{"id":"https://openalex.org/W3133589290","doi":"https://doi.org/10.1002/1873-3468.14065","title":"PARP1\u2013RNA interaction analysis: PARP1 regulates the expression of extracellular matrix\u2010related genes in HK\u20102 renal proximal tubular epithelial cells","display_name":"PARP1\u2013RNA interaction analysis: PARP1 regulates the expression of extracellular matrix\u2010related genes in HK\u20102 renal proximal tubular epithelial cells","publication_year":2021,"publication_date":"2021-02-28","ids":{"openalex":"https://openalex.org/W3133589290","doi":"https://doi.org/10.1002/1873-3468.14065","mag":"3133589290","pmid":"https://pubmed.ncbi.nlm.nih.gov/33641169"},"language":"en","primary_location":{"id":"doi:10.1002/1873-3468.14065","doi":"https://doi.org/10.1002/1873-3468.14065","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14065","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14065","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14065","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029359431","display_name":"Jing Ke","orcid":"https://orcid.org/0000-0001-8042-277X","observed_orcids":["https://orcid.org/0000-0001-8042-277X"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Ke","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":"https://orcid.org/0000-0001-8042-277X","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415323","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0003-1270-4585","observed_orcids":["https://orcid.org/0000-0003-1270-4585"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Liu","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113798931","display_name":"Yafang Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yafang Tu","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059934886","display_name":"Zhitao Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhitao Cai","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110701375","display_name":"Yu Luo","orcid":"https://orcid.org/0000-0003-2473-4933","observed_orcids":["https://orcid.org/0000-0003-2473-4933"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Luo","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101638710","display_name":"Xiongfei Wu","orcid":"https://orcid.org/0000-0002-0291-1620","observed_orcids":["https://orcid.org/0000-0002-0291-1620"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiongfei Wu","raw_affiliation_strings":["Department of Nephrology, Renmin Hospital of Wuhan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Renmin Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101638710"],"corresponding_institution_ids":["https://openalex.org/I4210140357"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":1.0511,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7381402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"595","issue":"9","first_page":"1375","last_page":"1387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9449999928474426},{"id":"https://openalex.org/keywords/extracellular-matrix-genes","display_name":"extracellular matrix genes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.875},{"id":"https://openalex.org/keywords/renal-proximal-tubular-epithelial-cells","display_name":"renal proximal tubular epithelial cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.48500001430511475},{"id":"https://openalex.org/keywords/tubular-cell-injury","display_name":"tubular cell injury","score":0.8289999961853027},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7370452880859375},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.6574939489364624},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6134699583053589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5994017720222473},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.552356481552124},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5375605821609497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5254297256469727},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49754098057746887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4958523213863373},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47269299626350403},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42588385939598083},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.35957014560699463},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.24491849541664124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22412142157554626}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1873-3468.14065","doi":"https://doi.org/10.1002/1873-3468.14065","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14065","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14065","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:33641169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33641169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1873-3468.14065","doi":"https://doi.org/10.1002/1873-3468.14065","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14065","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14065","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6248538032","display_name":"\u03b1\u03b2TCR+CD4-CD8- T\u6dcb\u5df4\u7ec6\u80de\u5728ConA\u8bf1\u5bfc\u7684\u514d\u75ab\u6027\u809d\u635f\u4f24\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u673a\u5236\u7814\u7a76","funder_award_id":"81570510","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133589290.pdf","grobid_xml":"https://content.openalex.org/works/W3133589290.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2021632347","https://openalex.org/W2053205462","https://openalex.org/W2058953427","https://openalex.org/W2061595278","https://openalex.org/W2063614307","https://openalex.org/W2070104321","https://openalex.org/W2133141667","https://openalex.org/W2144244630","https://openalex.org/W2147647489","https://openalex.org/W2166025982","https://openalex.org/W2410839893","https://openalex.org/W2471383130","https://openalex.org/W2510959831","https://openalex.org/W2593505005","https://openalex.org/W2732346161","https://openalex.org/W2744461100","https://openalex.org/W2768346406","https://openalex.org/W2777740229","https://openalex.org/W2809363852","https://openalex.org/W2904460723","https://openalex.org/W2916530639","https://openalex.org/W2920047897","https://openalex.org/W2944182984","https://openalex.org/W2946132178","https://openalex.org/W2961690164","https://openalex.org/W2963279792","https://openalex.org/W2964054456","https://openalex.org/W3000075870","https://openalex.org/W3014677172","https://openalex.org/W3016077210","https://openalex.org/W3087340685"],"related_works":["https://openalex.org/W2768346406","https://openalex.org/W2734366421","https://openalex.org/W2887884892","https://openalex.org/W2510959831","https://openalex.org/W1537637917","https://openalex.org/W2922203618","https://openalex.org/W2159367613","https://openalex.org/W2054928279","https://openalex.org/W2024435063","https://openalex.org/W4397045737"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"suggest":[2],"that":[3,59,84,109],"Poly(ADP-ribose)":[4],"polymerase":[5],"1":[6],"(PARP1)":[7],"acts":[8],"as":[9,131],"an":[10,132],"RNA-binding":[11,31,133],"protein":[12,134],"in":[13,42,93,112,135],"a":[14,49],"majority":[15],"of":[16,26,39,67,98,118,129],"renal":[17,44],"diseases":[18],"with":[19],"tubular":[20,45],"cell":[21],"injury.":[22],"However,":[23],"detailed":[24],"knowledge":[25],"RNA":[27],"targets":[28],"and":[29,56,101],"the":[30,126],"regions":[32,58],"for":[33],"PARP1":[34,75,92,99,130],"is":[35,60],"unknown.":[36],"Herein,":[37],"mapping":[38],"iRIP-seq":[40,102],"reads":[41],"HK-2":[43,94,136],"epithelial":[46],"cells":[47],"showed":[48,83],"biased":[50],"distribution":[51],"at":[52],"coding":[53],"sequence":[54],"(CDS)":[55],"intron":[57],"specific":[61],"to":[62],"these":[63],"cells.":[64,95,137],"A":[65],"total":[66],"1708":[68],"differentially":[69],"expressed":[70],"genes":[71,108],"were":[72],"identified":[73],"after":[74],"knockdown":[76],"using":[77],"RNA-seq.":[78],"Furthermore,":[79],"transcriptome":[80],"analysis":[81],"also":[82],"selective":[85],"variable":[86],"splicing":[87],"was":[88],"globally":[89],"regulated":[90],"by":[91],"By":[96],"comparison":[97],"RNA-seq":[100],"data,":[103],"we":[104],"found":[105],"68":[106],"overlapping":[107],"are":[110],"enriched":[111],"'extracellular":[113],"matrix'":[114],"pathway.":[115],"Follow-up":[116],"identification":[117],"their":[119],"interactions":[120],"may":[121],"contribute":[122],"vital":[123],"insights":[124],"into":[125],"regulatory":[127],"role":[128]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}
