{"id":"https://openalex.org/W3133592515","doi":"https://doi.org/10.1111/jre.12861","title":"Salivary levels of last generation specific pro\u2010resolving lipid mediators (SPMs) (protectin and maresin) in patients with cardiovascular and periodontal disease: A case\u2010control study","display_name":"Salivary levels of last generation specific pro\u2010resolving lipid mediators (SPMs) (protectin and maresin) in patients with cardiovascular and periodontal disease: A case\u2010control study","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3133592515","doi":"https://doi.org/10.1111/jre.12861","mag":"3133592515","pmid":"https://pubmed.ncbi.nlm.nih.gov/33650687"},"language":"en","primary_location":{"id":"doi:10.1111/jre.12861","doi":"https://doi.org/10.1111/jre.12861","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12861","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077330869","display_name":"Mehmet Artu\u011f \u00d6nal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Artu\u011f \u00d6nal","raw_affiliation_strings":["Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042088618","display_name":"\u00d6zlem Fento\u011flu","orcid":"https://orcid.org/0000-0003-2138-2004","observed_orcids":["https://orcid.org/0000-0003-2138-2004"]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"\u00d6zlem Fento\u011flu","raw_affiliation_strings":["Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":"https://orcid.org/0000-0003-2138-2004","affiliations":[{"raw_affiliation_string":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071022890","display_name":"Fatih Aksoy","orcid":"https://orcid.org/0000-0002-6480-4935","observed_orcids":["https://orcid.org/0000-0002-6480-4935","https://orcid.org/0000-0001-6749-4293"]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Aksoy","raw_affiliation_strings":["Department of Cardiology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072413498","display_name":"Mustafa Calapo\u011flu","orcid":"https://orcid.org/0000-0002-9567-7270","observed_orcids":["https://orcid.org/0000-0002-9567-7270"]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Calapo\u011flu","raw_affiliation_strings":["Department of Biochemistry Faculty of Science S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry Faculty of Science S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068648298","display_name":"Ercan Varol","orcid":"https://orcid.org/0000-0003-3460-6011","observed_orcids":["https://orcid.org/0000-0003-3460-6011"]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ercan Varol","raw_affiliation_strings":["Department of Cardiology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004131742","display_name":"Hikmet Orhan","orcid":"https://orcid.org/0000-0002-8389-1069","observed_orcids":["https://orcid.org/0000-0002-8389-1069"]},"institutions":[{"id":"https://openalex.org/I175124709","display_name":"S\u00fcleyman Demirel \u00dcniversitesi","ror":"https://ror.org/04fjtte88","country_code":"TR","type":"education","lineage":["https://openalex.org/I175124709"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hikmet Orhan","raw_affiliation_strings":["Department of Biostatistics and Medical Informatics Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey","institution_ids":["https://openalex.org/I175124709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042088618"],"corresponding_institution_ids":["https://openalex.org/I175124709"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":1.4194,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.770769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"56","issue":"3","first_page":"606","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protectins","display_name":"protectins","score":0.925000011920929},{"id":"https://openalex.org/keywords/maresins","display_name":"maresins","score":0.9929999709129333},{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.8679999709129333},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/host-modulation","display_name":"host modulation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7254087328910828},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.70389324426651},{"id":"https://openalex.org/C2780791200","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingivitis","level":2,"score":0.6938127875328064},{"id":"https://openalex.org/C2777968807","wikidata":"https://www.wikidata.org/wiki/Q4925923","display_name":"Bleeding on probing","level":3,"score":0.6228998303413391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6024394035339355},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5520973205566406},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.5279756188392639},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.4997103214263916},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45056644082069397},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4494650959968567},{"id":"https://openalex.org/C2778883934","wikidata":"https://www.wikidata.org/wiki/Q4692285","display_name":"Aggressive periodontitis","level":3,"score":0.4341529607772827},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.17903563380241394},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010510","descriptor_name":"Periodontal Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018957","descriptor_name":"CD59 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jre.12861","doi":"https://doi.org/10.1111/jre.12861","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12861","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:33650687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33650687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W74748164","https://openalex.org/W1275357281","https://openalex.org/W1512020104","https://openalex.org/W1820232851","https://openalex.org/W1836603403","https://openalex.org/W1852829898","https://openalex.org/W1879067085","https://openalex.org/W1938135874","https://openalex.org/W1967215547","https://openalex.org/W1967303282","https://openalex.org/W1971402418","https://openalex.org/W1974809253","https://openalex.org/W1986490257","https://openalex.org/W1987431872","https://openalex.org/W1994080141","https://openalex.org/W1994111233","https://openalex.org/W1997881172","https://openalex.org/W2006787294","https://openalex.org/W2008019870","https://openalex.org/W2021792184","https://openalex.org/W2037503835","https://openalex.org/W2047362520","https://openalex.org/W2049424212","https://openalex.org/W2057389581","https://openalex.org/W2063532716","https://openalex.org/W2065302528","https://openalex.org/W2083277816","https://openalex.org/W2090380630","https://openalex.org/W2093614380","https://openalex.org/W2096895770","https://openalex.org/W2099005050","https://openalex.org/W2101513524","https://openalex.org/W2101955146","https://openalex.org/W2107228383","https://openalex.org/W2108659216","https://openalex.org/W2112089166","https://openalex.org/W2131343690","https://openalex.org/W2151840463","https://openalex.org/W2154748957","https://openalex.org/W2157369877","https://openalex.org/W2162204819","https://openalex.org/W2165030669","https://openalex.org/W2165433466","https://openalex.org/W2170616879","https://openalex.org/W2176662908","https://openalex.org/W2196101891","https://openalex.org/W2214439439","https://openalex.org/W2230089242","https://openalex.org/W2338843516","https://openalex.org/W2476322086","https://openalex.org/W2512116430","https://openalex.org/W2558749882","https://openalex.org/W2591152589","https://openalex.org/W2612065901","https://openalex.org/W2767475267","https://openalex.org/W2808996141","https://openalex.org/W2818923169","https://openalex.org/W2869439706","https://openalex.org/W2888146508","https://openalex.org/W2898752447","https://openalex.org/W2937056199","https://openalex.org/W2937943000","https://openalex.org/W2962847594","https://openalex.org/W2995429038","https://openalex.org/W4230233764","https://openalex.org/W4236950366","https://openalex.org/W6684270761","https://openalex.org/W6761719643","https://openalex.org/W7073873518"],"related_works":["https://openalex.org/W2962847594","https://openalex.org/W4385513834","https://openalex.org/W2186941956","https://openalex.org/W2991080568","https://openalex.org/W4415382009","https://openalex.org/W4401158025","https://openalex.org/W2102027550","https://openalex.org/W1503561402","https://openalex.org/W2999953066","https://openalex.org/W4391880204"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,103],"OBJECTIVE:":[2],"Periodontal":[3],"disease":[4,7,251,303],"and":[5,41,55,67,82,93,99,116,131,141,183,198,240,249,257,269,284,304,318,323,342],"cardiovascular":[6],"(CVD),":[8],"which":[9],"are":[10,18,72],"both":[11,321],"deemed":[12],"to":[13,87,286],"be":[14,276],"triggered":[15],"by":[16,145,332],"inflammation,":[17],"recognized":[19],"as":[20,52,156],"public":[21,329],"health":[22,330],"problems.":[23],"Evidence":[24],"of":[25,91,107,111,139,150,238,244,293,296,310,320,336,338],"host":[26,312],"modulation":[27,313],"via":[28,65],"pro-resolving":[29],"lipid":[30,48],"shown":[31],"in":[32,78,95,224,231,247,263,298,315],"previous":[33],"studies":[34],"supports":[35],"a":[36,211,281],"two-way":[37],"relationship":[38,300],"between":[39,301],"periodontitis":[40,160],"CVD.":[42],"Last":[43],"generation":[44],"endogenous":[45],"specific":[46],"pro-resolution":[47],"mediators":[49],"(SPMs)":[50],"such":[51],"protectins":[53],"(PDs)":[54],"maresins":[56],"(MaRs)":[57],"may":[58,259,324],"have":[59],"potential":[60],"effects":[61],"on":[62,75],"inflammatory":[63],"pathogenesis":[64,264],"activation":[66],"resolution":[68],"mechanisms.":[69],"Currently,":[70],"there":[71],"no":[73],"data":[74],"SPM":[76],"levels":[77,90,138,187,237],"patients":[79,96,118,339],"with":[80,97,119,164,266,340],"CVD":[81,98,121,165,248,305,341],"periodontal":[83,100,133,148,172,250,270,302,343],"disease.":[84,101,344],"We":[85],"aimed":[86],"evaluate":[88],"salivary":[89,127,178,185,236],"PD":[92,140,179,220,239],"MaR":[94,142,186,228,241],"MATERIALS":[102],"METHODS:":[104],"At":[105],"total":[106,126],"181":[108],"individuals":[109],"comprising":[110],"79":[112],"healthy":[113,282],"controls":[114],"(C)":[115],"102":[117],"diagnosed":[120],"were":[122,129,135,143,202,242],"included":[123],"cross-sectionally.":[124],"Unstimulated":[125],"samples":[128],"obtained,":[130],"clinical":[132,171],"parameters":[134,173],"determined.":[136],"Salivary":[137],"evaluated":[144],"ELISA.":[146],"The":[147,207,235],"status":[149],"the":[151,192,219,225,232,294,299,308,316,334],"study":[152],"population":[153],"was":[154,222,229],"classified":[155],"gingivitis":[157],"(g)":[158],"or":[159],"(p).":[161],"RESULTS:":[162],"Patients":[163],"showed":[166],"lower":[167],"sociodemographic":[168],"characteristics,":[169],"increased":[170,184],"(p":[174,180,188,204,215,252],"<":[175,181,205,216],".05),":[176],"decreased":[177],".001),":[182],">":[189,253],".05).":[190,206,217,254],"In":[191],"CVDg":[193],"group,":[194,227],"leukocyte,":[195],"hemoglobin,":[196],"hematocrit,":[197],"high-density":[199],"lipoprotein":[200],"values":[201],"higher":[203,212],"CVDp":[208,233],"group":[209],"had":[210],"neutrophil-to-lymphocyte":[213],"ratio":[214],"While":[218],"level":[221],"highest":[223,230],"Cg":[226],"group.":[234],"independent":[243],"other":[245],"confounders":[246],"CONCLUSION(S):":[255],"PDs":[256],"MaRs":[258],"play":[260],"effective":[261],"roles":[262],"associated":[265],"worsening":[267],"cardiometabolic":[268],"status.":[271],"These":[272],"SPMs":[273,297],"could":[274],"also":[275,325],"predictors":[277],"for":[278],"conversion":[279],"from":[280],"(systemically":[283],"periodontally)":[285],"diseased":[287],"state":[288],"(CVD":[289],"and/or":[290],"periodontitis).":[291],"Elucidation":[292],"role":[295],"will":[306],"enable":[307],"development":[309],"new":[311],"strategies":[314],"prevention":[317],"treatment":[319],"diseases,":[322],"constitute":[326],"an":[327],"important":[328],"step":[331],"increasing":[333],"quality":[335],"life":[337]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}
