e9gina Ara\u00fajo Fernandes","orcid":"https://orcid.org/0000-0001-6120-761X","observed_orcids":["https://orcid.org/0000-0001-6120-761X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Di\u00e9gina Ara\u00fajo Fernandes","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089012474","display_name":"La\u00edsa Vilar Cordeiro","orcid":"https://orcid.org/0000-0002-8884-7331","observed_orcids":["https://orcid.org/0000-0002-8884-7331"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"La\u00edsa Vilar Cordeiro","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039852613","display_name":"Mar\u00eda de F\u00e1tima Vanderlei de Souza","orcid":"https://orcid.org/0000-0002-9936-7130","observed_orcids":["https://orcid.org/0000-0002-9936-7130"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria de F\u00e1tima Vanderlei de Souza","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040254525","display_name":"Hilzeth de Luna Freire P\u00eassoa","orcid":"https://orcid.org/0000-0002-7420-2014","observed_orcids":["https://orcid.org/0000-0002-7420-2014"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hilzeth de Luna Freire Pessoa","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102390400","display_name":"Abrah\u00e3o Alves de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41455075","display_name":"Universidade Federal de Campina Grande","ror":"https://ror.org/00eftnx64","country_code":"BR","type":"education","lineage":["https://openalex.org/I41455075"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Abrah\u00e3o Alves de Oliveira","raw_affiliation_strings":["Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Campina Grande, Patos, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Campina Grande, Patos, Brasil","institution_ids":["https://openalex.org/I41455075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086178457","display_name":"Rita de C\u00e1ssia da Silveira e S\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rita de C\u00e1ssia da Silveira e S\u00e1","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica de Medicamentos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brasil","institution_ids":["https://openalex.org/I169045520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4358,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58149506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"42","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.17649999260902405,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitexin","display_name":"vitexin","score":1.0},{"id":"https://openalex.org/keywords/flavonoid-glycosides","display_name":"flavonoid glycosides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/toxicity-profiling","display_name":"toxicity profiling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8889999985694885},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.796999990940094},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.5830000042915344},{"id":"https://openalex.org/keywords/anticarcinogenic-activity","display_name":"anticarcinogenic activity","score":0.765999972820282},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8358138799667358},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7697211503982544},{"id":"https://openalex.org/C2779301978","wikidata":"https://www.wikidata.org/wiki/Q259075","display_name":"Vitexin","level":4,"score":0.6643761396408081},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5271786451339722},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5150275230407715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5012264251708984},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4272632300853729},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37093767523765564},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25396254658699036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18734443187713623},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14263224601745605},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10959786176681519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04312396049499512},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4322/2179-443x.0709","doi":"https://doi.org/10.4322/2179-443x.0709","is_oa":true,"landing_page_url":"https://doi.org/10.4322/2179-443x.0709","pdf_url":null,"source":{"id":"https://openalex.org/S4306526592","display_name":"Revista de ciencias farmaceuticas","issn_l":"1808-4532","issn":["1808-4532","2179-443X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eautica B\u00e1sica e Aplicadas - RCFBA","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:453698bcd9134a3daefd1e41d2fb9851","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/453698bcd9134a3daefd1e41d2fb9851","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada, Vol 42, Pp 1-9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4322/2179-443x.0709","doi":"https://doi.org/10.4322/2179-443x.0709","is_oa":true,"landing_page_url":"https://doi.org/10.4322/2179-443x.0709","pdf_url":null,"source":{"id":"https://openalex.org/S4306526592","display_name":"Revista de ciencias farmaceuticas","issn_l":"1808-4532","issn":["1808-4532","2179-443X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eautica B\u00e1sica e Aplicadas - RCFBA","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7015280140","https://openalex.org/W7064229795","https://openalex.org/W2619398488","https://openalex.org/W3187446280","https://openalex.org/W7136662988","https://openalex.org/W4412063765","https://openalex.org/W3111502457","https://openalex.org/W3173314190","https://openalex.org/W7217771820","https://openalex.org/W3134611756"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,43,102],"evaluate":[4],"the":[5,15,44,48,56,72,88,92],"in":[6,8,31,35,94,100,122],"silico,":[7],"vitro,":[9],"and":[10,25,37,52,78,110,115,127,148],"ex-vivo":[11,38],"toxicity":[12,85,130,150],"of":[13,47,59,62,91],"vitexin,":[14],"flavonoid":[16],"5,7,4'-":[17],"trihydroxyflavone-8-C-\u03b2-glucopyranoside":[18],"from":[19],"Waltheria":[20],"viscosissima.":[21],"The":[22,34,84,135],"chemical":[23],"structure":[24],"predicted":[26],"bioactive":[27],"properties":[28],"were":[29,40,53],"also":[30],"silico":[32,68],"analyzed.":[33],"vitro":[36],"assays":[39],"performed":[41],"according":[42],"Ethics":[45,57],"Code":[46],"World":[49],"Medical":[50],"Association":[51],"approved":[54],"by":[55],"Committee":[58],"University":[60],"Center":[61],"Patos":[63],"(protocol":[64],"number:":[65],"3.621.284).":[66],"In":[67],"analysis":[69],"suggested":[70],"that":[71,138],"molecule":[73,93,143],"presents":[74],"good":[75,79],"oral":[76,132],"bioavailability":[77],"absorption;":[80],"penetrating":[81],"biological":[82],"membranes.":[83],"tests":[86],"revealed":[87],"potential":[89],"effectiveness":[90],"cellular":[95,129],"protection":[96],"against":[97,131],"free":[98],"radicals,":[99],"addition":[101],"possible":[103,145],"antimutagenic,":[104],"anticarcinogenic,":[105],"antioxidant,":[106],"antineoplastic,":[107],"anti-inflammatory,":[108],"anti-hemorrhagic":[109],"apoptosis":[111],"agonist":[112],"activity.":[113],"Hemolytic":[114],"genotoxic":[116],"assessment":[117],"detected":[118],"low":[119],"hemolysis":[120],"rates":[121],"human":[123],"red":[124],"blood":[125],"cells":[126],"no":[128],"mucosa":[133],"cells.":[134],"data":[136],"suggest":[137],"vitexin":[139],"is":[140],"a":[141],"safe":[142],"for":[144,154],"therapeutic":[146],"application":[147],"its":[149],"profile":[151],"indicates":[152],"viability":[153],"future":[155],"studies.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
