{"id":"https://openalex.org/W3134514714","doi":"https://doi.org/10.1117/1.jbo.26.7.076501","title":"Method for measurement of collagen monomer orientation in fluorescence microscopy","display_name":"Method for measurement of collagen monomer orientation in fluorescence microscopy","publication_year":2021,"publication_date":"2021-07-08","ids":{"openalex":"https://openalex.org/W3134514714","doi":"https://doi.org/10.1117/1.jbo.26.7.076501","mag":"3134514714","pmid":"https://pubmed.ncbi.nlm.nih.gov/34240588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8265821"},"language":"en","primary_location":{"id":"doi:10.1117/1.jbo.26.7.076501","doi":"https://doi.org/10.1117/1.jbo.26.7.076501","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.26.7.076501","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-7/076501/Method-for-measurement-of-collagen-monomer-orientation-in-fluorescence-microscopy/10.1117/1.JBO.26.7.076501.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-7/076501/Method-for-measurement-of-collagen-monomer-orientation-in-fluorescence-microscopy/10.1117/1.JBO.26.7.076501.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088039288","display_name":"Rodrigo P. Alzola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I189977406","display_name":"Universidad de Los Andes, Chile","ror":"https://ror.org/03v0qd864","country_code":"CL","type":"education","lineage":["https://openalex.org/I189977406"]}],"countries":["CL","US"],"is_corresponding":true,"raw_author_name":"Rodrigo P. Alzola","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts","Univ. de los Andes (Chile)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Univ. de los Andes (Chile)","institution_ids":["https://openalex.org/I189977406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071320970","display_name":"Seyed Mohammad Siadat","orcid":"https://orcid.org/0000-0002-5063-0305","observed_orcids":["https://orcid.org/0000-0002-5063-0305"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seyed M. Siadat","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Bioengineering, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5063-0305","affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Bioengineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089605535","display_name":"Anuj Gajjar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuj Gajjar","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057334226","display_name":"Rickard Stureborg","orcid":"https://orcid.org/0000-0002-5337-9291","observed_orcids":["https://orcid.org/0000-0002-5337-9291"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rickard Stureborg","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053843419","display_name":"Jeffrey W. Ruberti","orcid":"https://orcid.org/0000-0003-1595-6702","observed_orcids":["https://orcid.org/0000-0003-1595-6702"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Ruberti","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Bioengineering, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Bioengineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069489409","display_name":"Jos\u00e9 F. Delpiano","orcid":"https://orcid.org/0000-0001-9794-5649","observed_orcids":["https://orcid.org/0000-0001-9794-5649"]},"institutions":[{"id":"https://openalex.org/I162096671","display_name":"Universidad de Los Andes","ror":"https://ror.org/02mhbdp94","country_code":"CO","type":"education","lineage":["https://openalex.org/I162096671"]},{"id":"https://openalex.org/I4210143738","display_name":"Universidad de Los Andes","ror":"https://ror.org/04pqpvr75","country_code":"BO","type":"education","lineage":["https://openalex.org/I4210143738"]}],"countries":["BO","CO"],"is_corresponding":false,"raw_author_name":"Jose F. Delpiano","raw_affiliation_strings":["Univ. de los Andes","Universidad de los Andes, Optical Communications Lab, School of Engineering and Applied Sciences, Sa"],"raw_orcid":"https://orcid.org/0000-0001-9794-5649","affiliations":[{"raw_affiliation_string":"Univ. de los Andes","institution_ids":["https://openalex.org/I162096671","https://openalex.org/I4210143738"]},{"raw_affiliation_string":"Universidad de los Andes, Optical Communications Lab, School of Engineering and Applied Sciences, Sa","institution_ids":["https://openalex.org/I162096671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053391965","display_name":"Charles A. DiMarzio","orcid":"https://orcid.org/0000-0002-5646-5945","observed_orcids":["https://orcid.org/0000-0002-5646-5945"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. DiMarzio","raw_affiliation_strings":["Northeastern Univ","Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5646-5945","affiliations":[{"raw_affiliation_string":"Northeastern Univ","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088039288"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I189977406"],"apc_list":{"value":1675,"currency":"USD","value_usd":1675},"apc_paid":{"value":1675,"currency":"USD","value_usd":1675},"fwci":0.2117,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.38906164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"07","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-fibril-formation","display_name":"collagen fibril formation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/collagen-orientation","display_name":"collagen orientation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fluorescence-microscopy","display_name":"fluorescence microscopy","score":0.5460000038146973},{"id":"https://openalex.org/keywords/gabor-filters","display_name":"Gabor filters","score":0.7870000004768372},{"id":"https://openalex.org/keywords/convolutional-neural-networks","display_name":"convolutional neural networks","score":0.871999979019165},{"id":"https://openalex.org/keywords/synthetic-training-data","display_name":"synthetic training data","score":0.6359999775886536},{"id":"https://openalex.org/keywords/collagen-remodeling","display_name":"collagen remodeling","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6707403659820557},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.6547375917434692},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6082452535629272},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.5933586955070496},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5398797988891602},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.5378493666648865},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.49428582191467285},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4442695081233978},{"id":"https://openalex.org/C3019161014","wikidata":"https://www.wikidata.org/wiki/Q26868","display_name":"Collagen fibril","level":2,"score":0.4368777573108673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33868733048439026},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33318424224853516},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2191970944404602},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.11605256795883179},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09120437502861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08279752731323242},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07282260060310364},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.06804448366165161},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1117/1.jbo.26.7.076501","doi":"https://doi.org/10.1117/1.jbo.26.7.076501","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.26.7.076501","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-7/076501/Method-for-measurement-of-collagen-monomer-orientation-in-fluorescence-microscopy/10.1117/1.JBO.26.7.076501.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},{"id":"pmid:34240588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34240588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical optics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8265821","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8265821/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Opt","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1117/1.jbo.26.7.076501","doi":"https://doi.org/10.1117/1.jbo.26.7.076501","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.26.7.076501","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-7/076501/Method-for-measurement-of-collagen-monomer-orientation-in-fluorescence-microscopy/10.1117/1.JBO.26.7.076501.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3583292729","display_name":"Exploring flow-induced crystallization as a critical mechanism driving corneal stromal lamellogenesis","funder_award_id":"R21EY029167","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G531140057","display_name":null,"funder_award_id":"1180685","funder_id":"https://openalex.org/F4320334812","funder_display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G700213943","display_name":null,"funder_award_id":"FB0008","funder_id":"https://openalex.org/F4320334812","funder_display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134514714.pdf","grobid_xml":"https://content.openalex.org/works/W3134514714.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W48830290","https://openalex.org/W1572078619","https://openalex.org/W1901129140","https://openalex.org/W1975280071","https://openalex.org/W2006500012","https://openalex.org/W2050608843","https://openalex.org/W2054705416","https://openalex.org/W2056370875","https://openalex.org/W2061166048","https://openalex.org/W2112162870","https://openalex.org/W2144985870","https://openalex.org/W2330702127","https://openalex.org/W2518624505","https://openalex.org/W2752782242","https://openalex.org/W2936304641","https://openalex.org/W2948368977","https://openalex.org/W2963420686","https://openalex.org/W3129115185","https://openalex.org/W3215909416"],"related_works":["https://openalex.org/W7221401726","https://openalex.org/W2045545319","https://openalex.org/W2073599119","https://openalex.org/W1501498976","https://openalex.org/W2705563477","https://openalex.org/W7154727096","https://openalex.org/W2016626843","https://openalex.org/W2800640005","https://openalex.org/W1996453069","https://openalex.org/W2412958850"],"abstract_inverted_index":{"SIGNIFICANCE:":[0],"Collagen":[1],"is":[2,10,32,42,52,60,73,77,88,151],"the":[3,23,55,66,86,135,155],"most":[4],"abundant":[5],"protein":[6],"in":[7,12],"vertebrates":[8],"and":[9,19,30,47,72,107,116,143,157,191],"found":[11],"tissues":[13],"that":[14,149],"regularly":[15],"experience":[16],"tension,":[17],"compression,":[18],"shear":[20],"forces.":[21],"However,":[22],"underlying":[24],"mechanism":[25],"of":[26,57,137,162,165,180],"collagen":[27,40,58,181,185],"fibril":[28,189],"formation":[29,190],"remodeling":[31],"poorly":[33],"understood.":[34],"AIM:":[35],"We":[36,99],"explore":[37],"how":[38,48],"a":[39,62,69,90,105,127,166],"monomer":[41,67,106,168],"visualized":[43],"using":[44,95],"fluorescence":[45,81,96,170],"microscopy":[46],"its":[49,109],"spatial":[50],"orientation":[51,56,94,158],"determined.":[53],"Defining":[54],"monomers":[59,182],"not":[61],"trivial":[63],"problem,":[64],"as":[65],"has":[68],"weak":[70],"contrast":[71],"relatively":[74],"small.":[75],"It":[76],"possible":[78,152],"to":[79,153,177],"attach":[80],"tags":[82],"for":[83,92,103],"contrast,":[84],"but":[85],"size":[87],"still":[89],"problem":[91],"detecting":[93,104],"microscopy.":[97,171],"APPROACH:":[98],"present":[100],"two":[101,139],"methods":[102],"classifying":[108],"orientation.":[110],"A":[111],"modified":[112],"Gabor":[113],"filter":[114],"set":[115],"an":[117,160],"automatic":[118],"classifier":[119],"trained":[120],"by":[121],"convolutional":[122],"neural":[123],"network":[124],"based":[125],"on":[126],"synthetic":[128,142],"dataset":[129],"were":[130],"used.":[131],"RESULTS:":[132],"By":[133],"evaluating":[134],"performance":[136],"these":[138],"approaches":[140],"with":[141,159,169,184],"experimental":[144],"data,":[145],"our":[146,178],"results":[147],"show":[148],"it":[150],"determine":[154],"location":[156],"error":[161],"\u223c37":[163],"deg":[164],"single":[167],"CONCLUSIONS:":[172],"These":[173],"findings":[174],"can":[175],"contribute":[176],"understanding":[179],"interaction":[183],"fibrils":[186],"surface":[187],"during":[188],"remodeling.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}