{"id":"https://openalex.org/W3134824205","doi":"https://doi.org/10.1186/s13287-021-02249-1","title":"Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head","display_name":"Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head","publication_year":2021,"publication_date":"2021-03-12","ids":{"openalex":"https://openalex.org/W3134824205","doi":"https://doi.org/10.1186/s13287-021-02249-1","mag":"3134824205","pmid":"https://pubmed.ncbi.nlm.nih.gov/33712030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7953570"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-021-02249-1","doi":"https://doi.org/10.1186/s13287-021-02249-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02249-1","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02249-1","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02249-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039996746","display_name":"Meiling Zhou","orcid":"https://orcid.org/0000-0003-2250-4966","observed_orcids":["https://orcid.org/0000-0003-2250-4966"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiling Zhou","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102119018","display_name":"Jiaoya Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaoya Xi","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620925","display_name":"Yaofeng Cheng","orcid":"https://orcid.org/0000-0002-3875-3070","observed_orcids":["https://orcid.org/0000-0002-3875-3070"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210095236","display_name":"Suizhou Central Hospital","ror":"https://ror.org/00q3p9p08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095236"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaofeng Cheng","raw_affiliation_strings":["Department of Orthopedics, Suizhou Central Hospital, Hubei University of Medicine, Suizhou, Hubei, China","Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Suizhou Central Hospital, Hubei University of Medicine, Suizhou, Hubei, China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210095236"]},{"raw_affiliation_string":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050941412","display_name":"Denglong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Denglong Sun","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Shu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Shu","raw_affiliation_strings":["Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082428365","display_name":"Shuiqing Chi","orcid":"https://orcid.org/0000-0002-7537-0255","observed_orcids":["https://orcid.org/0000-0002-7537-0255"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuiqing Chi","raw_affiliation_strings":["Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021285930","display_name":"Shuo Tian","orcid":"https://orcid.org/0000-0001-9883-2961","observed_orcids":["https://orcid.org/0000-0001-9883-2961"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Tian","raw_affiliation_strings":["Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033402435","display_name":"Shunan Ye","orcid":"https://orcid.org/0000-0001-7601-5610","observed_orcids":["https://orcid.org/0000-0001-7601-5610"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shunan Ye","raw_affiliation_strings":["Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. shunany@126.com","Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China"],"raw_orcid":"https://orcid.org/0000-0001-7601-5610","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. shunany@126.com","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033402435"],"corresponding_institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":11.4956,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.99459879,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"175","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avascular-necrosis-of-the-femoral-head","display_name":"osteonecrosis of the femoral head","score":0.984000027179718},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5329999923706055},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.8090000152587891},{"id":"https://openalex.org/keywords/steroid-induced-osteonecrosis","display_name":"steroid-induced osteonecrosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8847264647483826},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7237026691436768},{"id":"https://openalex.org/C2779100257","wikidata":"https://www.wikidata.org/wiki/Q582849","display_name":"Femoral head","level":2,"score":0.5715564489364624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.569365382194519},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5519543886184692},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48047202825546265},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47214773297309875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4178307056427002},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35497379302978516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22688916325569153},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21365121006965637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15771251916885376},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.11067870259284973},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13287-021-02249-1","doi":"https://doi.org/10.1186/s13287-021-02249-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02249-1","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02249-1","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:33712030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33712030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7953570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7953570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9895524e794c48e1b6129b9d2cf128a1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9895524e794c48e1b6129b9d2cf128a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-021-02249-1","doi":"https://doi.org/10.1186/s13287-021-02249-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02249-1","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02249-1","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6808577397","display_name":null,"funder_award_id":"81472083","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321883","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53"},{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320336027","display_name":"Tongji Medical College, Huazhong University of Science and Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134824205.pdf","grobid_xml":"https://content.openalex.org/works/W3134824205.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W14346475","https://openalex.org/W145265202","https://openalex.org/W1526509972","https://openalex.org/W1557562380","https://openalex.org/W1599870084","https://openalex.org/W1786308441","https://openalex.org/W1915697590","https://openalex.org/W1963317358","https://openalex.org/W1965172590","https://openalex.org/W1968102151","https://openalex.org/W1974652937","https://openalex.org/W1974777246","https://openalex.org/W1983942478","https://openalex.org/W1990533831","https://openalex.org/W1996059719","https://openalex.org/W1998417918","https://openalex.org/W2000227147","https://openalex.org/W2002217631","https://openalex.org/W2007772114","https://openalex.org/W2009508208","https://openalex.org/W2025371271","https://openalex.org/W2026622347","https://openalex.org/W2036659055","https://openalex.org/W2040738774","https://openalex.org/W2043303130","https://openalex.org/W2047885845","https://openalex.org/W2049446122","https://openalex.org/W2052004719","https://openalex.org/W2057734869","https://openalex.org/W2060291986","https://openalex.org/W2069160495","https://openalex.org/W2082223061","https://openalex.org/W2093989693","https://openalex.org/W2102016724","https://openalex.org/W2106569604","https://openalex.org/W2107277218","https://openalex.org/W2110114018","https://openalex.org/W2131214811","https://openalex.org/W2138977668","https://openalex.org/W2146253518","https://openalex.org/W2159999899","https://openalex.org/W2318776028","https://openalex.org/W2400126885","https://openalex.org/W2404007660","https://openalex.org/W2460822283","https://openalex.org/W2466623373","https://openalex.org/W2518933576","https://openalex.org/W2547146160","https://openalex.org/W2573584439","https://openalex.org/W2590858549","https://openalex.org/W2797737760","https://openalex.org/W2803265029","https://openalex.org/W2887238772","https://openalex.org/W2898114410","https://openalex.org/W2903455456","https://openalex.org/W2952425682","https://openalex.org/W2953083239","https://openalex.org/W3005507476"],"related_works":["https://openalex.org/W6901999231","https://openalex.org/W4303962271","https://openalex.org/W4380290879","https://openalex.org/W1245201416","https://openalex.org/W4417411618","https://openalex.org/W2525286621","https://openalex.org/W2074086534","https://openalex.org/W2160094808","https://openalex.org/W2400126885","https://openalex.org/W3013062320"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cellular":[1],"therapy":[2,35],"based":[3],"on":[4],"mesenchymal":[5],"stem":[6,69],"cells":[7,70],"(MSCs)":[8],"is":[9,24,36],"a":[10],"promising":[11],"novel":[12],"therapeutic":[13],"strategy":[14],"for":[15,29],"the":[16,19,33,54,81,84,98,101,133,178,181,204,236,250,255,265,281,285,292,313,317],"osteonecrosis":[17],"of":[18,47,50,88,100,123,180,203,226,232,238,252,284,300,303,316],"femoral":[20,102,205,286,318],"head":[21,206],"(ONFH),":[22],"which":[23,72,132],"gradually":[25],"becoming":[26],"popular,":[27],"particularly":[28],"early-stage":[30],"ONFH.":[31],"Nonetheless,":[32],"MSC-based":[34],"challenging":[37],"due":[38],"to":[39,75,129,230,269],"certain":[40],"limitations,":[41],"such":[42],"as":[43],"limited":[44],"self-renewal":[45],"capability":[46],"cells,":[48],"availability":[49],"donor":[51,58],"MSCs,":[52],"and":[53,95,169,188,195,222,242,254,276,296,310],"costs":[55],"involved":[56],"in":[57,185,218,258,272,280,312],"screening.":[59],"As":[60],"an":[61,259],"alternative":[62],"approach,":[63],"MSCs":[64,114,138],"derived":[65],"from":[66],"induced":[67],"pluripotent":[68],"(iPSCs),":[71],"may":[73],"lead":[74],"further":[76],"standardized-cell":[77],"preparations.":[78],"METHODS:":[79],"In":[80],"present":[82],"study,":[83],"bone":[85,112,274,278,308],"marrow":[86,199],"samples":[87],"patients":[89,96,125],"with":[90,97,193],"ONFH":[91,124,182,260],"(n":[92,104,150],"=":[93,105,151],"16)":[94],"fracture":[99],"neck":[103],"12)":[106],"were":[107,116,127,135,144,191,228],"obtained":[108],"during":[109],"operation.":[110],"The":[111,215],"marrow-derived":[113],"(BMSCs)":[115],"isolated":[117],"by":[118],"density":[119],"gradient":[120],"centrifugation.":[121],"BMSCs":[122,166,194,257,271],"(ONFH-BMSCs)":[126],"reprogrammed":[128],"iPSCs,":[130],"following":[131,148],"iPSCs":[134],"differentiated":[136],"into":[137,147],"(iPSC-MSCs).":[139],"Forty":[140],"adult":[141],"male":[142],"rats":[143,184],"randomly":[145],"divided":[146],"groups":[149],"10":[152],"per":[153],"group):":[154],"(a)":[155],"normal":[156,233,256,270],"control":[157],"group,":[158,162,168],"(b)":[159],"methylprednisolone":[160],"(MPS)":[161],"(c)":[163],"MPS":[164,171],"+":[165,172],"treated":[167],"(d)":[170],"iPSC-MSC-treated":[173,189],"group.":[174],"Eight":[175],"weeks":[176],"after":[177,211],"establishment":[179],"model,":[183],"BMSC-treated":[186],"group":[187,190],"implanted":[192],"iPSC-MSCs":[196,227,239,253,266,304],"through":[197],"intrabone":[198],"injection.":[200],"Bone":[201],"repair":[202,279,309],"necrosis":[207,282,314],"area":[208,315],"was":[209,240,246,267],"analyzed":[210],"MSC":[212],"transplantation.":[213],"RESULTS:":[214],"morphology,":[216],"immunophenotype,":[217],"vitro":[219],"differentiation":[220],"potential,":[221],"DNA":[223,297],"methylation":[224,298],"patterns":[225,299],"similar":[229],"those":[231],"BMSCs,":[234],"while":[235],"proliferation":[237],"higher":[241],"no":[243],"tumorigenic":[244],"ability":[245],"exhibited.":[247],"Furthermore,":[248],"comparing":[249],"effectiveness":[251],"rat":[261],"model":[262],"revealed":[263],"that":[264],"equivalent":[268],"preventing":[273],"loss":[275],"promoting":[277],"region":[283],"head.":[287,319],"CONCLUSION:":[288],"Reprogramming":[289],"can":[290],"reverse":[291],"abnormal":[293],"proliferation,":[294],"differentiation,":[295],"ONFH-BMSCs.":[301],"Transplantation":[302],"could":[305],"effectively":[306],"promote":[307],"angiogenesis":[311]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
