{"id":"https://openalex.org/W3133736562","doi":"https://doi.org/10.1126/scitranslmed.abc2823","title":"Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer","display_name":"Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer","publication_year":2021,"publication_date":"2021-03-03","ids":{"openalex":"https://openalex.org/W3133736562","doi":"https://doi.org/10.1126/scitranslmed.abc2823","mag":"3133736562","pmid":"https://pubmed.ncbi.nlm.nih.gov/33658352"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.abc2823","doi":"https://doi.org/10.1126/scitranslmed.abc2823","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.abc2823","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/55d398j1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073637787","display_name":"Heng\u2010Hsiung Wu","orcid":"https://orcid.org/0000-0002-7220-8519","observed_orcids":["https://orcid.org/0000-0002-7220-8519"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Heng-Hsiung Wu","raw_affiliation_strings":["Drug Development Center, China Medical University, Taichung 40402, Taiwan","Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-7220-8519","affiliations":[{"raw_affiliation_string":"Drug Development Center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111765367","display_name":"Lung\u2010Hung Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lung-Hung Tsai","raw_affiliation_strings":["Drug Development Center, China Medical University, Taichung 40402, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development Center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042051897","display_name":"Chun-Kai Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Kai Huang","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065798896","display_name":"Pang\u2010Hung Hsu","orcid":"https://orcid.org/0000-0001-6873-6434","observed_orcids":["https://orcid.org/0000-0001-6873-6434"]},"institutions":[{"id":"https://openalex.org/I153512688","display_name":"National Taiwan Ocean University","ror":"https://ror.org/03bvvnt49","country_code":"TW","type":"education","lineage":["https://openalex.org/I153512688"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pang-Hung Hsu","raw_affiliation_strings":["Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan","Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-6873-6434","affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan","institution_ids":["https://openalex.org/I153512688"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007104952","display_name":"Mei\u2010Yu Chen","orcid":"https://orcid.org/0000-0002-5765-9178","observed_orcids":["https://orcid.org/0000-0002-5765-9178"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mei-Yu Chen","raw_affiliation_strings":["Drug Development Center, China Medical University, Taichung 40402, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development Center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167412","display_name":"Y.M. Chen","orcid":"https://orcid.org/0000-0001-5302-0433","observed_orcids":["https://orcid.org/0000-0001-5302-0433"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ing Chen","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-5302-0433","affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667817","display_name":"Chun\u2010Mei Hu","orcid":"https://orcid.org/0000-0002-4248-0896","observed_orcids":["https://orcid.org/0000-0002-4248-0896"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Mei Hu","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-4248-0896","affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061050276","display_name":"Chia\u2010Ning Shen","orcid":"https://orcid.org/0000-0002-0747-217X","observed_orcids":["https://orcid.org/0000-0002-0747-217X"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Ning Shen","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-0747-217X","affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101760977","display_name":"Chen\u2010Chen Lee","orcid":"https://orcid.org/0000-0003-1271-5591","observed_orcids":["https://orcid.org/0000-0003-1271-5591"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Chen Lee","raw_affiliation_strings":["Department of Microbiology and Immunology, China Medical University, Taichung 40402, Taiwan","Drug Development Center, China Medical University, Taichung 40402, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-1271-5591","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Drug Development Center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108095423","display_name":"Ming\u2010Chu Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Chu Chang","raw_affiliation_strings":["Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085610498","display_name":"Yu\u2010Ting Chang","orcid":"https://orcid.org/0000-0002-5912-3406","observed_orcids":["https://orcid.org/0000-0002-5912-3406"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Ting Chang","raw_affiliation_strings":["Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012873714","display_name":"Yu\u2010Wen Tien","orcid":"https://orcid.org/0000-0002-9126-2705","observed_orcids":["https://orcid.org/0000-0002-9126-2705"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Wen Tien","raw_affiliation_strings":["Department of Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9126-2705","affiliations":[{"raw_affiliation_string":"Department of Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041457441","display_name":"Yung\u2010Ming Jeng","orcid":"https://orcid.org/0000-0002-3878-4491","observed_orcids":["https://orcid.org/0000-0002-3878-4491","https://orcid.org/0000-0002-9986-7194","https://orcid.org/0000-0001-7030-2774"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yung-Ming Jeng","raw_affiliation_strings":["Department of Pathology, National Taiwan University Hospital, Taipei 10041, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National Taiwan University Hospital, Taipei 10041, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111145268","display_name":"Eva Y.-H.P. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Eva Y.-H.P. Lee","raw_affiliation_strings":["Department of Biological Chemistry, University of California, Irvine, CA 92697, USA","Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061314864","display_name":"Wen\u2010Hwa Lee","orcid":"https://orcid.org/0000-0002-3117-931X","observed_orcids":["https://orcid.org/0000-0002-3117-931X"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW","US"],"is_corresponding":true,"raw_author_name":"Wen-Hwa Lee","raw_affiliation_strings":["Department of Biological Chemistry, University of California, Irvine, CA 92697, USA","Drug Development Center, China Medical University, Taichung 40402, Taiwan","Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3117-931X","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Drug Development Center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5061314864"],"corresponding_institution_ids":["https://openalex.org/I184693016","https://openalex.org/I204250578","https://openalex.org/I4210087491","https://openalex.org/I84653119"],"apc_list":null,"apc_paid":null,"fwci":2.1957,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88677702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"13","issue":"583","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-17b","display_name":"IL-17B","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tak1","display_name":"TAK1","score":0.6539999842643738},{"id":"https://openalex.org/keywords/act1","display_name":"Act1","score":0.7070000171661377},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/homodimerization","display_name":"homodimerization","score":0.7910000085830688},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.5389999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5606175065040588},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4561064541339874},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4493258595466614},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4373956322669983},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4339079260826111},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4280270040035248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41626590490341187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29335862398147583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22673794627189636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17671653628349304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09336686134338379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05219140648841858}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053722","descriptor_name":"Receptors, Interleukin-17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.abc2823","doi":"https://doi.org/10.1126/scitranslmed.abc2823","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.abc2823","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:33658352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33658352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt55d398j1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/55d398j1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Translational Medicine, vol 13, iss 583","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt55d398j1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/55d398j1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Translational Medicine, vol 13, iss 583","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1504920623","https://openalex.org/W1543653831","https://openalex.org/W1608726638","https://openalex.org/W1805155421","https://openalex.org/W1935617463","https://openalex.org/W1975204978","https://openalex.org/W2009145571","https://openalex.org/W2018786027","https://openalex.org/W2019678439","https://openalex.org/W2020233428","https://openalex.org/W2020466484","https://openalex.org/W2021674244","https://openalex.org/W2033702347","https://openalex.org/W2048785398","https://openalex.org/W2065136791","https://openalex.org/W2066925516","https://openalex.org/W2067962322","https://openalex.org/W2068994108","https://openalex.org/W2083361647","https://openalex.org/W2083405359","https://openalex.org/W2085605492","https://openalex.org/W2087851913","https://openalex.org/W2087898932","https://openalex.org/W2090236851","https://openalex.org/W2098301815","https://openalex.org/W2098778820","https://openalex.org/W2101500685","https://openalex.org/W2103961090","https://openalex.org/W2116537360","https://openalex.org/W2119763611","https://openalex.org/W2121401155","https://openalex.org/W2122165025","https://openalex.org/W2136292231","https://openalex.org/W2137846138","https://openalex.org/W2138393066","https://openalex.org/W2140373863","https://openalex.org/W2158591788","https://openalex.org/W2159651336","https://openalex.org/W2166609587","https://openalex.org/W2171829791","https://openalex.org/W2171889601","https://openalex.org/W2253076690","https://openalex.org/W2418108029","https://openalex.org/W2560712571","https://openalex.org/W2590599688","https://openalex.org/W2594618407","https://openalex.org/W2751476301","https://openalex.org/W2753044843","https://openalex.org/W2764326999","https://openalex.org/W2922490226","https://openalex.org/W2948320314","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W4390915336","https://openalex.org/W1899756346","https://openalex.org/W2136292231","https://openalex.org/W4407162961","https://openalex.org/W4382806851","https://openalex.org/W4386328213","https://openalex.org/W3018104115","https://openalex.org/W4393093697","https://openalex.org/W4399389890","https://openalex.org/W2071568678"],"abstract_inverted_index":{"The":[0],"members":[1],"of":[2,88,121,157,163,185,196,200],"the":[3,48,107,182],"interleukin-17":[4],"(IL-17)":[5],"cytokine":[6],"family":[7],"and":[8,25,27,41,66,130,170,178,180,203],"their":[9,149],"receptors":[10],"were":[11],"identified":[12],"decades":[13],"ago.":[14],"Unlike":[15],"IL-17":[16],"receptor":[17],"A":[18],"(IL-17RA),":[19],"which":[20,52,123],"heterodimerizes":[21],"with":[22,45,82,97,101,141,153],"IL-17RB,":[23,122],"IL-17RC,":[24],"IL-17RD":[26],"mediates":[28],"proinflammatory":[29],"gene":[30],"expression,":[31],"IL-17RB":[32,53,62,90,105,139,164,201],"plays":[33],"a":[34,64,72,154,193,211],"distinct":[35],"role":[36],"in":[37,84,91,173],"promoting":[38],"tumor":[39,92],"growth":[40],"metastasis":[42,179],"upon":[43,80],"stimulation":[44],"IL-17B.":[46],"However,":[47],"molecular":[49],"basis":[50],"by":[51],"promotes":[54],"oncogenesis":[55],"is":[56],"unknown.":[57],"Here,":[58],"we":[59],"report":[60],"that":[61],"forms":[63],"homodimer":[65],"recruits":[67,106],"mixed-lineage":[68],"kinase":[69],"4":[70],"(MLK4),":[71],"dual":[73],"kinase,":[74],"to":[75,114,119,133,161],"phosphorylate":[76],"it":[77],"at":[78,143],"tyrosine-447":[79,145],"treatment":[81],"IL-17B":[83],"vitro.":[85],"Higher":[86],"amounts":[87],"phosphorylated":[89],"specimens":[93],"obtained":[94],"from":[95],"patients":[96],"pancreatic":[98,188,215],"cancer":[99],"correlated":[100],"worse":[102],"prognosis.":[103],"Phosphorylated":[104],"ubiquitin":[108,117],"ligase":[109],"tripartite":[110],"motif":[111],"containing":[112],"56":[113],"add":[115],"lysine-63-linked":[116],"chains":[118],"lysine-470":[120,147,171],"further":[124],"assembles":[125],"NF-\u03baB":[126],"activator":[127],"1":[128],"(ACT1)":[129],"other":[131],"factors":[132],"propagate":[134],"downstream":[135],"oncogenic":[136,150],"signaling.":[137],"Consequentially,":[138],"mutants":[140],"substitution":[142],"either":[144],"or":[146],"lose":[148],"activity.":[151],"Treatment":[152],"peptide":[155],"consisting":[156],"amino":[158],"acids":[159],"403":[160],"416":[162],"blocks":[165],"MLK4":[166],"binding,":[167],"tyrosine-477":[168],"phosphorylation,":[169],"ubiquitination":[172],"vivo,":[174],"thereby":[175],"inhibiting":[176],"tumorigenesis":[177],"prolonging":[181],"life":[183],"span":[184],"mice":[186],"bearing":[187],"tumors.":[189],"These":[190],"results":[191],"establish":[192],"clear":[194],"pathway":[195,209],"how":[197,207],"proximal":[198],"signaling":[199],"occurs":[202],"provides":[204,210],"insight":[205],"into":[206],"this":[208],"therapeutic":[212],"target":[213],"for":[214],"cancer.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
