{"id":"https://openalex.org/W3134934729","doi":"https://doi.org/10.1002/smll.202008155","title":"Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features","display_name":"Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features","publication_year":2021,"publication_date":"2021-03-07","ids":{"openalex":"https://openalex.org/W3134934729","doi":"https://doi.org/10.1002/smll.202008155","mag":"3134934729","pmid":"https://pubmed.ncbi.nlm.nih.gov/33682363"},"language":"en","primary_location":{"id":"doi:10.1002/smll.202008155","doi":"https://doi.org/10.1002/smll.202008155","is_oa":true,"landing_page_url":"https://doi.org/10.1002/smll.202008155","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smll.202008155","source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smll.202008155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024128859","display_name":"Sara Cavallaro","orcid":"https://orcid.org/0000-0002-5077-3218","observed_orcids":["https://orcid.org/0000-0002-5077-3218"]},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Sara Cavallaro","raw_affiliation_strings":["Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-5077-3218","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066197698","display_name":"Federico Pevere","orcid":"https://orcid.org/0000-0001-5304-913X","observed_orcids":["https://orcid.org/0000-0001-5304-913X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Federico Pevere","raw_affiliation_strings":["Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5304-913X","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026781190","display_name":"Fredrik Stridfeldt","orcid":"https://orcid.org/0000-0002-8561-3986","observed_orcids":["https://orcid.org/0000-0002-8561-3986"]},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fredrik Stridfeldt","raw_affiliation_strings":["Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011018836","display_name":"Andr\u00e9 G\u00f6rgens","orcid":"https://orcid.org/0000-0001-9198-0857","observed_orcids":["https://orcid.org/0000-0001-9198-0857"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 G\u00f6rgens","raw_affiliation_strings":["Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK","Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, 45141 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK","institution_ids":[]},{"raw_affiliation_string":"Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, 45141 Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047906830","display_name":"Carolina Paba","orcid":"https://orcid.org/0000-0002-0836-8024","observed_orcids":["https://orcid.org/0000-0002-0836-8024"]},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carolina Paba","raw_affiliation_strings":["Politecnico di Torino, Turin, 10129 Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Torino, Turin, 10129 Italy","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080275679","display_name":"Siddharth Sourabh Sahu","orcid":"https://orcid.org/0000-0002-2794-9158","observed_orcids":["https://orcid.org/0000-0002-2794-9158"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Siddharth S. Sahu","raw_affiliation_strings":["Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034112515","display_name":"Doste Rashid Mamand","orcid":"https://orcid.org/0000-0002-4785-0796","observed_orcids":["https://orcid.org/0000-0002-4785-0796"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Doste R. Mamand","raw_affiliation_strings":["Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077308963","display_name":"Dhanu Gupta","orcid":"https://orcid.org/0000-0003-0163-2678","observed_orcids":["https://orcid.org/0000-0003-0163-2678"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dhanu Gupta","raw_affiliation_strings":["Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059897226","display_name":"Samir EL Andaloussi","orcid":"https://orcid.org/0000-0003-4468-9113","observed_orcids":["https://orcid.org/0000-0003-4468-9113"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Samir El Andaloussi","raw_affiliation_strings":["Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK"],"raw_orcid":"https://orcid.org/0000-0003-4468-9113","affiliations":[{"raw_affiliation_string":"Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, 17177 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Evox Therapeutics Limited, Oxford Science Park, Oxford, OX4 4HG UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073719928","display_name":"Jan Linnros","orcid":"https://orcid.org/0000-0002-5260-5322","observed_orcids":["https://orcid.org/0000-0002-5260-5322"]},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Linnros","raw_affiliation_strings":["Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-5260-5322","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029586629","display_name":"Apurba Dev","orcid":"https://orcid.org/0000-0002-6235-2891","observed_orcids":["https://orcid.org/0000-0002-6235-2891"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Apurba Dev","raw_affiliation_strings":["Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden","Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-6235-2891","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, 10691 Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Department of Electrical Engineering The \u00c5ngstr\u00f6m Laboratory Uppsala University  Uppsala 75121 Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024128859","https://openalex.org/A5029586629"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I86987016"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.9941,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.71706667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"14","first_page":"e2008155","last_page":"e2008155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/small-extracellular-vesicles","display_name":"small extracellular vesicles","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tetraspanins","display_name":"tetraspanins","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cd9","display_name":"CD9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd63","display_name":"CD63","score":1.0},{"id":"https://openalex.org/keywords/cd81","display_name":"CD81","score":1.0},{"id":"https://openalex.org/keywords/vesicle-heterogeneity","display_name":"vesicle heterogeneity","score":0.875},{"id":"https://openalex.org/keywords/vesicle-size","display_name":"vesicle size","score":0.7319999933242798},{"id":"https://openalex.org/keywords/young-s-modulus","display_name":"Young's modulus","score":0.8379999995231628},{"id":"https://openalex.org/keywords/membrane-protein-composition","display_name":"membrane protein composition","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/monocytic-leukemia-cells","display_name":"monocytic leukemia cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2777208748","wikidata":"https://www.wikidata.org/wiki/Q24773957","display_name":"Tetraspanin","level":3,"score":0.8651169538497925},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5737826824188232},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5677940845489502},{"id":"https://openalex.org/C2776507628","wikidata":"https://www.wikidata.org/wiki/Q21131199","display_name":"CD81","level":4,"score":0.5299160480499268},{"id":"https://openalex.org/C144618238","wikidata":"https://www.wikidata.org/wiki/Q902601","display_name":"Fluorescence correlation spectroscopy","level":3,"score":0.5260893106460571},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5100329518318176},{"id":"https://openalex.org/C2776385711","wikidata":"https://www.wikidata.org/wiki/Q4035583","display_name":"CD63","level":5,"score":0.4983940124511719},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4830058813095093},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4828096330165863},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4424348771572113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43812867999076843},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4139198958873749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38835838437080383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.386189341545105},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.37433671951293945},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31104663014411926},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3052160143852234},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.28838667273521423},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2462514340877533},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17464110255241394},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.15910330414772034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11704781651496887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08939185738563538},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059470","descriptor_name":"Tetraspanins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/smll.202008155","doi":"https://doi.org/10.1002/smll.202008155","is_oa":true,"landing_page_url":"https://doi.org/10.1002/smll.202008155","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smll.202008155","source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},{"id":"doi:10.1101/2021.01.22.427773","doi":"https://doi.org/10.1101/2021.01.22.427773","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.22.427773","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/01/23/2021.01.22.427773.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33682363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33682363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-441700","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441700","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00163687","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/33682363","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/smll.202008155","doi":"https://doi.org/10.1002/smll.202008155","is_oa":true,"landing_page_url":"https://doi.org/10.1002/smll.202008155","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smll.202008155","source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3252852852","display_name":null,"funder_award_id":"2019\u20132023","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8619795818","display_name":"Functional microfluidics and electrokinetic modulation in transistor-based nano-scale sensors for single molecule analysis","funder_award_id":"2016-05051","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320318502","display_name":"International Society for Advancement of Cytometry","ror":"https://ror.org/03ffsht37"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134934729.pdf","grobid_xml":"https://content.openalex.org/works/W3134934729.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1862400297","https://openalex.org/W2033112925","https://openalex.org/W2064329260","https://openalex.org/W2080418767","https://openalex.org/W2089946359","https://openalex.org/W2114456475","https://openalex.org/W2170852633","https://openalex.org/W2214616458","https://openalex.org/W2259481044","https://openalex.org/W2288512038","https://openalex.org/W2341984331","https://openalex.org/W2549542099","https://openalex.org/W2549976854","https://openalex.org/W2565271826","https://openalex.org/W2597876129","https://openalex.org/W2613857401","https://openalex.org/W2754569507","https://openalex.org/W2765562346","https://openalex.org/W2778160381","https://openalex.org/W2779044993","https://openalex.org/W2781579322","https://openalex.org/W2787077101","https://openalex.org/W2788593837","https://openalex.org/W2791050980","https://openalex.org/W2808148330","https://openalex.org/W2889000610","https://openalex.org/W2892381113","https://openalex.org/W2907665228","https://openalex.org/W2910661483","https://openalex.org/W2922144466","https://openalex.org/W2923606319","https://openalex.org/W2924530200","https://openalex.org/W2925523925","https://openalex.org/W2933304441","https://openalex.org/W2935163132","https://openalex.org/W2939080157","https://openalex.org/W2942233973","https://openalex.org/W2952272517","https://openalex.org/W2952499863","https://openalex.org/W2956865263","https://openalex.org/W2969837995","https://openalex.org/W2974164599","https://openalex.org/W3040239801","https://openalex.org/W6600062558","https://openalex.org/W6600960895","https://openalex.org/W6603054696","https://openalex.org/W6823760572"],"related_works":["https://openalex.org/W4408957242","https://openalex.org/W3083690139","https://openalex.org/W7017737680","https://openalex.org/W4412952198","https://openalex.org/W3096218229","https://openalex.org/W3036417914","https://openalex.org/W3131864752","https://openalex.org/W4404073782","https://openalex.org/W4412351241","https://openalex.org/W3048271914"],"abstract_inverted_index":{"Being":[0],"a":[1,179],"key":[2],"player":[3],"in":[4,33,75,155,174,197],"intercellular":[5],"communications,":[6],"nanoscale":[7],"extracellular":[8],"vesicles":[9],"(EVs)":[10],"offer":[11],"unique":[12],"opportunities":[13],"for":[14,40],"both":[15,104],"diagnostics":[16],"and":[17,23,36,52,66,73,96,106,120,122,142,166,191],"therapeutics.":[18],"However,":[19],"their":[20,34,71,135],"cellular":[21,77],"origin":[22],"functional":[24],"identity":[25],"remain":[26],"elusive":[27],"due":[28],"to":[29,184],"the":[30,41,115,126,137,152],"high":[31,157],"heterogeneity":[32,74],"molecular":[35],"physical":[37],"features.":[38],"Here,":[39],"first":[42],"time,":[43],"multiple":[44],"EV":[45,189],"parameters":[46],"involving":[47],"membrane":[48],"protein":[49],"composition,":[50],"size":[51],"mechanical":[53],"properties":[54],"on":[55,84],"single":[56],"small":[57],"EVs":[58],"(sEVs)":[59],"are":[60,79,132,144],"simultaneously":[61],"studied":[62],"by":[63],"combined":[64],"fluorescence":[65],"atomic":[67],"force":[68],"microscopy.":[69],"Furthermore,":[70],"correlation":[72],"different":[76],"sources":[78],"investigated.":[80],"The":[81],"study,":[82],"performed":[83],"sEVs":[85,131],"derived":[86],"from":[87],"human":[88,97],"embryonic":[89],"kidney":[90],"293,":[91],"cord":[92],"blood":[93],"mesenchymal":[94],"stromal":[95],"acute":[98],"monocytic":[99],"leukemia":[100],"cell":[101,107,176],"lines,":[102],"identifies":[103],"common":[105,116],"line-specific":[108],"sEV":[109,148],"subpopulations":[110],"bearing":[111],"distinct":[112],"distributions":[113],"of":[114,129,134,140,163],"tetraspanins":[117,154],"(CD9,":[118],"CD63,":[119],"CD81)":[121],"biophysical":[123],"properties.":[124],"Although":[125],"tetraspanin":[127],"abundances":[128],"individual":[130],"independent":[133],"sizes,":[136],"expression":[138],"levels":[139],"CD9":[141],"CD63":[143],"strongly":[145],"correlated.":[146],"A":[147],"population":[149],"co-expressing":[150],"all":[151,175],"three":[153],"relatively":[156,167],"abundance,":[158],"however,":[159],"having":[160],"average":[161],"diameters":[162],"<100":[164],"nm":[165],"low":[168],"Young":[169],"moduli,":[170],"is":[171,182],"also":[172],"found":[173],"lines.":[177],"Such":[178],"multiparametric":[180],"approach":[181],"expected":[183],"provide":[185],"new":[186],"insights":[187],"regarding":[188],"biology":[190],"functions,":[192],"potentially":[193],"deciphering":[194],"unsolved":[195],"questions":[196],"this":[198],"field.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
