{"id":"https://openalex.org/W3134847525","doi":"https://doi.org/10.5281/zenodo.2661149","title":"Anticancer Effect of Doxorubicin Using Injectable Hydrogel","display_name":"Anticancer Effect of Doxorubicin Using Injectable Hydrogel","publication_year":2014,"publication_date":"2014-07-05","ids":{"openalex":"https://openalex.org/W3134847525","doi":"https://doi.org/10.5281/zenodo.2661149","mag":"3134847525"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:2661150","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/2661150","pdf_url":"https://zenodo.org/record/2661150","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacological and Pharmaceutical Sciences 8.0(7)","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/2661150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013833471","display_name":"Prasamsha Panta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasamsha Panta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002346770","display_name":"Da Yeon Kim","orcid":"https://orcid.org/0000-0003-4696-0501","observed_orcids":["https://orcid.org/0000-0003-4696-0501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Da Yeon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020796611","display_name":"Ja Yong Jang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jang, Ja Yong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745135","display_name":"Min-Jae Kim","orcid":"https://orcid.org/0009-0003-0550-2317","observed_orcids":["https://orcid.org/0009-0003-0550-2317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Min Jae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Jae Ho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072408448","display_name":"Moon Suk Kim","orcid":"https://orcid.org/0000-0002-6689-1825","observed_orcids":["https://orcid.org/0000-0002-6689-1825","https://orcid.org/0000-0001-9281-7111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Moon Suk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32977303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/in-situ-forming-hydrogels","display_name":"in situ forming hydrogels","score":0.8889999985694885},{"id":"https://openalex.org/keywords/intratumoral-chemotherapy","display_name":"intratumoral chemotherapy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6150000095367432},{"id":"https://openalex.org/keywords/thermosensitive-hydrogel","display_name":"thermosensitive hydrogel","score":0.7879999876022339},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.875},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8033528327941895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38366904854774475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34907907247543335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24024119973182678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.164434015750885},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11349740624427795}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:zenodo.org:2661150","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/2661150","pdf_url":"https://zenodo.org/record/2661150","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacological and Pharmaceutical Sciences 8.0(7)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.2661149","doi":"https://doi.org/10.5281/zenodo.2661149","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.2661149","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.2661150","doi":"https://doi.org/10.5281/zenodo.2661150","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.2661150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:3134847525","doi":null,"is_oa":false,"landing_page_url":"https://panel.waset.org/abstracts//9290","pdf_url":null,"source":{"id":"https://openalex.org/S2765006805","display_name":"World Academy of Science, Engineering and Technology, International Journal of Pharmacological and Pharmaceutical Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"World Academy of Science, Engineering and Technology, International Journal of Pharmacological and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:zenodo.org:2661150","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/2661150","pdf_url":"https://zenodo.org/record/2661150","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacological and Pharmaceutical Sciences 8.0(7)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134847525.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068327773","https://openalex.org/W3086567404","https://openalex.org/W2262119483","https://openalex.org/W3023306406","https://openalex.org/W2328706491","https://openalex.org/W2048278858","https://openalex.org/W2168972911","https://openalex.org/W2460673741","https://openalex.org/W1989989015","https://openalex.org/W2049432230"],"abstract_inverted_index":{"Introduction:":[0],"Among":[1],"the":[2,48,52,57,118,137,174,237,251],"many":[3,18],"anticancer":[4,49,62],"drugs":[5,15],"used":[6,14],"clinically,":[7],"doxorubicin":[8],"(Dox),":[9],"was":[10,146,169,176,183,187],"one":[11],"of":[12,20,32,47,61,90,98,139,166,228,243,255,265],"widely":[13],"to":[16,41,51,94,233],"treat":[17],"types":[19],"solid":[21],"tumors":[22],"such":[23],"as":[24],"liver,":[25],"colon,":[26],"breast,":[27],"or":[28],"lung.":[29],"Intratumoral":[30],"injection":[31,227],"chemotherapeutic":[33],"agents":[34],"is":[35,93],"a":[36],"potentially":[37],"more":[38],"effective":[39],"alternative":[40],"systemic":[42],"administration":[43],"because":[44,72],"direct":[45],"delivery":[46],"drug":[50,78,168,207],"target":[53],"may":[54],"improve":[55],"both":[56],"stability":[58],"and":[59,84,110,116,126,133,159,191,239],"efficacy":[60,115],"drugs.":[63],"Injectable":[64],"in":[65,103,114,120,198,215,236],"situ-forming":[66,104],"gels":[67,212],"have":[68,205],"attracted":[69],"considerable":[70],"attention":[71],"they":[73],"can":[74],"achieve":[75],"site":[76],"specific":[77],"delivery,":[79],"long":[80],"term":[81],"action":[82],"periods,":[83],"improved":[85],"patient":[86],"compliance.":[87],"Objective:":[88],"Objective":[89],"present":[91],"study":[92],"confirm":[95],"clinical":[96,253],"benefit":[97],"intratumoral":[99],"chemotherapy":[100],"using":[101,171],"injectable":[102],"poly(ethylene":[105],"glycol)-b-polycaprolactone":[106],"diblock":[107],"copolymer":[108],"(MP)":[109],"Dox":[111,167,232,268],"with":[112,122,148,189,271],"increase":[113],"reducing":[117],"toxicity":[119],"patients":[121],"cancer":[123,220],"diseases.":[124],"Methods":[125],"methodology:":[127],"We":[128],"prepared":[129],"biodegradable":[130,206],"MP":[131,151,161,204,211,230,259],"hydrogel":[132],"measured":[134,170],"viscosity":[135],"for":[136],"evaluation":[138],"thermo-sensitive":[140],"property.":[141,209],"In":[142],"vivo":[143],"antitumor":[144],"activity":[145],"performed":[147],"normal":[149],"saline,":[150],"only,":[152],"single":[153],"free":[154,157],"Dox,":[155,158],"repeat":[156],"Dox-loaded":[160,203,210,229,258],"gel.":[162],"The":[163,196],"remaining":[164],"amount":[165],"HPLC":[172],"after":[173],"mouse":[175],"sacrified.":[177],"For":[178],"cytotoxicity":[179,217],"studies":[180],"WST-1":[181],"assay":[182],"performed.":[184],"Histological":[185],"analysis":[186],"done":[188],"H&E":[190],"TUNEL":[192],"processes":[193],"respectively.":[194],"Results:":[195],"works":[197],"this":[199,223],"experiment":[200],"showed":[201,213],"that":[202,226],"depot":[208],"remarkable":[214],"vitro":[216],"activities":[218],"against":[219],"cells.":[221],"Finally,":[222],"work":[224,248],"indicates":[225],"allowed":[231],"act":[234],"effectively":[235],"tumor":[238,244],"induced":[240],"long-lasting":[241],"supression":[242],"growth.":[245],"Conclusion:":[246],"This":[247],"has":[249],"examined":[250],"potential":[252],"utility":[254],"intratumorally":[256],"injected":[257],"gel,":[260],"which":[261],"shows":[262],"significant":[263],"effect":[264],"higher":[266],"local":[267],"retention":[269],"compared":[270],"systemically":[272],"administered":[273],"Dox.":[274]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2021-03-15T00:00:00"}