{"id":"https://openalex.org/W3134841325","doi":"https://doi.org/10.1007/s43440-021-00239-x","title":"Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies","display_name":"Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies","publication_year":2021,"publication_date":"2021-03-08","ids":{"openalex":"https://openalex.org/W3134841325","doi":"https://doi.org/10.1007/s43440-021-00239-x","mag":"3134841325","pmid":"https://pubmed.ncbi.nlm.nih.gov/33686610","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994227"},"language":"en","primary_location":{"id":"doi:10.1007/s43440-021-00239-x","doi":"https://doi.org/10.1007/s43440-021-00239-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43440-021-00239-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43440-021-00239-x.pdf","source":{"id":"https://openalex.org/S180401253","display_name":"Pharmacological Reports","issn_l":"1734-1140","issn":["1734-1140","2299-5684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s43440-021-00239-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091573775","display_name":"Piotr J. Rudzki","orcid":"https://orcid.org/0000-0002-4622-4849","observed_orcids":["https://orcid.org/0000-0002-4622-4849"]},"institutions":[{"id":"https://openalex.org/I4210129336","display_name":"\u0141ukasiewicz Research Network","ror":"https://ror.org/036f4sz05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210129336"]},{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr J. Rudzki","raw_affiliation_strings":["\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-4622-4849","affiliations":[{"raw_affiliation_string":"\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129336","https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057080645","display_name":"Katarzyna Jarus\u2010Dziedzic","orcid":"https://orcid.org/0009-0006-0289-0571","observed_orcids":["https://orcid.org/0009-0006-0289-0571"]},"institutions":[{"id":"https://openalex.org/I4210090471","display_name":"BioVirtus (Poland)","ror":"https://ror.org/00ddfwx17","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210090471"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Jarus-Dziedzic","raw_affiliation_strings":["BioVirtus Research Site Sp, ul. Borowa 14/18, 05-400, Otwock, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioVirtus Research Site Sp, ul. Borowa 14/18, 05-400, Otwock, Poland","institution_ids":["https://openalex.org/I4210090471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044877811","display_name":"Monika Filist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129336","display_name":"\u0141ukasiewicz Research Network","ror":"https://ror.org/036f4sz05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210129336"]},{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Filist","raw_affiliation_strings":["\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129336","https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081769009","display_name":"Edyta Gilant","orcid":"https://orcid.org/0000-0002-8365-993X","observed_orcids":["https://orcid.org/0000-0002-8365-993X"]},"institutions":[{"id":"https://openalex.org/I4210129336","display_name":"\u0141ukasiewicz Research Network","ror":"https://ror.org/036f4sz05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210129336"]},{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Edyta Gilant","raw_affiliation_strings":["\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129336","https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008084398","display_name":"Katarzyna Bu\u015b\u2010Kwa\u015bnik","orcid":"https://orcid.org/0000-0003-4484-7142","observed_orcids":["https://orcid.org/0000-0003-4484-7142"]},"institutions":[{"id":"https://openalex.org/I4210129336","display_name":"\u0141ukasiewicz Research Network","ror":"https://ror.org/036f4sz05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210129336"]},{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Bu\u015b-Kwa\u015bnik","raw_affiliation_strings":["\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-4484-7142","affiliations":[{"raw_affiliation_string":"\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129336","https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035003555","display_name":"Andrzej Le\u015b","orcid":"https://orcid.org/0000-0002-6020-0851","observed_orcids":["https://orcid.org/0000-0002-6020-0851"]},"institutions":[{"id":"https://openalex.org/I4210129336","display_name":"\u0141ukasiewicz Research Network","ror":"https://ror.org/036f4sz05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210129336"]},{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Le\u015b","raw_affiliation_strings":["\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0141ukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129336","https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076230876","display_name":"M Sasinowska-Motyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Sasinowska-Motyl","raw_affiliation_strings":["Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086211481","display_name":"\u0141ukasz Nagraba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"\u0141ukasz Nagraba","raw_affiliation_strings":["Orthopedic and Rehabilitation Department, Medical University of Warsaw, ul. Kondratowicza 8, 03-242, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic and Rehabilitation Department, Medical University of Warsaw, ul. Kondratowicza 8, 03-242, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054226470","display_name":"Magdalena Bujalska\u2010Zadro\u017cny","orcid":"https://orcid.org/0000-0002-4270-6373","observed_orcids":["https://orcid.org/0000-0002-4270-6373"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Magdalena Bujalska-Zadro\u017cny","raw_affiliation_strings":["Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland. magdalena.bujalska@wum.edu.pl","Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-4270-6373","affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland. magdalena.bujalska@wum.edu.pl","institution_ids":["https://openalex.org/I268303160"]},{"raw_affiliation_string":"Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054226470"],"corresponding_institution_ids":["https://openalex.org/I268303160"],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":{"value":2780,"currency":"USD","value_usd":2780},"fwci":0.8405,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68661428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"2","first_page":"604","last_page":"614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.40529999136924744,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.40529999136924744,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.13420000672340393,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/magnesium-ions","display_name":"magnesium ions","score":0.8949999809265137},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/o-desmethyltramadol","display_name":"O-desmethyltramadol","score":0.9549999833106995},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/analgesic-synergy","display_name":"synergistic analgesia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6240000128746033},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.9344871044158936},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8763574361801147},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6946638226509094},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6711609959602356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.615871250629425},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5621798038482666},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5578815340995789},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5475724935531616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5340446829795837},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4685474634170532},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.4571076035499573},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45684659481048584},{"id":"https://openalex.org/C40222840","wikidata":"https://www.wikidata.org/wiki/Q185049","display_name":"Geometric mean","level":2,"score":0.45637616515159607},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.430130273103714},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4129675030708313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2241002321243286},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s43440-021-00239-x","doi":"https://doi.org/10.1007/s43440-021-00239-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43440-021-00239-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43440-021-00239-x.pdf","source":{"id":"https://openalex.org/S180401253","display_name":"Pharmacological Reports","issn_l":"1734-1140","issn":["1734-1140","2299-5684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reports","raw_type":"journal-article"},{"id":"pmid:33686610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33686610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological reports : PR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7994227","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7994227/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacol Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s43440-021-00239-x","doi":"https://doi.org/10.1007/s43440-021-00239-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43440-021-00239-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43440-021-00239-x.pdf","source":{"id":"https://openalex.org/S180401253","display_name":"Pharmacological Reports","issn_l":"1734-1140","issn":["1734-1140","2299-5684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G6869442547","display_name":null,"funder_award_id":"INNOTECH-K2IN2/70/183154/NCBR/13","funder_id":"https://openalex.org/F4320335039","funder_display_name":"Narodowe Centrum Bada\u0144 i Rozwoju"}],"funders":[{"id":"https://openalex.org/F4320335039","display_name":"Narodowe Centrum Bada\u0144 i Rozwoju","ror":"https://ror.org/05pwfyy15"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134841325.pdf","grobid_xml":"https://content.openalex.org/works/W3134841325.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W180858830","https://openalex.org/W1512490653","https://openalex.org/W1588124378","https://openalex.org/W1900249832","https://openalex.org/W1965591318","https://openalex.org/W1970275647","https://openalex.org/W1976280582","https://openalex.org/W1982874357","https://openalex.org/W1984302112","https://openalex.org/W2007440728","https://openalex.org/W2013594289","https://openalex.org/W2019462692","https://openalex.org/W2023745848","https://openalex.org/W2037698344","https://openalex.org/W2049517532","https://openalex.org/W2059335403","https://openalex.org/W2060622064","https://openalex.org/W2060679305","https://openalex.org/W2068175659","https://openalex.org/W2079486253","https://openalex.org/W2085846663","https://openalex.org/W2095024445","https://openalex.org/W2135121504","https://openalex.org/W2149093506","https://openalex.org/W2164274363","https://openalex.org/W2226035679","https://openalex.org/W2300421333","https://openalex.org/W2400397434","https://openalex.org/W2541971015","https://openalex.org/W2550833707","https://openalex.org/W2612893562","https://openalex.org/W2638477903","https://openalex.org/W2738920882","https://openalex.org/W2770070688","https://openalex.org/W2898323862","https://openalex.org/W2911232630","https://openalex.org/W2915730910","https://openalex.org/W2995530130","https://openalex.org/W3006924821","https://openalex.org/W3008729083","https://openalex.org/W3010299589"],"related_works":["https://openalex.org/W1480155300","https://openalex.org/W2550833707","https://openalex.org/W2888233297","https://openalex.org/W579872989","https://openalex.org/W4313414803","https://openalex.org/W2980818129","https://openalex.org/W2011525667","https://openalex.org/W7203605836","https://openalex.org/W2102869868","https://openalex.org/W2076922790"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Magnesium":[2],"ions":[3],"(Mg2+)":[4],"increase":[5],"and":[6,12,57,64,79,88,108,120,126,132,144,153,161,170,205,213,226],"prolong":[7],"opioid":[8],"analgesia":[9],"in":[10,85,200,210,235],"chronic":[11],"acute":[13],"pain.":[14,243],"The":[15,103,138,155,172,218],"nature":[16],"of":[17,45,76,106,118,193,215,220,242],"this":[18,230],"synergistic":[19],"analgesic":[20],"interaction":[21,222],"has":[22],"not":[23,187],"yet":[24],"been":[25],"explained.":[26],"Our":[27,37],"aim":[28],"was":[29,40,50,71],"to":[30,41,52],"investigate":[31],"whether":[32],"Mg2+":[33,59,70,221],"alter":[34],"tramadol":[35,83,107,150,167,224],"pharmacokinetics.":[36],"secondary":[38,133],"goal":[39],"assess":[42],"the":[43,46,124,182,194,211,236,240],"safety":[44,207,227],"combination.":[47],"Methods":[48],"Tramadol":[49],"administered":[51,72],"healthy":[53],"Caucasian":[54],"subjects":[55,122],"with":[56,223],"without":[58],"as":[60],"(1)":[61],"single":[62],"100-mg":[63],"(2)":[65],"multiple":[66],"50-mg":[67],"oral":[68],"doses.":[69],"orally":[73],"at":[74],"doses":[75],"150":[77],"mg":[78,81],"75":[80],"per":[82],"dosing":[84],"a":[86],"single-":[87,125],"multiple-dose":[89,127],"study,":[90,128],"respectively.":[91,129],"Both":[92,130],"studies":[93],"were":[94,113,136,151,168,180,208],"randomized,":[95],"open":[96],"label,":[97],"laboratory-blinded,":[98],"two-period,":[99],"two-treatment,":[100],"crossover":[101],"trials.":[102],"plasma":[104],"concentrations":[105],"its":[109],"active":[110],"metabolite,":[111],"O-desmethyltramadol,":[112],"measured.":[114],"Results":[115],"A":[116],"total":[117],"25":[119],"26":[121],"completed":[123],"primary":[131,177],"pharmacokinetic":[134,178],"parameters":[135,179],"similar.":[137],"90%":[139,156,173],"confidence":[140,157,174],"intervals":[141,158,175],"for":[142,149,159,166,176,239],"Cmax":[143],"AUC0-t":[145],"geometric":[146,163],"mean":[147,164],"ratios":[148,165],"91.95\u2013102.40%":[152],"93.22\u2013102.76%.":[154],"Cmax,ss":[160],"AUC0-\u03c4":[162],"93.85\u2013103.31%":[169],"99.04\u2013105.27%.":[171],"within":[181],"acceptance":[183],"range.":[184],"ANOVA":[185],"did":[186],"show":[188],"any":[189],"statistically":[190],"significant":[191],"contribution":[192],"formulation":[195],"factor":[196],"(p":[197],">":[198],"0.05)":[199],"either":[201],"study.":[202],"Adverse":[203],"events":[204],"clinical":[206,237],"similar":[209],"presence":[212],"absence":[214,219],"Mg2+.":[216],"Conclusions":[217],"pharmacokinetics":[225],"suggests":[228],"that":[229],"combination":[231],"may":[232],"be":[233],"used":[234],"practice":[238],"pharmacotherapy":[241],"Graphic":[244],"abstract":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}