{"id":"https://openalex.org/W3133975353","doi":"https://doi.org/10.1097/dcr.0000000000001971","title":"Accuracy of Using a Patient-Derived Tumor Organoid Culture Model to Predict the Response to Chemotherapy Regimens In Stage IV Colorectal Cancer","display_name":"Accuracy of Using a Patient-Derived Tumor Organoid Culture Model to Predict the Response to Chemotherapy Regimens In Stage IV Colorectal Cancer","publication_year":2021,"publication_date":"2021-03-12","ids":{"openalex":"https://openalex.org/W3133975353","doi":"https://doi.org/10.1097/dcr.0000000000001971","mag":"3133975353","pmid":"https://pubmed.ncbi.nlm.nih.gov/33709991"},"language":"en","primary_location":{"id":"doi:10.1097/dcr.0000000000001971","doi":"https://doi.org/10.1097/dcr.0000000000001971","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dcr.0000000000001971","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon & Rectum","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100427929","display_name":"Ting Wang","orcid":"https://orcid.org/0000-0002-2425-4684","observed_orcids":["https://orcid.org/0000-0002-2425-4684"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029335998","display_name":"Wenjun Pan","orcid":"https://orcid.org/0009-0009-9061-3735","observed_orcids":["https://orcid.org/0009-0009-9061-3735"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Pan","raw_affiliation_strings":["Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101851518","display_name":"Hang Zheng","orcid":"https://orcid.org/0000-0001-7562-887X","observed_orcids":["https://orcid.org/0000-0001-7562-887X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Zheng","raw_affiliation_strings":["Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China","Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110584091","display_name":"Hongping Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongping Zheng","raw_affiliation_strings":["Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China","Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102705916","display_name":"Zhejun Wang","orcid":"https://orcid.org/0000-0002-1227-1823","observed_orcids":["https://orcid.org/0000-0002-1227-1823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhejun Wang","raw_affiliation_strings":["Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045858108","display_name":"Jia J. Li","orcid":"https://orcid.org/0000-0003-3676-5657","observed_orcids":["https://orcid.org/0000-0003-3676-5657"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia J. Li","raw_affiliation_strings":["Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050911555","display_name":"Chu\u2010Xia Deng","orcid":"https://orcid.org/0000-0001-8033-3902","observed_orcids":["https://orcid.org/0000-0001-8033-3902","https://orcid.org/0000-0003-0031-9962"]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Chuxia Deng","raw_affiliation_strings":["Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100778540","display_name":"Jun Yan","orcid":"https://orcid.org/0000-0003-1373-4380","observed_orcids":["https://orcid.org/0000-0003-1373-4380"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Yan","raw_affiliation_strings":["Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, Guangzhou, Guangdong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100778540"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":4.4017,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96899362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"64","issue":"7","first_page":"833","last_page":"850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.12880000472068787,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patient-derived-tumor-organoids","display_name":"patient-derived tumor organoids","score":0.9549999833106995},{"id":"https://openalex.org/keywords/stage-iv-colorectal-cancer","display_name":"stage IV colorectal cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chemotherapy-response-prediction","display_name":"chemotherapy response prediction","score":0.9620000123977661},{"id":"https://openalex.org/keywords/prediction-accuracy","display_name":"prediction accuracy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/half-maximal-inhibitory-concentration","display_name":"half maximal inhibitory concentration","score":0.9179999828338623},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5699999928474426},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.48500001430511475},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8759289979934692},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8169232606887817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8011585474014282},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7222411036491394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5783881545066833},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5710864663124084},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5430992245674133},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5376570820808411},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.43763408064842224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3360975980758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10206213593482971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/dcr.0000000000001971","doi":"https://doi.org/10.1097/dcr.0000000000001971","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dcr.0000000000001971","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon & Rectum","raw_type":"journal-article"},{"id":"pmid:33709991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33709991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the colon and rectum","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1741548448","https://openalex.org/W2002513358","https://openalex.org/W2010916968","https://openalex.org/W2019607817","https://openalex.org/W2026548544","https://openalex.org/W2112727687","https://openalex.org/W2121368761","https://openalex.org/W2128447158","https://openalex.org/W2139132031","https://openalex.org/W2157416388","https://openalex.org/W2312491311","https://openalex.org/W2415856576","https://openalex.org/W2586712356","https://openalex.org/W2601380465","https://openalex.org/W2773981699","https://openalex.org/W2788735115","https://openalex.org/W2799444748","https://openalex.org/W2889646458","https://openalex.org/W2896450660","https://openalex.org/W2905447079","https://openalex.org/W2908930063","https://openalex.org/W2913284684","https://openalex.org/W2939543377","https://openalex.org/W2941179507","https://openalex.org/W2943439515","https://openalex.org/W2948496414","https://openalex.org/W2951196366","https://openalex.org/W2978373708","https://openalex.org/W2980113327","https://openalex.org/W2994559322","https://openalex.org/W6929768629"],"related_works":["https://openalex.org/W4214481212","https://openalex.org/W4382241201","https://openalex.org/W4323822280","https://openalex.org/W2980113327","https://openalex.org/W4387872983","https://openalex.org/W4415356733","https://openalex.org/W3215141374","https://openalex.org/W4387081051","https://openalex.org/W4318586816","https://openalex.org/W4282833866"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patient-derived":[1,168],"tumor":[2,26,57,92,110,169,186,262,292],"organoid":[3,27,58,93,111,170,187,202,263,293],"culture":[4,28,59,94,112,171,203,294],"has":[5,12],"emerged":[6],"as":[7],"a":[8,97,279,284,361,384,414,440,478,560,601,648,684],"preclinical":[9],"model":[10,60,113,188,264,295],"that":[11],"the":[13,21,51,55,79,84,90,104,108,142,155,184,214,229,241,260],"potential":[14],"to":[15,32,49,63,77,86,102,116,191,236,268,299],"predict":[16],"individual":[17,304],"drug":[18,205],"response.":[19],"However,":[20],"predictive":[22,52,105,181],"accuracy":[23,53,106,182,258],"of":[24,45,54,83,107,134,183,201,228,259],"patient-derived":[25,56,91,109,185,261,291],"models":[29],"for":[30,61,114,189,265,303],"responses":[31,62,115,190,267,298],"chemotherapy":[33,64,87,117,173,192,230,238,269,301],"regimens":[34,65,88,174,193,270,302],"in":[35,66,89,138],"stage":[36,67,127],"IV":[37,68,128,336,395,494],"colorectal":[38,69,129],"cancer":[39,130],"remains":[40],"unknown.":[41],"OBJECTIVE:":[42],"The":[43,180,197,224,254,290],"purpose":[44],"this":[46],"study":[47,74,99,281],"was":[48,75,100,194,207,232,278],"evaluate":[50,103],"cancer.":[70],"DESIGN:":[71],"A":[72],"pilot":[73,143,215],"performed":[76,101],"define":[78],"half-maximal":[80,225],"inhibitory":[81,226],"concentration":[82,227],"response":[85,231],"model.":[95],"Then,":[96],"blinded":[98,156,242,280],"regimens.":[118],"SETTINGS:":[119],"Cancer":[120],"samples":[121,151,164,218,245],"were":[122,147,152,160,165,175,221,251,271],"collected":[123],"from":[124,248],"patients":[125,146,159,250],"with":[126],"at":[131,308],"Nanfang":[132,498],"Hospital":[133,497],"Southern":[135],"Medical":[136],"University":[137],"China.":[139],"PATIENTS:":[140],"In":[141,154,213,240],"study,":[144,157,216,243],"30":[145,217,512,589],"enrolled,":[148,161],"and":[149,162,172,204,257,274],"43":[150,517],"collected.":[153,166],"71":[158,525],"96":[163,530],"INTERVENTION:":[167],"tested.":[176],"MAIN":[177],"OUTCOME":[178],"MEASURES:":[179],"measured.":[195],"RESULTS:":[196],"median":[198],"(range)":[199],"time":[200],"testing":[206],"9":[208,578],"days":[209],"(range,":[210],"7-14":[211],"d).":[212],"(69.77%":[219],"[30/43])":[220,591],"successfully":[222,252],"cultured.":[223,253],"10":[233,606],"\u00b5mol/L":[234],"according":[235],"clinical":[237],"outcomes.":[239],"77":[244,625],"(80.21%":[246],"[77/96])":[247,628],"57":[249,630],"sensitivity,":[255],"specificity,":[256],"predicting":[266],"63.33%,":[272],"94.12%,":[273],"79.69%.":[275],"LIMITATIONS:":[276],"This":[277],"rather":[282],"than":[283],"prospective":[285],"randomized":[286],"controlled":[287],"study.":[288],"CONCLUSIONS:":[289],"effectively":[296],"predicts":[297],"existing":[300],"patients.":[305],"Video":[306,694],"Abstract":[307],"http://links.lww.com/DCR/B511.":[309,697],"PRECISIN":[310],"EN":[311,332],"EL":[312],"USO":[313],"DE":[314,316,318,322,330,546],"MODELOS":[315],"CULTIVO":[317],"ORGANOIDES":[319],"TUMORALES":[320],"DERIVADOS":[321],"PACIENTES":[323],"PARA":[324],"PREDECIR":[325],"LA":[326],"RESPUESTA":[327],"DEL":[328],"RGIMEN":[329],"QUIMIOTERAPIA":[331],"CNCER":[333],"COLORRECTAL":[334],"ESTADIO":[335],"ESTUDIO":[337],"CIEGO:":[338],"ANTECEDENTES:El":[339],"cultivo":[340,374,405,449,469,570,674],"de":[341,357,373,375,379,387,404,409,417,437,443,448,453,468,473,481,485,487,499,534,536,543,563,567,569,574,577,598,605,613,629,651,665,673,678,687],"organoides":[342,376,535],"tumorales":[343,377],"derivado":[344,408,452,472,554,641,677],"del":[345,402,466,503,539,550,555,637,642],"paciente":[346,540,556,643],"ha":[347],"surgido":[348],"como":[349],"un":[350,362,427,458,660,666],"modelo":[351,403,447,467,551,638,672],"precl\u00ednico":[352],"que":[353],"tiene":[354],"el":[355,390,420,446,496,507,520,582,618],"potencial":[356],"predecir":[358,645],"la":[359,367,399,432,438,463,500,599,602,614],"respuesta":[360,439,600],"f\u00e1rmaco":[363],"individual.":[364],"Sin":[365],"embargo,":[366],"exactitud":[368,400,464],"predictiva":[369,401,465,549],"en":[370,389,393,419,423,445,492,495,505,663,696],"los":[371,385,415,441,479,561,611,649,685],"modelos":[372],"derivados":[378,538],"pacientes":[380,410,474,488,513,526,679,691],"para":[381,411,430,461,475,557,644,690],"las":[382,412,476,558,646,682],"respuestas":[383,413,477,559,647,683],"reg\u00edmenes":[386,416,442,480,542,562,650,686],"quimioterapia":[388,418,444,603,615,652,688],"c\u00e1ncer":[391,421,486,490],"colorrectal":[392,422,491],"estadio":[394,424,493],"sigue":[396],"siendo":[397],"desconocida.OBJETIVO:Evaluar":[398],"organoide":[406,450,470,552,571,639,675],"tumoral":[407,451,471,553,640,676],"IV.DISE\u00d1O:Se":[425],"realiz\u00f3":[426,457],"estudio":[428,459,508,521,583,619,661,667],"piloto":[429],"definir":[431],"concentraci\u00f3n":[433,594],"inhibitoria":[434],"media":[435,596],"m\u00e1xima":[436,597],"pacientes.":[454,631],"Luego,":[455],"se":[456,510,515,523,528,585,621],"ciego":[460,662],"evaluar":[462],"quimioterapia.AJUSTE:Se":[482],"recolectaron":[483,516,529],"muestras":[484,626],"con":[489,587,623],"Universidad":[501],"M\u00e9dica":[502],"Sur":[504],"China.PACIENTES:En":[506],"piloto,":[509,584],"inscribieron":[511,524],"y":[514,527,541,572,635,656,670],"muestras.":[518,592],"En":[519,581,617],"ciego,":[522,620],"muestras.INTERVENCI\u00d3N:Se":[531],"probaron":[532],"cultivos":[533],"tumores":[537],"quimioterapia.PRINCIPALES":[544],"MEDIDAS":[545],"RESULTADO:La":[547],"precisi\u00f3n":[548,636],"quimioterapia.RESULTADOS:La":[564],"mediana":[565],"(rango)":[566],"tiempo":[568],"prueba":[573],"drogas":[575],"fue":[576,604,659],"(7-14)":[579],"d\u00edas.":[580],"cultivaron":[586,622],"\u00e9xito":[588,624],"(69,77%":[590],"La":[593,632],"inhibidora":[595],"\u00b5mol":[607],"/":[608],"L":[609],"seg\u00fan":[610],"resultados":[612],"cl\u00ednica.":[616],"(80,21%":[627],"sensibilidad,":[633],"especificidad":[634],"fueron":[653],"63,33%,":[654],"94,12%":[655],"79,69%,":[657],"respectivamente.LIMITACIONES:Este":[658],"lugar":[664],"prospectivo,":[668],"aleatorizado":[669],"controlado.CONCLUSIONES:El":[671],"predice":[680],"eficazmente":[681],"existentes":[689],"individuales.":[692],"Consulte":[693],"Resumen":[695]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}