{"id":"https://openalex.org/W3133627818","doi":null,"title":"Glycomic and proteomic studies of colorectal cancer","display_name":"Glycomic and proteomic studies of colorectal cancer","publication_year":2021,"publication_date":"2021-01-18","ids":{"openalex":"https://openalex.org/W3133627818","mag":"3133627818"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/324801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/324801","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/324801","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084039109","display_name":"Matilda Holm","orcid":"https://orcid.org/0000-0001-8453-3936","observed_orcids":["https://orcid.org/0000-0001-8453-3936"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Holm, Matilda","raw_affiliation_strings":["Doctoral Programme in Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Programme in Biomedicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084039109"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycomics","display_name":"glycomics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.5059999823570251},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7559999823570251},{"id":"https://openalex.org/keywords/glycan-profiling","display_name":"glycan profiling","score":0.4429999887943268},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.40700000524520874},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.35499998927116394},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.8709999918937683},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.717966616153717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48328807950019836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45623162388801575},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3802846372127533},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3395869731903076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26719802618026733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24847650527954102}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/324801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/324801","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/324801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/324801","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W1182461782","https://openalex.org/W1480141401","https://openalex.org/W1536690700","https://openalex.org/W1548511028","https://openalex.org/W1578083272","https://openalex.org/W1663153674","https://openalex.org/W1677573439","https://openalex.org/W1759644316","https://openalex.org/W1830146239","https://openalex.org/W1859037964","https://openalex.org/W1934094702","https://openalex.org/W1968592882","https://openalex.org/W1974120002","https://openalex.org/W1974728334","https://openalex.org/W1975340808","https://openalex.org/W1976080134","https://openalex.org/W1982772252","https://openalex.org/W1983532504","https://openalex.org/W1984328540","https://openalex.org/W1986887325","https://openalex.org/W1988755416","https://openalex.org/W1991434242","https://openalex.org/W1999775778","https://openalex.org/W2000435171","https://openalex.org/W2001258296","https://openalex.org/W2002963962","https://openalex.org/W2004102690","https://openalex.org/W2005049215","https://openalex.org/W2005948867","https://openalex.org/W2009117616","https://openalex.org/W2009781085","https://openalex.org/W2010174939","https://openalex.org/W2013180631","https://openalex.org/W2015336843","https://openalex.org/W2023258833","https://openalex.org/W2023807377","https://openalex.org/W2029348349","https://openalex.org/W2031079181","https://openalex.org/W2031598261","https://openalex.org/W2033005195","https://openalex.org/W2037876225","https://openalex.org/W2038993108","https://openalex.org/W2039220388","https://openalex.org/W2046673558","https://openalex.org/W2048359072","https://openalex.org/W2049198730","https://openalex.org/W2051609814","https://openalex.org/W2052257846","https://openalex.org/W2052496581","https://openalex.org/W2059529313","https://openalex.org/W2061181901","https://openalex.org/W2063243157","https://openalex.org/W2066138347","https://openalex.org/W2068382972","https://openalex.org/W2069305509","https://openalex.org/W2072671787","https://openalex.org/W2073292063","https://openalex.org/W2074768718","https://openalex.org/W2079080809","https://openalex.org/W2079167500","https://openalex.org/W2079628081","https://openalex.org/W2081277484","https://openalex.org/W2083900941","https://openalex.org/W2085718801","https://openalex.org/W2088479878","https://openalex.org/W2089686959","https://openalex.org/W2093930900","https://openalex.org/W2094229819","https://openalex.org/W2094390470","https://openalex.org/W2097786984","https://openalex.org/W2099628919","https://openalex.org/W2100370963","https://openalex.org/W2101666723","https://openalex.org/W2101815035","https://openalex.org/W2102719470","https://openalex.org/W2103502575","https://openalex.org/W2105915644","https://openalex.org/W2106489008","https://openalex.org/W2106789440","https://openalex.org/W2109737505","https://openalex.org/W2109740395","https://openalex.org/W2110065044","https://openalex.org/W2117838569","https://openalex.org/W2118210036","https://openalex.org/W2119580931","https://openalex.org/W2120293016","https://openalex.org/W2122694766","https://openalex.org/W2123636561","https://openalex.org/W2124886112","https://openalex.org/W2125452425","https://openalex.org/W2126415088","https://openalex.org/W2126945850","https://openalex.org/W2128146359","https://openalex.org/W2130078150","https://openalex.org/W2130742597","https://openalex.org/W2131760952","https://openalex.org/W2132565869","https://openalex.org/W2137723853","https://openalex.org/W2147923982","https://openalex.org/W2150780222","https://openalex.org/W2152106804","https://openalex.org/W2152205589","https://openalex.org/W2155311724","https://openalex.org/W2155915495","https://openalex.org/W2157769714","https://openalex.org/W2158307919","https://openalex.org/W2160061952","https://openalex.org/W2160433176","https://openalex.org/W2160759097","https://openalex.org/W2164837623","https://openalex.org/W2165208590","https://openalex.org/W2165606389","https://openalex.org/W2166401510","https://openalex.org/W2166982925","https://openalex.org/W2168193025","https://openalex.org/W2168680994","https://openalex.org/W2169258800","https://openalex.org/W2185223750","https://openalex.org/W2223464287","https://openalex.org/W2266012197","https://openalex.org/W2268148666","https://openalex.org/W2270126973","https://openalex.org/W2291402311","https://openalex.org/W2291806982","https://openalex.org/W2302003756","https://openalex.org/W2319179997","https://openalex.org/W2363537531","https://openalex.org/W2502347551","https://openalex.org/W2506104246","https://openalex.org/W2516486789","https://openalex.org/W2531319683","https://openalex.org/W2535115137","https://openalex.org/W2543412381","https://openalex.org/W2561259078","https://openalex.org/W2569086487","https://openalex.org/W2586403573","https://openalex.org/W2598363796","https://openalex.org/W2605964154","https://openalex.org/W2616335683","https://openalex.org/W2620163964","https://openalex.org/W2624883208","https://openalex.org/W2766046358","https://openalex.org/W2766182477","https://openalex.org/W2771952185","https://openalex.org/W2793725491","https://openalex.org/W2794889098","https://openalex.org/W2794961243","https://openalex.org/W2795004907","https://openalex.org/W2796242903","https://openalex.org/W2797272414","https://openalex.org/W2803327664","https://openalex.org/W2803889339","https://openalex.org/W2807784181","https://openalex.org/W2809895957","https://openalex.org/W2866490332","https://openalex.org/W2884004932","https://openalex.org/W2889522041","https://openalex.org/W2889646458","https://openalex.org/W2902642730","https://openalex.org/W2903169604","https://openalex.org/W2950199735","https://openalex.org/W2951438828","https://openalex.org/W2969090057","https://openalex.org/W3030505384","https://openalex.org/W4251700885"],"related_works":["https://openalex.org/W1949270717","https://openalex.org/W2523343093","https://openalex.org/W2190722838","https://openalex.org/W2984892387","https://openalex.org/W3178658331","https://openalex.org/W7098163298","https://openalex.org/W2890711961","https://openalex.org/W2589803447","https://openalex.org/W6946104550","https://openalex.org/W4399862242"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,8,17,25,29,105,115,382,475,483,632,647],"(CRC)":[2],"is":[3,20,40,45,137,167,198,660],"the":[4,15,35,60,75,128,157,175,181,187,191,194,203,222,237,334,370,384,408,486,553,583,595,620,668],"third":[5],"most":[6],"common":[7],"worldwide,":[9],"accounting":[10],"for":[11,59,171,212,537,565,645],"around":[12,41],"10%":[13],"of":[14,28,62,70,77,114,126,147,153,177,183,193,220,224,233,242,357,410,438,452,488,506,522,546,580,597,643,656,670],"global":[16],"burden,":[18],"and":[19,79,97,106,120,150,186,205,215,226,239,252,263,273,277,292,327,339,366,386,400,417,433,448,498,527,552,574,586,600,611,630,673],"second":[21],"only":[22,371],"to":[23,140,174,201,209,216,396,443,513,531,559,619,627,665],"lung":[24],"in":[26,90,100,111,131,156,207,250,348,374,383,407,458,516,594],"terms":[27],"death.":[30],"For":[31],"patients":[32,307,380,472,480],"with":[33,244,381,473,481],"CRC,":[34],"overall":[36],"5-year":[37],"survival":[38,535,563],"rate":[39],"65%,":[42],"although":[43],"it":[44,179,189,623],"highly":[46],"dependent":[47],"on":[48,247,256,466,485,604,678],"stage":[49,364,431,446,538,566],"at":[50,311,582],"diagnosis.":[51],"Biomarkers":[52],"are":[53,83,102,108,159,686],"molecules":[54],"that":[55,85,588,622,640],"can":[56,591],"be":[57,592,625,642],"used":[58,200],"detection":[61],"a":[63,132,168,245],"disease,":[64],"follow-up":[65],"after":[66],"radical":[67],"surgery,":[68],"monitoring":[69],"progression,":[71],"detecting":[72],"or":[73,135,683],"assessing":[74],"risk":[76],"recurrence,":[78],"predicting":[80,646],"prognosis.":[81],"Glycans":[82,266],"carbohydrates":[84],"play":[86],"important":[87,626],"physiological":[88],"roles":[89],"processes":[91],"such":[92,116,142,258,524,606],"as":[93,117,143,259,525,607,633],"cell":[94],"signaling,":[95],"growth,":[96],"motility.":[98],"Changes":[99,155],"glycans":[101,107,225,411,599,672],"seen":[103,161,351,390,406,593],"during":[104,162,229],"directly":[109],"involved":[110],"different":[112,361],"aspects":[113],"proliferation,":[118],"invasion,":[119],"metastasis.":[121],"The":[122,164,231,315,345,436],"proteome,":[123],"which":[124,358,507],"consists":[125],"all":[127],"proteins":[129,178,227,423,440,503,523,602,639,675],"expressed":[130],"cell,":[133],"tissue,":[134],"organism,":[136],"dynamic":[138],"due":[139,173],"factors":[141,257,605],"posttranslational":[144],"modifications,":[145],"regulation":[146],"gene":[148],"expression,":[149],"differential":[151],"splicing":[152],"mRNAs.":[154],"proteome":[158,166,206],"also":[160,463,687],"cancer.":[163,230],"plasma":[165,288,422,459,489,502,520,544,601,638,674],"good":[169],"candidate":[170],"studies":[172,576,664],"multitude":[176],"contains,":[180],"ease":[182],"obtaining":[184],"samples,":[185],"way":[188],"reflects":[190],"condition":[192],"host.":[195],"Mass":[196,300],"spectrometry":[197],"often":[199],"study":[202,235],"glycome":[204],"order":[208],"discover":[210],"candidates":[211],"new":[213,218,578],"biomarkers":[214],"obtain":[217],"knowledge":[219,579],"how":[221],"levels":[223,254,350,362,376,409,427,437,461,509,521,545,596,669],"change":[228],"aim":[232],"this":[234],"was":[236],"glycomic":[238,573],"proteomic":[240,575],"profiling":[241],"CRC":[243,270,450,540,568,581,679],"focus":[246],"studying":[248],"differences":[249,347,373,404,457,515,590],"glycan":[251,349,375],"protein":[253,460,490,550,556],"depending":[255,465,603,677],"tumor":[260,398,418,454,468,608,681],"location,":[261,610,682],"stage,":[262,609,680],"patient":[264,612,651,684],"outcome.":[265,518,613],"were":[267,290,304,317,352,389,393,405,424,441,462,504,510,529,557,653],"isolated":[268],"from":[269,306,379,471,477,479],"tissue":[271,276,419],"samples":[272,289,303,378,392,478],"healthy":[274,415],"colonic":[275],"analyzed":[278,293,318,493],"using":[279,294,319,494],"matrix-assisted":[280],"laser":[281],"desorption/ionization":[282],"time-of-flight":[283],"mass":[284],"spectrometry.":[285],"Separately,":[286],"preoperative":[287],"processed":[291],"Ultra":[295],"Performance":[296],"Liquid":[297],"Chromatography-Ultra":[298],"Definition":[299],"Spectrometry.":[301],"All":[302],"obtained":[305],"who":[308],"underwent":[309],"surgery":[310],"Helsinki":[312],"University":[313],"Hospital.":[314],"results":[316,615],"methods":[320],"including":[321],"principal":[322,495],"component":[323,496],"analysis,":[324,333],"Mann-Whitney":[325],"U":[326],"ANOVA":[328],"tests,":[329,338],"hierarchical":[330,499],"clustering,":[331],"pathway":[332],"Kaplan-Meier":[335],"method,":[336],"log-rank":[337],"Cox":[340],"proportional":[341],"hazards":[342],"regression":[343],"analysis.":[344],"main":[346],"between":[353,363,377,414,430,445],"acidic":[354],"glycans,":[355],"several":[356],"had":[359],"significantly":[360,429,532,560],"II":[365,432,447,539],"III":[367,434,449,567],"CRC.":[368,435],"Surprisingly,":[369],"significant":[372,403,514,589],"right":[385],"left":[387],"colon":[388,416,482,629],"when":[391,412,492],"divided":[394],"according":[395],"both":[397],"location":[399],"stage.":[401],"Many":[402],"compared":[413],"samples.":[420],"Multiple":[421],"identified":[425,505],"whose":[426],"differed":[428],"13":[439],"found":[442],"differ":[444,676],"regardless":[451],"primary":[453,467],"location.":[455,469],"Significant":[456],"observed":[464],"Samples":[470],"rectal":[474,631],"separated":[476],"solely":[484],"basis":[487],"expression":[491],"analysis":[497],"clustering.":[500],"Several":[501],"altered":[508],"independently":[511],"linked":[512,530,558],"long-term":[517,534,562],"Higher":[519],"ceruloplasmin":[526],"fetuin-B":[528],"improved":[533],"rates":[536,564],"patients,":[541],"while":[542],"higher":[543],"signal-induced":[547],"proliferation-associated":[548],"1-like":[549],"1":[551],"CNK3/IPCEF1":[554],"fusion":[555],"poorer":[561],"patients.":[569],"In":[570],"conclusion,":[571],"these":[572],"provide":[577],"molecular":[584],"level":[585],"show":[587],"specific":[598],"These":[614],"lend":[616],"further":[617],"support":[618],"notion":[621],"may":[624],"consider":[628],"separate":[634],"entities.":[635],"While":[636],"multiple":[637],"could":[641],"value":[644],"progression":[648],"and,":[649],"separately,":[650],"outcome":[652,685],"identified,":[654],"validation":[655],"their":[657],"clinical":[658],"utility":[659],"still":[661],"needed.":[662],"Further":[663],"investigate":[666],"why":[667],"certain":[671],"warranted.":[688]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2021-03-15T00:00:00"}
