{"id":"https://openalex.org/W3134638552","doi":"https://doi.org/10.1016/j.anai.2021.02.029","title":"Inhibitory effect of calcium channel blockers on the deterioration of lung function in adult-onset asthma","display_name":"Inhibitory effect of calcium channel blockers on the deterioration of lung function in adult-onset asthma","publication_year":2021,"publication_date":"2021-03-09","ids":{"openalex":"https://openalex.org/W3134638552","doi":"https://doi.org/10.1016/j.anai.2021.02.029","mag":"3134638552","pmid":"https://pubmed.ncbi.nlm.nih.gov/33705916"},"language":"en","primary_location":{"id":"doi:10.1016/j.anai.2021.02.029","doi":"https://doi.org/10.1016/j.anai.2021.02.029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.anai.2021.02.029","pdf_url":"http://www.annallergy.org/article/S1081120621001757/pdf","source":{"id":"https://openalex.org/S153558830","display_name":"Annals of Allergy Asthma & Immunology","issn_l":"1081-1206","issn":["1081-1206","1534-4436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Allergy, Asthma &amp; Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.annallergy.org/article/S1081120621001757/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068807068","display_name":"Ryuta Tsuzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryuta Tsuzuki","raw_affiliation_strings":["Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113994429","display_name":"Masako To","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masako To","raw_affiliation_strings":["Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110621973","display_name":"Satoshi Yamawaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Yamawaki","raw_affiliation_strings":["Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006423166","display_name":"Yuta Kono","orcid":"https://orcid.org/0000-0002-4098-496X","observed_orcids":["https://orcid.org/0000-0002-4098-496X"]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Kono","raw_affiliation_strings":["Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan; Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan","Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan; Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027940462","display_name":"Yasuo To","orcid":"https://orcid.org/0000-0002-0099-4696","observed_orcids":["https://orcid.org/0000-0002-0099-4696"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yasuo To","raw_affiliation_strings":["Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan. Electronic address: ytou-alg@umin.ac.jp","Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan. Electronic address: ytou-alg@umin.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027940462"],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.4587,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.57192696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"126","issue":"6","first_page":"731","last_page":"733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.972000002861023},{"id":"https://openalex.org/keywords/adult-onset-asthma","display_name":"adult-onset asthma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.8009999990463257},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oral-corticosteroids","display_name":"oral corticosteroids","score":0.6970000267028809},{"id":"https://openalex.org/keywords/biologics","display_name":"biologics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/asthma-phenotypes","display_name":"asthma phenotypes","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8894339203834534},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7242233157157898},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.5591856837272644},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48286110162734985},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.43574583530426025},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4203651249408722},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.415638267993927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3928612470626831},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3410983681678772},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.34039077162742615},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3122616410255432}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.anai.2021.02.029","doi":"https://doi.org/10.1016/j.anai.2021.02.029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.anai.2021.02.029","pdf_url":"http://www.annallergy.org/article/S1081120621001757/pdf","source":{"id":"https://openalex.org/S153558830","display_name":"Annals of Allergy Asthma & Immunology","issn_l":"1081-1206","issn":["1081-1206","1534-4436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Allergy, Asthma &amp; Immunology","raw_type":"journal-article"},{"id":"pmid:33705916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33705916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.anai.2021.02.029","doi":"https://doi.org/10.1016/j.anai.2021.02.029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.anai.2021.02.029","pdf_url":"http://www.annallergy.org/article/S1081120621001757/pdf","source":{"id":"https://openalex.org/S153558830","display_name":"Annals of Allergy Asthma & Immunology","issn_l":"1081-1206","issn":["1081-1206","1534-4436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Allergy, Asthma &amp; Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134638552.pdf","grobid_xml":"https://content.openalex.org/works/W3134638552.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W129276365","https://openalex.org/W157357255","https://openalex.org/W1986142113","https://openalex.org/W2114196542","https://openalex.org/W2132480509","https://openalex.org/W2150269596","https://openalex.org/W2621431721","https://openalex.org/W2973046020","https://openalex.org/W3002951928"],"related_works":["https://openalex.org/W2003844784","https://openalex.org/W4294129259","https://openalex.org/W2763120518","https://openalex.org/W2411275400","https://openalex.org/W2408314993","https://openalex.org/W3017223231","https://openalex.org/W2506940778","https://openalex.org/W6982689692","https://openalex.org/W2142590472","https://openalex.org/W2038102847"],"abstract_inverted_index":{"Even":[0],"with":[1],"the":[2,34,42],"recent":[3],"developments":[4],"in":[5],"asthma":[6,9],"therapy,":[7],"severe":[8],"(SA)":[10],"remains":[11],"difficult":[12],"to":[13,17],"treat":[14],"and":[15,20,50],"leads":[16],"considerable":[18],"morbidity":[19],"mortality.":[21],"Chronic":[22],"oral":[23],"corticosteroid":[24],"use":[25],"increases":[26],"adverse":[27],"effects.":[28],"Biologics":[29],"were":[30],"recently":[31],"introduced":[32],"for":[33,74],"treatment":[35,43],"of":[36],"SA.":[37],"They":[38],"have":[39],"markedly":[40],"improved":[41],"results.":[44],"However,":[45],"they":[46],"are":[47,51,65],"very":[48],"expensive":[49],"geared":[52],"only":[53],"toward":[54],"TH2":[55],"prone":[56],"allergic":[57],"asthma.":[58],"Affordable":[59],"therapeutics":[60],"that":[61],"benefit":[62],"all":[63],"phenotypes":[64],"needed.":[66],"Drug":[67],"repositioning":[68],"might":[69],"be":[70],"a":[71],"good":[72],"option":[73],"this":[75],"purpose.":[76]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
