{"id":"https://openalex.org/W3133933815","doi":"https://doi.org/10.3389/fimmu.2021.577766","title":"Sunitinib Exerts In Vitro Immunomodulatory Activity on Sarcomas via Dendritic Cells and Synergizes With PD-1 Blockade","display_name":"Sunitinib Exerts In Vitro Immunomodulatory Activity on Sarcomas via Dendritic Cells and Synergizes With PD-1 Blockade","publication_year":2021,"publication_date":"2021-02-26","ids":{"openalex":"https://openalex.org/W3133933815","doi":"https://doi.org/10.3389/fimmu.2021.577766","mag":"3133933815","pmid":"https://pubmed.ncbi.nlm.nih.gov/33717062","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7952316"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.577766","doi":"https://doi.org/10.3389/fimmu.2021.577766","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.577766","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2021.577766","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002381343","display_name":"Darina O\u010dadl\u00edkov\u00e1","orcid":"https://orcid.org/0000-0002-6976-4450","observed_orcids":["https://orcid.org/0000-0002-6976-4450"]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Darina Ocadlikova","raw_affiliation_strings":["Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna, Bologna, Italy","IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073016552","display_name":"Mariangela Lecciso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Lecciso","raw_affiliation_strings":["IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023576532","display_name":"Javier Mart\u00edn\u2010Broto","orcid":"https://orcid.org/0000-0001-7350-6916","observed_orcids":["https://orcid.org/0000-0001-7350-6916"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Martin Broto","raw_affiliation_strings":["Virgen del Rocio University Hospital, Institute of Biomedicine Research (IBIS), Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virgen del Rocio University Hospital, Institute of Biomedicine Research (IBIS), Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015636061","display_name":"Katia Scotlandi","orcid":"https://orcid.org/0000-0001-6114-9499","observed_orcids":["https://orcid.org/0000-0001-6114-9499"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Katia Scotlandi","raw_affiliation_strings":["Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926851","display_name":"Mich\u00e8le Cavo","orcid":"https://orcid.org/0000-0003-4514-3227","observed_orcids":["https://orcid.org/0000-0003-4514-3227"]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Cavo","raw_affiliation_strings":["Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna, Bologna, Italy","IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072253025","display_name":"Antonio Curti","orcid":"https://orcid.org/0000-0002-7752-6049","observed_orcids":["https://orcid.org/0000-0002-7752-6049"]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Curti","raw_affiliation_strings":["IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \"Ser\u00e0gnoli\", Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080548972","display_name":"Emanuela Palmerini","orcid":"https://orcid.org/0000-0003-3406-6705","observed_orcids":["https://orcid.org/0000-0003-3406-6705"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emanuela Palmerini","raw_affiliation_strings":["Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080548972"],"corresponding_institution_ids":["https://openalex.org/I4210121742"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.1008,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.90500038,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"577766","last_page":"577766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.25119999051094055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6359999775886536},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7900000214576721},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibitors","display_name":"receptor tyrosine kinase inhibitors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4729999899864197},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6420000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.39500001072883606},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/dc-maturation","display_name":"DC maturation","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.7218167781829834},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6736375689506531},{"id":"https://openalex.org/C2776910622","wikidata":"https://www.wikidata.org/wiki/Q2619315","display_name":"Synovial sarcoma","level":3,"score":0.5084015727043152},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.48663124442100525},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.46099379658699036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4247291088104248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32643163204193115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3106476366519928},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1797870695590973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16061902046203613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12293308973312378}],"mesh":[{"descriptor_ui":"D000077210","descriptor_name":"Sunitinib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.3389/fimmu.2021.577766","doi":"https://doi.org/10.3389/fimmu.2021.577766","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.577766","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:33717062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33717062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7952316","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7952316/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:www.repositoriosalud.es:10668/17350","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952316/pdf","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.577766/pdf","source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:cris.unibo.it:11585/856247","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11585/856247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/261717","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/261717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:f47503fa1f334b9dbe83c6daf7a0ec6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f47503fa1f334b9dbe83c6daf7a0ec6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"},{"id":"pmh:oai:www.repositoriosalud.es:10668/4011","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10668/4011","pdf_url":null,"source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.577766","doi":"https://doi.org/10.3389/fimmu.2021.577766","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.577766","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320324659","display_name":"Istituto Ortopedico Rizzoli di Bologna","ror":"https://ror.org/02ycyys66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133933815.pdf","grobid_xml":"https://content.openalex.org/works/W3133933815.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1494329257","https://openalex.org/W1984257684","https://openalex.org/W2000767839","https://openalex.org/W2000884139","https://openalex.org/W2105453522","https://openalex.org/W2120426523","https://openalex.org/W2123334268","https://openalex.org/W2129411754","https://openalex.org/W2395453884","https://openalex.org/W2513951655","https://openalex.org/W2536322725","https://openalex.org/W2745476617","https://openalex.org/W2762797139","https://openalex.org/W2774372124","https://openalex.org/W2780840511","https://openalex.org/W2785838318","https://openalex.org/W2794419219","https://openalex.org/W2801774047","https://openalex.org/W2911812451","https://openalex.org/W2912458609","https://openalex.org/W2913745075","https://openalex.org/W2921882381","https://openalex.org/W2930737113","https://openalex.org/W2941109595","https://openalex.org/W2944423827","https://openalex.org/W2978475020","https://openalex.org/W2980316201","https://openalex.org/W2998268542","https://openalex.org/W3024334228","https://openalex.org/W3027587114","https://openalex.org/W3031942086","https://openalex.org/W3047001933","https://openalex.org/W3100757401","https://openalex.org/W6678456434","https://openalex.org/W6712147513"],"related_works":["https://openalex.org/W2891837461","https://openalex.org/W3201921321","https://openalex.org/W148401973","https://openalex.org/W4292588891","https://openalex.org/W3100757401","https://openalex.org/W2091463916","https://openalex.org/W2890515735","https://openalex.org/W2354013635","https://openalex.org/W4402581840","https://openalex.org/W2969365220"],"abstract_inverted_index":{"Background":[0],"High-grade":[1],"sarcomas":[2],"are":[3,20,329],"a":[4,234,299],"heterogeneous":[5],"group":[6],"of":[7,32,50,60,84,103,265,285,307],"aggressive":[8],"tumors":[9],"arising":[10],"in":[11,40,56,57,248,258,312,316],"bone":[12,198],"and":[13,30,52,67,80,100,131,135,146,170,189,199,227,290,309,314,326,332],"soft":[14],"tissues.":[15],"After":[16,77],"relapse,":[17],"treatment":[18,210,264],"options":[19],"limited.":[21],"The":[22,63],"multi-targeted":[23],"receptor":[24,323],"tyrosine":[25],"kinase":[26],"inhibitors":[27,325],"(TKIs)":[28],"sunitinib":[29,154,209,247,269],"inhibitor":[31],"PD-1":[33,53,119,220,238,241,294],"(anti-PD-1)":[34],"nivolumab":[35,137,244,297],"have":[36],"shown":[37],"antitumor":[38],"activity":[39],"selected":[41],"subtypes.":[42],"In":[43],"this":[44],"study,":[45],"we":[46],"examine":[47],"the":[48,101,263,305],"role":[49],"TKIs":[51],"based":[54],"therapy":[55],"vitro":[58,259],"cocultures":[59],"sarcoma.":[61],"Methods":[62],"human":[64],"osteosarcoma":[65],"(SaOS-2)":[66],"synovial":[68,200],"sarcoma":[69,92,151,159,163,201,216,266],"(SYO-1)":[70],"cell":[71,78,128,152,187,191,202,217,276],"lines":[72,203,218],"were":[73,94,113,139],"treated":[74],"with":[75,96,115,143,246,268,296,302],"sunitinib.":[76],"death":[79],"proliferation":[81,188],"assessment,":[82],"expression":[83,120],"PD-L1":[85,156],"was":[86,106,194],"analyzed":[87],"by":[88,108,243],"flow":[89,109],"cytometry.":[90,110],"Sunitinib-treated":[91],"cells":[93,98,164,178,226,267,289],"cocultured":[95],"dendritic":[97],"(DCs),":[99],"phenotype":[102],"mature":[104],"DCs":[105,112,166,207],"determined":[107],"Mature":[111],"cultured":[114],"autologous":[116],"T":[117,122,126,177,186,190,225,252,288],"cells.":[118,160,253],"on":[121,150,158,185,222,274],"cells,":[123],"their":[124,172,341],"proliferation,":[125],"regulatory":[127],"(Tregs)":[129],"induction":[130],"IFN-\u03b3":[132],"production,":[133],"before":[134],"after":[136],"exposure,":[138],"analyzed.":[140],"Results":[141],"Along":[142],"its":[144],"anti-proliferative":[145],"direct":[147],"pro-apoptotic":[148],"effect":[149,184,301],"lines,":[153],"prompted":[155],"upregulation":[157,221],"Interestingly,":[161],"sunitinib-treated":[162],"drive":[165],"to":[167,174,179,282,338],"full":[168],"maturation":[169],"increase":[171],"capacity":[173],"induce":[175],"sarcoma-reactive":[176],"produce":[180],"IFN-\u03b3.":[181],"Conversely,":[182],"no":[183],"subpopulation":[192],"composition":[193],"observed.":[195],"Moreover,":[196],"both":[197,223],"induced":[204,219],"Tregs":[205,228],"through":[206],"but":[208],"completely":[211],"abrogated":[212],"Treg":[213,292],"induction.":[214,293],"Finally,":[215],"effector":[224,251,287],"when":[229],"loaded":[230],"into":[231],"DCs,":[232],"providing":[233],"rationale":[235],"for":[236],"using":[237],"blockade.":[239],"Indeed,":[240],"blockade":[242,295],"synergized":[245],"inducing":[249],"IFN-\u03b3-producing":[250,286],"Conclusions":[254],"Taken":[255],"together,":[256],"our":[257,333],"data":[260],"indicate":[261],"that":[262],"can":[270],"exert":[271],"significant":[272],"changes":[273],"immune":[275,279],"subsets":[277],"toward":[278],"activation,":[280],"leading":[281],"DC-based":[283],"cross-priming":[284],"reduced":[291],"has":[298],"synergistic":[300],"sunitinib,":[303],"supporting":[304],"use":[306],"TKI":[308],"anti-PD-1":[310],"approach":[311],"sarcomas,":[313],"perhaps":[315],"other":[317],"cancers.":[318],"DC-targeted":[319],"drugs,":[320],"including":[321],"toll-like":[322],"3":[324],"CD47":[327],"inhibitors,":[328],"under":[330],"development":[331],"preclinical":[334],"model":[335],"might":[336],"help":[337],"better":[339],"design":[340],"clinical":[342],"application.":[343]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
