{"id":"https://openalex.org/W3134547978","doi":null,"title":"The Role of Atypical Protein Kinase C in Colorectal Cancer Cells Carcinogenesis","display_name":"The Role of Atypical Protein Kinase C in Colorectal Cancer Cells Carcinogenesis","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3134547978","mag":"3134547978"},"language":"en","primary_location":{"id":"pmh:oai:scholarcommons.usf.edu:etd-9848","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/8651","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=9848&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=9848&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041015853","display_name":"Sayemul Islam","orcid":"https://orcid.org/0000-0001-6062-1974","observed_orcids":["https://orcid.org/0000-0001-6062-1974"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sayemul Islam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6062-1974","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041015853"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-protein-kinase-c","display_name":"atypical protein kinase C","score":0.9879999756813049},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibitors","display_name":"PKC inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/5-fluorouracil-combination-therapy","display_name":"5-fluorouracil combination therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6392171382904053},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6143757104873657},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.524864673614502},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5136680006980896},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.4569840729236603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4193335175514221},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4153841733932495},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41255050897598267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33731162548065186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25911208987236023},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.20883634686470032}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarcommons.usf.edu:etd-9848","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/8651","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=9848&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:digitalcommons.usf.edu:etd-9848","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/etd/8651","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"mag:3134547978","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=9848&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarcommons.usf.edu:etd-9848","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/8651","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=9848&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134547978.pdf","grobid_xml":"https://content.openalex.org/works/W3134547978.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W1484094963","https://openalex.org/W1487365829","https://openalex.org/W1555790021","https://openalex.org/W1560056935","https://openalex.org/W1576671418","https://openalex.org/W1604468403","https://openalex.org/W1879219667","https://openalex.org/W1905451018","https://openalex.org/W1916777863","https://openalex.org/W1920706136","https://openalex.org/W1964839077","https://openalex.org/W1967803088","https://openalex.org/W1968309496","https://openalex.org/W1973201073","https://openalex.org/W1973932751","https://openalex.org/W1974638880","https://openalex.org/W1975912195","https://openalex.org/W1983933800","https://openalex.org/W1984328540","https://openalex.org/W1986937402","https://openalex.org/W1993435692","https://openalex.org/W1996167718","https://openalex.org/W1998349282","https://openalex.org/W2002357878","https://openalex.org/W2002900988","https://openalex.org/W2003601985","https://openalex.org/W2003736664","https://openalex.org/W2005095805","https://openalex.org/W2008757142","https://openalex.org/W2014999693","https://openalex.org/W2018425992","https://openalex.org/W2019157776","https://openalex.org/W2020409921","https://openalex.org/W2026952389","https://openalex.org/W2030777833","https://openalex.org/W2031879122","https://openalex.org/W2038088851","https://openalex.org/W2040006901","https://openalex.org/W2042726246","https://openalex.org/W2042945898","https://openalex.org/W2044785751","https://openalex.org/W2050642264","https://openalex.org/W2053086049","https://openalex.org/W2056811680","https://openalex.org/W2057583190","https://openalex.org/W2058194940","https://openalex.org/W2063537542","https://openalex.org/W2064351475","https://openalex.org/W2066928961","https://openalex.org/W2067577465","https://openalex.org/W2068609129","https://openalex.org/W2068819405","https://openalex.org/W2071199281","https://openalex.org/W2074695556","https://openalex.org/W2076814669","https://openalex.org/W2077073773","https://openalex.org/W2077482758","https://openalex.org/W2080176881","https://openalex.org/W2081205300","https://openalex.org/W2083320231","https://openalex.org/W2086265159","https://openalex.org/W2087877138","https://openalex.org/W2089109453","https://openalex.org/W2089435983","https://openalex.org/W2089591149","https://openalex.org/W2095692554","https://openalex.org/W2097413644","https://openalex.org/W2097533133","https://openalex.org/W2098354753","https://openalex.org/W2100648267","https://openalex.org/W2102290191","https://openalex.org/W2105845694","https://openalex.org/W2108860858","https://openalex.org/W2110831371","https://openalex.org/W2114918609","https://openalex.org/W2115836236","https://openalex.org/W2115899458","https://openalex.org/W2117029515","https://openalex.org/W2118769864","https://openalex.org/W2119683782","https://openalex.org/W2120627294","https://openalex.org/W2122264749","https://openalex.org/W2125256744","https://openalex.org/W2127004748","https://openalex.org/W2128635872","https://openalex.org/W2131554707","https://openalex.org/W2132396140","https://openalex.org/W2133472355","https://openalex.org/W2134555179","https://openalex.org/W2134634216","https://openalex.org/W2135105302","https://openalex.org/W2138289111","https://openalex.org/W2142451896","https://openalex.org/W2144323242","https://openalex.org/W2145367033","https://openalex.org/W2146857332","https://openalex.org/W2146989813","https://openalex.org/W2147084578","https://openalex.org/W2147561113","https://openalex.org/W2150080475","https://openalex.org/W2150625137","https://openalex.org/W2155403085","https://openalex.org/W2156656429","https://openalex.org/W2159255277","https://openalex.org/W2165886816","https://openalex.org/W2167847781","https://openalex.org/W2168127415","https://openalex.org/W2170486320","https://openalex.org/W2171761187","https://openalex.org/W2262414037","https://openalex.org/W2288278122","https://openalex.org/W2460764691","https://openalex.org/W2509073831","https://openalex.org/W2520632143","https://openalex.org/W2562184414","https://openalex.org/W2741653330","https://openalex.org/W2760838127","https://openalex.org/W2793509923","https://openalex.org/W2898789672","https://openalex.org/W2900281356","https://openalex.org/W2902527990","https://openalex.org/W2911188335"],"related_works":["https://openalex.org/W2793509923","https://openalex.org/W2741653330","https://openalex.org/W4256319792","https://openalex.org/W2991328773","https://openalex.org/W2900281356","https://openalex.org/W3083138011","https://openalex.org/W2733324675","https://openalex.org/W2588309963","https://openalex.org/W2109084174","https://openalex.org/W1968422325"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"is":[3,20],"the":[4,10,52,74,97,129,177,182,199,207,217,227,244],"third":[5],"most":[6,12],"common":[7,13],"malignancy":[8],"and":[9,37,110,124,151,166,168,186,195,219,256],"fourth":[11],"cause":[14],"of":[15,32,54,70,131,149,156,188,201,229,246],"cancer-related":[16],"death":[17],"worldwide.":[18],"CRC":[19,45,56,138,171,190,224,252],"a":[21,48,71,104],"life-threatening":[22],"disease":[23],"due":[24],"to":[25,90,215,250],"therapy-resistant":[26],"cancerous":[27],"cells.":[28,172,225,240],"The":[29,158],"exact":[30],"mechanisms":[31],"cell":[33,120,159,253],"growth,":[34,121,184,254],"survival,":[35,123],"metastasis":[36,187],"inter":[38],"&":[39],"intracellular":[40],"signaling":[41],"pathways":[42],"involved":[43],"in":[44,223],"are":[46,179],"still":[47],"significant":[49,235],"challenge.":[50],"Moreover,":[51,198],"treatment":[53],"metastatic":[55,170,189],"considered":[57],"palliative":[58],"for":[59,63,76,81,181],"many":[60],"years":[61],"aimed":[62],"an":[64,147,154],"improved":[65],"life,":[66],"with":[67,107,206],"little":[68],"hope":[69],"cure,":[72],"highlighting":[73],"need":[75],"developing":[77],"novel":[78],"targeted":[79],"therapy":[80],"CRC.":[82],"Hence,":[83],"investigating":[84],"new":[85],"molecular":[86],"mechanism(s)":[87],"that":[88,176],"lead":[89],"colorectal":[91],"carcinogenesis":[92],"may":[93],"give":[94],"insight":[95],"into":[96],"therapeutic":[98],"target.":[99],"Human":[100],"protein":[101],"kinases":[102],"constitute":[103],"complicated":[105],"system":[106],"complex":[108],"internal":[109],"external":[111],"interactions,":[112],"which":[113],"stimulates":[114],"various":[115],"cellular":[116],"processes":[117],"such":[118,211],"as":[119,212],"metabolism,":[122],"apoptosis.":[125],"In":[126],"this":[127],"study,":[128],"role":[130],"atypical":[132],"Protein":[133],"Kinase":[134],"C":[135],"(aPKC)":[136],"on":[137,237],"was":[139],"investigated":[140],"by":[141],"using":[142],"two":[143],"inhibitors:":[144],"1)":[145],"ICA-I,":[146],"inhibitor":[148,155,249],"PKC-\u03b9,":[150],"2)":[152],"\u03b6-Stat,":[153],"PKC-\u03b6.":[157],"lines":[160],"tested":[161],"were":[162],"CCD18CO":[163,238],"normal":[164],"colorectal;":[165],"LoVo":[167],"RKO":[169],"Our":[173],"findings":[174],"suggest":[175,243],"aPKCs":[178,230],"responsible":[180],"abnormal":[183],"proliferation,":[185,255],"cells":[191],"via":[192],"aPKC/Rac1/Pak1/\u03b2-Catenin":[193],"pathway":[194],"aPKC/Slingshot/cofilin":[196],"pathways.":[197],"combination":[200],"aPKC":[202],"inhibitors":[203],"works":[204],"synergistically":[205],"clinically":[208],"available":[209],"drug":[210],"5-Fluorouracil":[213],"(5-FU)":[214],"retard":[216],"proliferation":[218],"induce":[220],"massive":[221],"apoptosis":[222],"However,":[226],"inhibition":[228],"did":[231],"not":[232],"bring":[233],"any":[234],"toxicity":[236],"healthy":[239],"These":[241],"results":[242],"possibility":[245],"utilizing":[247],"PKC-\u03b6":[248],"block":[251],"metastasis.":[257]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}
