{"id":"https://openalex.org/W3134954040","doi":"https://doi.org/10.3390/ijms22052296","title":"Phytochemicals in Chinese Chive (Allium tuberosum) Induce the Skeletal Muscle Cell Proliferation via PI3K/Akt/mTOR and Smad Pathways in C2C12 Cells","display_name":"Phytochemicals in Chinese Chive (Allium tuberosum) Induce the Skeletal Muscle Cell Proliferation via PI3K/Akt/mTOR and Smad Pathways in C2C12 Cells","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3134954040","doi":"https://doi.org/10.3390/ijms22052296","mag":"3134954040","pmid":"https://pubmed.ncbi.nlm.nih.gov/33669060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7956299"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22052296","doi":"https://doi.org/10.3390/ijms22052296","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052296","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2296/pdf?version=1614679003","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/5/2296/pdf?version=1614679003","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070805653","display_name":"Mira Oh","orcid":"https://orcid.org/0000-0002-8667-8431","observed_orcids":["https://orcid.org/0000-0002-8667-8431"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mira Oh","raw_affiliation_strings":["College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101972413","display_name":"Seo\u2010Young Kim","orcid":"https://orcid.org/0000-0002-5351-8044","observed_orcids":["https://orcid.org/0000-0002-5351-8044"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seo-Young Kim","raw_affiliation_strings":["Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059462165","display_name":"SeonJu Park","orcid":"https://orcid.org/0000-0002-0532-5977","observed_orcids":["https://orcid.org/0000-0002-0532-5977"]},"institutions":[{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SeonJu Park","raw_affiliation_strings":["Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0532-5977","affiliations":[{"raw_affiliation_string":"Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","institution_ids":["https://openalex.org/I4210139925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053946593","display_name":"Kil\u2010Nam Kim","orcid":"https://orcid.org/0000-0002-7712-7697","observed_orcids":["https://orcid.org/0000-0002-7712-7697","https://orcid.org/0000-0003-2613-0674"]},"institutions":[{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kil-Nam Kim","raw_affiliation_strings":["Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7712-7697","affiliations":[{"raw_affiliation_string":"Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","institution_ids":["https://openalex.org/I4210139925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053946593","display_name":"Kil\u2010Nam Kim","orcid":"https://orcid.org/0000-0002-7712-7697","observed_orcids":["https://orcid.org/0000-0002-7712-7697","https://orcid.org/0000-0003-2613-0674"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Hyun Kim","raw_affiliation_strings":["Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2613-0674","affiliations":[{"raw_affiliation_string":"Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"College of pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053946593"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210139925"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":2.9054,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.9034521,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"2296","last_page":"2296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allium-tuberosum","display_name":"Allium tuberosum","score":1.0},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9760000109672546},{"id":"https://openalex.org/keywords/flavonoid-glycosides","display_name":"flavonoid glycosides","score":0.9629999995231628},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.9269999861717224},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9639999866485596},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/skeletal-muscle-growth","display_name":"skeletal muscle growth","score":0.8429999947547913},{"id":"https://openalex.org/keywords/medicinal-food","display_name":"medicinal food","score":0.5559999942779541},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7261399030685425},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6665452718734741},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.6025358438491821},{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.5659454464912415},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5393490791320801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5342240929603577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5080525875091553},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.5009899139404297},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4187772274017334},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.37221479415893555},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3595369756221771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3376274108886719},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.32267165184020996},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.20135661959648132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11751729249954224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11530348658561707}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027782","descriptor_name":"Chive","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms22052296","doi":"https://doi.org/10.3390/ijms22052296","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052296","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2296/pdf?version=1614679003","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:33669060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33669060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7956299","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7956299/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms22052296","doi":"https://doi.org/10.3390/ijms22052296","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052296","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2296/pdf?version=1614679003","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1271398877","display_name":null,"funder_award_id":"2018R1A6A1A03023718","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3248798548","display_name":null,"funder_award_id":"2020R1A2C101263211","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134954040.pdf","grobid_xml":"https://content.openalex.org/works/W3134954040.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W18381781","https://openalex.org/W1606710785","https://openalex.org/W1970519691","https://openalex.org/W1971703620","https://openalex.org/W1996657560","https://openalex.org/W2002985111","https://openalex.org/W2012819260","https://openalex.org/W2018285105","https://openalex.org/W2023396831","https://openalex.org/W2025450971","https://openalex.org/W2039982119","https://openalex.org/W2045567756","https://openalex.org/W2071597980","https://openalex.org/W2088784385","https://openalex.org/W2110144210","https://openalex.org/W2116961946","https://openalex.org/W2140630050","https://openalex.org/W2170495419","https://openalex.org/W2226255784","https://openalex.org/W2313718944","https://openalex.org/W2407917507","https://openalex.org/W2418194153","https://openalex.org/W2489932309","https://openalex.org/W2548357532","https://openalex.org/W2748736264","https://openalex.org/W2800712778","https://openalex.org/W2892268363","https://openalex.org/W2892986281","https://openalex.org/W2896393620","https://openalex.org/W2899872192","https://openalex.org/W2922423473","https://openalex.org/W2981624513","https://openalex.org/W3005641548","https://openalex.org/W3006204624","https://openalex.org/W3025883815","https://openalex.org/W3038844106","https://openalex.org/W3140867854"],"related_works":["https://openalex.org/W2363749726","https://openalex.org/W2591257421","https://openalex.org/W2500505189","https://openalex.org/W2267800624","https://openalex.org/W2393370623","https://openalex.org/W7112216227","https://openalex.org/W4415611142","https://openalex.org/W3135117422","https://openalex.org/W2037083441","https://openalex.org/W2080869094"],"abstract_inverted_index":{"Chinese":[0,68,142],"chive":[1],"(Allium":[2],"tuberosum)":[3],"is":[4,9],"a":[5,28,41,110],"medicinal":[6],"food":[7],"that":[8,138,154],"cultivated":[10],"and":[11,20,53,81,84,102,117,145],"consumed":[12],"mainly":[13],"in":[14,151],"Asian":[15],"countries.":[16],"Its":[17],"various":[18],"phytochemicals":[19,30],"physiological":[21],"effects":[22],"have":[23],"been":[24],"reported,":[25],"but":[26],"only":[27],"few":[29],"are":[31,128],"available":[32],"for":[33,86],"skeletal":[34,91,114,132,156],"muscle":[35,92,115,133,157],"cell":[36],"proliferation.":[37],"Herein,":[38],"we":[39,136],"isolated":[40,71,99],"new":[42],"compound,":[43],"kaempferol-3-O-(6\u2033-feruloyl)-sophoroside":[44],"(1),":[45],"along":[46],"with":[47],"one":[48],"known":[49],"flavonoid":[50,100],"glycoside":[51],"(2)":[52],"six":[54],"amino":[55,146],"acid":[56],"(3\u20138)":[57],"compounds":[58,72],"from":[59],"the":[60,64,67,95,124],"water-soluble":[61],"fraction":[62],"of":[63,66,131,141],"shoot":[65],"chive.":[69],"The":[70],"were":[73],"identified":[74],"using":[75],"extensive":[76],"spectroscopic":[77],"methods,":[78],"including":[79],"1D":[80],"2D":[82],"NMR,":[83],"evaluated":[85],"their":[87],"proliferation":[88],"activity":[89],"on":[90,113],"cells.":[93],"Among":[94],"tested":[96],"compounds,":[97],"newly":[98],"(1)":[101],"5-aminouridine":[103],"(7)":[104],"up-regulated":[105],"PI3K/Akt/mTOR":[106],"pathways,":[107,126],"which":[108,127],"implies":[109],"positive":[111],"effect":[112],"growth":[116],"differentiation.":[118],"In":[119],"particular,":[120],"compound":[121],"1":[122],"down-regulated":[123],"Smad":[125],"negative":[129],"regulators":[130],"growth.":[134,158],"Collectively,":[135],"suggest":[137],"major":[139],"constituents":[140],"chive,":[143],"flavonoids":[144],"acids,":[147],"might":[148],"be":[149],"used":[150],"dietary":[152],"supplements":[153],"aid":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-03-15T00:00:00"}