{"id":"https://openalex.org/W3133886945","doi":"https://doi.org/10.1080/19420862.2021.1893426","title":"Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2","display_name":"Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3133886945","doi":"https://doi.org/10.1080/19420862.2021.1893426","mag":"3133886945","pmid":"https://pubmed.ncbi.nlm.nih.gov/33666135","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7939556"},"language":"en","primary_location":{"id":"doi:10.1080/19420862.2021.1893426","doi":"https://doi.org/10.1080/19420862.2021.1893426","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2021.1893426","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/19420862.2021.1893426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052175708","display_name":"Shion An Lim","orcid":"https://orcid.org/0000-0003-2136-2732","observed_orcids":["https://orcid.org/0000-0003-2136-2732"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shion A. Lim","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006298755","display_name":"Josef A. Gramespacher","orcid":"https://orcid.org/0000-0003-3478-0183","observed_orcids":["https://orcid.org/0000-0003-3478-0183"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josef A. Gramespacher","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068735332","display_name":"Katarina Pance","orcid":"https://orcid.org/0000-0003-0983-8347","observed_orcids":["https://orcid.org/0000-0003-0983-8347"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarina Pance","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003376555","display_name":"Nicholas J. Rettko","orcid":"https://orcid.org/0000-0002-4332-2697","observed_orcids":["https://orcid.org/0000-0002-4332-2697"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Rettko","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069058478","display_name":"Paige E. Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Solomon","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4405258483","display_name":"Vitalant Research Institute","ror":"https://ror.org/00r2ye360","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157777","https://openalex.org/I4405258483"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Jin","raw_affiliation_strings":["Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405258483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089211264","display_name":"Irene Lui","orcid":"https://orcid.org/0000-0002-6171-5443","observed_orcids":["https://orcid.org/0000-0002-6171-5443"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Lui","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039141899","display_name":"Susanna K. Elledge","orcid":"https://orcid.org/0000-0002-9621-3881","observed_orcids":["https://orcid.org/0000-0002-9621-3881"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna K. Elledge","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409762","display_name":"Jia Liu","orcid":"https://orcid.org/0000-0003-3612-6089","observed_orcids":["https://orcid.org/0000-0003-3612-6089"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Liu","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036044300","display_name":"Colton J. Bracken","orcid":"https://orcid.org/0000-0003-3499-7032","observed_orcids":["https://orcid.org/0000-0003-3499-7032"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colton J. Bracken","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068608033","display_name":"Graham Simmons","orcid":"https://orcid.org/0000-0002-9615-7023","observed_orcids":["https://orcid.org/0000-0002-9615-7023"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4405258483","display_name":"Vitalant Research Institute","ror":"https://ror.org/00r2ye360","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157777","https://openalex.org/I4405258483"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham Simmons","raw_affiliation_strings":["Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405258483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028654503","display_name":"Xin X. Zhou","orcid":"https://orcid.org/0000-0002-8198-2856","observed_orcids":["https://orcid.org/0000-0002-8198-2856","https://orcid.org/0000-0001-6681-1568"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin X. Zhou","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059923951","display_name":"Kevin Leung","orcid":"https://orcid.org/0000-0002-2087-4974","observed_orcids":["https://orcid.org/0000-0002-2087-4974"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin K. Leung","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055441920","display_name":"James A. Wells","orcid":"https://orcid.org/0000-0001-8267-5519","observed_orcids":["https://orcid.org/0000-0001-8267-5519"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. Wells","raw_affiliation_strings":["Chan Zuckerberg Biohub, San Francisco, California, USA","Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA","Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, California, USA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055441920"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210100286"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":2.3157,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90848339,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"1893426","last_page":"1893426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/spike-receptor-binding-domain","display_name":"spike protein receptor-binding domain","score":0.7279999852180481},{"id":"https://openalex.org/keywords/non-neutralizing-antibodies","display_name":"non-neutralizing antibodies","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.6700000166893005},{"id":"https://openalex.org/keywords/antibody-potency","display_name":"antibody potency","score":0.5440000295639038},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.5149999856948853},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.7260000109672546},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.7484627366065979},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.731212854385376},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7116575241088867},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6978985071182251},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.657394289970398},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5553407669067383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5290298461914062},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.49372681975364685},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41142722964286804},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3471207320690155},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2670682668685913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25156205892562866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10802462697029114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10464397072792053},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08933836221694946}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1080/19420862.2021.1893426","doi":"https://doi.org/10.1080/19420862.2021.1893426","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2021.1893426","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7939556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7939556","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"},{"id":"pmid:33666135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33666135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:58387a18a15c49f9b2ec691ffba6d02b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/58387a18a15c49f9b2ec691ffba6d02b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mAbs, Vol 13, Iss 1 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4v56594p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4v56594p","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mAbs, vol 13, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19420862.2021.1893426","doi":"https://doi.org/10.1080/19420862.2021.1893426","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2021.1893426","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2140861112","display_name":null,"funder_award_id":"DRG-2297-17","funder_id":"https://openalex.org/F4320306271","funder_display_name":"Damon Runyon Cancer Research Foundation"},{"id":"https://openalex.org/G7188858076","display_name":null,"funder_award_id":"GA33116","funder_id":"https://openalex.org/F4320334294","funder_display_name":"Harrington Discovery Institute, University Hospitals"},{"id":"https://openalex.org/G9000909801","display_name":"Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolution","funder_award_id":"R35GM122451","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320308318","display_name":"Helen Hay Whitney Foundation","ror":"https://ror.org/037ebw447"},{"id":"https://openalex.org/F4320309029","display_name":"George Mason University","ror":"https://ror.org/02jqj7156"},{"id":"https://openalex.org/F4320334294","display_name":"Harrington Discovery Institute, University Hospitals","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1966286047","https://openalex.org/W1987023378","https://openalex.org/W2001483547","https://openalex.org/W2045877726","https://openalex.org/W2100717755","https://openalex.org/W2111823261","https://openalex.org/W2129978599","https://openalex.org/W2262255609","https://openalex.org/W2752678874","https://openalex.org/W2956900353","https://openalex.org/W2998925601","https://openalex.org/W3007643904","https://openalex.org/W3014656992","https://openalex.org/W3015490759","https://openalex.org/W3020695284","https://openalex.org/W3020828664","https://openalex.org/W3023698680","https://openalex.org/W3024602798","https://openalex.org/W3025744748","https://openalex.org/W3025905826","https://openalex.org/W3026408172","https://openalex.org/W3032255042","https://openalex.org/W3033872698","https://openalex.org/W3034202401","https://openalex.org/W3034425032","https://openalex.org/W3034548712","https://openalex.org/W3035459690","https://openalex.org/W3035950190","https://openalex.org/W3036386821","https://openalex.org/W3036529319","https://openalex.org/W3041222256","https://openalex.org/W3043740800","https://openalex.org/W3044050454","https://openalex.org/W3044660350","https://openalex.org/W3047003416","https://openalex.org/W3048907206","https://openalex.org/W3049142173","https://openalex.org/W3049726469","https://openalex.org/W3080152332","https://openalex.org/W3080610776","https://openalex.org/W3084236163","https://openalex.org/W3085508151","https://openalex.org/W3093802804","https://openalex.org/W3094211096","https://openalex.org/W3096751000","https://openalex.org/W3103844685","https://openalex.org/W3173635501","https://openalex.org/W4236325732"],"related_works":["https://openalex.org/W7159586552","https://openalex.org/W7196923172","https://openalex.org/W3094211096","https://openalex.org/W3048927344","https://openalex.org/W4210336276","https://openalex.org/W4296654914","https://openalex.org/W4362474630","https://openalex.org/W4322766122","https://openalex.org/W3199227831","https://openalex.org/W6920893605"],"abstract_inverted_index":{"Numerous":[0],"neutralizing":[1,43,78,89,130],"antibodies":[2],"that":[3,53,123,127],"target":[4],"SARS-CoV-2":[5,90,148],"have":[6],"been":[7],"reported,":[8],"and":[9,104,131,139],"most":[10],"directly":[11],"block":[12,59],"binding":[13],"of":[14,101,114,147],"the":[15,93,99,102,111,115,145],"viral":[16],"Spike":[17],"receptor-binding":[18],"domain":[19],"(RBD)":[20],"to":[21,42,92,143],"angiotensin-converting":[22],"enzyme":[23],"II":[24],"(ACE2).":[25],"Here,":[26],"we":[27,81],"deliberately":[28],"exploit":[29],"non-neutralizing":[30,68,132],"RBD":[31],"antibodies,":[32],"showing":[33],"they":[34],"can":[35],"dramatically":[36],"assist":[37],"in":[38,88],"neutralization":[39],"when":[40],"linked":[41],"binders.":[44],"We":[45],"identified":[46],"antigen-binding":[47],"fragments":[48],"(Fabs)":[49],"by":[50],"phage":[51],"display":[52],"bind":[54],"RBD,":[55],"but":[56],"do":[57],"not":[58],"ACE2":[60],"or":[61,98],"neutralize":[62],"virus":[63],"as":[64],"IgGs.":[65],"When":[66],"these":[67],"Fabs":[69],"were":[70],"assembled":[71],"into":[72],"bispecific":[73,116,125],"VH/Fab":[74],"IgGs":[75],"with":[76],"a":[77,83,124,137],"VH":[79],"domain,":[80],"observed":[82],"~":[84],"25-fold":[85],"potency":[86,146],"improvement":[87],"compared":[91],"mono-specific":[94],"bi-valent":[95],"VH-Fc":[96,103],"alone":[97],"cocktail":[100],"IgG.":[105],"This":[106],"effect":[107],"was":[108],"epitope-dependent,":[109],"reflecting":[110],"unique":[112],"geometry":[113],"antibody":[117,126],"toward":[118],"Spike.":[119],"Our":[120],"results":[121],"show":[122],"combines":[128],"both":[129],"epitopes":[133],"on":[134],"Spike-RBD":[135],"is":[136],"promising":[138],"rapid":[140],"engineering":[141],"strategy":[142],"improve":[144],"antibodies.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-03-15T00:00:00"}