{"id":"https://openalex.org/W3133631674","doi":"https://doi.org/10.1093/g3journal/jkab062","title":"Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations","display_name":"Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3133631674","doi":"https://doi.org/10.1093/g3journal/jkab062","mag":"3133631674","pmid":"https://pubmed.ncbi.nlm.nih.gov/33677482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8759814"},"language":"en","primary_location":{"id":"doi:10.1093/g3journal/jkab062","doi":"https://doi.org/10.1093/g3journal/jkab062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/g3journal/jkab062","pdf_url":"https://academic.oup.com/g3journal/article-pdf/11/4/jkab062/37082782/jkab062.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/g3journal/article-pdf/11/4/jkab062/37082782/jkab062.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077123205","display_name":"Cory A. Weller","orcid":"https://orcid.org/0000-0001-6965-5599","observed_orcids":["https://orcid.org/0000-0001-6965-5599"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cory A Weller","raw_affiliation_strings":["Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"],"raw_orcid":"https://orcid.org/0000-0001-6965-5599","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville, VA 22904, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059971825","display_name":"Susanne Tilk","orcid":"https://orcid.org/0000-0002-9156-9360","observed_orcids":["https://orcid.org/0000-0002-9156-9360"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne Tilk","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081023551","display_name":"Subhash Rajpurohit","orcid":"https://orcid.org/0000-0001-9149-391X","observed_orcids":["https://orcid.org/0000-0001-9149-391X"]},"institutions":[{"id":"https://openalex.org/I52527943","display_name":"Ahmedabad University","ror":"https://ror.org/02swff503","country_code":"IN","type":"education","lineage":["https://openalex.org/I52527943"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhash Rajpurohit","raw_affiliation_strings":["Department of Biological and Life Sciences, Ahmedabad University, Ahmedabad 380009, India"],"raw_orcid":"https://orcid.org/0000-0001-9149-391X","affiliations":[{"raw_affiliation_string":"Department of Biological and Life Sciences, Ahmedabad University, Ahmedabad 380009, India","institution_ids":["https://openalex.org/I52527943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064588905","display_name":"Alan O. Bergland","orcid":"https://orcid.org/0000-0001-7145-7575","observed_orcids":["https://orcid.org/0000-0001-7145-7575"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan O Bergland","raw_affiliation_strings":["Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville, VA 22904, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077123205"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":2330,"currency":"USD","value_usd":2330},"apc_paid":{"value":2330,"currency":"USD","value_usd":2330},"fwci":0.2822,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.49128391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hybrid-swarm","display_name":"hybrid swarm","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genome-reconstruction","display_name":"genome reconstruction","score":0.5989999771118164},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mapping-population","display_name":"mapping population","score":0.5320000052452087},{"id":"https://openalex.org/keywords/inbred-lines","display_name":"inbred lines","score":0.6959999799728394},{"id":"https://openalex.org/keywords/recombinant-inbred-lines","display_name":"recombinant inbred lines","score":0.9670000076293945},{"id":"https://openalex.org/keywords/phased-haplotypes","display_name":"phased haplotypes","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drosophila-genetic-reference-panel","display_name":"Drosophila Genetic Reference Panel","score":0.8399999737739563},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"genetic architecture","score":0.5649999976158142},{"id":"https://openalex.org/keywords/quantitative-traits","display_name":"quantitative traits","score":0.699999988079071},{"id":"https://openalex.org/keywords/monogenic-traits","display_name":"monogenic traits","score":0.8050000071525574},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.7689999938011169},{"id":"https://openalex.org/keywords/outbreeding","display_name":"outbreeding","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7338199019432068},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.715548038482666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5731770992279053},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5518480539321899},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.5502170324325562},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.5382371544837952},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5030941367149353},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.45504605770111084},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4498337209224701},{"id":"https://openalex.org/C134443026","wikidata":"https://www.wikidata.org/wiki/Q4809584","display_name":"Association mapping","level":5,"score":0.44660383462905884},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44407007098197937},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.44329750537872314},{"id":"https://openalex.org/C192953774","wikidata":"https://www.wikidata.org/wiki/Q7307127","display_name":"Reference genome","level":4,"score":0.4266166687011719},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4018966555595398},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.34246546030044556},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3353617191314697},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.32563865184783936},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2797890901565552},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15464147925376892},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/g3journal/jkab062","doi":"https://doi.org/10.1093/g3journal/jkab062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/g3journal/jkab062","pdf_url":"https://academic.oup.com/g3journal/article-pdf/11/4/jkab062/37082782/jkab062.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/671925","doi":"https://doi.org/10.1101/671925","is_oa":true,"landing_page_url":"https://doi.org/10.1101/671925","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/01/27/671925.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8759814","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8759814","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"},{"id":"pmid:33677482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33677482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:479aae4e48ea40f292d0c33fbf19d485","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/479aae4e48ea40f292d0c33fbf19d485","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/g3journal/jkab062","doi":"https://doi.org/10.1093/g3journal/jkab062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/g3journal/jkab062","pdf_url":"https://academic.oup.com/g3journal/article-pdf/11/4/jkab062/37082782/jkab062.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8174433570","display_name":"The genetic and physiological architecture of rapid and cyclic adaptation","funder_award_id":"R35GM119686","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133631674.pdf","grobid_xml":"https://content.openalex.org/works/W3133631674.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1511128892","https://openalex.org/W1577451703","https://openalex.org/W1636567173","https://openalex.org/W1771507701","https://openalex.org/W1816932740","https://openalex.org/W1817243811","https://openalex.org/W1864923122","https://openalex.org/W1964558095","https://openalex.org/W1970726947","https://openalex.org/W1974956115","https://openalex.org/W1976604752","https://openalex.org/W1978124765","https://openalex.org/W2000186580","https://openalex.org/W2002014416","https://openalex.org/W2004882302","https://openalex.org/W2006617902","https://openalex.org/W2008063826","https://openalex.org/W2009144436","https://openalex.org/W2009588715","https://openalex.org/W2040912377","https://openalex.org/W2041959263","https://openalex.org/W2044712627","https://openalex.org/W2067620870","https://openalex.org/W2078823676","https://openalex.org/W2079418384","https://openalex.org/W2090075367","https://openalex.org/W2094248448","https://openalex.org/W2097600042","https://openalex.org/W2100294575","https://openalex.org/W2102214912","https://openalex.org/W2102907886","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2108830997","https://openalex.org/W2112551996","https://openalex.org/W2113244577","https://openalex.org/W2117925179","https://openalex.org/W2118165948","https://openalex.org/W2118299921","https://openalex.org/W2118308505","https://openalex.org/W2119180969","https://openalex.org/W2120029762","https://openalex.org/W2123159591","https://openalex.org/W2127298691","https://openalex.org/W2128711701","https://openalex.org/W2130365449","https://openalex.org/W2134036574","https://openalex.org/W2136367805","https://openalex.org/W2136678168","https://openalex.org/W2138098072","https://openalex.org/W2149992227","https://openalex.org/W2156685906","https://openalex.org/W2163285329","https://openalex.org/W2166879882","https://openalex.org/W2167315684","https://openalex.org/W2233072870","https://openalex.org/W2238851414","https://openalex.org/W2322536880","https://openalex.org/W2474836229","https://openalex.org/W2540136877","https://openalex.org/W2573031217","https://openalex.org/W2587454003","https://openalex.org/W2610718786","https://openalex.org/W2612591211","https://openalex.org/W2748316994","https://openalex.org/W2766485915","https://openalex.org/W2802784998","https://openalex.org/W2807773783","https://openalex.org/W2883011667","https://openalex.org/W2913216229","https://openalex.org/W2952499863","https://openalex.org/W3009501570","https://openalex.org/W3102206080","https://openalex.org/W4237269866","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W4213221736","https://openalex.org/W2097066870","https://openalex.org/W2130062599","https://openalex.org/W2068714781","https://openalex.org/W2111741198","https://openalex.org/W2586661380","https://openalex.org/W7135096590","https://openalex.org/W2792428198","https://openalex.org/W1975921811","https://openalex.org/W4416392655"],"abstract_inverted_index":{"Genetic":[0,159],"association":[1],"studies":[2],"seek":[3],"to":[4,78,103,108],"uncover":[5],"the":[6,57,91,109,120,157,171,180,221,224,247,250],"link":[7],"between":[8],"genotype":[9],"and":[10,12,42,118,173,189,201,216,229],"phenotype,":[11],"often":[13],"utilize":[14],"inbred":[15,26,51,81,105,183,186,232],"reference":[16,27,52],"panels":[17,28,53,211],"as":[18,162,164,253],"a":[19,46,72,127,194,254],"replicable":[20],"source":[21],"of":[22,40,60,80,111,175,196,223,249,257],"genetic":[23,58,154,202,259],"variation.":[24],"However,":[25],"can":[29],"differ":[30],"substantially":[31],"from":[32,135,145,156,166],"wild":[33],"populations":[34,143,192],"in":[35,63,140,213],"their":[36,214],"genotypic":[37],"distribution,":[38],"patterns":[39],"linkage-disequilibrium,":[41],"nucleotide":[43],"diversity.":[44],"As":[45],"result,":[47],"associations":[48],"discovered":[49],"using":[50,153,179],"may":[54],"not":[55,238],"reflect":[56],"basis":[59],"phenotypic":[61],"variation":[62,155,165],"natural":[64],"populations.":[65],"To":[66,114],"address":[67],"this":[68],"problem,":[69],"we":[70,89,125],"evaluated":[71],"mapping":[73,210],"population":[74],"design":[75],"where":[76],"dozens":[77],"hundreds":[79],"lines":[82,106,187,233],"are":[83],"outbred":[84,191],"for":[85,234,239],"few":[86],"generations,":[87],"which":[88],"call":[90],"Hybrid":[92,95,121,141,181,227,251],"Swarm.":[93],"The":[94,226],"Swarm":[96,122,142,252],"approach":[97,123],"has":[98],"likely":[99],"remained":[100],"underutilized":[101],"relative":[102],"pre-sequenced":[104],"due":[107],"costs":[110,117],"genome-wide":[112],"genotyping.":[113],"reduce":[115],"sequencing":[116],"make":[119],"feasible,":[124],"developed":[126],"computational":[128],"pipeline":[129],"that":[130,207],"reconstructs":[131],"accurate":[132],"whole":[133],"genomes":[134],"ultra-low-coverage":[136],"(0.05X)":[137],"sequence":[138],"data":[139],"derived":[144],"ancestors":[146],"with":[147],"phased":[148],"haplotypes.":[149],"We":[150,169],"evaluate":[151],"reconstructions":[152],"Drosophila":[158],"Reference":[160],"Panel":[161],"well":[163],"neutral":[167],"simulations.":[168],"compared":[170],"power":[172,215],"precision":[174],"Genome-Wide":[176],"Association":[177],"Studies":[178],"Swarm,":[182],"lines,":[184],"recombinant":[185],"(RILs),":[188],"highly":[190],"across":[193],"range":[195],"allele":[197],"frequencies,":[198],"effect":[199],"sizes,":[200],"architectures.":[203],"Our":[204],"simulations":[205],"show":[206],"these":[208],"different":[209],"vary":[212],"precision,":[217],"largely":[218],"depending":[219],"on":[220],"architecture":[222],"trait.":[225],"Swam":[228],"RILs":[230],"outperform":[231],"quantitative":[235],"traits,":[236],"but":[237],"monogenic":[240],"ones.":[241],"Taken":[242],"together,":[243],"our":[244],"results":[245],"demonstrate":[246],"feasibility":[248],"cost-effective":[255],"method":[256],"fine-scale":[258],"mapping.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}