{"id":"https://openalex.org/W3133601933","doi":"https://doi.org/10.2147/ijn.s298900","title":"New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2","display_name":"New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3133601933","doi":"https://doi.org/10.2147/ijn.s298900","mag":"3133601933","pmid":"https://pubmed.ncbi.nlm.nih.gov/33688191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7936690"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s298900","doi":"https://doi.org/10.2147/ijn.s298900","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s298900","pdf_url":"https://www.dovepress.com/article/download/62648","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/62648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096938327","display_name":"Soad A. Mohamad","orcid":"https://orcid.org/0000-0002-5668-7898","observed_orcids":["https://orcid.org/0000-0002-5668-7898"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Soad A Mohamad","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-5668-7898","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068729724","display_name":"Eman Maher Zahran","orcid":"https://orcid.org/0000-0002-5517-082X","observed_orcids":["https://orcid.org/0000-0002-5517-082X"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Eman Maher Zahran","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-5517-082X","affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089931479","display_name":"Maha Raafat Abd El Fadeel","orcid":"https://orcid.org/0000-0002-7457-5005","observed_orcids":["https://orcid.org/0000-0002-7457-5005"]},"institutions":[{"id":"https://openalex.org/I4210108518","display_name":"Veterinary Serum and Vaccine Research Institute","ror":"https://ror.org/02jg20617","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210108518"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Maha Raafat Abdel Fadeel","raw_affiliation_strings":["Veterinary Serum and Vaccine Research Institute (VSVRI), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Serum and Vaccine Research Institute (VSVRI), Cairo, Egypt","institution_ids":["https://openalex.org/I4210108518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029330727","display_name":"Amgad Albohy","orcid":"https://orcid.org/0000-0003-3021-8767","observed_orcids":["https://orcid.org/0000-0003-3021-8767"]},"institutions":[{"id":"https://openalex.org/I154023281","display_name":"British University in Egypt","ror":"https://ror.org/0066fxv63","country_code":"EG","type":"education","lineage":["https://openalex.org/I154023281"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amgad Albohy","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, 1837, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, 1837, Egypt","institution_ids":["https://openalex.org/I154023281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087332307","display_name":"Mohamed A. Safwat","orcid":"https://orcid.org/0000-0002-0512-7479","observed_orcids":["https://orcid.org/0000-0002-0512-7479"]},"institutions":[{"id":"https://openalex.org/I189575948","display_name":"South Valley University","ror":"https://ror.org/00jxshx33","country_code":"EG","type":"education","lineage":["https://openalex.org/I189575948"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed A Safwat","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, 83523, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-0512-7479","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, 83523, Egypt","institution_ids":["https://openalex.org/I189575948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068729724"],"corresponding_institution_ids":["https://openalex.org/I4401727001"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.1313,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71316405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"Volume 16","issue":null,"first_page":"1789","last_page":"1804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-assembled-nanofibers","display_name":"self-assembled nanofibers","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bovine-coronavirus","display_name":"bovine coronavirus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mpro-inhibitors","display_name":"Mpro inhibitors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.800000011920929},{"id":"https://openalex.org/keywords/core-shell-nanofibers","display_name":"core-shell nanofibers","score":0.9139999747276306},{"id":"https://openalex.org/keywords/biodegradable-nanofibers","display_name":"biodegradable nanofibers","score":0.9020000100135803},{"id":"https://openalex.org/keywords/herbal-drug-delivery","display_name":"herbal drug delivery","score":0.5830000042915344},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5062026381492615},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.4821621775627136},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.41680383682250977},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40430325269699097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2451157569885254},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017938","descriptor_name":"Coronavirus, Bovine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s298900","doi":"https://doi.org/10.2147/ijn.s298900","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s298900","pdf_url":"https://www.dovepress.com/article/download/62648","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:33688191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33688191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7936690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7936690/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:edf8dea044cc40d099f62171e8aff482","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/edf8dea044cc40d099f62171e8aff482","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 16, Pp 1789-1804 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/62648","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/new-acaciin-loaded-self-assembled-nanofibers-as-mpro-inhibitors-agains-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s298900","doi":"https://doi.org/10.2147/ijn.s298900","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s298900","pdf_url":"https://www.dovepress.com/article/download/62648","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133601933.pdf","grobid_xml":"https://content.openalex.org/works/W3133601933.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1590784435","https://openalex.org/W1592150026","https://openalex.org/W1970193304","https://openalex.org/W1971679225","https://openalex.org/W1974338066","https://openalex.org/W1975535872","https://openalex.org/W1976499904","https://openalex.org/W1979208912","https://openalex.org/W1996031729","https://openalex.org/W2005081670","https://openalex.org/W2029222418","https://openalex.org/W2034635647","https://openalex.org/W2037636933","https://openalex.org/W2038783912","https://openalex.org/W2068467434","https://openalex.org/W2069206672","https://openalex.org/W2074473216","https://openalex.org/W2075936548","https://openalex.org/W2085911180","https://openalex.org/W2086130473","https://openalex.org/W2091742793","https://openalex.org/W2095969440","https://openalex.org/W2098880422","https://openalex.org/W2132052735","https://openalex.org/W2138867398","https://openalex.org/W2142961138","https://openalex.org/W2151344009","https://openalex.org/W2157365560","https://openalex.org/W2170232520","https://openalex.org/W2415040854","https://openalex.org/W2432199735","https://openalex.org/W2581870981","https://openalex.org/W2592312478","https://openalex.org/W2593436234","https://openalex.org/W2604751640","https://openalex.org/W2762306080","https://openalex.org/W2918756535","https://openalex.org/W2933160061","https://openalex.org/W2936612757","https://openalex.org/W2954297401","https://openalex.org/W2964367200","https://openalex.org/W2971996283","https://openalex.org/W2972546838","https://openalex.org/W2985346127","https://openalex.org/W2988568862","https://openalex.org/W3000927371","https://openalex.org/W3002764058","https://openalex.org/W3004061780","https://openalex.org/W3011701533","https://openalex.org/W3013602382","https://openalex.org/W3013800395","https://openalex.org/W3014067025","https://openalex.org/W3015313862","https://openalex.org/W3015608194","https://openalex.org/W3015959833","https://openalex.org/W3020654962","https://openalex.org/W3033660780","https://openalex.org/W3037820956","https://openalex.org/W3045339903","https://openalex.org/W3092886840","https://openalex.org/W3095472005","https://openalex.org/W3106543642","https://openalex.org/W3107293957","https://openalex.org/W4252629618"],"related_works":["https://openalex.org/W4409067447","https://openalex.org/W4368359960","https://openalex.org/W4387026187","https://openalex.org/W4406563971","https://openalex.org/W7024730617","https://openalex.org/W4213164523","https://openalex.org/W4285086240","https://openalex.org/W4398146673","https://openalex.org/W4365149448","https://openalex.org/W4296132261"],"abstract_inverted_index":{"Background:":[0],"SARS-COVID-2":[1],"has":[2],"recently":[3],"been":[4],"one":[5],"of":[6,20,78,89,102,154,171,179,188,205,227,229],"the":[7,32,66,79,87,90,100,103,172,203,209,225,233],"most":[8],"life-threatening":[9],"problems":[10],"which":[11,105,135],"urgently":[12],"needs":[13],"new":[14,33],"therapeutic":[15],"antiviral":[16,42,109,169],"agents,":[17],"especially":[18],"those":[19],"herbal":[21,230],"origin.":[22],"Purpose:":[23],"The":[24,168,195],"study":[25,69],"aimed":[26],"to":[27,98,164],"load":[28],"acaciin":[29],"(ACA)":[30],"into":[31],"self-assembled":[34],"nanofibers":[35],"(NFs)":[36],"followed":[37,107],"by":[38,108],"investigating":[39],"their":[40],"possible":[41],"effect":[43],"against":[44,111,191,235],"bovine":[45],"coronavirus":[46],"(BCV)":[47],"as":[48,113,115],"a":[49,76,147,160,176,198],"surrogate":[50],"model":[51],"for":[52,86,202,211,224,232],"SARS-COV-2.":[53],"Methods:":[54],"ACA":[55],"was":[56,70,84],"identified":[57],"using":[58,72,118],"1":[59,157],"H-NMR":[60],"and":[61,75,146,159],"DEPT-Q":[62],"13":[63],"C-NMR":[64],"spectroscopy,":[65],"molecular":[67,240],"docking":[68],"performed":[71],"Autodock":[73],"4":[74],"modification":[77],"traditional":[80],"solvent":[81],"injection":[82],"method":[83],"applied":[85],"synthesis":[88,204],"biodegradable":[91,206],"NFs.":[92],"Different":[93],"characterization":[94],"techniques":[95],"were":[96,133],"used":[97],"inspect":[99],"formation":[101],"NFs,":[104,123],"is":[106],"investigation":[110,170],"BCV":[112,192],"well":[114],"MTT":[116],"assay":[117],"MDBK":[119],"cells.":[120,193],"Results:":[121],"Core/shell":[122],"ranging":[124],"between":[125],"80\u2013":[126],"330":[127],"nm":[128],"with":[129,185],"tiny":[130],"thorn-like":[131],"branches,":[132],"formed":[134,173],"attained":[136],"an":[137,221],"enhanced":[138],"encapsulation":[139],"efficiency":[140],"(97.5":[141],"\u00b1":[142,181],"0.53%,":[143],"P<":[144],"0.05)":[145,184],"dual":[148],"controlled":[149],"release":[150,153,162],"(a":[151],"burst":[152],"65%":[155],"at":[156],"h":[158],"sustained":[161],"up":[163],">":[165],"24":[166],"h).":[167],"NFs":[174,207],"revealed":[175],"significant":[177],"inhibition":[178],"98.88":[180],"0.16%":[182],"(P<":[183],"IC":[186],"50":[187],"12.6":[189],"\u03bcM":[190],"Conclusion:":[194],"results":[196],"introduced":[197],"new,":[199],"time/cost-saving":[200],"strategy":[201],"without":[208],"need":[210],"electric":[212],"current":[213],"or":[214],"hazardous":[215],"cross-linking":[216],"agents.":[217],"Moreover,":[218],"it":[219],"provided":[220],"innovative":[222],"avenue":[223],"discovery":[226],"drugs":[228],"origin":[231],"fight":[234],"SARS-CoV-2":[236],"infection.":[237],"Keywords:":[238],"acaciin,":[239],"docking,":[241],"nanofibers,":[242],"core-shell,":[243],"BCV/SARS-COV-2":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}