{"id":"https://openalex.org/W3134632036","doi":"https://doi.org/10.1021/acscatal.0c05450","title":"Engineering an Amine Transaminase for the Efficient Production of a Chiral Sacubitril Precursor","display_name":"Engineering an Amine Transaminase for the Efficient Production of a Chiral Sacubitril Precursor","publication_year":2021,"publication_date":"2021-03-10","ids":{"openalex":"https://openalex.org/W3134632036","doi":"https://doi.org/10.1021/acscatal.0c05450","mag":"3134632036"},"language":"en","primary_location":{"id":"doi:10.1021/acscatal.0c05450","doi":"https://doi.org/10.1021/acscatal.0c05450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.0c05450","pdf_url":null,"source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acscatal.0c05450","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026393129","display_name":"Scott J. Novick","orcid":"https://orcid.org/0000-0001-9099-1386","observed_orcids":["https://orcid.org/0000-0001-9099-1386"]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott J. Novick","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045736392","display_name":"Nikki Dellas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikki Dellas","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064470458","display_name":"Ravi Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Garcia","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012553136","display_name":"Charlene Ching","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlene Ching","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027054070","display_name":"Abigail Bautista","orcid":"https://orcid.org/0009-0000-6538-3469","observed_orcids":["https://orcid.org/0009-0000-6538-3469"]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Bautista","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102390214","display_name":"David Homan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Homan","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078461356","display_name":"Oscar Alvizo","orcid":"https://orcid.org/0000-0002-3545-1317","observed_orcids":["https://orcid.org/0000-0002-3545-1317"]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Alvizo","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080990349","display_name":"David A. Entwistle","orcid":"https://orcid.org/0000-0001-6268-1399","observed_orcids":["https://orcid.org/0000-0001-6268-1399"]},"institutions":[{"id":"https://openalex.org/I175381709","display_name":"Codexis (United States)","ror":"https://ror.org/00f76ab84","country_code":"US","type":"company","lineage":["https://openalex.org/I175381709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Entwistle","raw_affiliation_strings":["Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States"],"raw_orcid":"https://orcid.org/0000-0001-6268-1399","affiliations":[{"raw_affiliation_string":"Codexis, Inc, 200 Penobscot Dr, Redwood City, California 94063, United States","institution_ids":["https://openalex.org/I175381709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038342709","display_name":"Florian Kleinbeck","orcid":"https://orcid.org/0000-0002-2705-4629","observed_orcids":["https://orcid.org/0000-0002-2705-4629"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Florian Kleinbeck","raw_affiliation_strings":["Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2705-4629","affiliations":[{"raw_affiliation_string":"Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007682869","display_name":"Thierry Schlama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thierry Schlama","raw_affiliation_strings":["Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077097670","display_name":"Thomas Ruch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Ruch","raw_affiliation_strings":["Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026393129"],"corresponding_institution_ids":["https://openalex.org/I175381709"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":3.7139,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.95816838,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"11","issue":"6","first_page":"3762","last_page":"3770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amine-transaminase","display_name":"amine transaminase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enzyme-engineering","display_name":"enzyme engineering","score":0.7519999742507935},{"id":"https://openalex.org/keywords/sacubitril","display_name":"sacubitril","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chiral-precursors","display_name":"chiral precursors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/diastereoselectivity","display_name":"diastereoselectivity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.45899999141693115},{"id":"https://openalex.org/keywords/isopropylamine","display_name":"isopropylamine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.6880000233650208},{"id":"https://openalex.org/keywords/heart-failure-drugs","display_name":"heart failure drugs","score":0.6790000200271606},{"id":"https://openalex.org/keywords/enzyme-thermostability","display_name":"enzyme thermostability","score":0.503000020980835},{"id":"https://openalex.org/keywords/industrial-biocatalysis","display_name":"industrial biocatalysis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/amino-acid-synthesis","display_name":"amino acid synthesis","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.7482145428657532},{"id":"https://openalex.org/C2781206959","wikidata":"https://www.wikidata.org/wiki/Q420554","display_name":"Isopropylamine","level":2,"score":0.718704104423523},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.7114447951316833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6627678871154785},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5967597365379333},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.5659215450286865},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.4924562871456146},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4343380630016327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42011719942092896},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.40253132581710815},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38931387662887573},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.37596333026885986},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32295936346054077},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.21363627910614014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10056117177009583},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acscatal.0c05450","doi":"https://doi.org/10.1021/acscatal.0c05450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.0c05450","pdf_url":null,"source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acscatal.0c05450","doi":"https://doi.org/10.1021/acscatal.0c05450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.0c05450","pdf_url":null,"source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1732705840","https://openalex.org/W1742428893","https://openalex.org/W1986056153","https://openalex.org/W2022152775","https://openalex.org/W2032186948","https://openalex.org/W2036557444","https://openalex.org/W2041571635","https://openalex.org/W2053183206","https://openalex.org/W2057109554","https://openalex.org/W2058786334","https://openalex.org/W2059850101","https://openalex.org/W2086462671","https://openalex.org/W2089573090","https://openalex.org/W2090644990","https://openalex.org/W2112306226","https://openalex.org/W2113698123","https://openalex.org/W2144155706","https://openalex.org/W2153433577","https://openalex.org/W2160411775","https://openalex.org/W2496645452","https://openalex.org/W2518295168","https://openalex.org/W2524638452","https://openalex.org/W2600356273","https://openalex.org/W2778939204","https://openalex.org/W2782078732","https://openalex.org/W2809826342","https://openalex.org/W2898223435","https://openalex.org/W3024638214","https://openalex.org/W4235863842"],"related_works":["https://openalex.org/W7028261258","https://openalex.org/W4398241043","https://openalex.org/W2902052361","https://openalex.org/W4392554699","https://openalex.org/W4404882486","https://openalex.org/W4387477587","https://openalex.org/W7213862860","https://openalex.org/W2144155706","https://openalex.org/W4412842882","https://openalex.org/W3171440379"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"An":[7],"amine":[8],"transaminase":[9],"was":[10,103],"engineered":[11],"for":[12,46,158],"the":[13,31,47,79,86,97,141,148,159],"efficient":[14,160],"production":[15,163],"of":[16,52,88,124,132,140,164],"a":[17,27],"chiral":[18],"precursor":[19],"to":[20,78,119],"sacubitril,":[21],"(2":[22,99],"R,4":[23,100],"S":[24,101],")-5-([1,1\u2032-biphenyl]-4-yl)-4-amino-2-methylpentanoic":[25],"acid,":[26],"key":[28],"component":[29],"in":[30,81],"blockbuster":[32],"heart":[33],"failure":[34],"drug":[35],"Entresto.":[36],"Starting":[37],"from":[38],"an":[39,89],"enzyme":[40,53,74,142,155],"with":[41,72,76],"trace":[42],"activity":[43,151],"and":[44,84,113,129,152,161],"preference":[45],"undesired":[48],"diastereoisomer,":[49],"11":[50],"rounds":[51],"evolution":[54],"were":[55],"performed.":[56],"The":[57,92],"resultant":[58],"variant,":[59],"CDX-043,":[60],"showed":[61],"high":[62,110],"productivity":[63],"giving":[64],"90%":[65],"conversion":[66],"at":[67,125,133,166],"75":[68],"g/L":[69],"substrate":[70,80],"concentration":[71],"1%":[73],"loading":[75],"respect":[77],"24":[82],"h":[83],"without":[85],"use":[87],"organic":[90],"cosolvent.":[91],"product":[93],"diastereomeric":[94],"purity":[95],"toward":[96],"desired":[98],")-stereoisomer":[102],">99.9:0.1":[104],"d.r.":[105],"This":[106,154],"variant":[107,156],"also":[108],"exhibited":[109],"process":[111],"robustness":[112],"could":[114],"tolerate":[115],"reaction":[116,130],"temperatures":[117],"up":[118],"65":[120],"\u00b0C,":[121],"isopropylamine":[122],"concentrations":[123],"least":[126,134],"2":[127],"M,":[128],"times":[131],"5":[135],"days.":[136],"A":[137],"structural":[138],"analysis":[139],"variants":[143],"gave":[144],"insight":[145],"into":[146],"how":[147],"mutations":[149],"affected":[150],"selectivity.":[153],"allows":[157],"cost-effective":[162],"sacubitril":[165],"large":[167],"scale.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-03-15T00:00:00"}
