{"id":"https://openalex.org/W3133697443","doi":"https://doi.org/10.1117/1.jmi.8.1.014005","title":"Automated workflow for volumetric assessment of signal intensity ratio on T1-weighted MR images after multiple gadolinium administrations","display_name":"Automated workflow for volumetric assessment of signal intensity ratio on T1-weighted MR images after multiple gadolinium administrations","publication_year":2021,"publication_date":"2021-02-26","ids":{"openalex":"https://openalex.org/W3133697443","doi":"https://doi.org/10.1117/1.jmi.8.1.014005","mag":"3133697443","pmid":"https://pubmed.ncbi.nlm.nih.gov/33649733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7909664"},"language":"en","primary_location":{"id":"doi:10.1117/1.jmi.8.1.014005","doi":"https://doi.org/10.1117/1.jmi.8.1.014005","is_oa":false,"landing_page_url":"https://doi.org/10.1117/1.jmi.8.1.014005","pdf_url":null,"source":{"id":"https://openalex.org/S2765007747","display_name":"Journal of medical imaging","issn_l":"2329-4302","issn":["2329-4302","2329-4310"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7909664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103061655","display_name":"Chia\u2010Ying Liu","orcid":"https://orcid.org/0000-0002-6408-9089","observed_orcids":["https://orcid.org/0000-0002-6408-9089"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Ying Liu","raw_affiliation_strings":["Bayer HealthCare AG","US Medical Affairs, Bayer HealthCare, Whippany, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG","institution_ids":[]},{"raw_affiliation_string":"US Medical Affairs, Bayer HealthCare, Whippany, New Jersey","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015102011","display_name":"Marc Ramos","orcid":"https://orcid.org/0009-0006-6232-6673","observed_orcids":["https://orcid.org/0009-0006-6232-6673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Ramos","raw_affiliation_strings":["QMENTA, Inc","QMENTA Inc., Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QMENTA, Inc","institution_ids":[]},{"raw_affiliation_string":"QMENTA Inc., Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010176196","display_name":"David Moreno\u2010Dominguez","orcid":"https://orcid.org/0000-0003-3403-8173","observed_orcids":["https://orcid.org/0000-0003-3403-8173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Moreno-Dominguez","raw_affiliation_strings":["QMENTA, Inc","QMENTA Inc., Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-3403-8173","affiliations":[{"raw_affiliation_string":"QMENTA, Inc","institution_ids":[]},{"raw_affiliation_string":"QMENTA Inc., Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089411500","display_name":"Vesna Pr\u010dkovska","orcid":"https://orcid.org/0000-0003-4536-2286","observed_orcids":["https://orcid.org/0000-0003-4536-2286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vesna Prckovska","raw_affiliation_strings":["QMENTA, Inc","QMENTA Inc., Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QMENTA, Inc","institution_ids":[]},{"raw_affiliation_string":"QMENTA Inc., Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100326","display_name":"Paulo Rodrigues","orcid":"https://orcid.org/0000-0002-2102-1746","observed_orcids":["https://orcid.org/0000-0002-2102-1746","https://orcid.org/0000-0003-3258-0794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo Rodrigues","raw_affiliation_strings":["QMENTA, Inc","QMENTA Inc., Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QMENTA, Inc","institution_ids":[]},{"raw_affiliation_string":"QMENTA Inc., Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002072020","display_name":"Markus Blank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Blank","raw_affiliation_strings":["Bayer HealthCare AG","US Medical Affairs, Bayer HealthCare, Whippany, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG","institution_ids":[]},{"raw_affiliation_string":"US Medical Affairs, Bayer HealthCare, Whippany, New Jersey","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000138899","display_name":"Franklin G. Moser","orcid":"https://orcid.org/0000-0001-5267-2667","observed_orcids":["https://orcid.org/0000-0001-5267-2667"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210115780","display_name":"S. Mark Taper Foundation","ror":"https://ror.org/02cdjbt38","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franklin G. Moser","raw_affiliation_strings":["Cedars-Sinai Medical Ctr","S. Mark Taper Foundation Imaging Center, Cedars Sinai Medical Center, Department of Imaging, Los Ang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Ctr","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"S. Mark Taper Foundation Imaging Center, Cedars Sinai Medical Center, Department of Imaging, Los Ang","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210115780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089412205","display_name":"Jacob M. Agris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Agris","raw_affiliation_strings":["Bayer HealthCare AG","US Medical Affairs, Bayer HealthCare, Whippany, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG","institution_ids":[]},{"raw_affiliation_string":"US Medical Affairs, Bayer HealthCare, Whippany, New Jersey","institution_ids":["https://openalex.org/I150569930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0178414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"01","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.16439999639987946,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-intensity-ratio","display_name":"signal intensity ratio","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dentate-nucleus","display_name":"dentate nucleus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/passive-optical-networks","display_name":"passive optical networks","score":0.921999990940094},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":1.0},{"id":"https://openalex.org/keywords/3d-image-segmentation","display_name":"3D image segmentation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/automated-image-analysis","display_name":"automated image analysis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/t1-weighted-mri","display_name":"T1-weighted imaging","score":0.8059999942779541},{"id":"https://openalex.org/keywords/deep-brain-structures","display_name":"deep brain structures","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8359590768814087},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7335081100463867},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.6931604743003845},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.4889727830886841},{"id":"https://openalex.org/C2778897929","wikidata":"https://www.wikidata.org/wiki/Q192570","display_name":"Pons","level":2,"score":0.47716134786605835},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.47066912055015564},{"id":"https://openalex.org/C2777830160","wikidata":"https://www.wikidata.org/wiki/Q2004185","display_name":"Dentate nucleus","level":3,"score":0.44312477111816406},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35250604152679443},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14732909202575684},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10532620549201965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0920805037021637},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09105756878852844},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07032349705696106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/1.jmi.8.1.014005","doi":"https://doi.org/10.1117/1.jmi.8.1.014005","is_oa":false,"landing_page_url":"https://doi.org/10.1117/1.jmi.8.1.014005","pdf_url":null,"source":{"id":"https://openalex.org/S2765007747","display_name":"Journal of medical imaging","issn_l":"2329-4302","issn":["2329-4302","2329-4310"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Imaging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7909664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7909664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Imaging (Bellingham)","raw_type":"Text"},{"id":"pmid:33649733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33649733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical imaging (Bellingham, Wash.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7909664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7909664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Imaging (Bellingham)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970928383","https://openalex.org/W1993470842","https://openalex.org/W2015513982","https://openalex.org/W2019587683","https://openalex.org/W2022514814","https://openalex.org/W2058914126","https://openalex.org/W2082240739","https://openalex.org/W2140036864","https://openalex.org/W2145661921","https://openalex.org/W2155961553","https://openalex.org/W2169262628","https://openalex.org/W2208386561","https://openalex.org/W2329592563","https://openalex.org/W2511259433","https://openalex.org/W2695045525","https://openalex.org/W2785383792","https://openalex.org/W2790269968","https://openalex.org/W2891480757","https://openalex.org/W2899663376","https://openalex.org/W2970860822"],"related_works":["https://openalex.org/W2400913366","https://openalex.org/W3032045645","https://openalex.org/W2560418152","https://openalex.org/W1993470842","https://openalex.org/W2800265459","https://openalex.org/W2955338278","https://openalex.org/W2782420155","https://openalex.org/W2579795798","https://openalex.org/W2511259433","https://openalex.org/W2140036864"],"abstract_inverted_index":{"Purpose:":[0],"Repeated":[1],"injections":[2],"of":[3,37,57,74,238],"linear":[4],"gadolinium-based":[5],"contrast":[6],"agent":[7],"(GBCA)":[8],"have":[9],"shown":[10],"correlations":[11],"with":[12,200],"increased":[13],"signal":[14],"intensities":[15],"(SI)":[16],"on":[17,27,111,118,146],"unenhanced":[18,112],"T1-weighted":[19],"(T1w)":[20],"images.":[21],"Assessment":[22],"is":[23,41,229],"usually":[24],"performed":[25],"manually":[26],"a":[28,38,47,81,197],"single":[29],"slice":[30,138],"and":[31,53,64,106,115,124,154,166,179],"the":[32,72,78,102,119,127,236,242,253,257,260],"SI":[33,55,100,203,239,247],"as":[34,134,136],"an":[35,230],"average":[36],"freehand":[39],"region-of-interest":[40],"reported.":[42],"We":[43],"aim":[44],"to":[45,61,68,126,195,219,234,255],"develop":[46],"fully":[48,226],"automated":[49],"software":[50],"that":[51],"segments":[52],"computes":[54],"ratio":[56],"dentate":[58],"nucleus":[59],"(DN)":[60],"pons":[62],"(DN/P)":[63],"globus":[65],"pallidus":[66],"(GP)":[67],"thalamus":[69,107],"(GP/T)":[70],"for":[71,259],"assessment":[73,190],"gadolinium":[75],"presence":[76],"in":[77,101,241,262],"brain":[79,244],"after":[80],"serial":[82],"GBCA":[83,95],"administrations.":[84],"Approach:":[85],"All":[86,208],"patients":[87],"(N":[88],"=":[89,206],"113)":[90],"underwent":[91],"at":[92,151,156,191],"least":[93],"eight":[94],"enhanced":[96],"scans.":[97],"The":[98,225],"modal":[99],"DN,":[103],"GP,":[104],"pons,":[105],"were":[108,160,173],"measured":[109],"volumetrically":[110],"T1w":[113],"images":[114],"corrected":[116],"based":[117],"reference":[120],"protocol":[121],"(measurement":[122,129,132,139,214],"1)":[123],"compared":[125,218],"SI-uncorrected-modal-volume":[128],"2),":[130],"SI-corrected-mean-volume":[131],"3),":[133],"well":[135],"SI-corrected-modal-single":[137],"4)":[140],"approaches.":[141],"Results:":[142],"Automatic":[143],"processing":[144],"worked":[145],"all":[147],"2119":[148],"studies":[149],"(1150":[150],"1.5":[152,192],"T":[153,193],"969":[155],"3":[157],"T).":[158,171,184],"DN/P":[159,186],"1.085":[161],"\u00b1":[162,168,175,181],"0.048":[163],"(1.5":[164,177],"T)":[165,178],"0.979":[167],"0.061":[169],"(3":[170,183],"GP/T":[172],"1.084":[174],"0.039":[176],"1.069":[180],"0.042":[182],"Modal":[185],"ratios":[187,240,248],"from":[188],"volumetric":[189],"failed":[194],"show":[196],"statistical":[198],"difference":[199],"or":[201],"without":[202],"corrections":[204],"(p":[205],"0.71).":[207],"other":[209],"t-tests":[210],"demonstrated":[211],"significant":[212],"differences":[213],"2,":[215],"3,":[216],"4":[217],"1,":[220],"p":[221],"<":[222],"0.001).":[223],"Conclusion:":[224],"automatic":[227],"method":[228],"effective":[231],"powerful":[232],"tool":[233],"streamline":[235],"analysis":[237],"deep":[243],"tissues.":[245],"Divergent":[246],"using":[249],"different":[250],"approaches":[251],"reinforces":[252],"need":[254],"standardize":[256],"measurement":[258],"research":[261],"this":[263],"field.":[264]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-15T00:00:00"}