{"id":"https://openalex.org/W3133788751","doi":"https://doi.org/10.18632/aging.202645","title":"90K predicts the prognosis of glioma patients and enhances tumor lysate-pulsed DC vaccine for immunotherapy of GBM in vitro","display_name":"90K predicts the prognosis of glioma patients and enhances tumor lysate-pulsed DC vaccine for immunotherapy of GBM in vitro","publication_year":2021,"publication_date":"2021-03-03","ids":{"openalex":"https://openalex.org/W3133788751","doi":"https://doi.org/10.18632/aging.202645","mag":"3133788751","pmid":"https://pubmed.ncbi.nlm.nih.gov/33686953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8034892"},"language":"en","primary_location":{"id":"doi:10.18632/aging.202645","doi":"https://doi.org/10.18632/aging.202645","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.202645","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8034892","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002857288","display_name":"Yu Zeng","orcid":"https://orcid.org/0000-0002-9415-0610","observed_orcids":["https://orcid.org/0000-0002-9415-0610"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zeng","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100363101"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":null,"apc_paid":null,"fwci":0.5559,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60407659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"6","first_page":"8355","last_page":"8368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.972000002861023},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7940000295639038},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7860000133514404},{"id":"https://openalex.org/keywords/il-12p70","display_name":"IL-12p70","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/u251-cells","display_name":"U251 cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7056431770324707},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6695574522018433},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6683993339538574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5190027952194214},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5136458277702332},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5054240226745605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32915961742401123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22808092832565308},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20171311497688293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.202645","doi":"https://doi.org/10.18632/aging.202645","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.202645","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8034892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8034892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:33686953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33686953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8034892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8034892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1539998657","https://openalex.org/W1552734319","https://openalex.org/W1971380501","https://openalex.org/W1996794807","https://openalex.org/W2003193695","https://openalex.org/W2016868018","https://openalex.org/W2023089611","https://openalex.org/W2023201722","https://openalex.org/W2033201741","https://openalex.org/W2038654243","https://openalex.org/W2043470138","https://openalex.org/W2048566686","https://openalex.org/W2052093038","https://openalex.org/W2063405392","https://openalex.org/W2085416106","https://openalex.org/W2089299919","https://openalex.org/W2091415172","https://openalex.org/W2096287682","https://openalex.org/W2112862477","https://openalex.org/W2114390384","https://openalex.org/W2162630386","https://openalex.org/W2164271487","https://openalex.org/W2176493842","https://openalex.org/W2400400159","https://openalex.org/W2480831986","https://openalex.org/W2590027393","https://openalex.org/W2611460276","https://openalex.org/W2624407975","https://openalex.org/W2632058739","https://openalex.org/W2736029115","https://openalex.org/W2740576505","https://openalex.org/W2756553142","https://openalex.org/W2765633257","https://openalex.org/W2774013218","https://openalex.org/W2789111683","https://openalex.org/W2795293588","https://openalex.org/W2796584001","https://openalex.org/W2797967795","https://openalex.org/W2801726678","https://openalex.org/W2801742464","https://openalex.org/W2807697713","https://openalex.org/W2883355533","https://openalex.org/W2884957596","https://openalex.org/W2902941439","https://openalex.org/W2916659228","https://openalex.org/W2939681859","https://openalex.org/W2965986205","https://openalex.org/W3005468192"],"related_works":["https://openalex.org/W2248472864","https://openalex.org/W2971028902","https://openalex.org/W7095692795","https://openalex.org/W1995024447","https://openalex.org/W4283363959","https://openalex.org/W2071130348","https://openalex.org/W2133499518","https://openalex.org/W2005482601","https://openalex.org/W4392374337","https://openalex.org/W2779471331"],"abstract_inverted_index":{"OBJECTIVES:":[0],".":[1],"METHODS:":[2],"The":[3,16,42,68,107,148],"expression":[4,21,69,89],"of":[5,31,44,58,70,109,150,155,161],"90K":[6,20,71,88,137,151],"protein":[7],"in":[8,75,92,116,121],"glioma":[9,76,95,105,143],"tissues":[10],"was":[11,33,48,72,90,113,132,138],"detected":[12,49,64],"by":[13,36,50,65,130],"western":[14],"blot.":[15],"relationship":[17],"between":[18],"the":[19,23,29,114,117,124,134,153],"and":[22,39,46,55,80,99,111,145],"tumor":[24,83],"grade":[25,84],"as":[26,28],"well":[27],"prognosis":[30],"patients":[32],"further":[34],"analyzed":[35],"mining":[37],"TCGA":[38],"CGGA":[40],"database.":[41],"concentration":[43,108],"IL-12p70":[45,110],"IL-10":[47],"ELISA.":[51],"T":[52,60],"lymphocyte":[53],"proliferation":[54],"lethal":[56],"effect":[57,154],"cytotoxic":[59],"cell":[61],"(CTL)":[62],"were":[63],"CCK-8.":[66],"RESULTS:":[67],"significantly":[73],"higher":[74],"than":[77,96],"normal":[78],"tissue":[79],"increased":[81],"with":[82],"(P<":[85],"0.05).":[86],"Higher":[87],"observed":[91],"IDH":[93,97],"wildtype":[94],"mutant":[98],"predicted":[100],"worse":[101],"overall":[102],"survival":[103],"for":[104,142,159],"patients.":[106],"IFN-\u03b3":[112],"highest":[115],"Apoptosis":[118,156],"U251-90K-DC":[119],"group,":[120],"which":[122],"group":[123],"ability":[125],"to":[126],"kill":[127],"U251":[128],"cells":[129],"CTL":[131],"also":[133],"strongest.":[135],"CONCLUSION:":[136],"a":[139],"useful":[140],"biomarker":[141],"malignancy":[144],"patient":[146],"prognosis.":[147],"appearance":[149],"enhanced":[152],"U251-DC":[157],"vaccine":[158],"immunotherapy":[160],"GBM.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
