{"id":"https://openalex.org/W3133613713","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1709.1709","title":"Immunoglobulin Heavy Chain Variable Region (IgHV) Unmutated, but Not Mutated, Chronic Lymphocytic Leukemia (CLL) Arises in a CD34+ Progenitor","display_name":"Immunoglobulin Heavy Chain Variable Region (IgHV) Unmutated, but Not Mutated, Chronic Lymphocytic Leukemia (CLL) Arises in a CD34+ Progenitor","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W3133613713","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1709.1709","mag":"3133613713"},"language":"en","primary_location":{"id":"mag:3133613713","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1709.1709","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/1709/79689/Immunoglobulin-Heavy-Chain-Variable-Region-IgHV","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040915445","display_name":"Brandy N. Perkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandy Perkins","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091275921","display_name":"Margaret M. Showel","orcid":"https://orcid.org/0000-0002-2112-8842","observed_orcids":["https://orcid.org/0000-0002-2112-8842"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M. Showel","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":"https://orcid.org/0000-0002-2112-8842","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005953560","display_name":"Laura Schoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Schoch","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009906581","display_name":"Philip Hollingsworth Imus","orcid":"https://orcid.org/0000-0001-8563-195X","observed_orcids":["https://orcid.org/0000-0001-8563-195X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Imus","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069374229","display_name":"Gabriel Ghiaur","orcid":"https://orcid.org/0000-0002-3955-7944","observed_orcids":["https://orcid.org/0000-0002-3955-7944"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Ghiaur","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":"https://orcid.org/0000-0002-3955-7944","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002822530","display_name":"Douglas Edward Gladstone","orcid":"https://orcid.org/0000-0001-8484-2990","observed_orcids":["https://orcid.org/0000-0001-8484-2990"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas E. Gladstone","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":"https://orcid.org/0000-0001-8484-2990","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036664711","display_name":"Richard John Jones","orcid":"https://orcid.org/0000-0002-2946-1164","observed_orcids":["https://orcid.org/0000-0002-2946-1164"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Jones","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD"],"raw_orcid":"https://orcid.org/0000-0002-2946-1164","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33300473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":null,"first_page":"1709","last_page":"1709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/unmutated-ighv","display_name":"unmutated IGHV","score":0.9160000085830688},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/del-13q","display_name":"del(13q)","score":0.7009999752044678},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.953000009059906},{"id":"https://openalex.org/keywords/del-11q","display_name":"del(11q)","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6299999952316284},{"id":"https://openalex.org/keywords/clonal-origin","display_name":"clonal origin","score":0.41499999165534973},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.9688762426376343},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6876944899559021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6575064063072205},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5239027738571167},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5231952667236328},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4609428644180298},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.45305365324020386},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.41079622507095337},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3514425754547119},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3499326705932617},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3181943893432617},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2903687655925751},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.28660640120506287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19199606776237488},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.16030040383338928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15115511417388916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3133613713","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1709.1709","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/1709/79689/Immunoglobulin-Heavy-Chain-Variable-Region-IgHV","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220954928","https://openalex.org/W2601274063","https://openalex.org/W3216978767","https://openalex.org/W2536242793","https://openalex.org/W2639428001","https://openalex.org/W2061658385","https://openalex.org/W1933022516","https://openalex.org/W2084467040","https://openalex.org/W2949696951","https://openalex.org/W2558062410"],"abstract_inverted_index":{"Abstract":[0],"Background:":[3],"It":[4],"is":[5,10,417],"now":[6],"clear":[7],"that":[8,38,333,373,412],"CLL":[9,60,83,100,124,131,142,349,365,403,416],"a":[11,43,90,110,227,380,419],"heterogeneous":[12],"disease":[13],"with":[14,62,75,84,120,127,216,245,253,264,267,270,273,277,322,351,367],"varied":[15],"prognoses.":[16,81],"Cytogenetics":[17],"and":[18,35,58,125,163,178,181,190,275,324],"IgHV":[19,39,64,77,86,98,123,130,218,247,326,375,402],"mutational":[20,40,376],"status":[21,41,377],"are":[22],"2":[23,221,250,286,385],"of":[24,56,135,207,230,239,258,314,348,355,390,398,415,470],"the":[25,51,133,139,156,197,259,306,315,337,345,374,423],"most":[26],"important":[27],"prognostic":[28],"variables.":[29],"Recent":[30],"data":[31,371],"from":[32,89,155,422],"our":[33],"group":[34],"others":[36],"suggest":[37,372],"has":[42],"greater":[44],"impact":[45],"on":[46],"prognosis":[47],"than":[48],"cytogenetics;":[49],"accordingly,":[50],"small":[52,228],"fraction":[53],"(about":[54,71],"25%)":[55],"del(17p)":[57],"del(11q)":[59],"patients":[61,74,119,215,244,252,263,288,321,350,366],"mutated":[63,85,122,217,368],"have":[65,78],"relatively":[66,79],"favorable":[67],"prognoses,":[68],"while":[69],"those":[70,320],"30%)":[72],"del(13q)":[73,323],"unmutated":[76,99,129,246,287,325,352,401],"unfavorable":[80],"Although":[82],"should":[87],"arise":[88,102],"post-germinal":[91],"center":[92],"B":[93,106],"cell,":[94],"we":[95],"studied":[96,117],"whether":[97],"could":[101,210,359],"as":[103,109],"early":[104],"in":[105,147,214,242,312,319,344,364,400,405],"cell":[107,397],"differentiation":[108],"CD34+CD19+":[111,136,182,208,291,299,316,334],"cell.":[112],"Methodology:":[114],"We":[115,331,358],"prospectively":[116],"20":[118],"overt":[121,128],"31":[126],"for":[132,176,196,303],"presence":[134],"cells":[137,152,169,183,209,241,281,292,300,335,363],"harboring":[138,336],"specific":[140,195],"patient's":[141,198],"cytogenetic":[143,200,260,339,356],"abnormality":[144,261,309,340],"by":[145,160,173],"fluorescence":[146],"situ":[148],"hybridization":[149],"(FISH).":[150],"CD34+":[151,240,280],"were":[153,170,186,282,301],"isolated":[154,168,302],"patients'":[157],"peripheral":[158],"blood":[159],"magnetic":[161],"bead":[162],"column":[164],"(Miltenyi":[165],"Biotec).":[166],"The":[167,285,395],"then":[171],"analyzed":[172],"flow":[174],"cytometry":[175],"CD34":[177],"CD19":[179],"expression,":[180],"(if":[184],"present)":[185],"sorted":[187],"onto":[188],"slides":[189],"FISH":[191,304],"performed":[192],"using":[193],"probes":[194],"known":[199],"abnormality.":[201,357],"Results:":[203],"Essentially":[204],"no":[205],"population":[206,238],"be":[211,342],"detected":[212,311],"circulating":[213,231],"(Figure":[219,248,327],"1,":[220],"representative":[222,251],"patients).":[223],"However,":[224],"there":[225],"was":[226,310],"(0.32%":[229],"cells,":[232,317],"range":[233],"0.15-1.5%),":[234],"but":[235],"easily":[236],"detectable,":[237],"29/31":[243],"2,":[249],"sorting":[254],"gates":[255],"shown)":[256],"regardless":[257,354],"[9":[262],"+12,":[265],"7":[266],"del(13q),":[268],"6":[269],"del(17p),":[271],"5":[272],"del(11q),":[274],"4":[276],"other).":[278],"These":[279,370],"exclusively":[283],"CD19+.":[284],"without":[289],"detectable":[290],"both":[293,389],"harbored":[294],"+12":[295],"abnormalities.":[296],"When":[297],"enough":[298],"analysis,":[305],"CLL-specific":[307,338],"chromosomal":[308],"99+1%":[313],"including":[318],"2A).":[328],"Conclusion:":[330],"show":[332],"can":[341],"found":[343],"vast":[346],"majorith":[347],"IgVH,":[353],"not":[360],"detect":[361],"these":[362],"IgHV.":[369],"may":[378,404],"provide":[379],"glimpse":[381],"into":[382],"at":[383],"least":[384],"biologically":[386],"distinct":[387],"diseases,":[388],"them":[391],"currently":[392],"called":[393],"CLL.":[394],"primitive":[396],"origin":[399],"part":[406],"explain":[407],"its":[408],"poorer":[409],"prognosis,and":[410],"suggests":[411],"this":[413],"form":[414],"indeed":[418],"leukemia,":[420],"arising":[421],"bone":[424],"marrow.":[425],"Download":[435,438,448,451],":":[436,449],"high-res":[439],"image":[440,453],"(247KB)":[441],"full-size":[452],"Disclosures":[465],"No":[467],"relevant":[468],"conflicts":[469],"interest":[471],"to":[472],"declare.":[473]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2021-03-15T00:00:00"}
