{"id":"https://openalex.org/W3133740126","doi":"https://doi.org/10.18113/s1p916","title":"Discovery and Characterization of a Multi-Drug Resistance Efflux System in Caulobacter Crescentus","display_name":"Discovery and Characterization of a Multi-Drug Resistance Efflux System in Caulobacter Crescentus","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3133740126","doi":"https://doi.org/10.18113/s1p916","mag":"3133740126"},"language":"en","primary_location":{"id":"pmh:oai:scholarsphere.psu.edu:bb561584-6398-4896-b9bc-cf477ce295e5","doi":null,"is_oa":true,"landing_page_url":"https://scholarsphere.psu.edu/resources/1f0593ff-1c79-46bd-b594-b5a75feacbec/downloads/2729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401507","display_name":"ScholarSphere (Penn State Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3130638595","host_organization_name":"Pangasinan State University","host_organization_lineage":["https://openalex.org/I3130638595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Research Paper"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarsphere.psu.edu/resources/1f0593ff-1c79-46bd-b594-b5a75feacbec/downloads/2729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070850645","display_name":"Mary Hannah Swaney","orcid":"https://orcid.org/0000-0003-4039-6970","observed_orcids":["https://orcid.org/0000-0003-4039-6970"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"MARY HANNAH SWANEY","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070850645"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21643613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.05310000106692314,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caulobacter-crescentus","display_name":"Caulobacter crescentus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antibiotic-resistance-mechanisms","display_name":"antibiotic resistance mechanisms","score":0.8270000219345093},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tetr-family-transcriptional-regulator","display_name":"TetR family transcriptional regulator","score":0.8320000171661377},{"id":"https://openalex.org/keywords/major-facilitator-superfamily-transporter","display_name":"major facilitator superfamily transporter","score":0.9150000214576721},{"id":"https://openalex.org/keywords/operon-regulation","display_name":"operon regulation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/efflux-pump-inhibitors","display_name":"efflux pump inhibitors","score":0.734000027179718},{"id":"https://openalex.org/keywords/burkholderia","display_name":"Burkholderia","score":0.6930000185966492},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778767192","wikidata":"https://www.wikidata.org/wiki/Q2943106","display_name":"Caulobacter crescentus","level":4,"score":0.9901819825172424},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.7393010854721069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34886133670806885},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2959382236003876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1674555540084839},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.16257613897323608}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarsphere.psu.edu:bb561584-6398-4896-b9bc-cf477ce295e5","doi":null,"is_oa":true,"landing_page_url":"https://scholarsphere.psu.edu/resources/1f0593ff-1c79-46bd-b594-b5a75feacbec/downloads/2729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401507","display_name":"ScholarSphere (Penn State Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3130638595","host_organization_name":"Pangasinan State University","host_organization_lineage":["https://openalex.org/I3130638595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Research Paper"},{"id":"mag:3133740126","doi":null,"is_oa":false,"landing_page_url":"https://scholarsphere.psu.edu/concern/generic_works/dv405s9155","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.18113/s1p916","doi":"https://doi.org/10.18113/s1p916","is_oa":true,"landing_page_url":"https://doi.org/10.18113/s1p916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401507","display_name":"ScholarSphere (Penn State Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3130638595","host_organization_name":"Pangasinan State University","host_organization_lineage":["https://openalex.org/I3130638595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:scholarsphere.psu.edu:bb561584-6398-4896-b9bc-cf477ce295e5","doi":null,"is_oa":true,"landing_page_url":"https://scholarsphere.psu.edu/resources/1f0593ff-1c79-46bd-b594-b5a75feacbec/downloads/2729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401507","display_name":"ScholarSphere (Penn State Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3130638595","host_organization_name":"Pangasinan State University","host_organization_lineage":["https://openalex.org/I3130638595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Research Paper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2610856225","https://openalex.org/W4395037766","https://openalex.org/W2381700717","https://openalex.org/W7099798473","https://openalex.org/W4380992896","https://openalex.org/W2076233570","https://openalex.org/W4319294851","https://openalex.org/W4321365735","https://openalex.org/W7078801869","https://openalex.org/W2036461921"],"abstract_inverted_index":{"The":[0,209],"study":[1,210],"of":[2,15,33,67,81,129,143,154,162,169,205,211,239],"antibiotic":[3,27],"resistance":[4,139,228],"mechanisms":[5],"is":[6,29,150],"crucial":[7],"in":[8,88,103,131,138,167,192,229],"order":[9,193],"to":[10,25,43,55,60,73,100,140,174,194],"combat":[11],"the":[12,31,49,82,147,155,163,170,176,180,206,224],"serious":[13],"issue":[14],"antibiotic-resistant":[16],"bacterial":[17,50],"infections.":[18],"One":[19],"way":[20],"that":[21,112,146,160],"bacteria":[22,58],"are":[23,39],"able":[24,42],"evade":[26],"stress":[28],"through":[30],"efflux":[32,36,110,118,156,171,182,207,216,240],"antibiotics":[34],"by":[35],"pumps,":[37],"which":[38,198],"proteinaceous":[40],"transporters":[41],"expel":[44],"drugs":[45],"and":[46,120,159,184,231,234],"toxins":[47],"from":[48,127],"cell.":[51],"Serial":[52],"passaging":[53],"methods":[54],"isolate":[56],"mutant":[57],"resistant":[59],"trans-translation":[61],"inhibitor":[62],"KKL-73":[63],"yielded":[64],"two":[65],"strains":[66,83],"C.":[68,133],"crescentus":[69,134],"with":[70],"decreased":[71],"susceptibility":[72],"several":[74,85,141],"structurally":[75],"dissimilar":[76],"compounds.":[77],"Whole-genome":[78],"sequencing":[79],"analysis":[80],"uncovered":[84],"mutations":[86],"present":[87],"CCNA_03832,":[89],"a":[90,108,115,121,151],"putative":[91,116],"TetR-family":[92],"transcriptional":[93],"regulator.":[94],"This":[95],"novel":[96,213],"gene":[97],"was":[98],"found":[99],"be":[101,200],"located":[102],"an":[104,136],"operon":[105,158],"coding":[106,178],"for":[107,179,202,226,237],"MDR":[109,117,181,215],"system":[111,157,217],"also":[113],"contains":[114],"pump":[119,183,241],"major":[122,185],"facilitator":[123,186],"superfamily":[124,187],"transporter.":[125],"Results":[126],"inactivation":[128],"CCNA_03832":[130],"wild-type":[132],"reveal":[135,219],"increase":[137],"classes":[142],"antibiotics,":[144],"suggesting":[145],"transcription":[148,164],"factor":[149,165],"negative":[152],"regulator":[153],"mutation":[161],"resulted":[166],"overexpression":[168],"system.":[172,208],"Techniques":[173],"inactivate":[175],"genes":[177],"transporter":[188],"were":[189],"carried":[190],"out":[191],"create":[195],"knockout":[196],"strains,":[197],"will":[199],"used":[201],"further":[203],"characterization":[204],"this":[212],"three-gene":[214],"may":[218,235],"clinically":[220],"relevant":[221],"information":[222],"about":[223],"potential":[225],"drug":[227],"Burkholderia":[230],"Pseudomonas":[232],"aeruginosa":[233],"allow":[236],"development":[238],"inhibitors":[242],"(EPIs).":[243]},"counts_by_year":[],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2021-03-15T00:00:00"}
