{"id":"https://openalex.org/W3134500249","doi":"https://doi.org/10.1016/j.ebiom.2021.103241","title":"Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency","display_name":"Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency","publication_year":2021,"publication_date":"2021-02-26","ids":{"openalex":"https://openalex.org/W3134500249","doi":"https://doi.org/10.1016/j.ebiom.2021.103241","mag":"3134500249","pmid":"https://pubmed.ncbi.nlm.nih.gov/33647768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7920823"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2021.103241","doi":"https://doi.org/10.1016/j.ebiom.2021.103241","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2021.103241","pdf_url":"http://www.thelancet.com/article/S2352396421000347/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thelancet.com/article/S2352396421000347/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075450493","display_name":"Jennifer M. Zerbato","orcid":"https://orcid.org/0000-0001-9888-661X","observed_orcids":["https://orcid.org/0000-0001-9888-661X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer M. Zerbato","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9888-661X","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055142643","display_name":"Georges Khoury","orcid":"https://orcid.org/0000-0002-2136-2487","observed_orcids":["https://orcid.org/0000-0002-2136-2487"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Georges Khoury","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011210191","display_name":"Wei Dong Zhao","orcid":"https://orcid.org/0000-0003-4337-4064","observed_orcids":["https://orcid.org/0000-0003-4337-4064"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wei Zhao","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029427213","display_name":"Matthew J. Gartner","orcid":"https://orcid.org/0000-0003-4953-9501","observed_orcids":["https://orcid.org/0000-0003-4953-9501"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew J. Gartner","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011579459","display_name":"Rachel D. Pascoe","orcid":"https://orcid.org/0000-0001-7707-1972","observed_orcids":["https://orcid.org/0000-0001-7707-1972"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rachel D. Pascoe","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054826203","display_name":"Ajantha Rhodes","orcid":"https://orcid.org/0000-0003-3576-4732","observed_orcids":["https://orcid.org/0000-0003-3576-4732"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ajantha Rhodes","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071421731","display_name":"Ashanti Dantanarayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ashanti Dantanarayana","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031316151","display_name":"Megan Gooey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Megan Gooey","raw_affiliation_strings":["HIV Characterisation Laboratory, Victorian Infectious Diseases Reference Laboratory, the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Characterisation Laboratory, Victorian Infectious Diseases Reference Laboratory, the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I4210088630","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041557054","display_name":"Jenny L. Anderson","orcid":"https://orcid.org/0000-0003-4636-6633","observed_orcids":["https://orcid.org/0000-0003-4636-6633"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jenny Anderson","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058779674","display_name":"Peter Bacchetti","orcid":"https://orcid.org/0000-0002-9323-2972","observed_orcids":["https://orcid.org/0000-0002-9323-2972"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Bacchetti","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063704053","display_name":"Steven G. Deeks","orcid":"https://orcid.org/0000-0001-6371-747X","observed_orcids":["https://orcid.org/0000-0001-6371-747X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G. Deeks","raw_affiliation_strings":["Department of Medicine, Division of HIV/AIDS, University of California San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of HIV/AIDS, University of California San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103024292","display_name":"James H. McMahon","orcid":"https://orcid.org/0000-0003-1460-5572","observed_orcids":["https://orcid.org/0000-0003-1460-5572"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James McMahon","raw_affiliation_strings":["Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081147347","display_name":"Michael Roche","orcid":"https://orcid.org/0000-0001-8819-0096","observed_orcids":["https://orcid.org/0000-0001-8819-0096"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Roche","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia","Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I82951845"]},{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005530326","display_name":"Thomas A. Rasmussen","orcid":"https://orcid.org/0000-0001-5354-2442","observed_orcids":["https://orcid.org/0000-0001-5354-2442"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Thomas A. Rasmussen","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049119347","display_name":"Damian F. J. Purcell","orcid":"https://orcid.org/0000-0002-4485-1726","observed_orcids":["https://orcid.org/0000-0002-4485-1726"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Damian FJ Purcell","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062645957","display_name":"Sharon R. Lewin","orcid":"https://orcid.org/0000-0002-0330-8241","observed_orcids":["https://orcid.org/0000-0002-0330-8241"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sharon R. Lewin","raw_affiliation_strings":["Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: sharon.lewin@unimelb.edu.au","Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia","Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0330-8241","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: sharon.lewin@unimelb.edu.au","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I2801993434","https://openalex.org/I4210105123","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I4210105123"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5062645957"],"corresponding_institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I2801993434","https://openalex.org/I4210105123","https://openalex.org/I56590836"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.5967,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.90967612,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"65","issue":null,"first_page":"103241","last_page":"103241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-latency-reversal","display_name":"HIV latency reversal","score":0.6589999794960022},{"id":"https://openalex.org/keywords/latency-reversing-agents","display_name":"latency-reversing agents","score":0.7419999837875366},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.4779999852180481},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/viral-rna-splicing","display_name":"viral RNA splicing","score":0.47600001096725464},{"id":"https://openalex.org/keywords/people-living-with-hiv","display_name":"people living with HIV","score":0.6489999890327454},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7861031293869019},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6968094110488892},{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.6784565448760986},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5781265497207642},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4876657724380493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4626525342464447},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4226696193218231},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3743673264980316},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36462754011154175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33699214458465576},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.2654752731323242},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.1884276568889618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16172590851783752},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11837419867515564}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054813","descriptor_name":"Polyhydroxyalkanoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1016/j.ebiom.2021.103241","doi":"https://doi.org/10.1016/j.ebiom.2021.103241","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2021.103241","pdf_url":"http://www.thelancet.com/article/S2352396421000347/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7920823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7920823","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Text"},{"id":"pmid:33647768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33647768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6ns7n3t4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6ns7n3t4","pdf_url":"https://escholarship.org/content/qt6ns7n3t4/qt6ns7n3t4.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, vol 65","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/273091","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/273091","pdf_url":"http://hdl.handle.net/11343/273091","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:alma61RMIT.INST:11301841120001341","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2021.103241","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d906ec4beead49649c5521b1bb6e22dd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d906ec4beead49649c5521b1bb6e22dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 65, Iss , Pp 103241- (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6ns7n3t4","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6ns7n3t4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/27541812","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Multiply_spliced_HIV_RNA_is_a_predictive_measure_of_virus_production_ex_vivo_and_in_vivo_following_reversal_of_HIV_latency/27541812","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/df1ec419-f4f9-4dd7-85af-69b7d90a4d8a","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/df1ec419-f4f9-4dd7-85af-69b7d90a4d8a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zerbato , J M , Khoury , G , Zhao , W , Gartner , M J , Pascoe , R D , Rhodes , A , Dantanarayana , A , Gooey , M , Anderson , J , Bacchetti , P , Deeks , S G , McMahon , J , Roche , M , Rasmussen , T A , Purcell , D F & Lewin , S R 2021 , ' Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency ' , EBioMedicine , vol. 65 , 103241 , pp. 103241 . https://doi.org/10.1016/j.ebiom.2021.103241","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2021.103241","doi":"https://doi.org/10.1016/j.ebiom.2021.103241","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2021.103241","pdf_url":"http://www.thelancet.com/article/S2352396421000347/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1797622899","display_name":"Addressing the major challenges in HIV vaccine and cure research","funder_award_id":"1149990","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G536165561","display_name":"Delaney AIDS Research Enterprise to Cure HIV","funder_award_id":"UM1AI126611","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6676880966","display_name":null,"funder_award_id":"UM1 AI126611","funder_id":"https://openalex.org/F4320309010","funder_display_name":"Delaney AIDS Research Enterprise"},{"id":"https://openalex.org/G8426186666","display_name":"RNA processing mechanisms controlling HIV latency","funder_award_id":"1129320","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309010","display_name":"Delaney AIDS Research Enterprise","ror":"https://ror.org/040gxv777"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134500249.pdf","grobid_xml":"https://content.openalex.org/works/W3134500249.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1497870368","https://openalex.org/W1603334203","https://openalex.org/W1880169023","https://openalex.org/W1964916693","https://openalex.org/W1967978337","https://openalex.org/W1971112771","https://openalex.org/W1972865566","https://openalex.org/W1980474989","https://openalex.org/W1981769364","https://openalex.org/W1984421295","https://openalex.org/W2005624767","https://openalex.org/W2034360565","https://openalex.org/W2038598840","https://openalex.org/W2055796578","https://openalex.org/W2059083953","https://openalex.org/W2059833881","https://openalex.org/W2089456191","https://openalex.org/W2098194107","https://openalex.org/W2101516953","https://openalex.org/W2115580899","https://openalex.org/W2120014878","https://openalex.org/W2122660117","https://openalex.org/W2137671068","https://openalex.org/W2145246179","https://openalex.org/W2151980311","https://openalex.org/W2158867438","https://openalex.org/W2177904182","https://openalex.org/W2417209002","https://openalex.org/W2463136097","https://openalex.org/W2470126287","https://openalex.org/W2480104137","https://openalex.org/W2512878063","https://openalex.org/W2593700719","https://openalex.org/W2598871150","https://openalex.org/W2605860823","https://openalex.org/W2606857030","https://openalex.org/W2735653597","https://openalex.org/W2766409016","https://openalex.org/W2785480387","https://openalex.org/W2789029405","https://openalex.org/W2802298459","https://openalex.org/W2805966967","https://openalex.org/W2895775323","https://openalex.org/W2895792705","https://openalex.org/W2900495690","https://openalex.org/W2900567433","https://openalex.org/W2902316506","https://openalex.org/W2911228036","https://openalex.org/W2925601131","https://openalex.org/W2943244514","https://openalex.org/W2948742834","https://openalex.org/W2964709937","https://openalex.org/W2978170382","https://openalex.org/W2978963496","https://openalex.org/W2998020292","https://openalex.org/W3001824894","https://openalex.org/W3005267901","https://openalex.org/W3007342444","https://openalex.org/W3084418555","https://openalex.org/W3091821209","https://openalex.org/W3116113145"],"related_works":["https://openalex.org/W2417293507","https://openalex.org/W3133513968","https://openalex.org/W2509017372","https://openalex.org/W2588138686","https://openalex.org/W2611053349","https://openalex.org/W2955267060","https://openalex.org/W2004995106","https://openalex.org/W3045041301","https://openalex.org/W4302621251","https://openalex.org/W1996808619"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"strategy":[2],"being":[3],"pursued":[4],"to":[5,23,134,140,208,226],"clear":[6],"latently":[7],"infected":[8],"cells":[9,68,114],"that":[10,36,149],"persist":[11],"in":[12,138,155,175,186,203,230],"people":[13],"living":[14],"with":[15,28,81,163,205],"HIV":[16,26,58,92,211],"(PLWH)":[17],"on":[18,73,99,117,157,193],"antiretroviral":[19],"therapy":[20],"(ART)":[21],"is":[22,223,234],"activate":[24],"latent":[25],"infection":[27],"a":[29,167,236],"latency":[30,241],"reversing":[31],"agent":[32],"(LRA).":[33],"Surrogate":[34],"markers":[35],"accurately":[37],"measure":[38],"virus":[39],"production":[40,232],"following":[41],"an":[42,217,228],"LRA":[43],"are":[44,150],"needed.":[45],"METHODS:":[46],"We":[47],"quantified":[48,96],"cell-associated":[49],"unspliced":[50],"(US),":[51],"multiply":[52],"spliced":[53],"(MS)":[54],"and":[55,64,76,90,110,177,188,233],"supernatant":[56],"(SN)":[57],"RNA":[59,93,122,129,199,222],"by":[60],"qPCR":[61],"from":[62,70,97,115],"total":[63,109],"resting":[65,111],"CD4+":[66,112],"T":[67,113],"isolated":[69],"seven":[71],"PLWH":[72,98,116,156,192],"ART":[74,100,194],"before":[75],"after":[77],"treatment":[78],"ex":[79,160],"vivo":[80,161],"different":[82],"LRAs,":[83,164],"including":[84],"histone":[85],"deacetylase":[86],"inhibitors":[87],"(HDACi).":[88],"MS":[89,128,136,178,198,221],"plasma":[91,210],"were":[94],"also":[95],"(n-11)":[101],"who":[102,195],"received":[103,196],"the":[104,146,171,182],"HDACi":[105],"panobinostat.":[106],"FINDINGS:":[107],"In":[108,191],"ART,":[118],"detection":[119,126],"of":[120,127,145,216,220,239],"US":[121,141,189],"was":[123,130,200],"common":[124],"while":[125],"infrequent.":[131],"Primers":[132],"used":[133],"detect":[135],"RNA,":[137,142,179],"contrast":[139],"bound":[143],"sites":[144],"viral":[147],"genome":[148],"commonly":[151],"mutated":[152],"or":[153],"deleted":[154],"ART.":[158],"Following":[159,214],"stimulation":[162],"we":[165],"identified":[166],"strong":[168],"correlation":[169],"between":[170],"fold":[172,183],"change":[173,184],"increase":[174,185,229],"SN":[176,187],"but":[180],"not":[181],"RNA.":[190,212],"panobinostat,":[197],"significantly":[201],"higher":[202],"samples":[204],"detectable":[206],"compared":[207],"non0detectable":[209],"INTERPRETATION:":[213],"administration":[215],"LRA,":[218],"quantification":[219],"more":[224],"likely":[225],"reflect":[227],"virion":[231],"therefore":[235],"better":[237],"indicator":[238],"meaningful":[240],"reversal.":[242],"FUNDING:":[243],"NHMRC,":[244],"NIH":[245],"DARE":[246],"collaboratory.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}