{"id":"https://openalex.org/W3133593799","doi":"https://doi.org/10.3390/ijms22052587","title":"NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR","display_name":"NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR","publication_year":2021,"publication_date":"2021-03-04","ids":{"openalex":"https://openalex.org/W3133593799","doi":"https://doi.org/10.3390/ijms22052587","mag":"3133593799","pmid":"https://pubmed.ncbi.nlm.nih.gov/33806698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7961436"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22052587","doi":"https://doi.org/10.3390/ijms22052587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052587","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2587/pdf?version=1615429970","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/5/2587/pdf?version=1615429970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064546936","display_name":"Do Hyeong Gwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do Hyeong Gwon","raw_affiliation_strings":["Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065743065","display_name":"Song I Kim","orcid":"https://orcid.org/0000-0002-4046-1755","observed_orcids":["https://orcid.org/0000-0002-4046-1755"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Song I. Kim","raw_affiliation_strings":["Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074125082","display_name":"Seoung Hun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seoung Hun Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022338342","display_name":"Chan Noh","orcid":"https://orcid.org/0000-0003-4904-148X","observed_orcids":["https://orcid.org/0000-0003-4904-148X"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chan Noh","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033899231","display_name":"Yeojung Kim","orcid":"https://orcid.org/0000-0002-2079-670X","observed_orcids":["https://orcid.org/0000-0002-2079-670X"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeojung Kim","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2079-670X","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054010038","display_name":"Sangwon Yun","orcid":"https://orcid.org/0000-0001-8233-4167","observed_orcids":["https://orcid.org/0000-0001-8233-4167"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangwon Yun","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102932693","display_name":"Won Hyung Lee","orcid":"https://orcid.org/0000-0002-1964-7141","observed_orcids":["https://orcid.org/0000-0002-1964-7141"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Hyung Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101451130","display_name":"Jun Young Oh","orcid":"https://orcid.org/0000-0003-3018-8246","observed_orcids":["https://orcid.org/0000-0003-3018-8246"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Young Oh","raw_affiliation_strings":["Department of Neuroscience and Physiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100756654","display_name":"Dong Woon Kim","orcid":"https://orcid.org/0000-0001-7691-1394","observed_orcids":["https://orcid.org/0000-0001-7691-1394"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Woon Kim","raw_affiliation_strings":["Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7691-1394","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Brain Research Institute, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068968670","display_name":"Jinpyo Hong","orcid":"https://orcid.org/0000-0002-4776-4396","observed_orcids":["https://orcid.org/0000-0002-4776-4396"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinpyo Hong","raw_affiliation_strings":["Department of Neuroscience and Physiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4776-4396","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034226548","display_name":"Sun Yeul Lee","orcid":"https://orcid.org/0000-0002-6124-5138","observed_orcids":["https://orcid.org/0000-0002-6124-5138"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sun Yeul Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6124-5138","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Korea","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034226548","https://openalex.org/A5068968670"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I196345858"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":2.9812,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91299567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"2587","last_page":"2587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nfat5","display_name":"NFAT5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9480000138282776},{"id":"https://openalex.org/keywords/formalin-induced-pain","display_name":"formalin-induced pain","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9089999794960022},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9309999942779541},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nmda-receptor-nr2b","display_name":"NMDA receptor NR2B","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5618339776992798},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.5411171317100525},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5173048973083496},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5155398845672607},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5154781937599182},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5052433609962463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.477560818195343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4444948434829712},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4308459758758545},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4307508170604706},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.427558958530426},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4251047670841217},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4150409996509552},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.3798736333847046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3694177269935608},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3329116404056549},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30373039841651917},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28847357630729675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2457457184791565},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12858882546424866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08575999736785889},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08231392502784729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms22052587","doi":"https://doi.org/10.3390/ijms22052587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052587","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2587/pdf?version=1615429970","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7961436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7961436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33806698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33806698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6f195fe6cc304d4a817b805823e446ad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f195fe6cc304d4a817b805823e446ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 2587, p 2587 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms22052587","doi":"https://doi.org/10.3390/ijms22052587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052587","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2587/pdf?version=1615429970","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G143171714","display_name":null,"funder_award_id":"2020R1C1C1005423","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3131957966","display_name":null,"funder_award_id":"2018-CF-019","funder_id":"https://openalex.org/F4320324569","funder_display_name":"Chungnam National University Hospital"},{"id":"https://openalex.org/G4056807778","display_name":null,"funder_award_id":"NRF-2020R1C1C1005423, 2020R1I1A1A01060928","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5414892815","display_name":null,"funder_award_id":"NRF-2020R1C1C1005423","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7380657235","display_name":null,"funder_award_id":"2020R1I1A1A01060928","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321204","display_name":"Chungnam National University","ror":"https://ror.org/0227as991"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320324569","display_name":"Chungnam National University Hospital","ror":"https://ror.org/04353mq94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133593799.pdf","grobid_xml":"https://content.openalex.org/works/W3133593799.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1509128008","https://openalex.org/W1853688909","https://openalex.org/W1921204327","https://openalex.org/W1966462399","https://openalex.org/W1967825747","https://openalex.org/W1968766082","https://openalex.org/W1969384722","https://openalex.org/W1977434574","https://openalex.org/W1983881747","https://openalex.org/W1987223426","https://openalex.org/W1990065094","https://openalex.org/W1999177020","https://openalex.org/W2001026574","https://openalex.org/W2001933690","https://openalex.org/W2009345240","https://openalex.org/W2018907902","https://openalex.org/W2028930604","https://openalex.org/W2033149248","https://openalex.org/W2039246411","https://openalex.org/W2062997380","https://openalex.org/W2080918508","https://openalex.org/W2102247629","https://openalex.org/W2111444310","https://openalex.org/W2129175496","https://openalex.org/W2129585918","https://openalex.org/W2129713711","https://openalex.org/W2130347002","https://openalex.org/W2136485117","https://openalex.org/W2166086438","https://openalex.org/W2167028704","https://openalex.org/W2511279127","https://openalex.org/W2587283693","https://openalex.org/W2598879240","https://openalex.org/W2602225041","https://openalex.org/W2620636282","https://openalex.org/W2620930308","https://openalex.org/W2744677152","https://openalex.org/W2784089299","https://openalex.org/W2874520653","https://openalex.org/W2884825035","https://openalex.org/W2898626730","https://openalex.org/W2900885865","https://openalex.org/W2903610594","https://openalex.org/W2914689409","https://openalex.org/W2924715631","https://openalex.org/W2961789225","https://openalex.org/W2968897954","https://openalex.org/W2973090875","https://openalex.org/W3029606718","https://openalex.org/W3043718387","https://openalex.org/W6735344869","https://openalex.org/W6742479822"],"related_works":["https://openalex.org/W2562350627","https://openalex.org/W2030667469","https://openalex.org/W4411506175","https://openalex.org/W2059103635","https://openalex.org/W7112361347","https://openalex.org/W2384039834","https://openalex.org/W2089550185","https://openalex.org/W2022872200","https://openalex.org/W2601808922","https://openalex.org/W1966035504"],"abstract_inverted_index":{"Nuclear":[0],"factor":[1,11],"of":[2,16,25,37,54,62,119,144,196,219],"activated":[3],"T":[4],"cells":[5,168],"(NFAT5)":[6],"is":[7,211],"a":[8,212],"well-known":[9],"transcription":[10],"that":[12,184],"regulates":[13],"the":[14,23,35,58,78,116,140,217],"expression":[15,117,199],"genes":[17],"involved":[18],"in":[19,27,39,89,139,152,164,176,205],"osmotic":[20],"stress.":[21],"However,":[22,98],"role":[24],"NFAT5":[26,38,185,210],"inflammatory":[28,40,48,190,220],"pain":[29,41,66,90,109,191],"remains":[30],"unknown.":[31],"Here,":[32],"we":[33,50],"studied":[34],"function":[36],"using":[42],"NFAT5-heterozygous":[43],"(Het)":[44],"mice.":[45,97,114,154],"To":[46],"study":[47],"pain,":[49],"injected":[51],"10":[52],"\u00b5L":[53],"2%":[55],"formalin":[56],"into":[57],"right":[59],"hind":[60],"paws":[61],"mice":[63,105,147],"and":[64,72,95,129,158,200],"monitored":[65],"behaviors,":[67],"such":[68],"as":[69],"licking,":[70],"lifting,":[71],"flinching,":[73],"for":[74,216],"60":[75],"min.":[76],"After":[77],"first":[79],"15":[80],"min":[81,101],"(phase":[82,102],"I),":[83],"there":[84],"were":[85,136,161,170],"no":[86],"significant":[87],"differences":[88],"behaviors":[91,110],"between":[92],"wild-type":[93],"(WT)":[94],"NFAT5-Het":[96,104,153],"from":[99],"15\u201360":[100],"II),":[103],"displayed":[106],"significantly":[107,137,162],"fewer":[108],"compared":[111],"to":[112],"WT":[113,146],"Further,":[115],"levels":[118,160],"inflammatory-pain-related":[120],"factors,":[121],"including":[122],"c-Fos,":[123,156],"phosphorylated":[124,130],"extracellular":[125],"signal-regulated":[126],"kinase":[127],"(p-ERK),":[128],"n-methyl-D-aspartate":[131],"receptor":[132],"subunit":[133],"2B":[134],"(p-NR2B),":[135],"elevated":[138,151],"spinal":[141,206],"dorsal":[142,207],"neurons":[143],"formalin-treated":[145],"but":[148,169],"was":[149],"not":[150,171],"Similarly,":[155],"p-ERK,":[157],"p-NR2B":[159],"higher":[163],"glutamate-treated":[165,177],"PC12":[166,178],"neuronal":[167],"affected":[172],"by":[173,192],"Nfat5":[174],"silencing":[175],"cells.":[179],"Altogether,":[180],"our":[181],"findings":[182],"suggest":[183],"deficiency":[186],"may":[187],"mitigate":[188],"formalin-induced":[189],"upregulating":[193],"mammalian":[194],"target":[195,215],"rapamycin":[197],"(mTOR)":[198],"downregulating":[201],"its":[202],"downstream":[203],"factors":[204],"neurons.":[208],"Therefore,":[209],"potential":[213],"therapeutic":[214],"treatment":[218],"pain.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}
