{"id":"https://openalex.org/W3134544387","doi":"https://doi.org/10.1021/acs.bioconjchem.1c00017","title":"High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography","display_name":"High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography","publication_year":2021,"publication_date":"2021-03-10","ids":{"openalex":"https://openalex.org/W3134544387","doi":"https://doi.org/10.1021/acs.bioconjchem.1c00017","mag":"3134544387","pmid":"https://pubmed.ncbi.nlm.nih.gov/33689293"},"language":"en","primary_location":{"id":"doi:10.1021/acs.bioconjchem.1c00017","doi":"https://doi.org/10.1021/acs.bioconjchem.1c00017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.1c00017","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pharesst.irsst.qc.ca/etudes-primaires/653","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061404532","display_name":"Mahmoud Mohamed Omar","orcid":"https://orcid.org/0000-0002-6719-1476","observed_orcids":["https://orcid.org/0000-0002-6719-1476"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahmoud M. Omar","raw_affiliation_strings":["Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","D\u00e9partement de g\u00e9nie des mines, de la m\u00e9tallurgie et des mat\u00e9riaux, Centre de recherche sur les mat\u00e9riaux avanc\u00e9s (CERMA), Universit\u00e9 Laval, Qu\u00e9bec G1V 0A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","institution_ids":["https://openalex.org/I4210093650"]},{"raw_affiliation_string":"D\u00e9partement de g\u00e9nie des mines, de la m\u00e9tallurgie et des mat\u00e9riaux, Centre de recherche sur les mat\u00e9riaux avanc\u00e9s (CERMA), Universit\u00e9 Laval, Qu\u00e9bec G1V 0A6, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079468273","display_name":"Myriam Laprise\u2010Pelletier","orcid":"https://orcid.org/0009-0008-6779-1018","observed_orcids":["https://orcid.org/0009-0008-6779-1018"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Myriam Laprise-Pelletier","raw_affiliation_strings":["Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","institution_ids":["https://openalex.org/I4210093650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013189137","display_name":"Pascale Chevallier","orcid":"https://orcid.org/0000-0002-0163-9936","observed_orcids":["https://orcid.org/0000-0002-0163-9936"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pascale Chevallier","raw_affiliation_strings":["Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","institution_ids":["https://openalex.org/I4210093650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091085956","display_name":"Ludovic Tuduri","orcid":"https://orcid.org/0000-0003-1930-6192","observed_orcids":["https://orcid.org/0000-0003-1930-6192"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210099840","display_name":"Environnements et Pal\u00e9oenvironnements Oc\u00e9aniques et Continentaux","ror":"https://ror.org/01tsa0x55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210088668","https://openalex.org/I4210099840","https://openalex.org/I4210134592","https://openalex.org/I4210148025","https://openalex.org/I4210160189","https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ludovic Tuduri","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche 5805, Environnements et Pal\u00e9oenvironnements Oc\u00e9aniques et Continentaux (EPOC), \u00c9quipe Physico et Toxico Chimie de l\u2019environnement, Universit\u00e9 de Bordeaux, Talence 33405, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche 5805, Environnements et Pal\u00e9oenvironnements Oc\u00e9aniques et Continentaux (EPOC), \u00c9quipe Physico et Toxico Chimie de l\u2019environnement, Universit\u00e9 de Bordeaux, Talence 33405, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210099840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018993699","display_name":"Marc\u2010Andr\u00e9 Fortin","orcid":"https://orcid.org/0000-0002-8601-466X","observed_orcids":["https://orcid.org/0000-0002-8601-466X"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marc-Andr\u00e9 Fortin","raw_affiliation_strings":["Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","D\u00e9partement de g\u00e9nie des mines, de la m\u00e9tallurgie et des mat\u00e9riaux, Centre de recherche sur les mat\u00e9riaux avanc\u00e9s (CERMA), Universit\u00e9 Laval, Qu\u00e9bec G1V 0A6, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8601-466X","affiliations":[{"raw_affiliation_string":"Axe M\u00e9decine r\u00e9g\u00e9n\u00e9ratrice, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec, 2705, boul. Laurier (T1-61a), Qu\u00e9bec G1V 4G2, Canada","institution_ids":["https://openalex.org/I4210093650"]},{"raw_affiliation_string":"D\u00e9partement de g\u00e9nie des mines, de la m\u00e9tallurgie et des mat\u00e9riaux, Centre de recherche sur les mat\u00e9riaux avanc\u00e9s (CERMA), Universit\u00e9 Laval, Qu\u00e9bec G1V 0A6, Canada","institution_ids":["https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018993699"],"corresponding_institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.6084,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55390966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"32","issue":"4","first_page":"729","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasmall-nanoparticles","display_name":"ultrasmall nanoparticles","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9380000233650208},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.8360000252723694},{"id":"https://openalex.org/keywords/diffusion-cell","display_name":"diffusion cell","score":0.8640000224113464},{"id":"https://openalex.org/keywords/89zr-radiolabeling","display_name":"89Zr radiolabeling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/time-delay","display_name":"time delay","score":0.8450000286102295},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cosmetic-formulation","display_name":"cosmetic formulation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/nanoparticle-imaging","display_name":"nanoparticle imaging","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8172780275344849},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.745557427406311},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5416581630706787},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5344352722167969},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.43903157114982605},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.41688382625579834},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3950895071029663},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.3891390860080719},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3522821068763733},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21981912851333618},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11338356137275696},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.089406818151474},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.bioconjchem.1c00017","doi":"https://doi.org/10.1021/acs.bioconjchem.1c00017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.1c00017","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:33689293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33689293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04583520v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04583520","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioconjugate Chemistry, 2021, 32 (4), pp.729-745. &#x27E8;10.1021/acs.bioconjchem.1c00017&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/68519","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/68519","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article de recherche"},{"id":"pmh:oai:pharesst.irsst.qc.ca:etudes-primaires-1661","doi":null,"is_oa":true,"landing_page_url":"https://pharesst.irsst.qc.ca/etudes-primaires/653","pdf_url":null,"source":{"id":"https://openalex.org/S7407064151","display_name":"PhareSST","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I14044430","host_organization_name":"Institut de recherche Robert-Sauv\u00e9 en sant\u00e9 et en s\u00e9curit\u00e9 du travail","host_organization_lineage":["https://openalex.org/I14044430"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u00c9tudes primaires","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pharesst.irsst.qc.ca:etudes-primaires-1661","doi":null,"is_oa":true,"landing_page_url":"https://pharesst.irsst.qc.ca/etudes-primaires/653","pdf_url":null,"source":{"id":"https://openalex.org/S7407064151","display_name":"PhareSST","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I14044430","host_organization_name":"Institut de recherche Robert-Sauv\u00e9 en sant\u00e9 et en s\u00e9curit\u00e9 du travail","host_organization_lineage":["https://openalex.org/I14044430"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u00c9tudes primaires","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W111584987","https://openalex.org/W159449496","https://openalex.org/W232225426","https://openalex.org/W290929610","https://openalex.org/W966782668","https://openalex.org/W1503601397","https://openalex.org/W1529281172","https://openalex.org/W1537756200","https://openalex.org/W1547456120","https://openalex.org/W1553081897","https://openalex.org/W1579884917","https://openalex.org/W1598115850","https://openalex.org/W1968044889","https://openalex.org/W1968770683","https://openalex.org/W1974918804","https://openalex.org/W1999313103","https://openalex.org/W2002191209","https://openalex.org/W2006366433","https://openalex.org/W2006777623","https://openalex.org/W2012548810","https://openalex.org/W2023283179","https://openalex.org/W2026494961","https://openalex.org/W2028349699","https://openalex.org/W2032209556","https://openalex.org/W2043941772","https://openalex.org/W2045800643","https://openalex.org/W2051715012","https://openalex.org/W2058836396","https://openalex.org/W2066835110","https://openalex.org/W2068569951","https://openalex.org/W2069572883","https://openalex.org/W2069788772","https://openalex.org/W2075573029","https://openalex.org/W2077228161","https://openalex.org/W2082168610","https://openalex.org/W2085016640","https://openalex.org/W2138837291","https://openalex.org/W2147072983","https://openalex.org/W2164477775","https://openalex.org/W2170750730","https://openalex.org/W2172187417","https://openalex.org/W2175932572","https://openalex.org/W2253868220","https://openalex.org/W2314261849","https://openalex.org/W2460429118","https://openalex.org/W2466480060","https://openalex.org/W2497659585","https://openalex.org/W2564076115","https://openalex.org/W2570052993","https://openalex.org/W2602491979","https://openalex.org/W2610893933","https://openalex.org/W2735551787","https://openalex.org/W2741251864","https://openalex.org/W2790617197","https://openalex.org/W2795811886","https://openalex.org/W2972276752","https://openalex.org/W2991534396","https://openalex.org/W3199994335","https://openalex.org/W4210952837","https://openalex.org/W4247390740","https://openalex.org/W4256245095"],"related_works":["https://openalex.org/W4310875786","https://openalex.org/W2012548810","https://openalex.org/W2068569951","https://openalex.org/W2767463670","https://openalex.org/W2902005465","https://openalex.org/W2075573029","https://openalex.org/W4376104959","https://openalex.org/W2079489167","https://openalex.org/W2017606654","https://openalex.org/W4403404972"],"abstract_inverted_index":{"Ultrasmall":[0],"nanoparticles":[1],"(US-NPs;":[2],"<20":[3],"nm":[4,79],"in":[5,11,71,74,150,187,202],"hydrodynamic":[6],"size)":[7],"are":[8,22],"now":[9],"included":[10],"a":[12,47,56,244],"variety":[13],"of":[14,31,34,67,99,105,127,133,145,166,196,217,224,251,255],"pharmacological":[15],"and":[16,19,87,138,157,180,231,257],"cosmetic":[17],"products,":[18],"new":[20],"technologies":[21],"needed":[23],"to":[24,51,63,209,214,222],"detect":[25],"at":[26,135,189],"high":[27],"sensitivity":[28],"the":[29,42,65,97,106,128,158,173,178,182,206,211,215,219,225,228,232,239,249],"passage":[30,66,144],"small":[32],"doses":[33],"these":[35],"products":[36],"across":[37],"biological":[38],"barriers":[39],"such":[40],"as":[41,191,193],"skin.":[43,240],"In":[44],"this":[45],"work,":[46],"diffusion":[48,100,159,229],"cell":[49],"adapted":[50],"positron":[52],"emission":[53],"tomography":[54],"(PET),":[55],"highly":[57,245],"sensitive":[58],"imaging":[59],"technology,":[60],"was":[61,153],"developed":[62],"measure":[64],"gold":[68],"NPs":[69],"(AuNPs)":[70],"skin":[72,151],"samples":[73,152],"continuous":[75,188,203],"mode.":[76],"US-AuNPs":[77,108],"(3.2":[78],"diam.;":[80],"TEM)":[81],"were":[82,110,161,185],"functionalized":[83,107],"with":[84,89],"deferoxamine":[85],"(DFO)":[86],"radiolabeled":[88],"89":[90,147,169],"Zr":[91,148,170],"(IV)":[92,149,171],"(half-life:":[93],"3.3":[94],"days,":[95],"matching":[96],"timeline":[98],"tests).":[101],"The":[102,143,164,198],"physicochemical":[103],"properties":[104],"(US-AuNPs-PEG-DFO)":[109],"characterized":[111],"by":[112,155],"FTIR":[113],"(DFO":[114],"grafting;":[115],"hydroxamate":[116],"peaks:":[117],"1629.0":[118],"cm":[119,122],"\u20131,":[120],"1569.0":[121],"\u20131":[123],"),":[124],"XPS":[125],"(presence":[126],"O\u2550C\u2013N":[129],"C":[130],"1s":[131],"peak":[132],"DFO":[134],"287.49":[136],"eV),":[137],"TGA":[139],"(organic":[140],"mass":[141],"fraction).":[142],"US-AuNPs-PEG-DFO-":[146,168],"measured":[154],"PET,":[156],"parameters":[160],"extracted":[162],"thereby.":[163],"signals":[165],"radioactive":[167],"leaving":[172],"donor":[174],"compartment,":[175],"passing":[176],"through":[177],"skin,":[179],"entering":[181],"acceptor":[183],"compartment":[184],"detected":[186],"concentrations":[190],"low":[192],"2.2":[194],"nM":[195],"Au.":[197],"high-sensitivity":[199],"acquisitions":[200],"performed":[201],"allowed":[204],"for":[205,235,248],"first":[207],"time":[208,213,221],"extract":[210],"lag":[212,220],"start":[216,223],"permeation,":[218],"steady":[226],"state,":[227],"coefficients,":[230],"influx":[233],"data":[234],"AuNPs":[236],"permeating":[237],"into":[238],"PET":[241],"could":[242],"represent":[243],"valuable":[246],"tool":[247],"development":[250],"nanoparticle-containing":[252],"topical":[253],"formulations":[254],"drugs":[256],"cosmetics.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}