{"id":"https://openalex.org/W3134882842","doi":"https://doi.org/10.4149/gpb_2020043","title":"CYP3A gene variability and cancer cells response to the treatment","display_name":"CYP3A gene variability and cancer cells response to the treatment","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3134882842","doi":"https://doi.org/10.4149/gpb_2020043","mag":"3134882842","pmid":"https://pubmed.ncbi.nlm.nih.gov/33655890"},"language":"en","primary_location":{"id":"doi:10.4149/gpb_2020043","doi":"https://doi.org/10.4149/gpb_2020043","is_oa":true,"landing_page_url":"https://doi.org/10.4149/gpb_2020043","pdf_url":"http://www.elis.sk/download_file.php?product_id=7109&session_id=r45bvjucuatoekvj7lrguvov20","source":{"id":"https://openalex.org/S175423236","display_name":"General Physiology and Biophysics","issn_l":"0231-5882","issn":["0231-5882","1338-4325"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.elis.sk/download_file.php?product_id=7109&session_id=r45bvjucuatoekvj7lrguvov20","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000350919","display_name":"Martina \u0160emel\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0002-0584-5331","observed_orcids":["https://orcid.org/0000-0002-0584-5331"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Martina \u0160emel\u00e1kov\u00e1","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023935296","display_name":"Lenka Malini\u010dov\u00e1","orcid":"https://orcid.org/0000-0002-3145-8028","observed_orcids":["https://orcid.org/0000-0002-3145-8028"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Lenka Malini\u010dov\u00e1","raw_affiliation_strings":["Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017061894","display_name":"M\u00e1ria Macejov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"M\u00e1ria Macejov\u00e1","raw_affiliation_strings":["Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046116208","display_name":"Peter Prista\u0161","orcid":"https://orcid.org/0000-0002-7948-2617","observed_orcids":["https://orcid.org/0000-0002-7948-2617"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Prista\u0161","raw_affiliation_strings":["Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology and Ecology, Faculty of Science, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000350919"],"corresponding_institution_ids":["https://openalex.org/I204881574"],"apc_list":null,"apc_paid":null,"fwci":0.4427,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.50224707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"40","issue":"01","first_page":"49","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyp3a5","display_name":"CYP3A5","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-p450-polymorphisms","display_name":"cytochrome P450 polymorphisms","score":0.8960000276565552},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7139999866485596},{"id":"https://openalex.org/keywords/oxaliplatin-resistance","display_name":"oxaliplatin resistance","score":0.8930000066757202},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.6449999809265137},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.6978769898414612},{"id":"https://openalex.org/C11824378","wikidata":"https://www.wikidata.org/wiki/Q5014970","display_name":"CYP3A","level":4,"score":0.6213012933731079},{"id":"https://openalex.org/C92137452","wikidata":"https://www.wikidata.org/wiki/Q17912018","display_name":"CYP3A5","level":4,"score":0.5710946321487427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475319027900696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5285438895225525},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5278774499893188},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5237852334976196},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47693103551864624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4602879583835602},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44032377004623413},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4347786009311676},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.37339216470718384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33609738945961},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32457464933395386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28709885478019714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18819588422775269},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1088942289352417}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4149/gpb_2020043","doi":"https://doi.org/10.4149/gpb_2020043","is_oa":true,"landing_page_url":"https://doi.org/10.4149/gpb_2020043","pdf_url":"http://www.elis.sk/download_file.php?product_id=7109&session_id=r45bvjucuatoekvj7lrguvov20","source":{"id":"https://openalex.org/S175423236","display_name":"General Physiology and Biophysics","issn_l":"0231-5882","issn":["0231-5882","1338-4325"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"journal-article"},{"id":"pmid:33655890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33655890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4149/gpb_2020043","doi":"https://doi.org/10.4149/gpb_2020043","is_oa":true,"landing_page_url":"https://doi.org/10.4149/gpb_2020043","pdf_url":"http://www.elis.sk/download_file.php?product_id=7109&session_id=r45bvjucuatoekvj7lrguvov20","source":{"id":"https://openalex.org/S175423236","display_name":"General Physiology and Biophysics","issn_l":"0231-5882","issn":["0231-5882","1338-4325"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8383413918","display_name":"Transkript\u00f3m, metabol\u00f3m a signal\u00f3m bioakt\u00edvnych l\u00e1tok s protin\u00e1dorov\u00fdm \u00fa\u010dinkom v rode Hypericum","funder_award_id":"APVV-14-0154","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"}],"funders":[{"id":"https://openalex.org/F4320323251","display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","ror":"https://ror.org/037nx0e70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134882842.pdf","grobid_xml":"https://content.openalex.org/works/W3134882842.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W74495713","https://openalex.org/W572729719","https://openalex.org/W1180197606","https://openalex.org/W1525448630","https://openalex.org/W1926666446","https://openalex.org/W1965302580","https://openalex.org/W1967098168","https://openalex.org/W1985848091","https://openalex.org/W1992867510","https://openalex.org/W1994631009","https://openalex.org/W2000180275","https://openalex.org/W2009486414","https://openalex.org/W2019378745","https://openalex.org/W2021775978","https://openalex.org/W2025661683","https://openalex.org/W2027694461","https://openalex.org/W2028092880","https://openalex.org/W2041694332","https://openalex.org/W2044911368","https://openalex.org/W2056772956","https://openalex.org/W2060066881","https://openalex.org/W2061871664","https://openalex.org/W2066881731","https://openalex.org/W2070536631","https://openalex.org/W2079011291","https://openalex.org/W2091528050","https://openalex.org/W2091604455","https://openalex.org/W2108115607","https://openalex.org/W2108167035","https://openalex.org/W2109279065","https://openalex.org/W2126772533","https://openalex.org/W2127624886","https://openalex.org/W2132965016","https://openalex.org/W2134861975","https://openalex.org/W2152207030","https://openalex.org/W2155268095","https://openalex.org/W2169193886","https://openalex.org/W2169302611","https://openalex.org/W2170439661","https://openalex.org/W2182775535","https://openalex.org/W2325140777","https://openalex.org/W2425415716","https://openalex.org/W2787945524","https://openalex.org/W3008716076","https://openalex.org/W3009043847","https://openalex.org/W3011902931","https://openalex.org/W3019065741"],"related_works":["https://openalex.org/W2741987021","https://openalex.org/W3032338307","https://openalex.org/W2105683481","https://openalex.org/W2019980810","https://openalex.org/W3029969918","https://openalex.org/W2000859128","https://openalex.org/W2077522929","https://openalex.org/W2163031022","https://openalex.org/W2424921816","https://openalex.org/W7135461540"],"abstract_inverted_index":{"The":[0,25,53,135],"treatment":[1],"of":[2,8,27,48,55,81,89,110,137,143],"cancer":[3,49,61,95,115],"depends":[4],"on":[5,152],"the":[6,9,20,34,46,60,90,100,104,108,141],"activity":[7,41,109],"cytochrome":[10],"P450":[11],"enzyme":[12],"family,":[13],"which":[14],"is":[15],"essentially":[16],"carried":[17],"out":[18],"by":[19],"CYP3A4":[21,35,56,91,111],"and":[22,42,66,107,130,148],"CYP3A5":[23],"enzymes.":[24],"aim":[26],"our":[28],"study":[29],"was":[30,70],"to":[31,39,45,51,123],"investigate":[32],"whether":[33],"polymorphism":[36,88],"could":[37],"contribute":[38],"protein":[40,105,112],"their":[43],"influence":[44],"response":[47,122],"cells":[50],"treatment.":[52],"variability":[54,136],"cDNA":[57],"profiles":[58],"between":[59,126],"cell":[62,96,116,127,132],"lines":[63,117],"parental":[64],"HT-29":[65,129],"resistant":[67],"HT-29-OxR":[68],"adenocarcinoma":[69],"detected":[71],"using":[72],"denaturing":[73],"gradient":[74],"gel":[75],"electrophoresis":[76],"(DGGE).":[77],"Subsequently,":[78],"sequence":[79],"analysis":[80],"CYP3A":[82,138],"family":[83],"members":[84],"(CYP3A4,":[85],"CYP3A5)":[86],"confirmed":[87],"gene":[92,101],"in":[93,113,146],"studied":[94],"lines.":[97],"Variations":[98],"at":[99],"expression":[102],"level,":[103],"level":[106],"12":[114],"were":[118],"observed,":[119],"also":[120],"different":[121],"drug":[124],"treatments":[125],"line":[128,133],"oxaliplatin-resistant":[131],"HT-29-OxR.":[134],"might":[139],"affect":[140],"efficiency":[142],"anti-cancer":[144],"drugs":[145],"general":[147],"have":[149],"an":[150],"impact":[151],"metabolism.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}