{"id":"https://openalex.org/W3133621131","doi":"https://doi.org/10.1038/s41598-021-84980-6","title":"Presence of tophi is associated with a rapid decline in the renal function in patients with gout","display_name":"Presence of tophi is associated with a rapid decline in the renal function in patients with gout","publication_year":2021,"publication_date":"2021-03-11","ids":{"openalex":"https://openalex.org/W3133621131","doi":"https://doi.org/10.1038/s41598-021-84980-6","mag":"3133621131","pmid":"https://pubmed.ncbi.nlm.nih.gov/33707563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7952381"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-84980-6","doi":"https://doi.org/10.1038/s41598-021-84980-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-84980-6","pdf_url":"https://www.nature.com/articles/s41598-021-84980-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-84980-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050047468","display_name":"Yoon-Jeong Oh","orcid":"https://orcid.org/0000-0003-1028-3481","observed_orcids":["https://orcid.org/0000-0003-1028-3481"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon-Jeong Oh","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065072134","display_name":"Ki Won Moon","orcid":"https://orcid.org/0000-0002-4182-8328","observed_orcids":["https://orcid.org/0000-0002-4182-8328"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ki Won Moon","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea. kiwonmoon@kangwon.ac.kr","Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea. kiwonmoon@kangwon.ac.kr","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065072134"],"corresponding_institution_ids":["https://openalex.org/I165507594"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":2.3466,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88361679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"5684","last_page":"5684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tophi","display_name":"tophi","score":0.984000027179718},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.906000018119812},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7360000014305115},{"id":"https://openalex.org/keywords/symptom-duration","display_name":"symptom duration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/multiple-joint-involvement","display_name":"multiple joint involvement","score":0.878000020980835},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/renal-function-monitoring","display_name":"renal function monitoring","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.9236806631088257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8612650632858276},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7292340397834778},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5254406332969666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46236518025398254},{"id":"https://openalex.org/C2780932893","wikidata":"https://www.wikidata.org/wiki/Q417296","display_name":"Febuxostat","level":4,"score":0.4107235074043274},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35655802488327026},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.2908201515674591},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.25160855054855347}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-021-84980-6","doi":"https://doi.org/10.1038/s41598-021-84980-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-84980-6","pdf_url":"https://www.nature.com/articles/s41598-021-84980-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:33707563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33707563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7952381","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7952381/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a9bad1185850440aa48cd512da8c8013","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a9bad1185850440aa48cd512da8c8013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-84980-6","doi":"https://doi.org/10.1038/s41598-021-84980-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-84980-6","pdf_url":"https://www.nature.com/articles/s41598-021-84980-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133621131.pdf","grobid_xml":"https://content.openalex.org/works/W3133621131.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W333202898","https://openalex.org/W787482168","https://openalex.org/W1966018233","https://openalex.org/W1976375861","https://openalex.org/W2007866008","https://openalex.org/W2055864845","https://openalex.org/W2113141019","https://openalex.org/W2136764746","https://openalex.org/W2137356391","https://openalex.org/W2139805665","https://openalex.org/W2147575954","https://openalex.org/W2163515440","https://openalex.org/W2170246607","https://openalex.org/W2217064679","https://openalex.org/W2313390241","https://openalex.org/W2414233082","https://openalex.org/W2461076353","https://openalex.org/W2500180409","https://openalex.org/W2607903621","https://openalex.org/W2625875004","https://openalex.org/W2768126653","https://openalex.org/W2773337571","https://openalex.org/W2792755412","https://openalex.org/W2998339629","https://openalex.org/W3014625294","https://openalex.org/W3022656983","https://openalex.org/W4248403572"],"related_works":["https://openalex.org/W3165566504","https://openalex.org/W2613501220","https://openalex.org/W2313390241","https://openalex.org/W1983840601","https://openalex.org/W3006586708","https://openalex.org/W7119524841","https://openalex.org/W1976375861","https://openalex.org/W7056374350","https://openalex.org/W4386844292","https://openalex.org/W1601636943"],"abstract_inverted_index":{"Abstract":[0],"We":[1,65],"aimed":[2],"to":[3,57],"compare":[4],"clinical":[5,67],"characteristics":[6,68],"of":[7,16,19,25,60,72,101,127,129,164,187,204],"patients":[8,34,140,212],"with":[9,39,86,124,141,169,191,213],"and":[10,21,27,69,97,117,201],"without":[11,107,146],"tophi":[12,26,61,142,165,188],"at":[13,41,62],"the":[14,17,23,42,58,63,70,76,134,174,185],"time":[15],"diagnosis":[18,200],"gout":[20,31,40,211],"investigate":[22],"association":[24],"renal":[28,73,195,205],"function":[29,206],"in":[30,133,139,144,173,210],"patients.":[32],"The":[33,131,162],"who":[35],"were":[36,47,51,121],"first":[37],"diagnosed":[38],"Kangwon":[43],"National":[44],"University":[45],"Hospital":[46],"retrospectively":[48],"studied.":[49],"Patients":[50],"divided":[52],"into":[53],"2":[54],"groups":[55],"according":[56],"presence":[59,163,186],"diagnosis.":[64],"compared":[66],"progression":[71],"dysfunction":[74],"between":[75],"two":[77],"groups.":[78],"Of":[79],"276":[80],"patients,":[81],"66":[82],"(25.5%)":[83],"initially":[84],"presented":[85],"tophi.":[87,108,130,214],"Tophi":[88],"group":[89],"was":[90,136,166,189],"older,":[91],"had":[92],"a":[93,98,170,192],"longer":[94],"symptom":[95,115],"duration,":[96],"higher":[99],"prevalence":[100],"multiple":[102,118],"joint":[103,119],"involvement":[104,120],"than":[105,143],"those":[106,145],"In":[109,183],"multivariate":[110],"logistic":[111],"regression":[112],"analysis,":[113],"prolonged":[114],"duration":[116],"significantly":[122,167],"associated":[123,168,190],"increased":[125],"risk":[126],"formation":[128],"decline":[132,172],"eGFR":[135,175],"more":[137],"prominent":[138],"(\u2212":[147],"4.8":[148],"\u00b1":[149,154],"14.5":[150],"vs.":[151],"\u2212":[152,178],"0.7":[153],"11.9":[155],"ml/min/1.73":[156],"m2/year,":[157],"respectively;":[158],"P":[159,180],"=":[160,177,181],"0.039).":[161],"rapid":[171,193],"(\u03b2":[176],"0.136;":[179],"0.042).":[182],"conclusion,":[184],"declining":[194],"function.":[196],"Therefore,":[197],"an":[198],"early":[199],"closely":[202],"monitoring":[203],"might":[207],"be":[208],"important":[209]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}