{"id":"https://openalex.org/W3134874937","doi":"https://doi.org/10.2174/1566523221666210224110454","title":"The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review","display_name":"The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3134874937","doi":"https://doi.org/10.2174/1566523221666210224110454","mag":"3134874937","pmid":"https://pubmed.ncbi.nlm.nih.gov/33655831"},"language":"en","primary_location":{"id":"doi:10.2174/1566523221666210224110454","doi":"https://doi.org/10.2174/1566523221666210224110454","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1566523221666210224110454","pdf_url":null,"source":{"id":"https://openalex.org/S31345238","display_name":"Current Gene Therapy","issn_l":"1566-5232","issn":["1566-5232","1875-5631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005962067","display_name":"Firoozeh Alavian","orcid":"https://orcid.org/0000-0001-6866-8988","observed_orcids":["https://orcid.org/0000-0001-6866-8988"]},"institutions":[{"id":"https://openalex.org/I64728393","display_name":"Farhangian University","ror":"https://ror.org/01rvhet58","country_code":"IR","type":"education","lineage":["https://openalex.org/I64728393"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Firoozeh Alavian","raw_affiliation_strings":["Department of Biology, School of Basic Sciences, Farhangian University, Tehran,Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, School of Basic Sciences, Farhangian University, Tehran,Iran","institution_ids":["https://openalex.org/I64728393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021604742","display_name":"Sorayya Ghasemi","orcid":"https://orcid.org/0000-0001-9986-4930","observed_orcids":["https://orcid.org/0000-0001-9986-4930","https://orcid.org/0000-0001-8504-7112"]},"institutions":[{"id":"https://openalex.org/I170350485","display_name":"Shahrekord University of Medical Sciences","ror":"https://ror.org/0506tgm76","country_code":"IR","type":"education","lineage":["https://openalex.org/I170350485"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Sorayya Ghasemi","raw_affiliation_strings":["Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord,Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord,Iran","institution_ids":["https://openalex.org/I170350485"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021604742"],"corresponding_institution_ids":["https://openalex.org/I170350485"],"apc_list":null,"apc_paid":null,"fwci":0.2804,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.2236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"230","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gene-delivery-vehicles","display_name":"gene carriers","score":0.6660000085830688},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.875},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.9150000214576721},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7936540842056274},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6511566638946533},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6365137696266174},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6226359009742737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5064138174057007},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4489601254463196},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4262511730194092},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4140239953994751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3354222774505615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2247527539730072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0863540768623352}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1566523221666210224110454","doi":"https://doi.org/10.2174/1566523221666210224110454","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1566523221666210224110454","pdf_url":null,"source":{"id":"https://openalex.org/S31345238","display_name":"Current Gene Therapy","issn_l":"1566-5232","issn":["1566-5232","1875-5631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Gene Therapy","raw_type":"journal-article"},{"id":"pmid:33655831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33655831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W175743129","https://openalex.org/W1758113392","https://openalex.org/W1859184750","https://openalex.org/W1957275635","https://openalex.org/W1965476230","https://openalex.org/W1979958131","https://openalex.org/W1981777363","https://openalex.org/W1982637919","https://openalex.org/W2004068369","https://openalex.org/W2008033906","https://openalex.org/W2015343062","https://openalex.org/W2037993233","https://openalex.org/W2041112300","https://openalex.org/W2042935377","https://openalex.org/W2049479334","https://openalex.org/W2063663680","https://openalex.org/W2077177292","https://openalex.org/W2078349205","https://openalex.org/W2084688858","https://openalex.org/W2087527154","https://openalex.org/W2101657078","https://openalex.org/W2121322725","https://openalex.org/W2122777061","https://openalex.org/W2137042343","https://openalex.org/W2150960322","https://openalex.org/W2162916643","https://openalex.org/W2169697985","https://openalex.org/W2208203124","https://openalex.org/W2285781213","https://openalex.org/W2332433189","https://openalex.org/W2334836181","https://openalex.org/W2431592911","https://openalex.org/W2509715372","https://openalex.org/W2518317305","https://openalex.org/W2518753001","https://openalex.org/W2530545213","https://openalex.org/W2541977230","https://openalex.org/W2550147904","https://openalex.org/W2573318906","https://openalex.org/W2587406652","https://openalex.org/W2602636407","https://openalex.org/W2610534367","https://openalex.org/W2612574006","https://openalex.org/W2621590878","https://openalex.org/W2623739851","https://openalex.org/W2624317658","https://openalex.org/W2762341360","https://openalex.org/W2765178824","https://openalex.org/W2769069333","https://openalex.org/W2801887850","https://openalex.org/W2885309162","https://openalex.org/W2885476574","https://openalex.org/W2888420135","https://openalex.org/W2904124450","https://openalex.org/W2908771924","https://openalex.org/W2914601585","https://openalex.org/W2935899679","https://openalex.org/W2939928460","https://openalex.org/W2944327096","https://openalex.org/W2950980129","https://openalex.org/W2964090597","https://openalex.org/W2997125990","https://openalex.org/W3022903699","https://openalex.org/W3092633501"],"related_works":["https://openalex.org/W4410517704","https://openalex.org/W2758568541","https://openalex.org/W4407750109","https://openalex.org/W4409270706","https://openalex.org/W2056024740","https://openalex.org/W7067730435","https://openalex.org/W4408652947","https://openalex.org/W3127523065","https://openalex.org/W2530545213","https://openalex.org/W2003902129"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"multiforme":[2],"(GBM)":[3],"is":[4,181,194],"the":[5,21,27,40,45,49,107,110,138,141,160,168,212,225,235],"most":[6,172,185],"common":[7,186],"and":[8,68,81,105,126,145,163,214,230],"fatal":[9],"type":[10,229],"of":[11,23,29,34,42,79,112,115,140,227],"glioma.":[12],"Nanoparticles":[13],"(NPs)":[14],"are":[15],"used":[16,72,174],"in":[17,26,48,55,124,127,176,192,217],"new":[18],"approaches":[19],"for":[20,83,190,220],"delivery":[22,216],"gene":[24,50,65,117,178,187,218,231],"therapy":[25,51,179,188,232],"treatment":[28],"GBM.":[30,56],"INTRODUCTION:":[31],"The":[32,58,95,129,171,184],"purpose":[33],"this":[35],"article":[36],"was":[37,99],"to":[38,73,87,167,210],"review":[39,98],"efficacy":[41],"NPs":[43,204],"as":[44,62],"targeted":[46],"carriers":[47,114],"aimed":[52],"at":[53],"apoptosis":[54,123,191],"METHODS:":[57],"appropriate":[59],"keywords":[60],"such":[61],"nanoparticle,":[63],"glioblastoma,":[64],"therapy,":[66],"apoptosis,":[67],"related":[69],"words":[70],"were":[71,132,148],"search":[74],"from":[75],"PubMed,":[76],"ISI":[77],"Web":[78],"Science,":[80],"Scopus":[82],"relevant":[84],"publications":[85],"up":[86],"September":[88],"4,":[89],"2020,":[90],"with":[91],"no":[92],"language":[93],"restrictions.":[94],"present":[96],"systematic":[97],"performed":[100,149],"based":[101],"on":[102,120,137],"PRISMA":[103],"protocol":[104],"reviewed":[106],"articles":[108,131,156],"evaluating":[109],"effects":[111],"nanoparticles,":[113],"various":[116],"therapies":[118,219],"essentials,":[119],"GBM":[121,177,193,221,236],"cells":[122],"vitro":[125],"vivo.":[128],"selected":[130],"considered":[133],"using":[134,195],"specific":[135,215],"scores":[136],"quality":[139,146],"articles.":[142],"Data":[143],"extraction":[144],"evaluation":[147],"by":[150],"two":[151],"reviewers.":[152],"RESULTS:":[153],"Of":[154],"101":[155],"retrieved,":[157],"forty-two":[158],"met":[159],"inclusion":[161],"criteria":[162],"were,":[164],"therefore,":[165],"subjected":[166],"final":[169],"deduction.":[170],"widely":[173],"NP":[175,228],"studies":[180,201],"polyamidoamine":[182],"(PAMAM).":[183],"approach":[189],"siRNAs.":[196],"CONCLUSION:":[197],"In":[198],"conclusion,":[199],"these":[200],"validated":[202],"that":[203],"could":[205],"be":[206],"a":[207],"practical":[208],"choice":[209,226],"enhance":[211],"efficiency":[213],"cell":[222,237],"apoptosis.":[223],"However,":[224],"mechanism":[233],"affect":[234],"apoptotic":[238],"efficiency.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
