{"id":"https://openalex.org/W3133838692","doi":"https://doi.org/10.3389/fgene.2021.639418","title":"Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population","display_name":"Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3133838692","doi":"https://doi.org/10.3389/fgene.2021.639418","mag":"3133838692","pmid":"https://pubmed.ncbi.nlm.nih.gov/33763119","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7982958"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2021.639418","doi":"https://doi.org/10.3389/fgene.2021.639418","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.639418","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2021.639418/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fgene.2021.639418/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022265134","display_name":"Robert W. Read","orcid":"https://orcid.org/0000-0002-6967-5634","observed_orcids":["https://orcid.org/0000-0002-6967-5634"]},"institutions":[{"id":"https://openalex.org/I60138030","display_name":"Desert Research Institute","ror":"https://ror.org/02vg22c33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I60138030"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Read","raw_affiliation_strings":["Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States","institution_ids":["https://openalex.org/I60138030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037111265","display_name":"Karen A. Schlauch","orcid":"https://orcid.org/0000-0001-6916-8571","observed_orcids":["https://orcid.org/0000-0001-6916-8571"]},"institutions":[{"id":"https://openalex.org/I60138030","display_name":"Desert Research Institute","ror":"https://ror.org/02vg22c33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I60138030"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen A. Schlauch","raw_affiliation_strings":["Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States","institution_ids":["https://openalex.org/I60138030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088904153","display_name":"Vincent C. Lombardi","orcid":"https://orcid.org/0000-0003-4474-8662","observed_orcids":["https://orcid.org/0000-0003-4474-8662"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent C. Lombardi","raw_affiliation_strings":["Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085172839","display_name":"Elizabeth T. Cirulli","orcid":"https://orcid.org/0000-0001-7808-2809","observed_orcids":["https://orcid.org/0000-0001-7808-2809"]},"institutions":[{"id":"https://openalex.org/I4210163239","display_name":"Helix (United States)","ror":"https://ror.org/056jgxp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163239"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth T. Cirulli","raw_affiliation_strings":["Helix Opco, LLC., San Mateo, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helix Opco, LLC., San Mateo, CA, United States","institution_ids":["https://openalex.org/I4210163239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025956553","display_name":"Nicole L. Washington","orcid":"https://orcid.org/0000-0001-8936-9143","observed_orcids":["https://orcid.org/0000-0001-8936-9143"]},"institutions":[{"id":"https://openalex.org/I4210163239","display_name":"Helix (United States)","ror":"https://ror.org/056jgxp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163239"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole L. Washington","raw_affiliation_strings":["Helix Opco, LLC., San Mateo, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helix Opco, LLC., San Mateo, CA, United States","institution_ids":["https://openalex.org/I4210163239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054952270","display_name":"James T. Lu","orcid":"https://orcid.org/0000-0002-1873-7049","observed_orcids":["https://orcid.org/0000-0002-1873-7049"]},"institutions":[{"id":"https://openalex.org/I4210163239","display_name":"Helix (United States)","ror":"https://ror.org/056jgxp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163239"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Lu","raw_affiliation_strings":["Helix Opco, LLC., San Mateo, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helix Opco, LLC., San Mateo, CA, United States","institution_ids":["https://openalex.org/I4210163239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065601881","display_name":"Joseph J. Grzymski","orcid":"https://orcid.org/0000-0003-2646-8958","observed_orcids":["https://orcid.org/0000-0003-2646-8958"]},"institutions":[{"id":"https://openalex.org/I2802417501","display_name":"Renown Health","ror":"https://ror.org/00w205b62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802417501"]},{"id":"https://openalex.org/I60138030","display_name":"Desert Research Institute","ror":"https://ror.org/02vg22c33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I60138030"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph J. Grzymski","raw_affiliation_strings":["Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States","Renown Health, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Desert Research Institute, Reno, NV, United States","institution_ids":["https://openalex.org/I60138030"]},{"raw_affiliation_string":"Renown Health, Reno, NV, United States","institution_ids":["https://openalex.org/I2802417501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065601881"],"corresponding_institution_ids":["https://openalex.org/I2802417501","https://openalex.org/I60138030"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.6963,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.83279417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"639418","last_page":"639418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.23739999532699585,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triglyceride-levels","display_name":"triglyceride levels","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6050000190734863},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.7200000286102295},{"id":"https://openalex.org/keywords/common-genetic-variants","display_name":"common genetic variants","score":0.6970000267028809},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6899999976158142},{"id":"https://openalex.org/keywords/phenome-wide-association-study","display_name":"phenome-wide association study","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.8080000281333923},{"id":"https://openalex.org/keywords/apoa5","display_name":"APOA5","score":0.9769999980926514},{"id":"https://openalex.org/keywords/zpr1","display_name":"ZPR1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/bud13","display_name":"BUD13","score":0.984000027179718},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.8579999804496765},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6440460681915283},{"id":"https://openalex.org/C7952369","wikidata":"https://www.wikidata.org/wiki/Q844116","display_name":"Phenome","level":4,"score":0.603054404258728},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5448415875434875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5275851488113403},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.518223762512207},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5051730275154114},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47437983751296997},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44883131980895996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43156898021698},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4303610324859619},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3335394859313965},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.31286758184432983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.290006160736084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13463550806045532},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11194601655006409},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2021.639418","doi":"https://doi.org/10.3389/fgene.2021.639418","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.639418","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2021.639418/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7982958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7982958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmid:33763119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33763119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9757112de7054ce1989e027de645a61b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9757112de7054ce1989e027de645a61b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2021.639418","doi":"https://doi.org/10.3389/fgene.2021.639418","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.639418","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2021.639418/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5850737185","display_name":null,"funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320309318","display_name":"Desert Research Institute","ror":"https://ror.org/02vg22c33"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133838692.pdf","grobid_xml":"https://content.openalex.org/works/W3133838692.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W52944452","https://openalex.org/W1503438909","https://openalex.org/W1823096250","https://openalex.org/W1835500549","https://openalex.org/W1965823055","https://openalex.org/W1969208427","https://openalex.org/W1972250180","https://openalex.org/W1976844911","https://openalex.org/W1978470249","https://openalex.org/W1992790805","https://openalex.org/W1993145512","https://openalex.org/W2000962819","https://openalex.org/W2003953419","https://openalex.org/W2007272726","https://openalex.org/W2007988561","https://openalex.org/W2008880591","https://openalex.org/W2016317262","https://openalex.org/W2020427316","https://openalex.org/W2025873235","https://openalex.org/W2028260332","https://openalex.org/W2033776118","https://openalex.org/W2036747551","https://openalex.org/W2047094134","https://openalex.org/W2052644460","https://openalex.org/W2077545788","https://openalex.org/W2083230171","https://openalex.org/W2087936498","https://openalex.org/W2094849123","https://openalex.org/W2100532651","https://openalex.org/W2102213696","https://openalex.org/W2102215872","https://openalex.org/W2102353891","https://openalex.org/W2104177528","https://openalex.org/W2105281057","https://openalex.org/W2106069050","https://openalex.org/W2107993173","https://openalex.org/W2108065192","https://openalex.org/W2109333627","https://openalex.org/W2109582706","https://openalex.org/W2110065044","https://openalex.org/W2112070970","https://openalex.org/W2112390338","https://openalex.org/W2112848098","https://openalex.org/W2113653941","https://openalex.org/W2114566287","https://openalex.org/W2115801316","https://openalex.org/W2117446594","https://openalex.org/W2120369611","https://openalex.org/W2125438242","https://openalex.org/W2128356496","https://openalex.org/W2129150286","https://openalex.org/W2133804898","https://openalex.org/W2137702285","https://openalex.org/W2142769596","https://openalex.org/W2143286837","https://openalex.org/W2143499400","https://openalex.org/W2143793221","https://openalex.org/W2145416541","https://openalex.org/W2147733682","https://openalex.org/W2149355521","https://openalex.org/W2149813409","https://openalex.org/W2153118028","https://openalex.org/W2158008755","https://openalex.org/W2159090847","https://openalex.org/W2159394707","https://openalex.org/W2160367614","https://openalex.org/W2161633633","https://openalex.org/W2163953557","https://openalex.org/W2169718193","https://openalex.org/W2169788444","https://openalex.org/W2170009139","https://openalex.org/W2187583278","https://openalex.org/W2257176259","https://openalex.org/W2259714666","https://openalex.org/W2339102023","https://openalex.org/W2361895605","https://openalex.org/W2398690791","https://openalex.org/W2443172870","https://openalex.org/W2509008931","https://openalex.org/W2519091057","https://openalex.org/W2534401479","https://openalex.org/W2558859232","https://openalex.org/W2617842398","https://openalex.org/W2735404270","https://openalex.org/W2753257463","https://openalex.org/W2765748387","https://openalex.org/W2775393828","https://openalex.org/W2778030995","https://openalex.org/W2790653691","https://openalex.org/W2795285287","https://openalex.org/W2804706833","https://openalex.org/W2806615521","https://openalex.org/W2808364546","https://openalex.org/W2886288605","https://openalex.org/W2887378263","https://openalex.org/W2891141463","https://openalex.org/W2896110878","https://openalex.org/W2898766522","https://openalex.org/W2898901851","https://openalex.org/W2899689685","https://openalex.org/W2904004659","https://openalex.org/W2912998668","https://openalex.org/W2921062076","https://openalex.org/W2950703594","https://openalex.org/W2951529834","https://openalex.org/W2951606856","https://openalex.org/W2952013316","https://openalex.org/W2955177623","https://openalex.org/W2959872456","https://openalex.org/W2963344102","https://openalex.org/W2980981612","https://openalex.org/W2987631374","https://openalex.org/W2994666947","https://openalex.org/W2996354955","https://openalex.org/W2997091875","https://openalex.org/W3003275163","https://openalex.org/W3007774890","https://openalex.org/W3012687886","https://openalex.org/W3016458988","https://openalex.org/W3094550675","https://openalex.org/W4242212377"],"related_works":["https://openalex.org/W3119543092","https://openalex.org/W2149813409","https://openalex.org/W2132992776","https://openalex.org/W1978136660","https://openalex.org/W2891141463","https://openalex.org/W2100339865","https://openalex.org/W2790872879","https://openalex.org/W7166503987","https://openalex.org/W2175432265","https://openalex.org/W3177198911"],"abstract_inverted_index":{"Clinical":[0],"conditions":[1],"correlated":[2],"with":[3,48,99,135,162,174,202,213],"elevated":[4,203],"triglyceride":[5,58,100,108,125,140,147,204],"levels":[6,141],"are":[7,20],"well-known:":[8],"coronary":[9],"heart":[10],"disease,":[11],"hypertension,":[12],"and":[13,17,82,102,169,189,195,199],"diabetes.":[14],"Underlying":[15],"genetic":[16],"phenotypic":[18],"mechanisms":[19],"not":[21,157],"fully":[22],"understood,":[23],"partially":[24],"due":[25],"to":[26,53,73,78,107],"lack":[27],"of":[28,37,44,56,152,180,207],"coordinated":[29],"genotypic-phenotypic":[30],"data.":[31],"Here":[32],"we":[33],"use":[34],"a":[35,42,91,136,159,181,185],"subset":[36],"the":[38,67,143,167,175],"Healthy":[39,61],"Nevada":[40,62],"Project,":[41],"population":[43],"9,183":[45],"sequenced":[46,65],"participants":[47,64],"longitudinal":[49],"electronic":[50,75],"health":[51],"records":[52,77],"examine":[54],"consequences":[55],"altered":[57],"levels.":[59,109],"Specifically,":[60],"Project":[63],"by":[66],"Helix":[68],"Exome+":[69],"platform":[70],"were":[71,149,172],"cross-referenced":[72],"their":[74],"medical":[76],"identify:":[79],"(1)":[80],"rare":[81,194],"common":[83,196],"single-variant":[84,115,182],"genome-wide":[85,183],"associations;":[86],"(2)":[87],"gene-based":[88,146,186],"associations":[89,98,116,148],"using":[90],"Sequence":[92],"Kernel":[93],"Association":[94],"Test;":[95],"(3)":[96],"phenome-wide":[97],"levels;":[101],"(4)":[103],"pleiotropic":[104],"variants":[105],"linked":[106],"The":[110,178],"study":[111],"identified":[112,193],"549":[113],"significant":[114,163],"(p<":[117],"8.75":[118],"\u00d7":[119],"10\u20139),":[120],"many":[121],"in":[122,139,142],"chromosome":[123],"11\u2019s":[124],"hotspot:ZPR1,BUD13,APOC3,APOA5.":[126],"A":[127],"well-known":[128],"protective":[129],"loss-of-function":[130],"variant":[131,161,168],"inAPOC3(R19X)":[132],"was":[133],"associated":[134,201],"51%":[137],"decrease":[138],"cohort.":[144],"Sixteen":[145],"identified;":[150],"six":[151],"these":[153],"genes":[154],"surprisingly":[155],"did":[156],"include":[158],"single":[160],"associations.":[164],"Results":[165],"at":[166],"gene":[170],"level":[171],"validated":[173],"UK":[176],"Biobank.":[177],"combination":[179],"association,":[184],"association":[187],"method,":[188],"phenome":[190],"wide-association":[191],"studies":[192],"variants,":[197],"genes,":[198],"phenotypes":[200],"levels,":[205],"some":[206],"which":[208],"may":[209],"have":[210],"been":[211],"overlooked":[212],"standard":[214],"approaches.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-15T00:00:00"}
