{"id":"https://openalex.org/W313446398","doi":null,"title":"DNA microarray analysis of differential gene expression of 6-year-old rat neural striatal progenitor cells during early differentiation.","display_name":"DNA microarray analysis of differential gene expression of 6-year-old rat neural striatal progenitor cells during early differentiation.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W313446398","mag":"313446398","pmid":"https://pubmed.ncbi.nlm.nih.gov/11847432"},"language":"en","primary_location":{"id":"pmid:11847432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11847432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative neurology and neuroscience","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101724106","display_name":"Feng C. Zhou","orcid":"https://orcid.org/0000-0001-7739-5694","observed_orcids":["https://orcid.org/0000-0001-7739-5694"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F C Zhou","raw_affiliation_strings":["Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. imce100@iupui.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. imce100@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058934157","display_name":"John R. Duguid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Duguid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044635265","display_name":"Howard J. Edenberg","orcid":"https://orcid.org/0000-0003-0344-9690","observed_orcids":["https://orcid.org/0000-0003-0344-9690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Edenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043430500","display_name":"Jeanette N. McClintick","orcid":"https://orcid.org/0000-0002-6548-4902","observed_orcids":["https://orcid.org/0000-0002-6548-4902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J McClintick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978661","display_name":"Peter Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.363,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.51808318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"2-3","first_page":"95","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/neurosphere-culture","display_name":"neurosphere culture","score":0.5649999976158142},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.597000002861023},{"id":"https://openalex.org/keywords/cell-adhesion-genes","display_name":"cell adhesion genes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9100000262260437},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5370000004768372},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.7839999794960022},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7837734222412109},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.7783920764923096},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6696250438690186},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6561304330825806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5880696773529053},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5639035701751709},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5531451106071472},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5289846658706665},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.4932388663291931},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45121127367019653},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.44763195514678955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3359192907810211},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.296476811170578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22318702936172485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11847432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11847432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative neurology and neuroscience","raw_type":"Journal Article"},{"id":"mag:313446398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11847432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8230719353","display_name":"ALCOHOL &BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS","funder_award_id":"R01AA012406","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W181243240","https://openalex.org/W1509485250","https://openalex.org/W1604240807","https://openalex.org/W1769479841","https://openalex.org/W1964451213","https://openalex.org/W1981203912","https://openalex.org/W1986468210","https://openalex.org/W1987145582","https://openalex.org/W1990483753","https://openalex.org/W1991054305","https://openalex.org/W1997551871","https://openalex.org/W2004260072","https://openalex.org/W2004706485","https://openalex.org/W2007472317","https://openalex.org/W2008972313","https://openalex.org/W2010449169","https://openalex.org/W2023890277","https://openalex.org/W2029441111","https://openalex.org/W2031865781","https://openalex.org/W2042959284","https://openalex.org/W2046006021","https://openalex.org/W2047591592","https://openalex.org/W2050387873","https://openalex.org/W2052057694","https://openalex.org/W2066825817","https://openalex.org/W2067856703","https://openalex.org/W2070367161","https://openalex.org/W2072772604","https://openalex.org/W2079356804","https://openalex.org/W2079958883","https://openalex.org/W2082316610","https://openalex.org/W2090349011","https://openalex.org/W2097270150","https://openalex.org/W2109328121","https://openalex.org/W2135725455","https://openalex.org/W2137868091","https://openalex.org/W2161800657","https://openalex.org/W2163513779","https://openalex.org/W2227607976","https://openalex.org/W7017300058"],"related_works":["https://openalex.org/W1598427976","https://openalex.org/W7140247198","https://openalex.org/W7095752814","https://openalex.org/W2130876797","https://openalex.org/W1526738019","https://openalex.org/W2040874970","https://openalex.org/W2378954366","https://openalex.org/W764867388","https://openalex.org/W7009985195","https://openalex.org/W1991848485"],"abstract_inverted_index":{"EGF-responsive":[0],"striatal":[1,122],"progenitor":[2,52],"cells":[3,31,53,60,183,203],"from":[4],"rat":[5],"brain":[6,34,196],"have":[7],"been":[8],"maintained":[9],"in":[10,12,32,54,72],"culture":[11],"the":[13,33,59,73,110,119,151,169,176,185],"form":[14],"of":[15,29,65,112,121,144,195],"neurospheres":[16],"for":[17,168,175,208],"six":[18],"years":[19],"without":[20],"exhausting":[21],"their":[22,55],"renewal":[23],"capacity.":[24],"The":[25,198],"events":[26],"surrounding":[27],"differentiation":[28],"stem":[30,182,202],"after":[35,63],"a":[36,40],"long":[37],"progenitorship":[38],"remain":[39],"mystery.":[41],"Using":[42],"DNA":[43],"microarray":[44],"analysis":[45],"we":[46],"investigated":[47],"differential":[48],"gene":[49],"expression,":[50],"comparing":[51],"neurosphere":[56],"state":[57],"with":[58,78],"24":[61],"hours":[62],"induction":[64],"differentiation.":[66,137],"Eighty-one":[67],"genes":[68,106,139,148,164],"showed":[69,140],"increased":[70,134],"expression":[71],"differentiated":[74],"condition.":[75],"Genes":[76],"associated":[77],"cellular":[79],"growth,":[80],"neurite":[81],"outgrowth,":[82],"and":[83,90,99,157,161,190,213],"synaptogenesis":[84],"were":[85,102],"activated,":[86],"including":[87],"both":[88],"anti-apoptotic":[89],"pro-apoptotic":[91],"genes.":[92],"Two":[93],"transmitter-":[94],"related":[95,149],"genes,":[96],"acetylcholine":[97],"receptor-beta":[98],"glutamate":[100],"receptor-beta-unit":[101],"also":[103,117],"elevated-,":[104],"these":[105],"not":[107],"only":[108],"fit":[109],"profile":[111],"early":[113],"neural":[114,136,201],"development,":[115],"but":[116],"reflect":[118],"characteristics":[120],"neurons.":[123],"In":[124],"addition,":[125],"there":[126],"are":[127,146,204],"approximately":[128],"30":[129],"expressed":[130],"sequence":[131],"tags":[132],"(ES7)":[133],"during":[135],"Forty-seven":[138],"decreased":[141],"expression;":[142],"half":[143],"them":[145],"known":[147],"to":[150,187],"cell":[152,154,162],"cycle,":[153],"adhesion,":[155],"transcription,":[156],"signaling.":[158],"Tbe":[159],"signaling":[160],"cycle":[163],"may":[165],"be":[166],"responsible":[167],"life-long":[170,180],"self-renewal.":[171],"These":[172],"data":[173],"demonstrate":[174],"first":[177],"time":[178],"that":[179],"quiescent":[181],"retain":[184],"potential":[186],"become":[188],"activated":[189],"develop":[191],"into":[192],"specific":[193],"types":[194],"cells.":[197],"six-year":[199],"long-term":[200],"an":[205],"excellent":[206],"model":[207],"studying":[209],"developmental":[210],"neurobiological":[211],"processes":[212],"aging.":[214]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}