{"id":"https://openalex.org/W3133910263","doi":"https://doi.org/10.1055/s-0041-1725024","title":"Delayed Craniospinal Metastasis of Aggressive Nonfunctioning Pituitary Adenomas as Pituitary Carcinomas","display_name":"Delayed Craniospinal Metastasis of Aggressive Nonfunctioning Pituitary Adenomas as Pituitary Carcinomas","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3133910263","doi":"https://doi.org/10.1055/s-0041-1725024","mag":"3133910263","pmid":"https://pubmed.ncbi.nlm.nih.gov/35832993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9272318"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1725024","doi":"https://doi.org/10.1055/s-0041-1725024","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1725024","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9272318","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013983115","display_name":"Ashley L. B. Raghu","orcid":"https://orcid.org/0000-0002-3866-3833","observed_orcids":["https://orcid.org/0000-0002-3866-3833"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ashley L. B. Raghu","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3866-3833","affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075732314","display_name":"Megan C. Everson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan C. Everson","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087429226","display_name":"Ahmed Helal","orcid":"https://orcid.org/0000-0003-3746-3685","observed_orcids":["https://orcid.org/0000-0003-3746-3685"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Helal","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":"https://orcid.org/0000-0003-3746-3685","affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065715027","display_name":"Satoshi Kiyofuji","orcid":"https://orcid.org/0000-0001-8780-5773","observed_orcids":["https://orcid.org/0000-0001-8780-5773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoshi Kiyofuji","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":"https://orcid.org/0000-0001-8780-5773","affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015688357","display_name":"Michelle J. Clarke","orcid":"https://orcid.org/0000-0003-0358-5633","observed_orcids":["https://orcid.org/0000-0003-0358-5633"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle J. Clarke","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104668934","display_name":"Michael J. Link","orcid":"https://orcid.org/0000-0002-2102-6897","observed_orcids":["https://orcid.org/0000-0002-2102-6897"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Link","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013983115"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.3521,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.55302758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"83","issue":"S 02","first_page":"e253","last_page":"e259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pituitary-carcinoma","display_name":"pituitary carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/delayed-metastasis","display_name":"delayed metastasis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dural-metastasis","display_name":"dural metastasis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/transsphenoidal-surgery","display_name":"transsphenoidal surgery","score":0.8539999723434448},{"id":"https://openalex.org/keywords/transcranial-resection","display_name":"transcranial resection","score":0.9629999995231628},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/temozolomide-chemotherapy","display_name":"temozolomide chemotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8097491264343262},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6080080270767212},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5405775904655457},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.5303567051887512},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.49601683020591736},{"id":"https://openalex.org/C2779231225","wikidata":"https://www.wikidata.org/wiki/Q356005","display_name":"Adenoid cystic carcinoma","level":3,"score":0.4487603008747101},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.423168420791626},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41745424270629883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39111021161079407},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.38632792234420776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35008108615875244},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.31930190324783325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3078550696372986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2472032606601715}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0041-1725024","doi":"https://doi.org/10.1055/s-0041-1725024","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1725024","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9272318","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9272318","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Surg B Skull Base","raw_type":"Text"},{"id":"pmid:35832993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35832993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurological surgery. Part B, Skull base","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9272318","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9272318","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Surg B Skull Base","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1537142267","https://openalex.org/W1563473388","https://openalex.org/W1626154384","https://openalex.org/W1969264988","https://openalex.org/W1975837880","https://openalex.org/W1987994414","https://openalex.org/W1992188773","https://openalex.org/W2001688786","https://openalex.org/W2011821840","https://openalex.org/W2052655103","https://openalex.org/W2073442773","https://openalex.org/W2076285703","https://openalex.org/W2093882050","https://openalex.org/W2099188940","https://openalex.org/W2104385475","https://openalex.org/W2112719621","https://openalex.org/W2116242713","https://openalex.org/W2161227192","https://openalex.org/W2166094499","https://openalex.org/W2286376938","https://openalex.org/W2292657992","https://openalex.org/W2314350526","https://openalex.org/W2329817847","https://openalex.org/W2337996509","https://openalex.org/W2424019359","https://openalex.org/W2508998628","https://openalex.org/W2519426044","https://openalex.org/W2567279443","https://openalex.org/W2591698132","https://openalex.org/W2592270240","https://openalex.org/W2606486871","https://openalex.org/W2610680628","https://openalex.org/W2741425433","https://openalex.org/W2746574162","https://openalex.org/W2766825024","https://openalex.org/W2784054425","https://openalex.org/W2792301013","https://openalex.org/W2793652393","https://openalex.org/W2794812607","https://openalex.org/W2887469571","https://openalex.org/W4239052513"],"related_works":["https://openalex.org/W6987205689","https://openalex.org/W4200274498","https://openalex.org/W1963825498","https://openalex.org/W4309015216","https://openalex.org/W4411530515","https://openalex.org/W2922075869","https://openalex.org/W2170335844","https://openalex.org/W3214840733","https://openalex.org/W2782196201","https://openalex.org/W4404246039"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Clinical":[2],"behavior":[3],"of":[4,61,67,81,137,146,167,183],"pituitary":[5,84,138],"neoplasms":[6],"is":[7,20,48,140,163,189],"peculiar":[8],"and":[9,27,71,95,119,154,179],"notoriously":[10],"difficult":[11],"to":[12,35,51,58,150],"predict.":[13],"While":[14],"aggressive":[15,83],"tumors":[16,42,69,99],"are":[17,29,43],"common,":[18],"metastasis":[19,136],"very":[21],"rare,":[22],"can":[23],"be":[24],"highly":[25],"delayed,":[26],"there":[28,47],"no":[30],"histological":[31],"or":[32],"clinical":[33],"features":[34],"meaningfully":[36],"predict":[37],"this":[38,56],"happening.":[39],"Endocrinologically":[40],"silent":[41,121],"particularly":[44],"difficult,":[45],"as":[46,108],"less":[49],"opportunity":[50],"detect":[52],"early":[53],"metastasis.":[54,73],"Together,":[55],"amounts":[57],"a":[59,92,109,115,120,128,180],"situation":[60],"uncertainty":[62],"over":[63],"the":[64,104,147,152,156,164],"appropriate":[65],"management":[66],"such":[68],"before":[70],"after":[72],"Case":[74],"Description":[75],"The":[76,125,169],"authors":[77],"report":[78],"two":[79,89],"cases":[80],"nonfunctioning":[82],"adenoma":[85],"(APA)":[86],"each":[87],"requiring":[88],"transsphenoidal":[90],"surgeries,":[91],"transcranial":[93],"resection":[94,145],"radiotherapy.":[96],"Both":[97],"these":[98],"subsequently":[100],"metastasized":[101],"caudally":[102],"along":[103],"neuraxis,":[105],"years":[106],"later,":[107],"null":[110],"cell":[111,123],"carcinoma":[112,139],"associated":[113],"with":[114,177],"germline":[116],"CHEK2":[117],"mutation":[118],"Crooke's":[122],"carcinoma.":[124],"former":[126],"represents":[127],"novel":[129],"oncogenetic":[130],"association.":[131],"Conclusion":[132],"Delayed":[133],"drop":[134],"dural":[135],"becoming":[141],"increasingly":[142],"recognized.":[143],"Surgical":[144],"distant":[148],"disease":[149],"confirm":[151],"diagnosis":[153],"relieve":[155],"mass":[157],"effect,":[158],"followed":[159],"by":[160],"temozolomide":[161],"chemotherapy,":[162],"current":[165],"treatment":[166],"choice.":[168],"need":[170],"for":[171],"both":[172],"long-term":[173],"follow-up":[174],"in":[175],"patients":[176],"APA,":[178],"high":[181],"degree":[182],"suspicion":[184],"toward":[185],"dural-based":[186],"radiographic":[187],"findings":[188],"emphasized.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-15T00:00:00"}
