{"id":"https://openalex.org/W3134432702","doi":null,"title":"Acute Metabolic Complications in Diabetes","display_name":"Acute Metabolic Complications in Diabetes","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W3134432702","mag":"3134432702"},"language":"en","primary_location":{"id":"mag:3134432702","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/NBK/NBK567993","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018210412","display_name":"Arleta Rewers","orcid":"https://orcid.org/0000-0002-2992-9273","observed_orcids":["https://orcid.org/0000-0002-2992-9273"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arleta Rewers","raw_affiliation_strings":["Dr. Arleta Rewers is Associate Professor, Department of Pediatrics at University of Colorado Denver School of Medicine, Aurora, CO"],"raw_orcid":"https://orcid.org/0000-0002-2992-9273","affiliations":[{"raw_affiliation_string":"Dr. Arleta Rewers is Associate Professor, Department of Pediatrics at University of Colorado Denver School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018210412"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":1.6408,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.8459778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-ketoacidosis","display_name":"diabetic ketoacidosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hyperosmolar-hyperglycemic-state","display_name":"hyperosmolar hyperglycemic state","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acute-complications-of-diabetes","display_name":"acute complications of diabetes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.4339999854564667},{"id":"https://openalex.org/keywords/diabetes-education","display_name":"diabetes education","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8941777944564819},{"id":"https://openalex.org/C2781283889","wikidata":"https://www.wikidata.org/wiki/Q1130148","display_name":"Diabetic ketoacidosis","level":3,"score":0.8484556674957275},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.8190779685974121},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.7567125558853149},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6520817279815674},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6323122978210449},{"id":"https://openalex.org/C187316915","wikidata":"https://www.wikidata.org/wiki/Q92307203","display_name":"Case fatality rate","level":3,"score":0.6059755086898804},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6013354659080505},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5500043630599976},{"id":"https://openalex.org/C2775849729","wikidata":"https://www.wikidata.org/wiki/Q1130148","display_name":"Ketoacidosis","level":4,"score":0.5025966167449951},{"id":"https://openalex.org/C100136789","wikidata":"https://www.wikidata.org/wiki/Q1772448","display_name":"Coma (optics)","level":2,"score":0.4433210492134094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31772205233573914},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.18239054083824158},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16472133994102478},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3134432702","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/NBK/NBK567993","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":201,"referenced_works":["https://openalex.org/W41202834","https://openalex.org/W43423868","https://openalex.org/W45424479","https://openalex.org/W52391068","https://openalex.org/W69045089","https://openalex.org/W189660595","https://openalex.org/W614574849","https://openalex.org/W1492041642","https://openalex.org/W1531505795","https://openalex.org/W1532424818","https://openalex.org/W1555038020","https://openalex.org/W1604542334","https://openalex.org/W1622002423","https://openalex.org/W1752782186","https://openalex.org/W1893959718","https://openalex.org/W1964680835","https://openalex.org/W1966850311","https://openalex.org/W1970738207","https://openalex.org/W1971108230","https://openalex.org/W1971493468","https://openalex.org/W1972861777","https://openalex.org/W1973552596","https://openalex.org/W1974467450","https://openalex.org/W1976178549","https://openalex.org/W1979197888","https://openalex.org/W1979342157","https://openalex.org/W1979559844","https://openalex.org/W1981165456","https://openalex.org/W1981378658","https://openalex.org/W1982140340","https://openalex.org/W1983884842","https://openalex.org/W1983892261","https://openalex.org/W1984452100","https://openalex.org/W1985057063","https://openalex.org/W1985417575","https://openalex.org/W1986783271","https://openalex.org/W1986930775","https://openalex.org/W1988801717","https://openalex.org/W1990421974","https://openalex.org/W1992108504","https://openalex.org/W1994520167","https://openalex.org/W1995533788","https://openalex.org/W1995787090","https://openalex.org/W1995993427","https://openalex.org/W1996160128","https://openalex.org/W1997771785","https://openalex.org/W1998886336","https://openalex.org/W1999955186","https://openalex.org/W2000561228","https://openalex.org/W2000571139","https://openalex.org/W2001111065","https://openalex.org/W2003854023","https://openalex.org/W2005174940","https://openalex.org/W2006178382","https://openalex.org/W2007456248","https://openalex.org/W2009813035","https://openalex.org/W2011129689","https://openalex.org/W2011278875","https://openalex.org/W2011797748","https://openalex.org/W2012745827","https://openalex.org/W2012785795","https://openalex.org/W2012986429","https://openalex.org/W2019065820","https://openalex.org/W2019564242","https://openalex.org/W2019959400","https://openalex.org/W2020358579","https://openalex.org/W2020535111","https://openalex.org/W2022278688","https://openalex.org/W2022887467","https://openalex.org/W2023863228","https://openalex.org/W2024146783","https://openalex.org/W2024366326","https://openalex.org/W2026246353","https://openalex.org/W2027719307","https://openalex.org/W2027916831","https://openalex.org/W2028402540","https://openalex.org/W2029149163","https://openalex.org/W2029878157","https://openalex.org/W2030103243","https://openalex.org/W2030556864","https://openalex.org/W2033003442","https://openalex.org/W2035452578","https://openalex.org/W2035530611","https://openalex.org/W2035820131","https://openalex.org/W2036652285","https://openalex.org/W2037313887","https://openalex.org/W2038604815","https://openalex.org/W2043311180","https://openalex.org/W2044643317","https://openalex.org/W2044770075","https://openalex.org/W2045485213","https://openalex.org/W2046852134","https://openalex.org/W2051973234","https://openalex.org/W2054115499","https://openalex.org/W2054472527","https://openalex.org/W2055195400","https://openalex.org/W2055653312","https://openalex.org/W2055717798","https://openalex.org/W2056783448","https://openalex.org/W2057043467","https://openalex.org/W2057334042","https://openalex.org/W2057795930","https://openalex.org/W2058014234","https://openalex.org/W2059790025","https://openalex.org/W2060734115","https://openalex.org/W2061252153","https://openalex.org/W2061852824","https://openalex.org/W2063510032","https://openalex.org/W2065684636","https://openalex.org/W2066633683","https://openalex.org/W2066938856","https://openalex.org/W2071098277","https://openalex.org/W2072789303","https://openalex.org/W2073424221","https://openalex.org/W2074042576","https://openalex.org/W2074943120","https://openalex.org/W2076485773","https://openalex.org/W2076649152","https://openalex.org/W2078411839","https://openalex.org/W2079014557","https://openalex.org/W2079671043","https://openalex.org/W2082268035","https://openalex.org/W2083616093","https://openalex.org/W2083980839","https://openalex.org/W2086775240","https://openalex.org/W2088735076","https://openalex.org/W2091211637","https://openalex.org/W2092597514","https://openalex.org/W2092764219","https://openalex.org/W2094334827","https://openalex.org/W2094390237","https://openalex.org/W2095285670","https://openalex.org/W2096854877","https://openalex.org/W2099583169","https://openalex.org/W2100499143","https://openalex.org/W2100998026","https://openalex.org/W2102624023","https://openalex.org/W2102877966","https://openalex.org/W2104113021","https://openalex.org/W2106699522","https://openalex.org/W2107419755","https://openalex.org/W2108180908","https://openalex.org/W2108371350","https://openalex.org/W2109316006","https://openalex.org/W2109446577","https://openalex.org/W2109583273","https://openalex.org/W2110806627","https://openalex.org/W2111379370","https://openalex.org/W2112025233","https://openalex.org/W2113423894","https://openalex.org/W2116024232","https://openalex.org/W2116230208","https://openalex.org/W2117854701","https://openalex.org/W2120670217","https://openalex.org/W2121528299","https://openalex.org/W2121584527","https://openalex.org/W2122098893","https://openalex.org/W2126288005","https://openalex.org/W2126375001","https://openalex.org/W2131462635","https://openalex.org/W2135450314","https://openalex.org/W2135977346","https://openalex.org/W2137508233","https://openalex.org/W2138923096","https://openalex.org/W2139421900","https://openalex.org/W2141344121","https://openalex.org/W2145583809","https://openalex.org/W2146251352","https://openalex.org/W2148593614","https://openalex.org/W2149337343","https://openalex.org/W2154475711","https://openalex.org/W2156480624","https://openalex.org/W2156674980","https://openalex.org/W2158200533","https://openalex.org/W2158242010","https://openalex.org/W2160260538","https://openalex.org/W2160761930","https://openalex.org/W2160880263","https://openalex.org/W2162257275","https://openalex.org/W2162693177","https://openalex.org/W2165563030","https://openalex.org/W2165593936","https://openalex.org/W2165907640","https://openalex.org/W2166158593","https://openalex.org/W2170287677","https://openalex.org/W2171969247","https://openalex.org/W2172138999","https://openalex.org/W2190748907","https://openalex.org/W2222338437","https://openalex.org/W2262318659","https://openalex.org/W2330677656","https://openalex.org/W2337454357","https://openalex.org/W2340562852","https://openalex.org/W2341525904","https://openalex.org/W2418999178","https://openalex.org/W2460971772","https://openalex.org/W2463570919","https://openalex.org/W2769264260","https://openalex.org/W2916931956","https://openalex.org/W4241675296","https://openalex.org/W4250583835"],"related_works":["https://openalex.org/W3120234128","https://openalex.org/W1964085337","https://openalex.org/W4247530307","https://openalex.org/W7097596616","https://openalex.org/W4241189903","https://openalex.org/W2080507230","https://openalex.org/W4237335713","https://openalex.org/W7128164407","https://openalex.org/W2055653312","https://openalex.org/W2148087164"],"abstract_inverted_index":{"Diabetic":[0],"ketoacidosis":[1,34],"(DKA),":[2],"hyperglycemic":[3],"hyperosmolar":[4],"state":[5,183],"(HHS),":[6],"lactic":[7],"acidosis":[8],"(LA),":[9],"and":[10,14,21,66,143,252,269,287,292],"hypoglycemia":[11,23,213],"are":[12,24,161,276],"acute":[13,274],"potentially":[15],"life-threatening":[16],"complications":[17,275],"of":[18,57,79,91,134,156,170,181,188,204,227,299],"diabetes.":[19,42,175,232],"DKA":[20,74,80,98,120],"severe":[22],"more":[25,37],"common":[26],"in":[27,51,73,99,115,141,152,194,207,211,220],"type":[28,40,63,69,101],"1":[29,64,102],"diabetes,":[30,103],"while":[31],"HHS":[32,160,166,176],"without":[33,265],"is":[35,86],"associated":[36],"frequently":[38],"with":[39,62,68,119,139,150],"2":[41,70],"In":[43,198],"the":[44,47,105,116,123,182,296],"United":[45,117],"States,":[46],"SEARCH":[48],"for":[49,95,159,168,202,259,283],"Diabetes":[50],"Youth":[52],"study":[53],"reported":[54],"that":[55],"29%":[56],"patients":[58,83,93,256,291],"age":[59],"<20":[60],"years":[61],"diabetes":[65,71,140,151,241,300],"10%":[67],"presented":[72],"at":[75,84],"diagnosis.":[76],"The":[77],"frequency":[78],"among":[81,255,289],"adult":[82],"diagnosis":[85],"unknown.":[87],"A":[88],"small":[89],"group":[90],"high-risk":[92],"accounts":[94],"most":[96],"recurring":[97],"longstanding":[100],"but":[104,179],"incidence":[106],"remains":[107,177,243],"high\u2014approximately":[108],"1\u201312":[109],"episodes":[110,248],"per":[111,136,147,249],"100":[112],"patient-years.":[113],"Deaths":[114],"States":[118],"listed":[121,215],"as":[122,216],"underlying":[124,218],"cause":[125,219],"during":[126],"2000\u20132009":[127],"decreased":[128],"35%,":[129],"from":[130],"an":[131,217],"annual":[132],"rate":[133],"12.9":[135],"100,000":[137,148],"people":[138,149],"2000":[142],"2001":[144],"to":[145,164,174,231,240,246,295],"8.4":[146],"2009.":[153],"Estimated":[154],"rates":[155],"hospital":[157],"admissions":[158,172],"lower":[162,260],"compared":[163],"DKA.":[165],"accounted":[167,201],"<1%":[169],"all":[171,205],"related":[173],"uncommon,":[178],"recognition":[180],"has":[184,253],"increased,":[185],"partially":[186],"because":[187],"high":[189,244,297],"case":[190],"fatality,":[191],"exceeding":[192],"20%":[193],"some":[195],"patient":[196],"groups.":[197],"2001\u20132010,":[199,212],"LA":[200],"1.2%":[203],"hospitalizations":[206,229],"diabetic":[208,290],"patients.":[209],"Also":[210],"was":[214],"nearly":[221],"288,000":[222],"hospitalizations,":[223,286],"which":[224],"represented":[225],"5.4%":[226],"total":[228],"due":[230],"Severe":[233],"hypoglycemia,":[234],"i.e.,":[235],"coma":[236],"or":[237],"seizure":[238],"secondary":[239],"treatment,":[242],"(up":[245],"five":[247],"10":[250],"patient-years)":[251],"increased":[254],"who":[257],"aim":[258],"glycosylated":[261],"hemoglobin":[262],"(A1c)":[263],"targets":[264],"appropriate":[266],"initial":[267],"education":[268],"ongoing":[270],"support.":[271],"All":[272],"four":[273],"theoretically":[277],"preventable;":[278],"unfortunately,":[279],"they":[280],"still":[281],"account":[282],"enormous":[284],"morbidity,":[285],"mortality":[288],"contribute":[293],"significantly":[294],"costs":[298],"care.":[301]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}