{"id":"https://openalex.org/W3134564264","doi":"https://doi.org/10.1021/acs.analchem.0c05002","title":"Ultra-High-Resolution IonStar Strategy Enhancing Accuracy and Precision of MS1-Based Proteomics and an Extensive Comparison with State-of-the-Art SWATH-MS in Large-Cohort Quantification","display_name":"Ultra-High-Resolution IonStar Strategy Enhancing Accuracy and Precision of MS1-Based Proteomics and an Extensive Comparison with State-of-the-Art SWATH-MS in Large-Cohort Quantification","publication_year":2021,"publication_date":"2021-03-09","ids":{"openalex":"https://openalex.org/W3134564264","doi":"https://doi.org/10.1021/acs.analchem.0c05002","mag":"3134564264","pmid":"https://pubmed.ncbi.nlm.nih.gov/33687211","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10666926"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.0c05002","doi":"https://doi.org/10.1021/acs.analchem.0c05002","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.0c05002","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10666926/pdf/nihms-1931805.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100422570","display_name":"Xue Wang","orcid":"https://orcid.org/0000-0002-5267-6083","observed_orcids":["https://orcid.org/0000-0002-5267-6083"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Wang","raw_affiliation_strings":["AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069355167","display_name":"Liang Jin","orcid":"https://orcid.org/0000-0002-8659-0536","observed_orcids":["https://orcid.org/0000-0002-8659-0536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Jin","raw_affiliation_strings":["AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States"],"raw_orcid":"https://orcid.org/0000-0002-8659-0536","affiliations":[{"raw_affiliation_string":"AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084680415","display_name":"Chenqi Hu","orcid":"https://orcid.org/0000-0002-0542-3198","observed_orcids":["https://orcid.org/0000-0002-0542-3198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenqi Hu","raw_affiliation_strings":["AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109402685","display_name":"Shichen Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shichen Shen","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046201389","display_name":"Shuo Qian","orcid":"https://orcid.org/0000-0002-9038-9704","observed_orcids":["https://orcid.org/0000-0002-9038-9704"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuo Qian","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101530811","display_name":"Min Ma","orcid":"https://orcid.org/0000-0002-4203-5215","observed_orcids":["https://orcid.org/0000-0002-4203-5215"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Ma","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014237355","display_name":"Xiaoyu Zhu","orcid":"https://orcid.org/0000-0003-1882-9530","observed_orcids":["https://orcid.org/0000-0003-1882-9530","https://orcid.org/0009-0009-5555-1030"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Zhu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027674029","display_name":"Fengzhi Li","orcid":"https://orcid.org/0000-0002-2299-7951","observed_orcids":["https://orcid.org/0000-0002-2299-7951"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fengzhi Li","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373514","display_name":"Jianmin Wang","orcid":"https://orcid.org/0000-0001-7527-0409","observed_orcids":["https://orcid.org/0000-0001-7527-0409"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianmin Wang","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064592898","display_name":"Yu Tian","orcid":"https://orcid.org/0000-0001-6645-269X","observed_orcids":["https://orcid.org/0000-0001-6645-269X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yu Tian","raw_affiliation_strings":["AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063759058","display_name":"Jun Qu","orcid":"https://orcid.org/0000-0002-1346-6809","observed_orcids":["https://orcid.org/0000-0002-1346-6809"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Qu","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States"],"raw_orcid":"https://orcid.org/0000-0002-1346-6809","affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063759058","https://openalex.org/A5064592898"],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I63190737"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.2791,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75851235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"93","issue":"11","first_page":"4884","last_page":"4893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-proteomics","display_name":"quantitative proteomics","score":0.890999972820282},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.6039999723434448},{"id":"https://openalex.org/keywords/time-course-proteomics","display_name":"time-course proteomics","score":0.7860000133514404},{"id":"https://openalex.org/keywords/micro-liquid-chromatography","display_name":"micro-liquid chromatography","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.8085411190986633},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.6291595697402954},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.627356767654419},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6147795915603638},{"id":"https://openalex.org/C2780841973","wikidata":"https://www.wikidata.org/wiki/Q2607924","display_name":"Orbitrap","level":3,"score":0.6019036769866943},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.5159605145454407},{"id":"https://openalex.org/C202799725","wikidata":"https://www.wikidata.org/wiki/Q272035","display_name":"Accuracy and precision","level":2,"score":0.5134840607643127},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5031618475914001},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.49276164174079895},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4408387839794159},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42456600069999695},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.41796618700027466},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3854702413082123},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.35308027267456055},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2868484854698181},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21911993622779846},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21663755178451538},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2123047411441803},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11404916644096375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1003732979297638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.analchem.0c05002","doi":"https://doi.org/10.1021/acs.analchem.0c05002","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.0c05002","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:33687211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33687211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10666926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10666926","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10666926/pdf/nihms-1931805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10666926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10666926","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10666926/pdf/nihms-1931805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2283601261","display_name":"Multiplex Mass Spectrometric Protein Assays for Precise Monitoring of the Pathophysiology of Obesity","funder_award_id":"U01DK124020","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2421118050","display_name":null,"funder_award_id":"HL103411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4914435748","display_name":null,"funder_award_id":"DK124020","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6210750348","display_name":"THE NETWORK BIOLOGY OF PATHOGEN-HOST INTERACTIONS DRIVING EXACERBATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)","funder_award_id":"W81XWH1910805","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000859013","display_name":"Systems Biology of Glycosylation","funder_award_id":"R01HL103411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134564264.pdf","grobid_xml":"https://content.openalex.org/works/W3134564264.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1566054158","https://openalex.org/W1574056173","https://openalex.org/W2006262026","https://openalex.org/W2012626734","https://openalex.org/W2045963360","https://openalex.org/W2046655465","https://openalex.org/W2062859898","https://openalex.org/W2079843936","https://openalex.org/W2154747925","https://openalex.org/W2155273887","https://openalex.org/W2317856197","https://openalex.org/W2319494906","https://openalex.org/W2329436915","https://openalex.org/W2346255325","https://openalex.org/W2346472194","https://openalex.org/W2417344110","https://openalex.org/W2529750106","https://openalex.org/W2606390777","https://openalex.org/W2608921204","https://openalex.org/W2777846224","https://openalex.org/W2790398313","https://openalex.org/W2797659909","https://openalex.org/W2800627455","https://openalex.org/W2886803588","https://openalex.org/W2887294942","https://openalex.org/W2899985843","https://openalex.org/W2912572417","https://openalex.org/W2932867787","https://openalex.org/W2940100346","https://openalex.org/W2950557897","https://openalex.org/W2963597305","https://openalex.org/W3013024175","https://openalex.org/W4238760040"],"related_works":["https://openalex.org/W4311027029","https://openalex.org/W2606390777","https://openalex.org/W2800627455","https://openalex.org/W7133502165","https://openalex.org/W2932867787","https://openalex.org/W2337768394","https://openalex.org/W3025831314","https://openalex.org/W2081697692","https://openalex.org/W2317856197","https://openalex.org/W2950557897"],"abstract_inverted_index":{"Quantitative":[0],"proteomics":[1],"in":[2,32,151,221,229,263],"large":[3,33,202],"cohorts":[4,34],"is":[5,205],"highly":[6],"valuable":[7],"for":[8,105,142,164,179,193,212,286],"clinical/pharmaceutical":[9],"investigations":[10],"but":[11],"often":[12],"suffers":[13],"from":[14],"severely":[15],"compromised":[16],"reliability,":[17],"accuracy,":[18,160],"and":[19,116,148,162,283,293],"reproducibility.":[20],"Here,":[21],"we":[22,74,216],"describe":[23],"an":[24,206],"ultra-high-resolution":[25,49],"IonStar":[26],"method":[27],"achieving":[28],"reproducible":[29],"protein":[30],"measurement":[31],"while":[35],"minimizing":[36],"the":[37,45,77,120,223,266],"ratio":[38],"compression":[39],"problem,":[40],"by":[41,253],"taking":[42],"advantage":[43],"of":[44,48,80,197,226,269],"exceptional":[46],"selectivity":[47],"(UHR)-MS1":[50],"detection":[51],"(240k_FWHM@":[52],"m":[53],"/":[54],"z":[55],"=":[56,72,234],"200).":[57],"Using":[58],"mixed-proteome":[59],"benchmark":[60],"sets":[61],"reflecting":[62],"large-cohort":[63,213,287],"analysis":[64,196],"with":[65,88,101,123,290],"technical":[66],"or":[67],"biological":[68,238,250],"replicates":[69],"(":[70,232],"N":[71,233],"56),":[73],"comprehensively":[75],"compared":[76,185,217],"quantitative":[78,159],"performances":[79],"UHR-IonStar":[81,155,188,218,245,256,278],"vs":[82,128,219],"a":[83,96,194,201,280],"state-of-the-art":[84],"SWATH-MS":[85,220,262],"method,":[86],"each":[87,198],"their":[89],"own":[90],"optimal":[91],"analytical":[92],"platforms.":[93],"We":[94],"confirmed":[95],"cutting-edge":[97],"micro-liquid":[98],"chromatography":[99],"(LC)/Triple-TOF":[100],"Spectronaut":[102],"outperforms":[103],"nano-LC/Orbitrap":[104],"SWATH-MS,":[106,187],"which":[107,204],"was":[108],"then":[109],"meticulously":[110],"developed/optimized":[111],"to":[112,186,272],"maximize":[113],"sensitivity,":[114],"reproducibility,":[115],"proteome":[117],"coverage.":[118],"While":[119],"two":[121],"methods":[122],"distinct":[124],"principles":[125],"(i.e.,":[126],"MS1-":[127],"MS2-based)":[129],"showed":[130,189,257],"similar":[131],"depth-of-analysis":[132],"(\u223c6700\u20137000":[133],"missing-data-free":[134],"proteins":[135,166,228],"quantified,":[136],"1%":[137],"protein-false":[138],"discovery":[139],"rate":[140],"(FDR)":[141],"entire":[143],"set,":[144,203],"2":[145],"unique":[146],"peptides/protein)":[147],"good":[149],"accuracy/precision":[150],"quantifying":[152],"high-abundance":[153],"proteins,":[154],"achieved":[156],"substantially":[157,247],"superior":[158,259],"precision,":[161],"reproducibility":[163],"lower-abundance":[165],"(a":[167],"category":[168],"that":[169],"includes":[170],"most":[171],"regulatory":[172],"proteins),":[173],"as":[174,176],"well":[175,243,270],"much-improved":[177],"sensitivity/selectivity":[178],"discovering":[180],"significantly":[181],"altered":[182,227],"proteins.":[183],"Furthermore,":[184],"markedly":[190,258],"higher":[191],"accuracy":[192,292],"single":[195],"sample":[199],"across":[200],"inadequately":[207],"investigated":[208],"albeit":[209],"critical":[210],"parameter":[211],"analysis.":[214],"Finally,":[215],"measuring":[222],"time":[224,267],"courses":[225,268],"paclitaxel-treated":[230],"cells":[231],"36),":[235],"where":[236],"dysregulated":[237],"pathways":[239],"have":[240],"been":[241],"very":[242],"established.":[244],"discovered":[246],"more":[248],"well-recognized":[249],"processes/pathways":[251],"induced":[252],"paclitaxel.":[254],"Additionally,":[255],"ability":[260],"than":[261],"accurately":[264],"depicting":[265],"known":[271],"be":[273],"paclitaxel-induced":[274],"biomarkers.":[275],"In":[276],"summary,":[277],"represents":[279],"reliable,":[281],"robust,":[282],"cost-effective":[284],"solution":[285],"proteomic":[288],"quantification":[289],"excellent":[291],"precision.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}
