{"id":"https://openalex.org/W3134855812","doi":"https://doi.org/10.1007/s10557-021-07191-1","title":"An Adapted Neural-Fuzzy Inference System Model Using Preprocessed Balance Data to Improve the Predictive Accuracy of Warfarin Maintenance Dosing in Patients After Heart Valve Replacement","display_name":"An Adapted Neural-Fuzzy Inference System Model Using Preprocessed Balance Data to Improve the Predictive Accuracy of Warfarin Maintenance Dosing in Patients After Heart Valve Replacement","publication_year":2021,"publication_date":"2021-04-20","ids":{"openalex":"https://openalex.org/W3134855812","doi":"https://doi.org/10.1007/s10557-021-07191-1","mag":"3134855812","pmid":"https://pubmed.ncbi.nlm.nih.gov/33877502"},"language":"en","primary_location":{"id":"doi:10.1007/s10557-021-07191-1","doi":"https://doi.org/10.1007/s10557-021-07191-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10557-021-07191-1","pdf_url":null,"source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-224969/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062429074","display_name":"Zhi\u2010Chun Gu","orcid":"https://orcid.org/0000-0002-1245-9690","observed_orcids":["https://orcid.org/0000-0002-1245-9690"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Chun Gu","raw_affiliation_strings":["Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-1245-9690","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010368511","display_name":"Shou-Rui Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shou-Rui Huang","raw_affiliation_strings":["Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101871045","display_name":"Li Dong","orcid":"https://orcid.org/0000-0001-7860-6510","observed_orcids":["https://orcid.org/0000-0001-7860-6510"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Dong","raw_affiliation_strings":["Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qin Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Zhou","raw_affiliation_strings":["Department of Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378671","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-2294-9981","observed_orcids":["https://orcid.org/0000-0003-2294-9981"]},"institutions":[{"id":"https://openalex.org/I4210161469","display_name":"Fourth Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/05x9zm716","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161469"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Career Development Division, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Career Development Division, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210161469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101405089","display_name":"Bo Fu","orcid":"https://orcid.org/0009-0000-2212-2402","observed_orcids":["https://orcid.org/0009-0000-2212-2402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Fu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Tianjin Central Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Tianjin Central Hospital, Tianjin, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089564180","display_name":"Jin Chen","orcid":"https://orcid.org/0000-0002-6497-4141","observed_orcids":["https://orcid.org/0000-0002-6497-4141","https://orcid.org/0000-0003-1297-6687"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Chen","raw_affiliation_strings":["Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China. ebm_chenjin@126.com","Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China. ebm_chenjin@126.com","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5089564180"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":1.467,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81891922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"36","issue":"5","first_page":"879","last_page":"889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-valve-replacement","display_name":"heart valve replacement","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neural-fuzzy-inference-system","display_name":"neural fuzzy inference system","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adaptive-neuro-fuzzy-inference-system","display_name":"adaptive neuro-fuzzy inference system","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/imbalanced-training-data","display_name":"imbalanced training data","score":0.652999997138977},{"id":"https://openalex.org/keywords/class-imbalance","display_name":"class imbalance","score":0.5590000152587891},{"id":"https://openalex.org/keywords/dose-prediction","display_name":"dose prediction","score":0.49300000071525574},{"id":"https://openalex.org/keywords/prediction-accuracy","display_name":"prediction accuracy","score":0.5350000262260437},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7139999866485596},{"id":"https://openalex.org/keywords/anticoagulation-management","display_name":"anticoagulation management","score":0.492000013589859},{"id":"https://openalex.org/keywords/low-dose-warfarin","display_name":"low-dose warfarin","score":0.5860000252723694},{"id":"https://openalex.org/keywords/anticoagulation-monitoring","display_name":"anticoagulation monitoring","score":0.33899998664855957},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.34200000762939453},{"id":"https://openalex.org/keywords/pharmacodynamic-variability","display_name":"pharmacodynamic variability","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C186108316","wikidata":"https://www.wikidata.org/wiki/Q352530","display_name":"Adaptive neuro fuzzy inference system","level":4,"score":0.7287041544914246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7226472496986389},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.6576895713806152},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6536495685577393},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.49785590171813965},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.3447215259075165},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3447096645832062},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23787817358970642},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22163090109825134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19358158111572266},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16748365759849548},{"id":"https://openalex.org/C195975749","wikidata":"https://www.wikidata.org/wiki/Q1475705","display_name":"Fuzzy control system","level":3,"score":0.1413474977016449},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006351","descriptor_name":"Heart Valves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10557-021-07191-1","doi":"https://doi.org/10.1007/s10557-021-07191-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10557-021-07191-1","pdf_url":null,"source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-224969/v1","doi":"https://doi.org/10.21203/rs.3.rs-224969/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-224969/v1","pdf_url":"https://www.researchsquare.com/article/rs-224969/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33877502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33877502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular drugs and therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-224969/v1","doi":"https://doi.org/10.21203/rs.3.rs-224969/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-224969/v1","pdf_url":"https://www.researchsquare.com/article/rs-224969/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G183914288","display_name":null,"funder_award_id":"81641021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2575477237","display_name":"\u57fa\u4e8e\u4e34\u5e8a\u5927\u6570\u636e\u591a\u5c42\u6b21\u591a\u7ef4\u5ea6\u667a\u80fd\u5316\u534e\u6cd5\u6797\u4e2a\u4f53\u5316\u5408\u7406\u7528\u836f\u6838\u5fc3\u8981\u7d20\u548c\u5173\u952e\u6280\u672f\u5faa\u8bc1\u7814\u7a76","funder_award_id":"71974137","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G725630720","display_name":null,"funder_award_id":"CXYJY2019ZD001","funder_id":"https://openalex.org/F4320335305","funder_display_name":"School of Medicine, Shanghai Jiao Tong University"},{"id":"https://openalex.org/G8241333094","display_name":null,"funder_award_id":"CXYJY2019ZD001","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G8874847691","display_name":null,"funder_award_id":"PY2018-III-06","funder_id":"https://openalex.org/F4320331064","funder_display_name":"Renji Hospital"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320331064","display_name":"Renji Hospital","ror":"https://ror.org/03y191s38"},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134855812.pdf","grobid_xml":"https://content.openalex.org/works/W3134855812.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1483996468","https://openalex.org/W1515782956","https://openalex.org/W1920947146","https://openalex.org/W1964837462","https://openalex.org/W1982973803","https://openalex.org/W1988201612","https://openalex.org/W1998269707","https://openalex.org/W2006566690","https://openalex.org/W2025144228","https://openalex.org/W2044869076","https://openalex.org/W2049743968","https://openalex.org/W2059587305","https://openalex.org/W2061739968","https://openalex.org/W2096558424","https://openalex.org/W2101980933","https://openalex.org/W2104988855","https://openalex.org/W2106504576","https://openalex.org/W2106828417","https://openalex.org/W2112940339","https://openalex.org/W2113312374","https://openalex.org/W2118978333","https://openalex.org/W2119155997","https://openalex.org/W2126850977","https://openalex.org/W2148215987","https://openalex.org/W2151936813","https://openalex.org/W2157065952","https://openalex.org/W2170483665","https://openalex.org/W2328491534","https://openalex.org/W2340487066","https://openalex.org/W2403979768","https://openalex.org/W2408157549","https://openalex.org/W2752786594","https://openalex.org/W2790380685","https://openalex.org/W2796841861","https://openalex.org/W2808966526","https://openalex.org/W2909731561","https://openalex.org/W2978310679","https://openalex.org/W2992654024","https://openalex.org/W3003559757","https://openalex.org/W3004014363","https://openalex.org/W4252734838"],"related_works":["https://openalex.org/W2796841861","https://openalex.org/W2978310679","https://openalex.org/W2808966526","https://openalex.org/W3174696773","https://openalex.org/W2997473456","https://openalex.org/W2044869076","https://openalex.org/W2910745345","https://openalex.org/W4382702397","https://openalex.org/W4411918261","https://openalex.org/W1751671986"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tailoring":[2],"warfarin":[3,44,86,176,228,320,346,369],"use":[4],"poses":[5],"a":[6,136,245,303],"challenge":[7],"for":[8,257],"physicians":[9],"and":[10,18,68,91,94,109,124,140,147,160,167,180,191,213,231,233,251,260,280,317,367],"pharmacists":[11],"due":[12],"to":[13,25,38,227,295,360],"its":[14],"narrow":[15],"therapeutic":[16],"window":[17],"huge":[19],"inter-individual":[20],"variability.":[21],"This":[22,56],"study":[23,58],"aimed":[24],"create":[26],"an":[27,261],"adapted":[28],"neural-fuzzy":[29],"inference":[30],"system":[31],"(ANFIS)":[32],"model":[33,139,269,283,301,341,358],"using":[34,145],"preprocessed":[35],"balance":[36],"data":[37,354],"improve":[39],"the":[40,81,95,100,104,110,154,158,197,203,209,216,267,281,296,299,309,318,331,345,356,365],"predictive":[41,97],"accuracy":[42,307],"of":[43,135,186],"maintenance":[45,229,347],"dosing":[46],"in":[47,75,164,196,202,208,215,265,308,349,364],"Chinese":[48],"patients":[49,60,188,350],"undergoing":[50],"heart":[51],"valve":[52],"replacement":[53],"(HVR).":[54],"Methods":[55],"retrospective":[57],"enrolled":[59],"who":[61],"underwent":[62],"HVR":[63],"between":[64,84,157,249],"June":[65,69],"1,":[66,70],"2012":[67],"2016":[71],"from":[72,330],"35":[73],"centers":[74],"China.":[76],"The":[77,115,242,328,339],"primary":[78,155],"outcomes":[79,156],"were":[80,118,173,189,222,240],"mean":[82,105,111,247],"difference":[83,248],"predicted":[85,102,250],"dose":[87,348],"by":[88,132],"ANFIS":[89,143,162,235,340],"models":[90,144,163,236],"actual":[92,252],"dose,":[93],"models\u2019":[96],"accuracy,":[98],"including":[99],"ideal":[101],"percentage,":[103],"absolute":[106],"error":[107,113],"(MAE),":[108],"squared":[112],"(MSE).":[114],"eligible":[116],"cases":[117],"divided":[119],"into":[120],"training,":[121],"internal":[122,166,210],"validation,":[123],"external":[125,168,217,332],"validation":[126,169,211,218,333],"groups.":[127,370],"We":[128,151],"explored":[129,223],"input":[130],"variables":[131,221],"univariate":[133],"analysis":[134],"general":[137],"liner":[138],"created":[141],"two":[142],"imbalanced":[146,159,198,232,268,297],"balanced":[148,161,204,234,282,300,357],"training":[149,199,205],"sets.":[150,170],"finally":[152],"compared":[153],"both":[165,266],"Stratified":[171],"analyses":[172],"conducted":[174],"across":[175],"doses":[177,253],"(low,":[178],"medium,":[179],"high":[181],"doses).":[182],"Results":[183],"A":[184],"total":[185],"15,108":[187],"included":[190],"grouped":[192],"as":[193,224],"follows:":[194],"12,086":[195],"set;":[200,206,212],"2,820":[201],"1,511":[207,214],"set.":[219],"Eight":[220],"predictors":[225],"related":[226],"doses,":[230],"with":[237],"multi-fuzzy":[238],"rules":[239],"developed.":[241],"results":[243,329],"showed":[244],"low":[246],"(<":[254],"0.3":[255],"mg/d":[256],"each":[258],"model)":[259],"accurate":[262],"prediction":[263,271,285,306,362],"property":[264],"(ideal":[270,284],"percentage:":[272,286],"74.39\u201378.16%,":[273],"MAE:":[274,288],"0.37":[275],"mg/daily,":[276],"MSE:":[277],"0.39":[278],"mg/daily)":[279],"73.46\u201375.31%,":[287],"0.42":[289],"mg/daily;":[290],"MSE,":[291],"0.43":[292],"mg/daily).":[293],"Compared":[294],"model,":[298],"had":[302],"significantly":[304],"higher":[305],"low-dose":[310],"(14.46%":[311],"vs.":[312,323],"3.01%;":[313],"P":[314,325],"<":[315],"0.001)":[316],"high-dose":[319,368],"groups":[321],"(34.71%":[322],"23.14%;":[324],"=":[326],"0.047).":[327],"cohort":[334],"confirmed":[335],"this":[336],"finding.":[337],"Conclusions":[338],"can":[342],"accurately":[343],"predict":[344],"after":[351],"HVR.":[352],"Through":[353],"preprocessing,":[355],"contributed":[359],"improved":[361],"ability":[363],"low-":[366]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-03-15T00:00:00"}