{"id":"https://openalex.org/W313400157","doi":null,"title":"Hypertension and myocarditis in rabbits exposed to hexachlorocyclohexane and endosulfan.","display_name":"Hypertension and myocarditis in rabbits exposed to hexachlorocyclohexane and endosulfan.","publication_year":1990,"publication_date":"1990-12-01","ids":{"openalex":"https://openalex.org/W313400157","mag":"313400157","pmid":"https://pubmed.ncbi.nlm.nih.gov/1702244"},"language":"en","primary_location":{"id":"pmid:1702244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1702244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and human toxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000833989","display_name":"Madhu Anand","orcid":"https://orcid.org/0000-0002-0699-4363","observed_orcids":["https://orcid.org/0000-0002-0699-4363"]},"institutions":[{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Anand","raw_affiliation_strings":["Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India","institution_ids":["https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Gulati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gulati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103214579","display_name":"Krishna Gopal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Gopal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G S Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108383104","display_name":"R. N. Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R N Khanna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109117029","display_name":"P. K. Ray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P K Ray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052025551","display_name":"Sunita Chandra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S V Chandra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.03119112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"32","issue":"6","first_page":"521","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexachlorocyclohexane","display_name":"hexachlorocyclohexane","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endosulfan","display_name":"endosulfan","score":0.9959999918937683},{"id":"https://openalex.org/keywords/organochlorine-pesticides","display_name":"organochlorine pesticides","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pesticide-toxicity","display_name":"pesticide toxicity","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9769999980926514},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myocardial-degeneration","display_name":"myocardial degeneration","score":0.8349999785423279},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.5879999995231628},{"id":"https://openalex.org/keywords/electrocardiographic-changes","display_name":"electrocardiographic changes","score":0.8259999752044678},{"id":"https://openalex.org/keywords/adrenal-hyperplasia","display_name":"adrenal hyperplasia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/long-term-exposure","display_name":"long-term exposure","score":0.34700000286102295},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2778614373","wikidata":"https://www.wikidata.org/wiki/Q7908033","display_name":"Vacuolization","level":2,"score":0.7615416049957275},{"id":"https://openalex.org/C2780040062","wikidata":"https://www.wikidata.org/wiki/Q424459","display_name":"Hexachlorocyclohexane","level":3,"score":0.7491810917854309},{"id":"https://openalex.org/C2779680598","wikidata":"https://www.wikidata.org/wiki/Q424208","display_name":"Endosulfan","level":3,"score":0.7224851250648499},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.7008922100067139},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5590848326683044},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5240533351898193},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.5228595733642578},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.45982861518859863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45066654682159424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4173714518547058},{"id":"https://openalex.org/C2993891245","wikidata":"https://www.wikidata.org/wiki/Q426809","display_name":"Organochlorine pesticide","level":3,"score":0.4119178056716919},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.39494526386260986},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.378927618265152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3678956925868988},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.351615846157074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2081213891506195},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001556","descriptor_name":"Hexachlorocyclohexane","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004726","descriptor_name":"Endosulfan","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1702244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1702244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and human toxicology","raw_type":"Journal Article"},{"id":"mag:313400157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1702244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2473192160","https://openalex.org/W2118001831","https://openalex.org/W2032761414","https://openalex.org/W2410378675","https://openalex.org/W2093608986","https://openalex.org/W2048815974","https://openalex.org/W4407236821","https://openalex.org/W4308147522","https://openalex.org/W2085318766","https://openalex.org/W7217678323"],"abstract_inverted_index":{"Male":[0],"albino":[1],"rabbits":[2,30,109],"were":[3],"exposed":[4,55,110],"to":[5,111],"the":[6,29,39,54],"organochlorinated":[7],"pesticides":[8,90],"hexachlorocyclohexane":[9],"(HCH)":[10],"and":[11,14,47,62,77,84,105,113],"endosulfan":[12],"(2.5":[13],"5.0":[15],"mg/kg,":[16],"ip)":[17],"twice":[18],"a":[19],"week":[20],"for":[21],"12":[22,32],"mo.":[23],"The":[24],"mean":[25],"body":[26],"weight":[27],"of":[28,38,73,86,98],"at":[31,100],"mo":[33],"was":[34,42,68],"lower":[35],"than":[36,96],"that":[37],"controls.":[40],"There":[41],"rise":[43],"in":[44,52,59,108],"blood":[45],"pressure":[46],"heart":[48],"rate.":[49],"Electrocardiograms":[50],"(ECG)":[51],"both":[53],"groups":[56],"showed":[57],"increases":[58,93],"PR,":[60],"QT":[61],"RR":[63],"intervals.":[64,103],"Extensive":[65],"myocardial":[66],"damage":[67],"recorded":[69],"with":[70],"marked":[71],"degeneration":[72],"muscle":[74],"fibers":[75],"vacuolization":[76],"leucocytic":[78],"infiltration.":[79],"Adrenals":[80],"had":[81],"thickened":[82],"capsules":[83],"hyperplasia":[85],"cortical":[87],"cells.":[88],"Both":[89],"produced":[91],"significant":[92],"(p":[94],"less":[95],"0.001)":[97],"11-hydroxycortisone":[99],"all":[101],"time":[102],"Hypertension":[104],"myocarditis":[106],"occurred":[107],"HCH":[112],"endosulfan.":[114]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}