{"id":"https://openalex.org/W3133870136","doi":"https://doi.org/10.29271/jcpsp.2021.02.128","title":"Concomitant Therapy versus Triple Therapy: Efficacy in H. Pylori Eradication and Predictors of Treatment Failure","display_name":"Concomitant Therapy versus Triple Therapy: Efficacy in H. Pylori Eradication and Predictors of Treatment Failure","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3133870136","doi":"https://doi.org/10.29271/jcpsp.2021.02.128","mag":"3133870136","pmid":"https://pubmed.ncbi.nlm.nih.gov/33645176"},"language":"en","primary_location":{"id":"doi:10.29271/jcpsp.2021.02.128","doi":"https://doi.org/10.29271/jcpsp.2021.02.128","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2021.02.128","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=bjhqaS81RGJKUDdmN25NdmtpUVpOZz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=bjhqaS81RGJKUDdmN25NdmtpUVpOZz09","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092136554","display_name":"Abdul Moeez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdul Moeez Kaiser Butt","raw_affiliation_strings":["Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]},{"raw_affiliation_string":"Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from","institution_ids":["https://openalex.org/I125830269"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shahid Sarwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shahid Sarwar","raw_affiliation_strings":["Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]},{"raw_affiliation_string":"Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from","institution_ids":["https://openalex.org/I125830269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037165995","display_name":"Muhammad Nadeem","orcid":"https://orcid.org/0000-0002-4246-1791","observed_orcids":["https://orcid.org/0000-0002-4246-1791"]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Muhammad Arif Nadeem","raw_affiliation_strings":["Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]},{"raw_affiliation_string":"Department of Medicine and Gastroenterology, Services Institute of Medical Sciences from","institution_ids":["https://openalex.org/I125830269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037165995"],"corresponding_institution_ids":["https://openalex.org/I125830269"],"apc_list":null,"apc_paid":null,"fwci":1.0571,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.74276319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"02","first_page":"128","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.8960000276565552},{"id":"https://openalex.org/keywords/concomitant-therapy","display_name":"concomitant therapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/triple-therapy","display_name":"triple therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9240000247955322},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8460000157356262},{"id":"https://openalex.org/keywords/predictors-of-treatment-failure","display_name":"predictors of treatment failure","score":0.9850000143051147},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.6570000052452087},{"id":"https://openalex.org/keywords/symptom-duration","display_name":"symptom duration","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8129845261573792},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7986086010932922},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.785265326499939},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7747578620910645},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6103931069374084},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.5538229942321777}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.29271/jcpsp.2021.02.128","doi":"https://doi.org/10.29271/jcpsp.2021.02.128","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2021.02.128","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=bjhqaS81RGJKUDdmN25NdmtpUVpOZz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},{"id":"pmid:33645176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33645176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.29271/jcpsp.2021.02.128","doi":"https://doi.org/10.29271/jcpsp.2021.02.128","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2021.02.128","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=bjhqaS81RGJKUDdmN25NdmtpUVpOZz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133870136.pdf","grobid_xml":"https://content.openalex.org/works/W3133870136.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W259617780","https://openalex.org/W1973678913","https://openalex.org/W1974497208","https://openalex.org/W1974793840","https://openalex.org/W1982725611","https://openalex.org/W2011487497","https://openalex.org/W2059710519","https://openalex.org/W2060234733","https://openalex.org/W2066650012","https://openalex.org/W2075988102","https://openalex.org/W2103434283","https://openalex.org/W2335572059","https://openalex.org/W2570938003","https://openalex.org/W2586960624","https://openalex.org/W2760668096","https://openalex.org/W2889353069","https://openalex.org/W2935703421","https://openalex.org/W2947788113"],"related_works":["https://openalex.org/W2972645263","https://openalex.org/W7220858759","https://openalex.org/W2145002241","https://openalex.org/W4387361464","https://openalex.org/W2040157385","https://openalex.org/W1974497208","https://openalex.org/W2116916903","https://openalex.org/W3142967331","https://openalex.org/W2808063991","https://openalex.org/W2144487124"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"concomitant":[3],"therapy":[4,8],"(CT)":[5],"and":[6,17,37,98,110,125,180,215],"triple":[7],"(TRT)":[9],"for":[10,186],"success":[11],"in":[12,121,127,135,147,156],"helicobacter":[13],"(H.)":[14],"pylori":[15,54,69,103,132,143,205,226],"eradication":[16,70,144,206],"identify":[18],"factors":[19],"associated":[20],"with":[21,52,101,119,139],"treatment":[22,93,198,227],"failure.":[23,94,199,228],"STUDY":[24],"DESIGN:":[25],"Quasi-experimental":[26],"comparative":[27],"study.":[28],"PLACE":[29],"AND":[30],"DURATION":[31],"OF":[32],"STUDY:":[33],"Department":[34],"of":[35,41,63,92,149,197,213,224],"Medicine":[36],"Gastroenterology,":[38],"Services":[39],"Institute":[40],"Medical":[42],"Sciences":[43],"from":[44],"December":[45],"2018":[46],"till":[47],"July":[48],"2019.":[49],"METHODOLOGY:":[50],"Patients":[51],"H.":[53,68,102,131,142,204,225,234],"infection":[55],"were":[56,117,192,221],"randomly":[57],"assigned":[58],"to":[59,154],"receive":[60],"two":[61],"weeks":[62,77,188],"either":[64],"CT":[65,120,150,201],"or":[66],"TRT.":[67,208],"was":[71,81,133,145],"confirmed":[72],"by":[73],"repeat":[74],"biopsy":[75],"four":[76],"post-treatment.":[78],"Treatment":[79],"outcome":[80],"compared":[82,153],"using":[83],"Chi-square":[84],"test,":[85],"while":[86],"binary":[87],"logistic":[88],"regression":[89],"identified":[90,193],"predictors":[91,196,223],"RESULTS:":[95],"Two":[96],"hundred":[97],"eleven":[99],"patients":[100,123,129,138],"infection,":[104],"having":[105],"mean":[106],"age":[107],"40.15":[108],"(\u00b113.04)":[109],"male/female":[111],"ratio":[112],"0.9/1":[113],"(100/111)":[114],"after":[115],"randomisation,":[116],"treated":[118],"105":[122],"(49.8%)":[124],"TRT":[126,157],"106":[128],"(50.2%).":[130],"eradicated":[134],"84.3%":[136],"(150/178)":[137],"completed":[140],"follow-up.":[141],"achieved":[146],"91.9%":[148],"group":[151,158],"as":[152,194],"77.2%":[155],"(p":[159,170,177,189],"=":[160,171,178,190],"0.007,":[161],"OR":[162],"3.38:":[163],"95%":[164],"CI":[165],"1.3-8.3).":[166],"Age":[167],"\u226540":[168],"years":[169],"0.02),":[172],"symptoms":[173],"duration":[174,212],">6":[175],"months":[176],"0.001),":[179],"prior":[181],"proton":[182,217],"pump":[183,218],"inhibitor":[184,219],"use":[185,220],">4":[187],"0.01),":[191],"independent":[195,222],"CONCLUSION:":[200],"achieves":[202],"better":[203],"than":[207],"Older":[209],"age,":[210],"longer":[211],"illness,":[214],"previous":[216],"Key":[229],"Words:":[230],"Concomitant":[231],"therapy,":[232],"Eradication,":[233],"pylori,":[235],"Triple":[236],"therapy.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}