{"id":"https://openalex.org/W3133965202","doi":"https://doi.org/10.1016/j.theriogenology.2021.01.019","title":"SUMO2, a small ubiquitin-like modifier, is essential for development of murine preimplantation embryos","display_name":"SUMO2, a small ubiquitin-like modifier, is essential for development of murine preimplantation embryos","publication_year":2021,"publication_date":"2021-02-27","ids":{"openalex":"https://openalex.org/W3133965202","doi":"https://doi.org/10.1016/j.theriogenology.2021.01.019","mag":"3133965202","pmid":"https://pubmed.ncbi.nlm.nih.gov/33677127"},"language":"en","primary_location":{"id":"doi:10.1016/j.theriogenology.2021.01.019","doi":"https://doi.org/10.1016/j.theriogenology.2021.01.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2021.01.019","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044641119","display_name":"Ying Yang","orcid":"https://orcid.org/0000-0002-8104-5985","observed_orcids":["https://orcid.org/0000-0002-8104-5985","https://orcid.org/0009-0004-6521-1666","https://orcid.org/0000-0002-2821-8541"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Yang","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yingbing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingbing Zhang","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peipei Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peipei Qiao","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080869729","display_name":"Bin Yang","orcid":"https://orcid.org/0000-0001-8081-2292","observed_orcids":["https://orcid.org/0000-0001-8081-2292"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Yang","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huiqun Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqun Jia","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419752","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0001-9811-3019","observed_orcids":["https://orcid.org/0000-0001-9811-3019"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai Province, 810016, PR China. Electronic address: zhangjunxn2003@163.com","Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai Province, 810016, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai Province, 810016, PR China. Electronic address: zhangjunxn2003@163.com","institution_ids":["https://openalex.org/I116265982"]},{"raw_affiliation_string":"Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai Province, 810016, PR China","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048676537","display_name":"Jianmin Su","orcid":"https://orcid.org/0000-0001-7353-1265","observed_orcids":["https://orcid.org/0000-0001-7353-1265"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianmin Su","raw_affiliation_strings":["College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China. Electronic address: sujm@nwafu.edu.cn","College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China. Electronic address: sujm@nwafu.edu.cn","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048676537"],"corresponding_institution_ids":["https://openalex.org/I116265982","https://openalex.org/I89652312"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":0.0724,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.09060176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"166","issue":null,"first_page":"29","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.17589999735355377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumo2","display_name":"SUMO2","score":1.0},{"id":"https://openalex.org/keywords/small-ubiquitin-like-modifier","display_name":"SUMO","score":0.9620000123977661},{"id":"https://openalex.org/keywords/preimplantation-embryo-development","display_name":"preimplantation embryo development","score":0.9599999785423279},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.871999979019165},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cdx2","display_name":"CDX2","score":0.8270000219345093},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":1.0},{"id":"https://openalex.org/keywords/pluripotency-genes","display_name":"pluripotency genes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8169999718666077},{"id":"https://openalex.org/keywords/embryonic-gene-expression","display_name":"embryonic gene expression","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.7980446815490723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6888203620910645},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.6461353898048401},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5615543723106384},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5582519769668579},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5262041687965393},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5193544626235962},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5188330411911011},{"id":"https://openalex.org/C2908926650","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Nanog Homeobox Protein","level":5,"score":0.4659633934497833},{"id":"https://openalex.org/C207168726","wikidata":"https://www.wikidata.org/wiki/Q18050439","display_name":"Rex1","level":5,"score":0.4469072222709656},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4419759511947632},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4287775754928589},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.42291516065597534},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.32933253049850464},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2939811944961548},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.27949976921081543},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23399445414543152},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1975841224193573},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.14287689328193665}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025841","descriptor_name":"Small Ubiquitin-Related Modifier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.theriogenology.2021.01.019","doi":"https://doi.org/10.1016/j.theriogenology.2021.01.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2021.01.019","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},{"id":"pmid:33677127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33677127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320335921","display_name":"Natural Science Foundation of Qinghai","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W164150744","https://openalex.org/W1514520124","https://openalex.org/W1520109974","https://openalex.org/W1799534295","https://openalex.org/W1949720728","https://openalex.org/W1972471503","https://openalex.org/W1988652723","https://openalex.org/W1991711696","https://openalex.org/W1994144105","https://openalex.org/W1996431377","https://openalex.org/W2006499356","https://openalex.org/W2006594553","https://openalex.org/W2044499746","https://openalex.org/W2049598074","https://openalex.org/W2050055581","https://openalex.org/W2063905858","https://openalex.org/W2070700342","https://openalex.org/W2080342872","https://openalex.org/W2086277161","https://openalex.org/W2108247013","https://openalex.org/W2114591766","https://openalex.org/W2128877497","https://openalex.org/W2156374607","https://openalex.org/W2157232603","https://openalex.org/W2262950395","https://openalex.org/W2290873962","https://openalex.org/W2294437982","https://openalex.org/W2801872537","https://openalex.org/W2893622456","https://openalex.org/W2905200397","https://openalex.org/W2915563981","https://openalex.org/W2980639267","https://openalex.org/W2989367454","https://openalex.org/W3084365237","https://openalex.org/W6606674401"],"related_works":["https://openalex.org/W2108247013","https://openalex.org/W4365816896","https://openalex.org/W2085171686","https://openalex.org/W2027200579","https://openalex.org/W2159309905","https://openalex.org/W2124841426","https://openalex.org/W4411865228","https://openalex.org/W4407794963","https://openalex.org/W2135422714","https://openalex.org/W3085988699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-03-15T00:00:00"}