{"id":"https://openalex.org/W3133576252","doi":"https://doi.org/10.1002/cam4.3790","title":"Circulating tumor cells detected with a microcavity array predict clinical outcome in hepatocellular carcinoma","display_name":"Circulating tumor cells detected with a microcavity array predict clinical outcome in hepatocellular carcinoma","publication_year":2021,"publication_date":"2021-03-06","ids":{"openalex":"https://openalex.org/W3133576252","doi":"https://doi.org/10.1002/cam4.3790","mag":"3133576252","pmid":"https://pubmed.ncbi.nlm.nih.gov/33675149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7982624"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.3790","doi":"https://doi.org/10.1002/cam4.3790","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.3790","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/cam4.3790","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101635314","display_name":"Kazuto Takahashi","orcid":"https://orcid.org/0000-0003-4952-8714","observed_orcids":["https://orcid.org/0000-0003-4952-8714"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuto Takahashi","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4952-8714","affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086087223","display_name":"Kazuya Ofuji","orcid":"https://orcid.org/0000-0003-2284-9438","observed_orcids":["https://orcid.org/0000-0003-2284-9438"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Ofuji","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2284-9438","affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041933560","display_name":"Katsushi Hiramatsu","orcid":"https://orcid.org/0000-0003-1377-8455","observed_orcids":["https://orcid.org/0000-0003-1377-8455"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsushi Hiramatsu","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005459843","display_name":"Takuto Nosaka","orcid":"https://orcid.org/0000-0002-1929-7305","observed_orcids":["https://orcid.org/0000-0002-1929-7305"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuto Nosaka","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102875895","display_name":"Tatsushi Naito","orcid":"https://orcid.org/0000-0001-5472-8193","observed_orcids":["https://orcid.org/0000-0001-5472-8193"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsushi Naito","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082964115","display_name":"Hidetaka Matsuda","orcid":"https://orcid.org/0000-0002-0860-1199","observed_orcids":["https://orcid.org/0000-0002-0860-1199"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetaka Matsuda","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katsuya Endo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891902","display_name":"Showa Denko Materials Co., Ltd. (Japan)","ror":"https://ror.org/01vgenm18","country_code":"JP","type":"company","lineage":["https://openalex.org/I4388891786","https://openalex.org/I4388891902"]},{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Endo","raw_affiliation_strings":["Hitachi Chemical Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hitachi Chemical Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4388891902","https://openalex.org/I65143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113739608","display_name":"Masayuki Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891902","display_name":"Showa Denko Materials Co., Ltd. (Japan)","ror":"https://ror.org/01vgenm18","country_code":"JP","type":"company","lineage":["https://openalex.org/I4388891786","https://openalex.org/I4388891902"]},{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Higuchi","raw_affiliation_strings":["Hitachi Chemical Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hitachi Chemical Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4388891902","https://openalex.org/I65143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027737711","display_name":"Masahiro Ohtani","orcid":"https://orcid.org/0000-0003-2408-5785","observed_orcids":["https://orcid.org/0000-0003-2408-5785"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Ohtani","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036863217","display_name":"Tomoyuki Nemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Nemoto","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090827058","display_name":"Yasunari Nakamoto","orcid":"https://orcid.org/0000-0002-3160-3555","observed_orcids":["https://orcid.org/0000-0002-3160-3555"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasunari Nakamoto","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090827058"],"corresponding_institution_ids":["https://openalex.org/I111966504"],"apc_list":{"value":3025,"currency":"USD","value_usd":3025},"apc_paid":{"value":3025,"currency":"USD","value_usd":3025},"fwci":1.7618,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84020359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"10","issue":"7","first_page":"2300","last_page":"2309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.3061999976634979,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/microcavity-arrays","display_name":"microcavity arrays","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ctc-isolation","display_name":"CTC isolation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glypican-3","display_name":"glypican-3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.925000011920929},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.9354453086853027},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8806756138801575},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6038581728935242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5785934925079346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5115588307380676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5020949840545654},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4139374792575836},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34402668476104736},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33025431632995605},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.23678380250930786}],"mesh":[{"descriptor_ui":"D000071858","descriptor_name":"Epithelial Cell Adhesion Molecule","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053673","descriptor_name":"Glypicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.3790","doi":"https://doi.org/10.1002/cam4.3790","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.3790","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7982624","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7982624/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7982624/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmid:33675149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33675149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:92207f70ba1c47d49d09513917b72bc9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92207f70ba1c47d49d09513917b72bc9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 10, Iss 7, Pp 2300-2309 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.3790","doi":"https://doi.org/10.1002/cam4.3790","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.3790","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3119758272","display_name":"Identification of liver cancer stem cell-like clones causing treatment resistance by cancer evolution","funder_award_id":"19H03637","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8411994638","display_name":"Elucidation of eicosanoid-related tumor progression mechanism in hepatocellular carcinoma microenvironment and research on novel treatment","funder_award_id":"19K17456","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8679366870","display_name":"Development of circulating tumor cell detection system in hepatocellular carcinoma","funder_award_id":"18K15808","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133576252.pdf","grobid_xml":"https://content.openalex.org/works/W3133576252.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1973861476","https://openalex.org/W1981570415","https://openalex.org/W1986971722","https://openalex.org/W1993998781","https://openalex.org/W2029634531","https://openalex.org/W2048452946","https://openalex.org/W2057378223","https://openalex.org/W2072554662","https://openalex.org/W2076341209","https://openalex.org/W2094351112","https://openalex.org/W2106513086","https://openalex.org/W2118236274","https://openalex.org/W2163486683","https://openalex.org/W2164683872","https://openalex.org/W2170424652","https://openalex.org/W2170845559","https://openalex.org/W2344070586","https://openalex.org/W2564739330","https://openalex.org/W2572403213","https://openalex.org/W2706881084","https://openalex.org/W2736137548","https://openalex.org/W2760616636","https://openalex.org/W2809450446","https://openalex.org/W3092683882","https://openalex.org/W3127015740","https://openalex.org/W4211183069","https://openalex.org/W4250621294"],"related_works":["https://openalex.org/W2118236274","https://openalex.org/W4308195258","https://openalex.org/W2400416652","https://openalex.org/W4200395277","https://openalex.org/W2747334573","https://openalex.org/W2357937746","https://openalex.org/W4254055490","https://openalex.org/W2526783333","https://openalex.org/W3098089811","https://openalex.org/W2741288106"],"abstract_inverted_index":{"The":[0,93,138,154,177,192,218],"present":[1],"study":[2],"aimed":[3],"to":[4,22,226],"establish":[5],"a":[6,16,268],"novel":[7,269],"isolation":[8],"strategy":[9],"for":[10],"circulating":[11],"tumor":[12,49],"cells":[13,50],"(CTCs)":[14],"using":[15,75,91],"microcavity":[17],"array":[18],"(MCA)":[19],"system":[20,222],"and":[21,70,101,106,110,118,127,131,135,183,234],"evaluate":[23],"the":[24,76,82,112,199,224],"clinical":[25,249],"significance":[26],"of":[27,37,59,85,156,179,243,251,257],"CTCs":[28,90,157,194,228,245,258],"in":[29,45,88,142,149,161,168,189,202,210,259,271],"hepatocellular":[30],"carcinoma":[31],"(HCC).":[32],"We":[33],"examined":[34],"recovery":[35,94],"rates":[36,95],"HCC":[38,74,133,143,163,170,205,214,230,262],"cell":[39],"lines":[40],"spiked":[41],"into":[42],"whole":[43],"blood":[44,55],"MCA":[46,77,221],"assay.":[47],"Circulating":[48],"were":[51,96,122],"isolated":[52,89,190],"from":[53,229,240],"peripheral":[54],"samples":[56],"(3":[57],"mL)":[58],"7":[60],"healthy":[61],"donors":[62],"(HD),":[63],"14":[64],"patients":[65,72,107,203,212,252,260],"with":[66,73,108,204,213,231,253,261],"liver":[67],"cirrhosis":[68],"(LC),":[69],"31":[71],"system.":[78],"Additionally,":[79],"we":[80],"investigated":[81],"mRNA":[83,235],"expression":[84,178,236],"liver-specific":[86],"genes":[87,186],"qPCR.":[92],"65.1%":[97],"(HepG2),":[98],"76.7%":[99],"(HuH7),":[100],"99.0%":[102],"(PLC/PRF/5).":[103],"In":[104],"HD":[105,125],"LC":[109,129,150],"HCC,":[111],"CTC":[113,120,139],"positivity":[114,140],"rate":[115,141],"(CTCs":[116,195],"\u226510)":[117,196],"average":[119],"number":[121,155],"as":[123,267],"follows:":[124],"0%":[126],"0.1,":[128],"14.3%":[130],"5.3,":[132],"54.8%":[134],"47.6,":[136],"respectively.":[137],"was":[144,158,187],"significantly":[145,159,197],"higher":[146,160],"than":[147,167],"that":[148],"(p":[151,174,206,215],"<":[152,175],"0.05).":[153,176],"metastatic":[162],"(102.2":[164],"\u00b1":[165,172],"160.6)":[166],"localized":[169,211],"(8.2":[171],"7.7)":[173],"AFP,":[180],"glypican-3,":[181],"EpCAM,":[182],"albumin":[184],"(ALB)":[185],"detected":[188],"CTCs.":[191,241],"positive":[193,244],"reduced":[198],"cumulative":[200],"survival":[201],"=":[207,216],"0.025),":[208],"especially":[209],"0.046).":[217],"newly":[219],"developed":[220],"has":[223],"potential":[225],"isolate":[227],"high":[232],"sensitivity,":[233],"could":[237],"be":[238],"measured":[239],"Identification":[242],"can":[246],"help":[247],"predict":[248],"outcome":[250],"HCC.":[254],"Thus,":[255],"analysis":[256],"may":[263],"provide":[264],"important":[265],"information":[266],"biomarker":[270],"disease":[272],"progression.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-03-15T00:00:00"}
