{"id":"https://openalex.org/W3133554377","doi":"https://doi.org/10.26452/ijrps.v11ispl4.4288","title":"The medicinal plant Calpurnia aurea leaves act as an anti-inflammatory source of 5-Lipoxygenase / Cyclooxygenase-2 dual inhibitors","display_name":"The medicinal plant Calpurnia aurea leaves act as an anti-inflammatory source of 5-Lipoxygenase / Cyclooxygenase-2 dual inhibitors","publication_year":2020,"publication_date":"2020-12-21","ids":{"openalex":"https://openalex.org/W3133554377","doi":"https://doi.org/10.26452/ijrps.v11ispl4.4288","mag":"3133554377"},"language":"en","primary_location":{"id":"doi:10.26452/ijrps.v11ispl4.4288","doi":"https://doi.org/10.26452/ijrps.v11ispl4.4288","is_oa":true,"landing_page_url":"https://doi.org/10.26452/ijrps.v11ispl4.4288","pdf_url":null,"source":{"id":"https://openalex.org/S2764443815","display_name":"International Journal of Research in Pharmaceutical Sciences","issn_l":"0975-7538","issn":["0975-7538"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4323283528","host_organization_name":"Pharmascope Foundation","host_organization_lineage":["https://openalex.org/P4323283528"],"host_organization_lineage_names":["Pharmascope Foundation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.26452/ijrps.v11ispl4.4288","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063157040","display_name":"Tesfay Weletnsae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tesfay Weletnsae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015645041","display_name":"Tekleweyni Tadege","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tekleweyni Tadege","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018968656","display_name":"Kidu Hintsa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kidu Hintsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006494637","display_name":"Velliyur Kanniappan Gopalakrishnan","orcid":"https://orcid.org/0000-0002-2097-1424","observed_orcids":["https://orcid.org/0000-0002-2097-1424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gopalakrishnan V K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067168168","display_name":"Zenebe Hagos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zenebe Hagos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078847422","display_name":"Berihu Tekluu","orcid":"https://orcid.org/0000-0001-9976-7209","observed_orcids":["https://orcid.org/0000-0001-9976-7209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Berihu Tekluu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076260442","display_name":"K Kamalakararao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamalakararao K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018875916","display_name":"M. Muthulingam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muthulingam M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108651574","display_name":"Krishna Chaithanya K","orcid":"https://orcid.org/0000-0002-4650-1973","observed_orcids":["https://orcid.org/0000-0002-4650-1973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishna Chaithanya K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"SPL4","first_page":"1269","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calpurnia-aurea","display_name":"Calpurnia aurea","score":1.0},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6970000267028809},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/5-lipoxygenase-inhibition","display_name":"5-lipoxygenase inhibition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cyclooxygenase-1-inhibition","display_name":"cyclooxygenase-1 inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.7239999771118164},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.8830000162124634},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.531000018119812},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.7557130455970764},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7059752941131592},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5542188286781311},{"id":"https://openalex.org/C2776148806","wikidata":"https://www.wikidata.org/wiki/Q912189","display_name":"Petroleum ether","level":3,"score":0.5131705403327942},{"id":"https://openalex.org/C2781213060","wikidata":"https://www.wikidata.org/wiki/Q49546","display_name":"Acetone","level":2,"score":0.5050941109657288},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.4801625609397888},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.44595199823379517},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.43828505277633667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.418315589427948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3572613298892975},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.34675276279449463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2846035957336426},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24702546000480652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24694690108299255},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23681756854057312},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15332567691802979},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.1411328911781311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13608938455581665}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26452/ijrps.v11ispl4.4288","doi":"https://doi.org/10.26452/ijrps.v11ispl4.4288","is_oa":true,"landing_page_url":"https://doi.org/10.26452/ijrps.v11ispl4.4288","pdf_url":null,"source":{"id":"https://openalex.org/S2764443815","display_name":"International Journal of Research in Pharmaceutical Sciences","issn_l":"0975-7538","issn":["0975-7538"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4323283528","host_organization_name":"Pharmascope Foundation","host_organization_lineage":["https://openalex.org/P4323283528"],"host_organization_lineage_names":["Pharmascope Foundation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Pharmaceutical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.26452/ijrps.v11ispl4.4288","doi":"https://doi.org/10.26452/ijrps.v11ispl4.4288","is_oa":true,"landing_page_url":"https://doi.org/10.26452/ijrps.v11ispl4.4288","pdf_url":null,"source":{"id":"https://openalex.org/S2764443815","display_name":"International Journal of Research in Pharmaceutical Sciences","issn_l":"0975-7538","issn":["0975-7538"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4323283528","host_organization_name":"Pharmascope Foundation","host_organization_lineage":["https://openalex.org/P4323283528"],"host_organization_lineage_names":["Pharmascope Foundation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392123246","https://openalex.org/W4403348758","https://openalex.org/W2569138246","https://openalex.org/W2997040960","https://openalex.org/W4360935693","https://openalex.org/W2291840913","https://openalex.org/W2169763528","https://openalex.org/W7172304047","https://openalex.org/W2096806790","https://openalex.org/W2606779391"],"abstract_inverted_index":{"Calpurnia":[0],"aurea":[1,40,82,94,121,193],"is":[2,198],"a":[3,43,111],"medicinal":[4],"plant":[5],"belonging":[6],"to":[7,58,110,144],"the":[8,15,21,33,36,54,60,92,125,168,174,191,203],"family":[9],"of":[10,23,38,48,53,72,75,80,91,105,151,158,165,184,207,216],"Fabaceae.":[11],"Traditionally":[12],"in":[13,126],"Ethiopia":[14],"leaves":[16,37,77,89,149,170],"have":[17],"been":[18],"used":[19],"for":[20,46,124,202,214],"treatment":[22],"diarrhea,":[24],"leishmaniasis,":[25],"swelling,":[26],"cough":[27],"and":[28,83,141,167,205,209,220],"snake":[29],"bite.":[30],"Based":[31],"on":[32],"traditional":[34],"use":[35],"C.":[39,81,93,120,192],"might":[41],"be":[42],"promising":[44],"source":[45,201],"development":[47,206],"anti-inflammatory":[49,128],"agents.":[50],"The":[51,87,147,186],"objective":[52],"current":[55,187],"research":[56],"was":[57,97],"explore":[59],"5-":[61,131],"Lipooxygenase":[62],"(5-LOX),":[63],"Cyclooxygenase-1":[64,133],"&":[65,68,134],"Cyclooxygenase-2":[66,135],"(COX-1":[67],"COX-2)":[69],"inhibitory":[70,136,156,179,212],"activity":[71,129,157,180],"inflammatory":[73,217,221],"enzymes":[74],"organic":[76,117],"crude":[78],"extract":[79,150,172,196],"its":[84],"phytochemical":[85,145],"analysis.":[86],"dried":[88],"powder":[90],"(100":[95],"g)":[96],"extracted":[98],"with":[99,163,181],"successive":[100],"soxhlet":[101],"extraction":[102],"by":[103,130,138],"solvents":[104],"low":[106],"polarity":[107],"(Petroleum":[108],"ether)":[109],"high":[112],"polar":[113],"solvent":[114],"(Ethanol).":[115],"These":[116],"leaf":[118,194],"extracts":[119],"were":[122],"assessed":[123],"vitro":[127],"Lipooxygenase,":[132],"activities":[137],"ELISA":[139],"method":[140],"further":[142],"subjected":[143],"screening.":[146],"ethanolic":[148],"C.aurea":[152,169],"showed":[153,173],"significant":[154],"5-LOX":[155,208],"51.07%":[159],"at":[160],"100":[161],"\u00b5g/ml":[162],"IC50":[164,183],"95.30\u00b5g/ml":[166],"acetone":[171,195],"selective":[175],"COX-2":[176,210],"index":[177],"(2.35)":[178],"an":[182],"200.75\u03bcg/ml.":[185],"work":[188],"revealed":[189],"that":[190],"(CALAC)":[197],"shows":[199],"potential":[200],"isolation":[204],"dual":[211],"compounds":[213],"management":[215],"related":[218],"diseases":[219],"cancers.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-03-15T00:00:00"}
