{"id":"https://openalex.org/W3134420150","doi":null,"title":"Age-related left ventricular diastolic dysfunction is associated withleukocyte telomere length","display_name":"Age-related left ventricular diastolic dysfunction is associated withleukocyte telomere length","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3134420150","mag":"3134420150"},"language":"en","primary_location":{"id":"mag:3134420150","doi":null,"is_oa":false,"landing_page_url":"https://www.scitechnol.com/peer-review/agerelated-left-ventricular-diastolic-dysfunction-is-associated-withleukocyte-telomere-length-zI1d.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210236695","display_name":"Journal of Aging and Geriatric Medicine","issn_l":"2576-3946","issn":["2576-3946"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging and Geriatric Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080307921","display_name":"\u041f\u043b\u043e\u0445\u043e\u0432\u0430 \u0415\u043a\u0430\u0442\u0435\u0440\u0438\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-5297-0760","observed_orcids":["https://orcid.org/0000-0001-5297-0760"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. V. Plokhova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9869-2153","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080307921"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02925611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"0","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.1395999938249588,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-diastolic-dysfunction","display_name":"left ventricular diastolic dysfunction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/leukocyte-telomere-length","display_name":"leukocyte telomere length","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8690000176429749},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.7850000262260437},{"id":"https://openalex.org/keywords/e-a-ratio","display_name":"E/A ratio","score":0.703000009059906},{"id":"https://openalex.org/keywords/myocardial-relaxation","display_name":"myocardial relaxation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.3799999952316284},{"id":"https://openalex.org/keywords/risk-factors-for-heart-failure","display_name":"heart failure risk","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7385355830192566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6881465911865234},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6606770753860474},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.649020254611969},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5963470339775085},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5622792840003967},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5027024745941162},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49342313408851624},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4391191899776459},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4386722445487976},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.19302406907081604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09250369668006897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3134420150","doi":null,"is_oa":false,"landing_page_url":"https://www.scitechnol.com/peer-review/agerelated-left-ventricular-diastolic-dysfunction-is-associated-withleukocyte-telomere-length-zI1d.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210236695","display_name":"Journal of Aging and Geriatric Medicine","issn_l":"2576-3946","issn":["2576-3946"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging and Geriatric Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412726486","https://openalex.org/W1807933617","https://openalex.org/W2327568272","https://openalex.org/W2288596652","https://openalex.org/W7221643255","https://openalex.org/W7099978553","https://openalex.org/W2317779312","https://openalex.org/W2791855169","https://openalex.org/W2099568752","https://openalex.org/W1988141264"],"abstract_inverted_index":{"Background:":[0],"With":[1],"advancing":[2,197],"age":[3,186,198,242],"the":[4,15,18,31,45,64,128,232,241],"left":[5],"ventricle":[6],"(LV)":[7],"undergoes":[8],"structural":[9],"and":[10,34,68,98,123,159,173,222,249,254],"functional":[11],"changes,":[12],"thereby":[13],"creating":[14],"substrate":[16],"for":[17,180],"development":[19],"of":[20,30,36,42,44,58,63,66,104,116,161,175,185,220,244],"diseases.":[21],"Agerelated":[22],"disturbance":[23],"in":[24,75,86,142,234],"diastolic":[25,84,163,246],"function":[26,164,247],"increases":[27],"a":[28,48,56,73,148,217,225],"risk":[29],"clinical":[32],"signs":[33],"symptoms":[35],"heart":[37,46],"failure.":[38],"One":[39],"possible":[40,181],"mechanism":[41],"aging":[43],"is":[47,55,92],"cellular":[49],"senescence.":[50],"Leukocyte":[51],"telomere":[52,76,95,209],"length":[53,77,210],"(LTL)":[54],"marker":[57],"replicative":[59],"aging.":[60],"The":[61,100,138,155,237],"populations":[62],"cells":[65,71,146],"myocardium":[67],"progenitor":[69],"cardiac":[70],"showed":[72],"reduction":[74],"with":[78,94,196,257],"age.":[79],"We":[80],"hypothesized":[81],"that":[82,230],"LV":[83,162,235,245],"dysfunction":[85],"elderly":[87,214],"people":[88],"without":[89,114],"cardiovascular":[90],"diseases":[91],"associated":[93,256],"length.":[96],"Methods":[97],"results:":[99],"study":[101],"population":[102],"consisted":[103],"303":[105],"healthy":[106],"non-obese":[107],"volunteers":[108],"aged":[109],"26":[110],"to":[111,201,208,240],"86":[112],"years":[113],"history":[115],"CVD,":[117],"significant":[118],"deviations":[119],"by":[120,147],"12-lead":[121],"electrocardiogram":[122],"treadmill":[124],"stress":[125],"test.":[126],"All":[127],"participants":[129,187],"underwent":[130],"standardized":[131],"echocardiography":[132],"using":[133,167],"available":[134],"system":[135],"(iE33;":[136],"Philips).":[137],"LTL":[139,158,193],"was":[140,188,194,204,216],"measured":[141],"peripheral":[143],"blood":[144],"mononuclear":[145],"real-time":[149],"quantitative":[150],"polymerase":[151],"chain":[152],"reaction":[153],"method.":[154],"association":[156],"between":[157],"indexes":[160],"were":[165,252],"evaluated":[166],"correlation":[168],"analysis,":[169],"linear":[170],"regression":[171],"analysis":[172,174],"variance":[176],"(ANOVA)":[177],"after":[178],"adjusting":[179],"confounders.":[182],"Mean":[183],"values":[184,219],"51.47":[189],"\u00b1":[190],"0.76":[191],"years.":[192],"decreases":[195],"from":[199],"12.72":[200],"8.3.":[202],"Age":[203],"significantly":[205],"negatively":[206],"correlated":[207],"(r=-0.36;":[211],"p<0.001).":[212],"In":[213],"there":[215],"lower":[218],"E/A":[221],"Em/Am":[223,250],"ratio,":[224],"higher":[226],"valuesof":[227],"IVRT,":[228],"DT":[229],"reflects":[231],"impairment":[233],"relaxation.":[236],"most":[238],"sensitive":[239],"parameters":[243],"(E/A":[248],"ratio)":[251],"positively":[253],"independently":[255],"LTL.":[258]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-03-15T00:00:00"}
