{"id":"https://openalex.org/W3133662338","doi":"https://doi.org/10.1093/jpp/rgaa023","title":"Propolis from southeastern Brazil produced by Apis mellifera affects innate immunity by modulating cell marker expression, cytokine production and intracellular pathways in human monocytes","display_name":"Propolis from southeastern Brazil produced by Apis mellifera affects innate immunity by modulating cell marker expression, cytokine production and intracellular pathways in human monocytes","publication_year":2020,"publication_date":"2020-12-31","ids":{"openalex":"https://openalex.org/W3133662338","doi":"https://doi.org/10.1093/jpp/rgaa023","mag":"3133662338","pmid":"https://pubmed.ncbi.nlm.nih.gov/33793799"},"language":"en","primary_location":{"id":"doi:10.1093/jpp/rgaa023","doi":"https://doi.org/10.1093/jpp/rgaa023","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jpp/rgaa023","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/208571","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024784828","display_name":"Fernanda Lopes Conte","orcid":"https://orcid.org/0000-0001-6973-4465","observed_orcids":["https://orcid.org/0000-0001-6973-4465"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Lopes Conte","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6973-4465","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071625694","display_name":"Karina Basso Santiago","orcid":"https://orcid.org/0000-0001-7034-3840","observed_orcids":["https://orcid.org/0000-0001-7034-3840"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karina Basso Santiago","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042521708","display_name":"Bruno Jos\u00e9 Conti","orcid":"https://orcid.org/0000-0001-7369-4910","observed_orcids":["https://orcid.org/0000-0001-7369-4910"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Jos\u00e9 Conti","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084481077","display_name":"Eliza de Oliveira Cardoso","orcid":"https://orcid.org/0000-0002-4722-3733","observed_orcids":["https://orcid.org/0000-0002-4722-3733"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eliza de Oliveira Cardoso","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082388016","display_name":"Lucas Pires Garcia Oliveira","orcid":"https://orcid.org/0000-0001-5464-1039","observed_orcids":["https://orcid.org/0000-0001-5464-1039"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas Pires Garcia Oliveira","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083878410","display_name":"G\u00e9orgia da Silva Feltran","orcid":"https://orcid.org/0000-0002-5743-5182","observed_orcids":["https://orcid.org/0000-0002-5743-5182"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ge\u00f3rgia da Silva Feltran","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089826042","display_name":"Willian Fernando Zambuzzi","orcid":"https://orcid.org/0000-0002-4149-5965","observed_orcids":["https://orcid.org/0000-0002-4149-5965"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Willian Fernando Zambuzzi","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082916266","display_name":"M\u00e1rjorie de Assis Golim","orcid":"https://orcid.org/0000-0002-4824-9441","observed_orcids":["https://orcid.org/0000-0002-4824-9441"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marjorie de Assis Golim","raw_affiliation_strings":["Botucatu Blood Center, School of Medicine, S\u00e3o Paulo State University (UNESP) , S\u00e3o Paulo,","Botucatu Blood Center, School of Medicine, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botucatu Blood Center, School of Medicine, S\u00e3o Paulo State University (UNESP) , S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Botucatu Blood Center, School of Medicine, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005031358","display_name":"Maria Teresa Cruz","orcid":"https://orcid.org/0000-0001-9846-6754","observed_orcids":["https://orcid.org/0000-0001-9846-6754"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Teresa Cruz","raw_affiliation_strings":["Center for Neurosciences and Cellular Biology, Faculty of Pharmacy, University of Coimbra , Coimbra,","Center for Neurosciences and Cellular Biology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurosciences and Cellular Biology, Faculty of Pharmacy, University of Coimbra , Coimbra,","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neurosciences and Cellular Biology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019939338","display_name":"Jos\u00e9 Maur\u00edcio Sforcin","orcid":"https://orcid.org/0000-0003-3466-4895","observed_orcids":["https://orcid.org/0000-0003-3466-4895"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Maur\u00edcio Sforcin","raw_affiliation_strings":["Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, S\u00e3o Paulo,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Chemical and Biological Sciences, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019939338"],"corresponding_institution_ids":["https://openalex.org/I879563668"],"apc_list":{"value":2200,"currency":"GBP","value_usd":3300},"apc_paid":null,"fwci":2.7016,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89699836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"73","issue":"2","first_page":"135","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apis-mellifera","display_name":"Apis mellifera","score":0.9909999966621399},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/escherichia-coli-heat-labile-enterotoxin","display_name":"Escherichia coli heat-labile enterotoxin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mage-a1","display_name":"MAGE-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7889999747276306},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.6620000004768372},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.9440365433692932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5776263475418091},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.5542593598365784},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.507986843585968},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.49456116557121277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46561503410339355},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4352743327617645},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.43273913860321045},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.33930426836013794},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3270246982574463},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.1928572952747345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0947367250919342},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08436411619186401},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jpp/rgaa023","doi":"https://doi.org/10.1093/jpp/rgaa023","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jpp/rgaa023","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:33793799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33793799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacy and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unesp.br:11449/208571","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/208571","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:repositorio.unesp.br:11449/208571","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/208571","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1843262047","display_name":null,"funder_award_id":"301925/2013-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G8056867607","display_name":null,"funder_award_id":"PROEX 0708/2018","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G8397748637","display_name":"Propolis: modulation of antigen presentation and differential activation of T lymphocytes","funder_award_id":"15/03493-3","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W179704473","https://openalex.org/W1152422006","https://openalex.org/W1548452743","https://openalex.org/W1597246335","https://openalex.org/W1618075023","https://openalex.org/W1636849021","https://openalex.org/W1904467505","https://openalex.org/W1966875398","https://openalex.org/W1999300863","https://openalex.org/W2003922100","https://openalex.org/W2004773897","https://openalex.org/W2011303793","https://openalex.org/W2041279219","https://openalex.org/W2046864860","https://openalex.org/W2073973554","https://openalex.org/W2080598208","https://openalex.org/W2086968599","https://openalex.org/W2097931810","https://openalex.org/W2107710305","https://openalex.org/W2110463517","https://openalex.org/W2134211439","https://openalex.org/W2147075251","https://openalex.org/W2149443985","https://openalex.org/W2161296689","https://openalex.org/W2170098987","https://openalex.org/W2170292069","https://openalex.org/W2293537897","https://openalex.org/W2344342419","https://openalex.org/W2474271254","https://openalex.org/W2508144585","https://openalex.org/W2529574536","https://openalex.org/W2536705204","https://openalex.org/W2574819148","https://openalex.org/W2893225667","https://openalex.org/W2901441398"],"related_works":["https://openalex.org/W1904467505","https://openalex.org/W2073973554","https://openalex.org/W7120706823","https://openalex.org/W2377616009","https://openalex.org/W7017050032","https://openalex.org/W2010840369","https://openalex.org/W2529574536","https://openalex.org/W1973550055","https://openalex.org/W2951071363","https://openalex.org/W4210768271"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Propolis":[1,92,120,128,149,180],"is":[2],"a":[3,159,172],"bee-made":[4],"product":[5],"used":[6],"for":[7],"centuries":[8],"due":[9],"to":[10],"its":[11,16,106,167],"diverse":[12],"biological":[13],"properties,":[14],"including":[15],"immunomodulatory":[17],"action.":[18],"This":[19],"work":[20],"aimed":[21],"at":[22],"investigating":[23],"whether":[24],"propolis":[25],"may":[26],"affect":[27],"monocyte":[28],"functions":[29],"challenged":[30],"with":[31,57,108,169],"retinoic":[32],"acid":[33],"(RA),":[34],"B":[35],"subunit":[36],"of":[37,65],"Escherichia":[38],"coli":[39],"heat-labile":[40],"enterotoxin":[41],"(EtxB),":[42],"human":[43],"melanoma-associated":[44],"antigen-1":[45],"(MAGE-1)":[46],"and":[47,99,136,143,166],"lipopolysaccharide":[48],"(LPS).":[49],"METHODS:":[50],"Monocytes":[51],"from":[52],"healthy":[53],"donors":[54],"were":[55],"treated":[56],"the":[58,63,103,118,176,187],"stimuli":[59],"separately":[60],"or":[61,111,134,141],"in":[62,102],"presence":[64],"propolis.":[66],"Cell":[67],"viability":[68],"was":[69,77],"evaluated":[70],"by":[71,79,84,88,117,154,185],"MTT":[72],"assay,":[73],"cell":[74,125],"marker":[75,126],"expression":[76,87,101,115,152,162,174],"assessed":[78],"flow":[80],"cytometry,":[81],"cytokine":[82],"production":[83],"ELISA,":[85],"gene":[86],"RT-qPCR.":[89],"KEY":[90],"FINDINGS:":[91],"alone":[93],"maintained":[94,121],"TLR-2,":[95],"TLR-4,":[96],"HLA-DR,":[97],"CD40":[98,114],"CD80":[100],"monocytes;":[104],"however,":[105],"combination":[107,168],"either":[109,132,139],"MAGE-1":[110],"LPS":[112],"decreased":[113],"triggered":[116],"stimuli.":[119],"RA":[122,140,170],"action":[123],"on":[124],"expression.":[127],"inhibited":[129],"TNF-\u03b1":[130],"(with":[131,138,146],"EtxB":[133],"MAGE-1)":[135,147],"IL-6":[137],"MAGE-1),":[142],"increased":[144],"IL-10":[145],"production.":[148],"downmodulated":[150],"LC3":[151],"induced":[153,158,171],"LPS.":[155],"It":[156],"also":[157],"lower":[160],"NF-kB":[161],"than":[163,175],"control":[164],"cells":[165],"higher":[173],"stimulus":[177],"alone.":[178],"CONCLUSIONS:":[179],"potentially":[181],"affected":[182],"innate":[183],"immunity":[184],"downmodulating":[186],"monocytes":[188],"pro-inflammatory":[189],"activity.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}
