{"id":"https://openalex.org/W3133658211","doi":"https://doi.org/10.1007/s40618-021-01534-3","title":"PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile","display_name":"PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile","publication_year":2021,"publication_date":"2021-03-04","ids":{"openalex":"https://openalex.org/W3133658211","doi":"https://doi.org/10.1007/s40618-021-01534-3","mag":"3133658211","pmid":"https://pubmed.ncbi.nlm.nih.gov/33661511","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8421290"},"language":"en","primary_location":{"id":"doi:10.1007/s40618-021-01534-3","doi":"https://doi.org/10.1007/s40618-021-01534-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-021-01534-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-021-01534-3.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40618-021-01534-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089391999","display_name":"Fabiana Faja","orcid":"https://orcid.org/0000-0002-5297-2448","observed_orcids":["https://orcid.org/0000-0002-5297-2448"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Faja","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5297-2448","affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082676383","display_name":"Federica Finocchi","orcid":"https://orcid.org/0000-0003-1551-5990","observed_orcids":["https://orcid.org/0000-0003-1551-5990"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Finocchi","raw_affiliation_strings":["Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy","Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]},{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036281715","display_name":"Tania Carlini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T. Carlini","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088078847","display_name":"Flavio Rizzo","orcid":"https://orcid.org/0000-0003-2191-3311","observed_orcids":["https://orcid.org/0000-0003-2191-3311"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Rizzo","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010978066","display_name":"Francesco Pallotti","orcid":"https://orcid.org/0000-0001-6042-6474","observed_orcids":["https://orcid.org/0000-0001-6042-6474"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Pallotti","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6042-6474","affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072096811","display_name":"Matteo Spaziani","orcid":"https://orcid.org/0000-0001-5645-5766","observed_orcids":["https://orcid.org/0000-0001-5645-5766"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Spaziani","raw_affiliation_strings":["Hormone Laboratory, Department of Experimental Medicine - Medical Pathophysiology Section, \"Sapienza\" University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormone Laboratory, Department of Experimental Medicine - Medical Pathophysiology Section, \"Sapienza\" University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087069678","display_name":"Giancarlo Balercia","orcid":"https://orcid.org/0000-0003-1286-1521","observed_orcids":["https://orcid.org/0000-0003-1286-1521"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Balercia","raw_affiliation_strings":["Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063939488","display_name":"Andrea Lenzi","orcid":"https://orcid.org/0000-0002-7711-0465","observed_orcids":["https://orcid.org/0000-0002-7711-0465"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Lenzi","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7711-0465","affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107387117","display_name":"Donatella Paoli","orcid":"https://orcid.org/0000-0002-9699-8703","observed_orcids":["https://orcid.org/0000-0002-9699-8703"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"D. Paoli","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. donatella.paoli@uniroma1.it","Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9699-8703","affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. donatella.paoli@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073804996","display_name":"Francesco Paolo Lombardo","orcid":"https://orcid.org/0000-0002-6943-2966","observed_orcids":["https://orcid.org/0000-0002-6943-2966"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Lombardo","raw_affiliation_strings":["Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6943-2966","affiliations":[{"raw_affiliation_string":"Laboratory of Seminology - \"Loredana Gandini\" Sperm Bank, Department of Experimental Medicine, \"Sapienza\" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107387117"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":1.3671,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78420276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"44","issue":"10","first_page":"2273","last_page":"2284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.367900013923645,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pde11a","display_name":"PDE11A","score":0.921999990940094},{"id":"https://openalex.org/keywords/testicular-germ-cell-tumors","display_name":"testicular germ cell tumors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7559999823570251},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8270000219345093},{"id":"https://openalex.org/keywords/semen-parameters","display_name":"semen parameters","score":0.7200000286102295},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.878000020980835},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/testicular-function","display_name":"testicular function","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5982173085212708},{"id":"https://openalex.org/C2776212926","wikidata":"https://www.wikidata.org/wiki/Q324464","display_name":"Testicular cancer","level":3,"score":0.5346106290817261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5015382766723633},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4789324700832367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45373833179473877},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4351198673248291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3928758203983307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3915829360485077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33483684062957764},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.33386266231536865},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32423874735832214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31848931312561035},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.308734655380249}],"mesh":[{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015106","descriptor_name":"3',5'-Cyclic-GMP Phosphodiesterases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1007/s40618-021-01534-3","doi":"https://doi.org/10.1007/s40618-021-01534-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-021-01534-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-021-01534-3.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},{"id":"pmid:33661511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33661511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8421290","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8421290/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocrinol Invest","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/1522999","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1522999","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1522999/1/Faja_PDE11A_2021.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/291885","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11566/291885","pdf_url":"https://iris.univpm.it/bitstream/11566/291885/2/Faja_PDE11A-gene-polymorphism_2021.pdf","source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniecampus.it:11389/62755","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11389/62755","pdf_url":null,"source":{"id":"https://openalex.org/S4306400077","display_name":"IRIS eCampus Telematic University (Universit\u00e0 degli Studi eCampus)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I167322064","host_organization_name":"Universit\u00e0 degli Studi eCampus","host_organization_lineage":["https://openalex.org/I167322064"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s40618-021-01534-3","doi":"https://doi.org/10.1007/s40618-021-01534-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-021-01534-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-021-01534-3.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2241683054","display_name":null,"funder_award_id":"PRIN 2015","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G5553811354","display_name":null,"funder_award_id":"MIUR-PRIN 2015","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G6557675175","display_name":null,"funder_award_id":"PRIN 2015- 2015XCR88M_006","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133658211.pdf","grobid_xml":"https://content.openalex.org/works/W3133658211.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1545971240","https://openalex.org/W1585612016","https://openalex.org/W1796620152","https://openalex.org/W1895020331","https://openalex.org/W1952016525","https://openalex.org/W1965227983","https://openalex.org/W1972914390","https://openalex.org/W1976921939","https://openalex.org/W1984848175","https://openalex.org/W1995578853","https://openalex.org/W1996431759","https://openalex.org/W2007474068","https://openalex.org/W2009871610","https://openalex.org/W2009917029","https://openalex.org/W2010417562","https://openalex.org/W2013543653","https://openalex.org/W2015298632","https://openalex.org/W2018787311","https://openalex.org/W2019222252","https://openalex.org/W2021334674","https://openalex.org/W2021616709","https://openalex.org/W2022999698","https://openalex.org/W2033756310","https://openalex.org/W2048888516","https://openalex.org/W2050809984","https://openalex.org/W2058658973","https://openalex.org/W2059082929","https://openalex.org/W2063377974","https://openalex.org/W2065516093","https://openalex.org/W2076960629","https://openalex.org/W2081343247","https://openalex.org/W2081499746","https://openalex.org/W2099910628","https://openalex.org/W2101972498","https://openalex.org/W2102443531","https://openalex.org/W2106787323","https://openalex.org/W2112421157","https://openalex.org/W2118999469","https://openalex.org/W2120365576","https://openalex.org/W2123420087","https://openalex.org/W2123779332","https://openalex.org/W2124127909","https://openalex.org/W2126203912","https://openalex.org/W2132403568","https://openalex.org/W2143885946","https://openalex.org/W2151282851","https://openalex.org/W2151503168","https://openalex.org/W2152069796","https://openalex.org/W2154559659","https://openalex.org/W2172279582","https://openalex.org/W2253549294","https://openalex.org/W2275322432","https://openalex.org/W2332224961","https://openalex.org/W2337777109","https://openalex.org/W2407414296","https://openalex.org/W2528781671","https://openalex.org/W2538727120","https://openalex.org/W2541054407","https://openalex.org/W2547126613","https://openalex.org/W2588259159","https://openalex.org/W2790567360","https://openalex.org/W2889646458","https://openalex.org/W2905267878","https://openalex.org/W2936847682","https://openalex.org/W2947048987","https://openalex.org/W3005522812","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7070391832","https://openalex.org/W2158738973","https://openalex.org/W3213138873","https://openalex.org/W2076257029","https://openalex.org/W2138609785","https://openalex.org/W2428918896","https://openalex.org/W2146019687","https://openalex.org/W2158844661","https://openalex.org/W4243487787","https://openalex.org/W2102443531"],"abstract_inverted_index":{"PURPOSE:":[0],"Testicular":[1],"germ":[2],"cell":[3],"tumours":[4],"(TGCTs)":[5],"is":[6,17,57],"the":[7,30,41,53,151,154,161,208,217],"most":[8],"common":[9,45],"malignancy":[10],"among":[11],"young":[12],"adult":[13],"males.":[14],"The":[15,82],"etiology":[16],"multifactorial":[18],"and":[19,22,32,46,50,79,92,109,113,123,144,153,180,194,215,223,232],"both":[20],"environmental":[21],"genetic":[23,48],"factors":[24],"play":[25],"an":[26,220],"important":[27],"role":[28,210],"in":[29,70,95,104,114,178,182,213],"origin":[31],"development":[33],"of":[34,43,52,84,156,191,211,219],"TGCT.":[35],"Genetic":[36],"susceptibility":[37,233],"may":[38],"result":[39],"from":[40],"interaction":[42],"multiple":[44],"low-penetrance":[47],"variants":[49],"one":[51],"main":[54],"candidate":[55],"genes":[56],"PDE11A.":[58],"Many":[59],"PDE11A":[60,93,124,164,212],"polymorphisms":[61,125,168],"were":[62,184],"found":[63],"responsible":[64],"for":[65],"a":[66,188,197],"reduced":[67],"PDE":[68],"activity":[69],"TGCT":[71,135],"patients,":[72],"who":[73],"often":[74],"also":[75,119],"display":[76],"impaired":[77],"hormone":[78,121],"sperm":[80,157,202],"profile.":[81],"aim":[83],"this":[85],"study":[86],"was":[87,102],"to":[88,234],"investigate":[89],"testicular":[90,96,192,235],"function":[91],"sequence":[94],"cancer":[97],"cases.":[98],"METHODS:":[99],"Semen":[100],"analysis":[101],"performed":[103],"116":[105],"patients":[106,136],"with":[107,172,187,200],"unilateral":[108],"bilateral":[110],"sporadic":[111],"TGCTs":[112,173],"120":[115],"cancer-free":[116],"controls.":[117],"We":[118],"investigated":[120],"profile":[122],"using":[126],"peripheral":[127],"blood":[128],"samples.":[129],"RESULTS:":[130],"Our":[131,205],"data":[132],"revealed":[133],"that":[134],"showed":[137],"lower":[138,189],"testosterone":[139],"levels,":[140],"higher":[141],"gonadotropins":[142],"levels":[143],"worse":[145],"semen":[146],"quality":[147],"than":[148],"controls,":[149],"although":[150],"mean":[152],"medians":[155],"parameters":[158],"are":[159],"within":[160],"reference":[162],"limits.":[163],"sequencing":[165],"detected":[166],"ten":[167],"not":[169],"yet":[170],"associated":[171,186],"before.":[174],"Among":[175],"these,":[176],"G223A":[177],"homozygosity":[179],"A288G":[181],"heterozygosity":[183],"significantly":[185],"risk":[190],"tumour":[193],"they":[195],"displayed":[196],"positive":[198],"correlation":[199],"total":[201],"number.":[203],"CONCLUSIONS:":[204],"findings":[206],"highlight":[207],"key":[209],"testis":[214],"suggest":[216],"presence":[218],"underlying":[221],"complex":[222],"fine":[224],"molecular":[225],"mechanism":[226],"which":[227],"controls":[228],"testis-specific":[229],"gene":[230],"expression":[231],"cancer.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
