{"id":"https://openalex.org/W3133877089","doi":"https://doi.org/10.3390/ijms22052767","title":"Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells","display_name":"Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells","publication_year":2021,"publication_date":"2021-03-09","ids":{"openalex":"https://openalex.org/W3133877089","doi":"https://doi.org/10.3390/ijms22052767","mag":"3133877089","pmid":"https://pubmed.ncbi.nlm.nih.gov/33803345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7967177"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22052767","doi":"https://doi.org/10.3390/ijms22052767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052767","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2767/pdf?version=1615353315","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/5/2767/pdf?version=1615353315","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072614932","display_name":"Kentaro Oh\u2010hashi","orcid":"https://orcid.org/0000-0002-3438-2102","observed_orcids":["https://orcid.org/0000-0002-3438-2102"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Oh-hashi","raw_affiliation_strings":["Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009827366","display_name":"Ayumi Yamamoto","orcid":"https://orcid.org/0000-0001-7741-594X","observed_orcids":["https://orcid.org/0000-0001-7741-594X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Yamamoto","raw_affiliation_strings":["Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryoichi Murase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoichi Murase","raw_affiliation_strings":["Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087004159","display_name":"Yoko Hirata","orcid":"https://orcid.org/0000-0002-7081-4937","observed_orcids":["https://orcid.org/0000-0002-7081-4937"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Hirata","raw_affiliation_strings":["Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7081-4937","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072614932"],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.6557,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56760901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"5","first_page":"2767","last_page":"2767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb3","display_name":"CREB3","score":1.0},{"id":"https://openalex.org/keywords/creb3l2","display_name":"CREB3L2","score":1.0},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8529999852180481},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/sel1l","display_name":"SEL1L","score":0.9850000143051147},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/brefeldin-a","display_name":"brefeldin A","score":0.796999990940094},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/monensin","display_name":"monensin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/kifunensine","display_name":"kifunensine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/alpha-mannosidase-inhibition","display_name":"alpha-mannosidase inhibition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/target-gene-expression","display_name":"target gene expression","score":0.5019999742507935},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.8946112990379333},{"id":"https://openalex.org/C2778506107","wikidata":"https://www.wikidata.org/wiki/Q3272916","display_name":"MG132","level":4,"score":0.7348965406417847},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.7077379822731018},{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.6503965854644775},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.6069344282150269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5111382603645325},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4959357678890228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4902229905128479},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4869872033596039},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.4820421636104584},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.47043153643608093},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4638310670852661},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.4569052755832672},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3963218629360199},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3626078963279724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2808126211166382},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.27566224336624146},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.2579295337200165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2150130271911621},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.14526411890983582}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms22052767","doi":"https://doi.org/10.3390/ijms22052767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052767","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2767/pdf?version=1615353315","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:33803345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33803345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:7967177","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7967177/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f8e2f3b16fca4677b95a0f603c01534a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8e2f3b16fca4677b95a0f603c01534a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 2767, p 2767 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms22052767","doi":"https://doi.org/10.3390/ijms22052767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052767","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2767/pdf?version=1615353315","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5298827990","display_name":"Analysis of novel mechanisms of aging-related diseases focusing on Golgi stress signaling","funder_award_id":"19H04030","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7818294679","display_name":"Exploration of ER-phagy substrates involved in brain aging and its application to the control of neuronal senescence","funder_award_id":"20K21751","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133877089.pdf","grobid_xml":"https://content.openalex.org/works/W3133877089.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1481795283","https://openalex.org/W1968502403","https://openalex.org/W1970090817","https://openalex.org/W1979733074","https://openalex.org/W1986698508","https://openalex.org/W1991892508","https://openalex.org/W2003171404","https://openalex.org/W2019424220","https://openalex.org/W2019498660","https://openalex.org/W2028279477","https://openalex.org/W2028453264","https://openalex.org/W2037757740","https://openalex.org/W2044588236","https://openalex.org/W2048165620","https://openalex.org/W2062562477","https://openalex.org/W2070155114","https://openalex.org/W2070924960","https://openalex.org/W2078241292","https://openalex.org/W2085966620","https://openalex.org/W2095905791","https://openalex.org/W2099386409","https://openalex.org/W2104085655","https://openalex.org/W2107424466","https://openalex.org/W2112628739","https://openalex.org/W2113914042","https://openalex.org/W2116657339","https://openalex.org/W2120611368","https://openalex.org/W2120736516","https://openalex.org/W2127609937","https://openalex.org/W2127639686","https://openalex.org/W2132869978","https://openalex.org/W2144065739","https://openalex.org/W2154500525","https://openalex.org/W2154651383","https://openalex.org/W2157910877","https://openalex.org/W2164783065","https://openalex.org/W2164942678","https://openalex.org/W2166247250","https://openalex.org/W2587294116","https://openalex.org/W2613916037","https://openalex.org/W2743054773","https://openalex.org/W2750416164","https://openalex.org/W2767756546","https://openalex.org/W2770052848","https://openalex.org/W2899448135","https://openalex.org/W2955417896","https://openalex.org/W2959211729"],"related_works":["https://openalex.org/W2959211729","https://openalex.org/W2770052848","https://openalex.org/W3127387610","https://openalex.org/W2108501377","https://openalex.org/W2255232285","https://openalex.org/W2242130558","https://openalex.org/W7096836662","https://openalex.org/W6894156002","https://openalex.org/W7128305122","https://openalex.org/W4246869221"],"abstract_inverted_index":{"We":[0],"performed":[1],"a":[2,101,147],"comparative":[3],"analysis":[4],"of":[5,40,48,77,94,107,136,157,186,189,230],"two":[6],"ER-resident":[7],"CREB3":[8,11,42,51,85,120,160,179,191,213],"family":[9],"proteins,":[10],"and":[12,19,23,35,43,114,121,161,192,198,201,214],"CREB3L2,":[13],"in":[14,104,173],"HEK293":[15],"cells":[16,144,175],"using":[17],"pharmacological":[18],"genome":[20],"editing":[21],"approaches":[22],"identified":[24],"several":[25,190],"differences":[26],"between":[27],"the":[28,38,46,49,62,66,74,78,92,105,134,177,184,187],"two.":[29],"Treatment":[30,111],"with":[31,70,100,112,141],"brefeldin":[32],"A":[33],"(BFA)":[34],"monensin":[36,63],"induced":[37],"cleavage":[39],"full-length":[41,50,79,96,138,159,167,178,212],"CREB3L2;":[44,162],"however,":[45,163],"level":[47,106],"protein,":[52,56],"but":[53,83,222],"not":[54,58],"CREB3L2":[55,80,97,122,168,193,215],"was":[57],"noticeably":[59],"reduced":[60],"by":[61,196,226],"treatment.":[64],"On":[65],"other":[67],"hand,":[68],"treatment":[69,165],"tunicamycin":[71],"(Tm)":[72],"shifted":[73],"molecular":[75],"weight":[76],"protein":[81,86,98,150,169,220],"downward":[82],"abolished":[84],"expression.":[87],"Thapsigargin":[88],"(Tg)":[89],"significantly":[90,132],"increased":[91,133,155],"expression":[93,156,170,188],"only":[95],"concomitant":[99],"slight":[102],"increase":[103],"its":[108],"cleaved":[109],"form.":[110],"cycloheximide":[113,164],"MG132":[115],"revealed":[116],"that":[117,209,237],"both":[118,137,158,210],"endogenous":[119,211],"are":[123,216,223,238],"proteasome":[124],"substrates.":[125],"In":[126,204],"addition,":[127],"kifunensine,":[128],"an":[129],"\u03b1-mannosidase":[130],"inhibitor,":[131],"levels":[135],"forms.":[139],"Consistent":[140],"these":[142],"findings,":[143],"lacking":[145],"SEL1L,":[146],"crucial":[148],"ER-associated":[149,219],"degradation":[151,221],"(ERAD)":[152],"component,":[153],"showed":[154],"downregulated":[166],"more":[171],"rapidly":[172],"SEL1L-deficient":[174],"than":[176],"protein.":[180],"Finally,":[181],"we":[182],"investigated":[183],"induction":[185],"target":[194],"genes":[195],"Tg":[197],"BFA":[199],"treatments":[200],"SEL1L":[202],"deficiency.":[203],"conclusion,":[205],"this":[206],"study":[207],"suggests":[208],"substrates":[217],"for":[218],"partially":[224],"regulated":[225],"distinct":[227,239],"mechanisms,":[228],"each":[229],"which":[231],"contributes":[232],"to":[233],"unique":[234],"cellular":[235],"responses":[236],"from":[240],"canonical":[241],"ER":[242],"signals.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
