{"id":"https://openalex.org/W3134771778","doi":"https://doi.org/10.1371/journal.pone.0247728","title":"Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma","display_name":"Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3134771778","doi":"https://doi.org/10.1371/journal.pone.0247728","mag":"3134771778","pmid":"https://pubmed.ncbi.nlm.nih.gov/33647018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7920365"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0247728","doi":"https://doi.org/10.1371/journal.pone.0247728","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247728","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247728&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247728&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058710999","display_name":"Taku Shigesawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Shigesawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025757104","display_name":"Goki Suda","orcid":"https://orcid.org/0000-0003-0098-9106","observed_orcids":["https://orcid.org/0000-0003-0098-9106"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Goki Suda","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0098-9106","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057000189","display_name":"Megumi Kimura","orcid":"https://orcid.org/0000-0002-9922-1027","observed_orcids":["https://orcid.org/0000-0002-9922-1027"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Kimura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091222313","display_name":"Osamu Maehara","orcid":"https://orcid.org/0009-0004-4137-0275","observed_orcids":["https://orcid.org/0009-0004-4137-0275"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Maehara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070335872","display_name":"Yoshimasa Tokuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Tokuchi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akinori Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Kubo","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966923","display_name":"Ren Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ren Yamada","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087097830","display_name":"Ken Furuya","orcid":"https://orcid.org/0000-0003-3373-4337","observed_orcids":["https://orcid.org/0000-0003-3373-4337"]},"institutions":[{"id":"https://openalex.org/I4210123166","display_name":"Hokkaido hospital","ror":"https://ror.org/02y005z64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123166","https://openalex.org/I4210132540"]},{"id":"https://openalex.org/I4210132540","display_name":"Japan Community Healthcare Organization","ror":"https://ror.org/03q11y497","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132540"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Furuya","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Japan Community Health Care Organization (JCHO) Hokkaido Hospital, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Japan Community Health Care Organization (JCHO) Hokkaido Hospital, Hokkaido, Japan","institution_ids":["https://openalex.org/I4210123166","https://openalex.org/I4210132540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040976202","display_name":"Masaru Baba","orcid":"https://orcid.org/0000-0002-4142-3267","observed_orcids":["https://orcid.org/0000-0002-4142-3267"]},"institutions":[{"id":"https://openalex.org/I4210123166","display_name":"Hokkaido hospital","ror":"https://ror.org/02y005z64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123166","https://openalex.org/I4210132540"]},{"id":"https://openalex.org/I4210132540","display_name":"Japan Community Healthcare Organization","ror":"https://ror.org/03q11y497","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132540"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Baba","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Japan Community Health Care Organization (JCHO) Hokkaido Hospital, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Japan Community Health Care Organization (JCHO) Hokkaido Hospital, Hokkaido, Japan","institution_ids":["https://openalex.org/I4210123166","https://openalex.org/I4210132540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047927868","display_name":"Takashi Kitagataya","orcid":"https://orcid.org/0000-0001-8833-8732","observed_orcids":["https://orcid.org/0000-0001-8833-8732"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kitagataya","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110029827","display_name":"Kazuharu Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuharu Suzuki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031216911","display_name":"Masatsugu Ohara","orcid":"https://orcid.org/0000-0002-4366-3184","observed_orcids":["https://orcid.org/0000-0002-4366-3184"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatsugu Ohara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020231124","display_name":"Naoki Kawagishi","orcid":"https://orcid.org/0000-0002-2953-6242","observed_orcids":["https://orcid.org/0000-0002-2953-6242"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Kawagishi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048212539","display_name":"Masato Nakai","orcid":"https://orcid.org/0000-0002-4860-1353","observed_orcids":["https://orcid.org/0000-0002-4860-1353"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Nakai","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053029290","display_name":"Takuya Sho","orcid":"https://orcid.org/0000-0001-7943-3842","observed_orcids":["https://orcid.org/0000-0001-7943-3842"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Sho","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047266289","display_name":"Mitsuteru Natsuizaka","orcid":"https://orcid.org/0000-0002-1819-1955","observed_orcids":["https://orcid.org/0000-0002-1819-1955"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuteru Natsuizaka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081579462","display_name":"Kenichi Morikawa","orcid":"https://orcid.org/0000-0002-3891-5113","observed_orcids":["https://orcid.org/0000-0002-3891-5113"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Morikawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075045544","display_name":"Koji Ogawa","orcid":"https://orcid.org/0000-0002-9221-6815","observed_orcids":["https://orcid.org/0000-0002-9221-6815"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Ogawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024713150","display_name":"Naoya Sakamoto","orcid":"https://orcid.org/0000-0003-0061-059X","observed_orcids":["https://orcid.org/0000-0003-0061-059X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoya Sakamoto","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025757104"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":1749,"currency":"USD","value_usd":1749},"apc_paid":{"value":1749,"currency":"USD","value_usd":1749},"fwci":0.7043,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.65102098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"16","issue":"3","first_page":"e0247728","last_page":"e0247728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":1.0},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fgf19","display_name":"FGF19","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":1.0},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.9319999814033508},{"id":"https://openalex.org/keywords/liver-function-deterioration","display_name":"liver function decline","score":0.7200000286102295},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/unresectable-liver-cancer","display_name":"unresectable liver cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.927156925201416},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8605262041091919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7698235511779785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6651911735534668},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6497637629508972},{"id":"https://openalex.org/C2909146873","wikidata":"https://www.wikidata.org/wiki/Q14912185","display_name":"Angiopoietin 2","level":4,"score":0.6319235563278198},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5122625231742859},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.42998209595680237},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4243495464324951},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.42196768522262573},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.36433154344558716},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33362746238708496},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.308408260345459},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.22879788279533386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21701115369796753}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0247728","doi":"https://doi.org/10.1371/journal.pone.0247728","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247728","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247728&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:33647018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33647018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7920365","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7920365/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:16bae927b72644ca84cea6b21b691046","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16bae927b72644ca84cea6b21b691046","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 16, Iss 3, p e0247728 (2021)","raw_type":"article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/81363","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/81363","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007194004","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/81363","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0247728","doi":"https://doi.org/10.1371/journal.pone.0247728","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247728","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247728&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2523824125","display_name":null,"funder_award_id":"JP20fk0210072, JP20fk0210064, JP20fk0210056, JP20fk0310101, JP20fk0210047, JP20fk0210048, JP20fk0210058, JP20fk0210066, and JP20fk0210067","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G2780668776","display_name":null,"funder_award_id":"JP20fk0210072","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G2882863282","display_name":null,"funder_award_id":"JP20fk0210066","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G2929850488","display_name":null,"funder_award_id":"JP20fk0310101","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G3061537743","display_name":"Identification of Factors Associated with Post-SVR Hepatocellular Carcinoma and Non-Improvement of Liver Fibrosis in Hepatitis C, and Therapeutic Implications","funder_award_id":"20K17008","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3496235411","display_name":null,"funder_award_id":"JP20fk0210067","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G3716890690","display_name":"Targeting the glycosylated structure of liver tissue stromal proteins to form the basis for glycosylation drug discovery for liver fibrosis.","funder_award_id":"20K21592","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4171107634","display_name":null,"funder_award_id":"JP20fk0210056","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4590517202","display_name":null,"funder_award_id":"JP20fk0210072, JP20fk0210064, JP20fk0210056, JP20fk0310101, JP20fk0210047, JP20fk0210048, JP20fk0210058, JP20fk0210066, JP20fk0210067","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4721518867","display_name":null,"funder_award_id":"JP20fk0210058","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G5299865180","display_name":null,"funder_award_id":"and JP20fk0210067","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G5625365522","display_name":null,"funder_award_id":"JP20fk0210048","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G5686649686","display_name":null,"funder_award_id":"JP20fk0210064","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6182096180","display_name":"Comprehensive screening of miviroenvirinmental factors that affect liver fibrosis","funder_award_id":"19H03630","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7557711891","display_name":null,"funder_award_id":"JP20fk0210047","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G760745854","display_name":"Mechanism of lenvatinib resistance in HCC-CSCs","funder_award_id":"20K17039","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8494169829","display_name":"High through anti-HBV drug screening by using reporter assay","funder_award_id":"19K08458","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134771778.pdf","grobid_xml":"https://content.openalex.org/works/W3134771778.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1964051982","https://openalex.org/W1971837077","https://openalex.org/W2008455196","https://openalex.org/W2028262440","https://openalex.org/W2046000826","https://openalex.org/W2079586464","https://openalex.org/W2100454247","https://openalex.org/W2119242310","https://openalex.org/W2120967735","https://openalex.org/W2560499218","https://openalex.org/W2617578435","https://openalex.org/W2785293290","https://openalex.org/W2787358630","https://openalex.org/W2795247401","https://openalex.org/W2888056309","https://openalex.org/W2888445348","https://openalex.org/W2893730472","https://openalex.org/W2908573150","https://openalex.org/W2949278321","https://openalex.org/W2953618138","https://openalex.org/W2963303825","https://openalex.org/W2981238164","https://openalex.org/W2988194539","https://openalex.org/W3004468778","https://openalex.org/W3015552590","https://openalex.org/W3016320614","https://openalex.org/W3021228866","https://openalex.org/W3025022288","https://openalex.org/W3027991621","https://openalex.org/W3036542274","https://openalex.org/W3127015740","https://openalex.org/W3139763557","https://openalex.org/W4210973123"],"related_works":["https://openalex.org/W3015552590","https://openalex.org/W3003135415","https://openalex.org/W4206394113","https://openalex.org/W3016320614","https://openalex.org/W3026788250","https://openalex.org/W7162310132","https://openalex.org/W7125636327","https://openalex.org/W3031271445","https://openalex.org/W7147269486","https://openalex.org/W3091975516"],"abstract_inverted_index":{"A":[0],"deteriorated":[1,98,137,179],"liver":[2],"functional":[3],"reserve":[4],"during":[5],"systemic":[6],"therapy":[7],"for":[8,153],"unresectable":[9,204],"hepatocellular":[10],"carcinoma":[11],"(HCC)":[12],"causes":[13],"poor":[14],"patient":[15,115],"outcomes.":[16],"We":[17],"aimed":[18],"to":[19,159],"identify":[20],"predictive":[21],"factors":[22],"associated":[23],"with":[24,37,136,169,188,203,209],"the":[25,185,198],"deterioration":[26,196],"of":[27,184,197],"Child-Pugh":[28,138,180,199],"score":[29,139,200],"at":[30],"8":[31],"weeks":[32],"after":[33],"lenvatinib":[34,210],"initiation.":[35],"Patients":[36],"adequate":[38],"clinical":[39,103],"data":[40,109],"and":[41,54,58,71,75,84,90,97,107,119,128,155,163,172,191,220],"baseline":[42,102,117,217],"preserved":[43],"serum":[44,218],"samples":[45],"available":[46],"were":[47,65,69,110,122,157],"included.":[48],"Baseline":[49],"fibroblast":[50],"growth":[51,61],"factor":[52,62],"(FGF)19":[53],"21,":[55],"angiopoietin":[56],"(ANG)2,":[57],"vascular":[59],"endothelial":[60],"(VEGF)":[63],"levels":[64,121],"evaluated.":[66],"Thirty-seven":[67],"patients":[68,93,135,168,186,202],"included,":[70],"6,":[72],"15,":[73],"14,":[74],"2":[76],"experienced":[77],"complete":[78],"response,":[79,81,106],"partial":[80],"stable":[82],"disease,":[83,86],"progressive":[85],"respectively.":[87,100,166],"Twenty-four":[88],"(65%)":[89],"13":[91],"(35%)":[92],"showed":[94],"a":[95,178],"maintained/improved":[96],"Child-Pugh-score,":[99],"While":[101],"data,":[104],"treatment":[105],"laboratory":[108],"similar":[111],"between":[112],"these":[113],"two":[114],"groups,":[116],"ANG2":[118,154,193,219],"VEGF":[120,156,171,190,221],"significantly":[123],"higher":[124],"(P":[125,130],"=":[126,131],"0.0017)":[127],"lower":[129],"0.0231),":[132],"respectively,":[133],"in":[134,141,201],"than":[140],"those":[142],"without.":[143],"Based":[144],"on":[145,215],"receiver":[146],"operating":[147],"characteristic":[148],"curve":[149],"analysis,":[150],"cut-off":[151],"values":[152],"found":[158],"be":[160,212],"3,108":[161],"pg/mL":[162],"514.9":[164],"pg/mL,":[165],"Among":[167],"low":[170,192],"high":[173,189],"ANG2,":[174],"89%":[175],"(8/9)":[176],"exhibited":[177],"score,":[181],"whereas":[182],"none":[183],"(0/9)":[187],"did.":[194],"The":[195],"HCC":[205],"who":[206],"are":[207],"treated":[208],"may":[211],"predictable":[213],"based":[214],"combined":[216],"levels.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
