{"id":"https://openalex.org/W3134892500","doi":"https://doi.org/10.1016/j.thromres.2021.02.034","title":"Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels","display_name":"Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3134892500","doi":"https://doi.org/10.1016/j.thromres.2021.02.034","mag":"3134892500","pmid":"https://pubmed.ncbi.nlm.nih.gov/33713867"},"language":"en","primary_location":{"id":"doi:10.1016/j.thromres.2021.02.034","doi":"https://doi.org/10.1016/j.thromres.2021.02.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.thromres.2021.02.034","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2078.1/244414","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076967294","display_name":"Anne-Lore Comans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne-Lore Comans","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Geriatric Department, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Geriatric Department, Yvoir, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066725980","display_name":"Anne\u2010Laure Sennesael","orcid":"https://orcid.org/0000-0003-3499-1466","observed_orcids":["https://orcid.org/0000-0003-3499-1466"]},"institutions":[{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne-Laure Sennesael","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Department of Pharmacy, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Department of Pharmacy, Yvoir, Belgium","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085434757","display_name":"Beno\u00eet Bihin","orcid":"https://orcid.org/0000-0002-8713-6319","observed_orcids":["https://orcid.org/0000-0002-8713-6319"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Bihin","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Scientific Support Unit, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Scientific Support Unit, Yvoir, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083913880","display_name":"Maxime R\u00e9gnier","orcid":"https://orcid.org/0000-0002-2175-1095","observed_orcids":["https://orcid.org/0000-0002-2175-1095"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maxime Regnier","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Scientific Support Unit, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Scientific Support Unit, Yvoir, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000944048","display_name":"Fran\u00e7ois Mullier","orcid":"https://orcid.org/0000-0001-6947-6099","observed_orcids":["https://orcid.org/0000-0001-6947-6099"]},"institutions":[{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Mullier","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Hematology Laboratory, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Hematology Laboratory, Yvoir, Belgium","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044424524","display_name":"Marie de Saint\u2010Hubert","orcid":"https://orcid.org/0000-0001-5021-7580","observed_orcids":["https://orcid.org/0000-0001-5021-7580"]},"institutions":[{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Marie de Saint-Hubert","raw_affiliation_strings":["Universit\u00e9 catholique de Louvain, CHU UCL Namur, Institut de recherche Sant\u00e9 Soci\u00e9t\u00e9, NARILIS, Geriatric Department, Yvoir, Belgium. Electronic address: marie.desainthubert@uclouvain.be","Universit\u00e9 catholique de Louvain, CHU UCL Namur, Institut de recherche Sant\u00e9 Soci\u00e9t\u00e9, NARILIS, Geriatric Department, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Institut de recherche Sant\u00e9 Soci\u00e9t\u00e9, NARILIS, Geriatric Department, Yvoir, Belgium. Electronic address: marie.desainthubert@uclouvain.be","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]},{"raw_affiliation_string":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, Institut de recherche Sant\u00e9 Soci\u00e9t\u00e9, NARILIS, Geriatric Department, Yvoir, Belgium","institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044424524"],"corresponding_institution_ids":["https://openalex.org/I4391767857","https://openalex.org/I95674353"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":0.5254,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64016137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"201","issue":null,"first_page":"139","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":1.0},{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9350000023841858},{"id":"https://openalex.org/keywords/off-label-dosing","display_name":"off-label dosing","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.746999979019165},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.9580000042915344},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8939999938011169},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.746999979019165},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7697242498397827},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7558764219284058},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7191864252090454},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5711817741394043},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.506117045879364},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47017592191696167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45308414101600647},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.43054667115211487},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2711806297302246}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.thromres.2021.02.034","doi":"https://doi.org/10.1016/j.thromres.2021.02.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.thromres.2021.02.034","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},{"id":"pmid:33713867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33713867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis research","raw_type":"Letter"},{"id":"pmh:oai:dial.uclouvain.be:boreal:244414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/244414","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thrombosis Research, Vol. 201, p. 139-142 (2021)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:245442","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/245442","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thrombosis research, Vol. 201, p. 139-142 (2021)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dial.uclouvain.be:boreal:244414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/244414","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thrombosis Research, Vol. 201, p. 139-142 (2021)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2167698566","https://openalex.org/W2419389447","https://openalex.org/W2603123984","https://openalex.org/W2752567906","https://openalex.org/W2762490623","https://openalex.org/W2769119980","https://openalex.org/W2901225653","https://openalex.org/W2913787029","https://openalex.org/W2945548851","https://openalex.org/W2981542323","https://openalex.org/W3016523239","https://openalex.org/W3033209457","https://openalex.org/W3082179368"],"related_works":["https://openalex.org/W3174848093","https://openalex.org/W4308738229","https://openalex.org/W3205692532","https://openalex.org/W7167340298","https://openalex.org/W2909811974","https://openalex.org/W3019384206","https://openalex.org/W2979629237","https://openalex.org/W2983011950","https://openalex.org/W3093204328","https://openalex.org/W2598632525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}