{"id":"https://openalex.org/W3134089809","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20200927.402","title":"[Effect of fucoxanthin on insulin resistance in obese mice induced by high fat diet].","display_name":"[Effect of fucoxanthin on insulin resistance in obese mice induced by high fat diet].","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3134089809","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20200927.402","mag":"3134089809","pmid":"https://pubmed.ncbi.nlm.nih.gov/33645067"},"language":"zh","primary_location":{"id":"pmid:33645067","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20200927.402","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33645067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li-Li Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Li Huang","raw_affiliation_strings":["College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072178740","display_name":"Xiaoqiang Huang","orcid":"https://orcid.org/0000-0002-1005-848X","observed_orcids":["https://orcid.org/0000-0002-1005-848X"]},"institutions":[{"id":"https://openalex.org/I92092256","display_name":"Huanghe Science and Technology College","ror":"https://ror.org/008p6rr25","country_code":"CN","type":"education","lineage":["https://openalex.org/I92092256"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Qiang Huang","raw_affiliation_strings":["Medical School, Huanghe Science & Technology College, Zhengzhou 450063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Huanghe Science & Technology College, Zhengzhou 450063, China","institution_ids":["https://openalex.org/I92092256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699777","display_name":"Xiaoqin Zhang","orcid":"https://orcid.org/0000-0002-0952-7445","observed_orcids":["https://orcid.org/0000-0002-0952-7445","https://orcid.org/0009-0004-2874-6207"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Qin Zhang","raw_affiliation_strings":["College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414633","display_name":"Jian Liu","orcid":"https://orcid.org/0000-0001-5904-6415","observed_orcids":["https://orcid.org/0000-0001-5904-6415"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Liu","raw_affiliation_strings":["College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773057","display_name":"Yiping Zhang","orcid":"https://orcid.org/0000-0003-4425-2165","observed_orcids":["https://orcid.org/0000-0003-4425-2165","https://orcid.org/0000-0002-8931-5716"]},"institutions":[{"id":"https://openalex.org/I4387155833","display_name":"State Oceanic Administration","ror":"https://ror.org/05pxfr638","country_code":"CN","type":"government","lineage":["https://openalex.org/I211433327","https://openalex.org/I4210127390","https://openalex.org/I4387155833"]},{"id":"https://openalex.org/I4405258546","display_name":"Third Institute of Oceanography","ror":"https://ror.org/00w6b9958","country_code":"CN","type":"facility","lineage":["https://openalex.org/I211433327","https://openalex.org/I4210127390","https://openalex.org/I4405258546"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Ping Zhang","raw_affiliation_strings":["State Oceanic Administration Technical Innovation Center for Utilization of Marine Biological Resources,Third Institute of Oceanography Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Oceanic Administration Technical Innovation Center for Utilization of Marine Biological Resources,Third Institute of Oceanography Xiamen 361005, China","institution_ids":["https://openalex.org/I4387155833","https://openalex.org/I4405258546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076824143","display_name":"Haiyu Zhao","orcid":"https://orcid.org/0000-0003-0035-1874","observed_orcids":["https://orcid.org/0000-0003-0035-1874"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Yu Zhao","raw_affiliation_strings":["Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085309861","display_name":"Mingqing Huang","orcid":"https://orcid.org/0000-0002-2853-1087","observed_orcids":["https://orcid.org/0000-0002-2853-1087"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Qing Huang","raw_affiliation_strings":["College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China","institution_ids":["https://openalex.org/I118783713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7453,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69161247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"46","issue":"1","first_page":"171","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.35690000653266907,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.35690000653266907,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.16609999537467957,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fucoxanthin","display_name":"fucoxanthin","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8320846557617188},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8204770088195801},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8180097341537476},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.6755279898643494},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6338789463043213},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5676321387290955},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5649474263191223},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.5191816091537476},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4996182918548584},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4735400080680847},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.4413510859012604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3973346948623657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3680461049079895},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33939409255981445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2800828218460083},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.21168023347854614},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20974743366241455},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.19068634510040283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1883598268032074}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024341","descriptor_name":"Xanthophylls","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:33645067","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20200927.402","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33645067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"Journal Article"},{"id":"mag:3134089809","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20200927.402","is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/33645067","pdf_url":null,"source":{"id":"https://openalex.org/S2756327665","display_name":"China Journal of Chinese Materia Medica","issn_l":"1001-5302","issn":["1001-5302"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"China Journal of Chinese Materia Medica","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981796916","https://openalex.org/W2883298284","https://openalex.org/W1617248832","https://openalex.org/W2016141715","https://openalex.org/W4281636642","https://openalex.org/W2127549588","https://openalex.org/W1629380343","https://openalex.org/W2014076063","https://openalex.org/W1970187819","https://openalex.org/W1483437421"],"abstract_inverted_index":{"The":[0,40,107,230],"aim":[1],"of":[2,12,17,121,161,179,193,198,220,257],"this":[3],"paper":[4],"was":[5,44,105,112],"to":[6,152,254],"study":[7],"the":[8,74,119,153,157,217,255],"effect":[9],"and":[10,36,52,65,77,96,101,118,133,172,182,195,203,239,241,248,260],"mechanism":[11,250],"fucoxanthin":[13,234],"on":[14],"insulin":[15,41,102,126,243],"resistance":[16,42,103,244],"obese":[18,246],"mice":[19,29,54,225],"induced":[20,45],"by":[21,114,148],"high-fat":[22,37,47],"diet.":[23],"Fifty":[24],"C57":[25],"BL/6":[26],"J":[27],"male":[28],"were":[30,55,84,99,146,186,207,226],"randomly":[31,56],"divided":[32,57],"into":[33,58],"control":[34],"group":[35,64,83],"diet":[38,48],"group.":[39,67],"model":[43,53,59,158],"with":[46,156,212],"for":[49,71],"12":[50],"weeks,":[51,73],"group,":[60,62,159],"fucoxanthin-0.2%":[61],"fucoxanthin-0.4%":[63],"metformin":[66],"After":[68],"dietary":[69],"treatment":[70,211],"6":[72],"body":[75,162],"weight":[76,80],"epididymal":[78,164],"fat":[79,165],"in":[81,110,125,144,184,205,223,245],"each":[82],"measured.":[85],"Fasting":[86],"blood":[87],"glucose(FBG),":[88],"fasting":[89],"insulin(FINS),":[90],"total":[91],"cholesterol(TC),":[92],"triglyceride(TG),":[93],"low-density":[94],"lipoprotein(LDL-C)":[95],"high-density":[97],"lipoprotein(HDL-C)":[98],"measured,":[100],"index(HOMA-IR)":[104],"calcula-ted.":[106],"pathological":[108,218],"morphology":[109],"liver":[111,145,185,206,221],"observed":[113],"hematoxylin":[115],"eosin":[116],"staining,":[117],"expressions":[120,178,197],"some":[122],"key":[123],"proteins":[124],"receptor":[127],"substrate":[128],"1(IRS-1)/posphoinositide":[129],"3-kinase(PI3":[130],"K)/serine-threonine":[131],"kinase(Akt)":[132],"peroxisome":[134],"proliferators-activated":[135],"receptor-\u03b3(PPAR\u03b3)/sterol":[136],"regulatory":[137],"element":[138],"binding":[139],"protein-1(SREBP-1)/fatty":[140],"acid":[141],"synthetase(FAS)":[142],"pathways":[143],"detected":[147],"Western":[149],"blot.":[150],"According":[151],"findings,":[154],"compared":[155],"levels":[160],"weight,":[163,166],"FBG,":[167],"FINS,":[168],"TC,":[169],"TG,":[170],"LDL-C":[171],"HOMA-IR,":[173],"as":[174,176],"well":[175],"protein":[177,196],"PPAR\u03b3,":[180],"SREBP-1":[181],"FAS":[183],"significantly":[187],"reduced(P<0.05":[188],"or":[189,214],"P<0.01),":[190],"while":[191],"level":[192],"HDL-C":[194],"p-IRS-1,":[199],"IRS-1,":[200],"PI3":[201],"K":[202],"p-Akt":[204],"signi-ficantly":[208],"increased":[209],"after":[210],"fucoxanthin(P<0.05":[213],"P<0.01).":[215],"And":[216],"changes":[219],"tissue":[222],"fucoxanthin-treated":[224],"also":[227],"improved":[228],"obviously.":[229],"results":[231],"showed":[232],"that":[233],"could":[235],"improve":[236],"obesity,":[237],"hyperglycemia":[238],"hyperlipidemia,":[240],"alleviate":[242],"mice,":[247],"its":[249],"is":[251],"possibly":[252],"related":[253],"regulation":[256],"IRS-1/PI3":[258],"K/Akt":[259],"PPAR\u03b3/SREBP-1/FAS":[261],"pathways.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2021-03-15T00:00:00"}
