{"id":"https://openalex.org/W3133763207","doi":"https://doi.org/10.3390/pharmaceutics13030344","title":"The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers","display_name":"The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers","publication_year":2021,"publication_date":"2021-03-06","ids":{"openalex":"https://openalex.org/W3133763207","doi":"https://doi.org/10.3390/pharmaceutics13030344","mag":"3133763207","pmid":"https://pubmed.ncbi.nlm.nih.gov/33800741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8001048"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics13030344","doi":"https://doi.org/10.3390/pharmaceutics13030344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13030344","pdf_url":"https://www.mdpi.com/1999-4923/13/3/344/pdf?version=1615542051","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/13/3/344/pdf?version=1615542051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jong-Hwa Lee","orcid":"https://orcid.org/0000-0002-5131-0514","observed_orcids":["https://orcid.org/0000-0002-5131-0514"]},"institutions":[{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Hwa Lee","raw_affiliation_strings":["Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5131-0514","affiliations":[{"raw_affiliation_string":"Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I4210100168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007204051","display_name":"Hyeong Sik Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeong Sik Jeong","raw_affiliation_strings":["Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101535945","display_name":"Jong\u2010Woo Jeong","orcid":"https://orcid.org/0000-0002-1456-3213","observed_orcids":["https://orcid.org/0000-0002-1456-3213"]},"institutions":[{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Woo Jeong","raw_affiliation_strings":["Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I4210100168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002562123","display_name":"Tae\u2010Sung Koo","orcid":"https://orcid.org/0000-0001-8046-6836","observed_orcids":["https://orcid.org/0000-0001-8046-6836"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Sung Koo","raw_affiliation_strings":["Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 35365, Korea"],"raw_orcid":"https://orcid.org/0000-0001-8046-6836","affiliations":[{"raw_affiliation_string":"Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101885720","display_name":"Do\u2010Kyun Kim","orcid":"https://orcid.org/0000-0002-3457-4868","observed_orcids":["https://orcid.org/0000-0002-3457-4868"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do-Kyun Kim","raw_affiliation_strings":["Korea Zoonosis Research Institute, Jeonbuk Natinal University, Iksan 54531, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk Natinal University, Iksan 54531, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030577718","display_name":"Young Ho Cho","orcid":"https://orcid.org/0000-0002-4570-2159","observed_orcids":["https://orcid.org/0000-0002-4570-2159"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Ho Cho","raw_affiliation_strings":["Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4570-2159","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078753157","display_name":"Gye Won Lee","orcid":"https://orcid.org/0000-0001-8551-8340","observed_orcids":["https://orcid.org/0000-0001-8551-8340"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Gye Won Lee","raw_affiliation_strings":["Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea","institution_ids":["https://openalex.org/I165028127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030577718","https://openalex.org/A5078753157"],"corresponding_institution_ids":["https://openalex.org/I165028127"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":2.1294,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85514813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"344","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":1.0},{"id":"https://openalex.org/keywords/hot-melt-extrusion","display_name":"melt extrusion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/amorphous-solid-dispersions","display_name":"amorphous solid dispersions","score":0.9580000042915344},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bcs-class-ii","display_name":"BCS class II","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.6039999723434448},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.7699999809265137},{"id":"https://openalex.org/keywords/central-composite-design","display_name":"central composite design","score":0.8510000109672546},{"id":"https://openalex.org/keywords/accelerated-stability-testing","display_name":"accelerated stability testing","score":0.4440000057220459},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cremophor-rh40","display_name":"Cremophor RH40","score":0.8330000042915344},{"id":"https://openalex.org/keywords/factor-xa-inhibitors","display_name":"factor Xa inhibitors","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.7884613275527954},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7536396980285645},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7360837459564209},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6278520822525024},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6074070930480957},{"id":"https://openalex.org/C46275449","wikidata":"https://www.wikidata.org/wiki/Q2458815","display_name":"Crystallinity","level":2,"score":0.564709484577179},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.5327211618423462},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.5232176780700684},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.48260796070098877},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.4462354779243469},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39151179790496826},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.38338562846183777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2877933979034424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2730643153190613},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.18189668655395508},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17158600687980652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12232115864753723},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.05671894550323486},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05335360765457153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.0},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics13030344","doi":"https://doi.org/10.3390/pharmaceutics13030344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13030344","pdf_url":"https://www.mdpi.com/1999-4923/13/3/344/pdf?version=1615542051","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:33800741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33800741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8001048","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8001048/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:00d8d89e6f424885ba98d2ea9809df4c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/00d8d89e6f424885ba98d2ea9809df4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 13, Iss 3, p 344 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics13030344","doi":"https://doi.org/10.3390/pharmaceutics13030344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13030344","pdf_url":"https://www.mdpi.com/1999-4923/13/3/344/pdf?version=1615542051","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133763207.pdf","grobid_xml":"https://content.openalex.org/works/W3133763207.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1505181639","https://openalex.org/W1989295556","https://openalex.org/W1994618196","https://openalex.org/W2008223612","https://openalex.org/W2026872442","https://openalex.org/W2028162842","https://openalex.org/W2028895013","https://openalex.org/W2051488350","https://openalex.org/W2061510929","https://openalex.org/W2078493246","https://openalex.org/W2085219848","https://openalex.org/W2088560132","https://openalex.org/W2115439624","https://openalex.org/W2119961487","https://openalex.org/W2130622649","https://openalex.org/W2140581145","https://openalex.org/W2165290439","https://openalex.org/W2167286960","https://openalex.org/W2327186139","https://openalex.org/W2338510100","https://openalex.org/W2414042740","https://openalex.org/W2502670554","https://openalex.org/W2529408514","https://openalex.org/W2537122513","https://openalex.org/W2775991828","https://openalex.org/W2892780624","https://openalex.org/W2923501994","https://openalex.org/W2941811147","https://openalex.org/W2985253493","https://openalex.org/W2992007157","https://openalex.org/W2996306650"],"related_works":["https://openalex.org/W4404313692","https://openalex.org/W2775991828","https://openalex.org/W4292687871","https://openalex.org/W7219390082","https://openalex.org/W4386209699","https://openalex.org/W7221467595","https://openalex.org/W7204880801","https://openalex.org/W7124443313","https://openalex.org/W4324352306","https://openalex.org/W4311796594"],"abstract_inverted_index":{"Rivaroxaban":[0],"(RXB),":[1],"a":[2,12,27,98,163],"novel":[3],"oral":[4,83,225],"anticoagulant":[5],"that":[6,179],"directly":[7],"inhibits":[8],"factor":[9],"Xa,":[10],"is":[11,36],"poorly":[13],"soluble":[14],"drug":[15,84,130,146,226],"belonging":[16],"to":[17,82,197],"Biopharmaceutics":[18],"Classification":[19],"System":[20],"(BCS)":[21],"class":[22],"II.":[23],"In":[24],"this":[25],"study,":[26],"hot-melt":[28,68,216],"extruded":[29,217],"amorphous":[30,92],"solid":[31,93],"dispersion":[32,94],"(HME-ASD)":[33],"containing":[34],"RXB":[35,199],"prepared":[37],"by":[38,208,229],"changing":[39],"the":[40,63,67,74,88,156,168,180,192,204,212,231],"drug:polymer":[41],"ratio":[42,107],"(Polyvinylpyrrolidione-vinyl":[43],"acetate":[44],"64,":[45],"1:1\u20131:4)":[46],"and":[47,59,78,86,140,167,189,234],"barrel":[48,109],"temperature":[49,110],"(200\u2013240":[50],"\u00b0C),":[51],"fixed":[52],"at":[53],"20%":[54],"of":[55,62,90,174,187,206,215],"Cremophor\u00ae":[56,113],"RH":[57,114],"40":[58,115],"15":[60,119],"rpm":[61],"screw":[64,117],"speed,":[65],"using":[66],"extruding":[69],"technique.":[70],"This":[71],"study":[72,132,173],"evaluates":[73],"solubility,":[75],"dissolution":[76,131,136,169,232],"behavior,":[77],"bioavailability":[79],"for":[80,124,159],"application":[81,205],"delivery":[85,227],"optimizes":[87],"formulation":[89,213],"rivaroxaban":[91],"(RXB-ASD).":[95],"Based":[96],"on":[97],"central":[99],"composite":[100],"design,":[101],"optimized":[102],"RXB-ASD":[103,152,175],"(PVP":[104],"VA":[105],"64":[106],"1:4.1,":[108],"216.1":[111],"\u00b0C,":[112],"20%,":[116],"speed":[118],"rpm)":[120],"showed":[121,178,203],"satisfactory":[122],"results":[123,202],"dependent":[125],"variables.":[126],"An":[127],"in":[128,137,148,165,176,185,211],"vitro":[129],"exhibited":[133],"relatively":[134],"high":[135],"four":[138],"media":[139],"achieved":[141],"around":[142],"an":[143,224],"80%":[144],"cumulative":[145],"release":[147],"120":[149],"min.":[150],"Optimized":[151],"was":[153,182],"stable":[154],"under":[155],"accelerated":[157],"condition":[158],"three":[160],"months":[161],"without":[162],"change":[164],"crystallinity":[166],"rate.":[170],"A":[171],"pharmacokinetic":[172],"rats":[177],"absorption":[181],"markedly":[183],"increased":[184],"terms":[186],"rate":[188,233],"amount,":[190],"i.e.,":[191],"systemic":[193],"exposure":[194],"values,":[195],"compared":[196],"raw":[198],"powder.":[200],"These":[201],"quality":[207],"design":[209],"(QbD)":[210],"development":[214],"RXB-ASD,":[218],"which":[219],"can":[220],"be":[221],"used":[222],"as":[223],"system":[228],"increasing":[230],"bioavailability.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}